{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:34:16Z","timestamp":1792078456694,"version":"4.4.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL076124"],"award-info":[{"award-number":["T32HL076124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31HL170514"],"award-info":[{"award-number":["F31HL170514"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL122489"],"award-info":[{"award-number":["R01HL122489"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23PRE1026713"],"award-info":[{"award-number":["23PRE1026713"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR230360"],"award-info":[{"award-number":["PR230360"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-53555-8","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:09:35Z","timestamp":1779206975000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regulatory T cell attracting therapy accelerates skeletal muscle functional recovery following injury"],"prefix":"10.1038","volume":"16","author":[{"given":"Matthew A.","family":"Borrelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan J. P.","family":"Warunek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Ann Varghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u0113th R.","family":"Turnquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"53555_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00469-8","volume":"9","author":"P Edouard","year":"2023","unstructured":"Edouard, P. et al. Traumatic muscle injury. Nat. Rev. Dis. Primers 9, 56. https:\/\/doi.org\/10.1038\/s41572-023-00469-8 (2023).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"53555_CR2","volume-title":"Repetitive Strain Injuries in Adults in the Past 3 Months: United States, 2021","author":"Centers for Disease, C. & Prevention","year":"2023","unstructured":"Centers for Disease, C. & Prevention. Repetitive Strain Injuries in Adults in the Past 3 Months: United States, 2021 (National Center for Health Statistics, 2023)."},{"key":"53555_CR3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.semarthrit.2016.07.013","volume":"46","author":"E Yelin","year":"2016","unstructured":"Yelin, E., Weinstein, S. & King, T. The burden of musculoskeletal diseases in the United States. Semin. Arthritis Rheum. 46, 259\u2013260. https:\/\/doi.org\/10.1016\/j.semarthrit.2016.07.013 (2016).","journal-title":"Semin. Arthritis Rheum."},{"key":"53555_CR4","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1177\/1941738113480934","volume":"5","author":"D Delos","year":"2013","unstructured":"Delos, D., Maak, T. G. & Rodeo, S. A. Muscle injuries in athletes: Enhancing recovery through scientific understanding and novel therapies. Sports Health 5, 346\u2013352. https:\/\/doi.org\/10.1177\/1941738113480934 (2013).","journal-title":"Sports Health"},{"key":"53555_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00087","volume":"11","author":"EE Howard","year":"2020","unstructured":"Howard, E. E., Pasiakos, S. M., Blesso, C. N., Fussell, M. A. & Rodriguez, N. R. Divergent roles of inflammation in skeletal muscle recovery from injury. Front. Physiol. 11, 87. https:\/\/doi.org\/10.3389\/fphys.2020.00087 (2020).","journal-title":"Front. Physiol."},{"key":"53555_CR6","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/ptj\/pzx056","volume":"97","author":"E Duchesne","year":"2017","unstructured":"Duchesne, E., Dufresne, S. S. & Dumont, N. A. Impact of inflammation and anti-inflammatory modalities on skeletal muscle healing: From fundamental research to the clinic. Phys. Ther. 97, 807\u2013817. https:\/\/doi.org\/10.1093\/ptj\/pzx056 (2017).","journal-title":"Phys. Ther."},{"key":"53555_CR7","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1152\/japplphysiol.00036.2013","volume":"115","author":"ML Urso","year":"2013","unstructured":"Urso, M. L. Anti-inflammatory interventions and skeletal muscle injury: Benefit or detriment?. J. Appl. Physiol. 115, 920\u2013928. https:\/\/doi.org\/10.1152\/japplphysiol.00036.2013 (2013).","journal-title":"J. Appl. Physiol."},{"key":"53555_CR8","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s40264-021-01085-9","volume":"44","author":"R Brennan","year":"2021","unstructured":"Brennan, R. et al. A scoping review of non-medical and extra-medical use of non-steroidal anti-inflammatory drugs (NSAIDs). Drug Saf. 44, 917\u2013928. https:\/\/doi.org\/10.1007\/s40264-021-01085-9 (2021).","journal-title":"Drug Saf."},{"key":"53555_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1139683","volume":"14","author":"Y Ren","year":"2023","unstructured":"Ren, Y., Backer, H., Muller, M. & Kienzle, A. The role of myeloