{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:11:21Z","timestamp":1784121081696,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-53489-1","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:05:20Z","timestamp":1778904320000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of intrasphincteric botulinum toxin on postoperative urinary retention following stapled hemorrhoidopexy: a randomized, double-blind, placebo-controlled trial"],"prefix":"10.1038","volume":"16","author":[{"given":"Mina","family":"Alvandipour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Safari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Vahidpoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava","family":"Ranjbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"issue":"1","key":"53489_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1055\/s-0035-1568145","volume":"29","author":"H Kunitake","year":"2016","unstructured":"Kunitake, H. & Poylin, V. Complications Following Anorectal Surgery. Clin. Colon Rectal Surg. 29(1), 14\u201321 (2016).","journal-title":"Clin. Colon Rectal Surg."},{"issue":"1","key":"53489_CR2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3393\/ac.2021.00304.0043","volume":"38","author":"HY Jeong","year":"2022","unstructured":"Jeong, H. Y., Song, S. G. & Lee, J. K. Predictors of postoperative urinary retention after semiclosed hemorrhoidectomy. Ann. Coloproctol. 38(1), 53\u201359 (2022).","journal-title":"Ann. Coloproctol"},{"issue":"2","key":"53489_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.4103\/sja.sja_88_24","volume":"18","author":"C Cambise","year":"2024","unstructured":"Cambise, C. et al. Postoperative urinary retention (POUR): A narrative review. Saudi J. Anaesth. 18(2), 265\u2013271 (2024).","journal-title":"Saudi J. Anaesth."},{"issue":"Suppl 3","key":"53489_CR4","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s12262-014-1087-5","volume":"77","author":"M Picchio","year":"2015","unstructured":"Picchio, M. et al. Clinical Outcome Following Hemorrhoid Surgery: a Narrative Review. Indian J. Surg. 77(Suppl 3), 1301\u20131307 (2015).","journal-title":"Indian J. Surg."},{"issue":"7","key":"53489_CR5","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1007\/s00384-005-0077-2","volume":"21","author":"T Toyonaga","year":"2006","unstructured":"Toyonaga, T. et al. Postoperative urinary retention after surgery for benign anorectal disease: potential risk factors and strategy for prevention. Int. J. Colorectal Dis. 21(7), 676\u2013682 (2006).","journal-title":"Int. J. Colorectal Dis."},{"issue":"1","key":"53489_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41598-025-29193-x","volume":"16","author":"A Ferreira","year":"2025","unstructured":"Ferreira, A. et al. Development of urinary impairment after spinal cord injury courses with altered urethral serotonin signalling in the female mice. Sci. Rep. 16(1), 8 (2025).","journal-title":"Sci. Rep."},{"key":"53489_CR7","doi-asserted-by":"publisher","first-page":"107454","DOI":"10.1016\/j.clineuro.2022.107454","volume":"222","author":"NS Hernandez","year":"2022","unstructured":"Hernandez, N. S. et al. Assessing the impact of spinal versus general anesthesia on postoperative urinary retention in elective spinal surgery patients. Clin. Neurol. Neurosurg. 222, 107454 (2022).","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"4","key":"53489_CR8","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.jcot.2018.07.014","volume":"10","author":"N Crouser","year":"2019","unstructured":"Crouser, N. et al. Urinary tract infection (UTI) at time of geriatric hip fracture surgery increases the risk of experiencing adverse 30-day outcomes. J. Clin. Orthop. Trauma. 10(4), 774\u2013778 (2019).","journal-title":"J. Clin. Orthop. Trauma."},{"key":"53489_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5313\/wja.v8.i1.1","volume":"8","author":"K Agrawal","year":"2019","unstructured":"Agrawal, K., Majhi, S. & Garg, R. Post-operative urinary retention: Review of literature. World J. Anesthesiology. 8, 1\u201312 (2019).","journal-title":"World J. Anesthesiology"},{"issue":"7","key":"53489_CR10","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12630-012-9717-5","volume":"59","author":"S Choi","year":"2012","unstructured":"Choi, S., Mahon, P. & Awad, I. T. Neuraxial anesthesia and bladder dysfunction in the perioperative period: a systematic review. Can. J. Anaesth. 59(7), 681\u2013703 (2012).","journal-title":"Can. J. Anaesth."},{"issue":"3","key":"53489_CR11","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1177\/2192568220904681","volume":"11","author":"AR Strickland","year":"2021","unstructured":"Strickland, A. R. et al. Evaluation of Risk Factors for Postoperative Urinary Retention in Elective Thoracolumbar Spinal Fusion Patients. Global Spine J. 11(3), 338\u2013344 (2021).","journal-title":"Global Spine J."},{"issue":"8","key":"53489_CR12","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1001\/jamasurg.2023.2137","volume":"158","author":"SM Croghan","year":"2023","unstructured":"Croghan, S. M. et al. Global Incidence and Risk Factors Associated With Postoperative Urinary Retention Following Elective Inguinal Hernia Repair: The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) Study. JAMA Surg. 158(8), 865\u2013873 (2023).","journal-title":"JAMA Surg."},{"key":"53489_CR13","doi-asserted-by":"crossref","unstructured":"Lohsiriwat, V. & Jitmungngan, R. Strategies to reduce post-hemorrhoidectomy pain: A systematic review. Medicine (Kaunas) 58(3). (2022).","DOI":"10.3390\/medicina58030418"},{"issue":"4","key":"53489_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.23922\/jarc.2020-027","volume":"4","author":"S Sirikurnpiboon","year":"2020","unstructured":"Sirikurnpiboon, S. & Jivapaisarnpong, P. Botulinum Toxin Injection for Analgesic Effect after Hemorrhoidectomy: A Randomized Control Trial. J. Anus Rectum Colon. 4(4), 186\u2013192 (2020).","journal-title":"J. Anus Rectum Colon"},{"key":"53489_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/jrms.JRMS_612_18","volume":"26","author":"M Alvandipour","year":"2021","unstructured":"Alvandipour, M. et al. Postoperative outcomes of intrasphincteric botox injection during hemorrhoidectomy: A double-blind clinical trial. J. Res. Med. Sci. 26, 53 (2021).","journal-title":"J. Res. Med. Sci."},{"issue":"5","key":"53489_CR16","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1097\/ALN.0b013e31819f7aea","volume":"110","author":"G Baldini","year":"2009","unstructured":"Baldini, G. et al. Postoperative urinary retention: anesthetic and perioperative considerations. Anesthesiology 110(5), 1139\u20131157 (2009).","journal-title":"Anesthesiology"},{"issue":"1","key":"53489_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/00000542-199907000-00010","volume":"91","author":"DJ Pavlin","year":"1999","unstructured":"Pavlin, D. J. et al. Management of bladder function after outpatient surgery. Anesthesiology 91(1), 42\u201350 (1999).","journal-title":"Anesthesiology"},{"issue":"6","key":"53489_CR18","first-page":"581","volume":"43","author":"SV Hosseini","year":"2018","unstructured":"Hosseini, S. V. et al. Effects of Stapled Hemorrhoidopexy on Anorectal Function: A Prospective Randomized Controlled Trial. Iran. J. Med. Sci. 43(6), 581\u2013586 (2018).","journal-title":"Iran. J. Med. Sci."},{"issue":"1","key":"53489_CR19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/bjs5.50114","volume":"3","author":"J Jackson","year":"2019","unstructured":"Jackson, J. et al. Systematic review of interventions for the prevention and treatment of postoperative urinary retention. BJS Open. 3(1), 11\u201323 (2019).","journal-title":"BJS Open."},{"key":"53489_CR20","doi-asserted-by":"crossref","unstructured":"Perez, N. E. et al. Neurogenic bladder physiology, pathogenesis, and management after spinal cord injury. J. Pers. Med. 12(6)  (2022).","DOI":"10.3390\/jpm12060968"},{"issue":"4","key":"53489_CR21","doi-asserted-by":"publisher","first-page":"342","DOI":"10.5152\/tjg.2020.19208","volume":"31","author":"N Andromanakos","year":"2020","unstructured":"Andromanakos, N. et al. Puborectalis muscle and External Anal Sphincter: a functional unit? Turk. J. Gastroenterol. 31(4), 342\u2013343 (2020).","journal-title":"Turk. J. Gastroenterol."},{"key":"53489_CR22","doi-asserted-by":"crossref","unstructured":"Jaekel, A. K. et al. The effects of botulinum Toxin A injections on patients with radiogenic lower urinary tract symptoms. Toxins (Basel)  17(4). (2025).","DOI":"10.3390\/toxins17040200"},{"issue":"1","key":"53489_CR23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4103\/0970-1591.109975","volume":"29","author":"B Orasanu","year":"2013","unstructured":"Orasanu, B. & Mahajan, S. T. The use of botulinum toxin for the treatment of overactive bladder syndrome. Indian J. Urol. 29(1), 2\u201311 (2013).","journal-title":"Indian J. Urol."},{"issue":"4","key":"53489_CR24","doi-asserted-by":"publisher","first-page":"400","DOI":"10.31486\/toj.19.0076","volume":"20","author":"L Desrosiers","year":"2020","unstructured":"Desrosiers, L. & Knoepp, L. R. Botulinum Toxin A: A Review of Potential Uses in Treatment of Female Urogenital and Pelvic Floor Disorders. Ochsner J. 20(4), 400\u2013409 (2020).","journal-title":"Ochsner J."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53489-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53489-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53489-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:02:53Z","timestamp":1784120573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53489-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["53489"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-53489-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]},"assertion":[{"value":"4 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"22222"}}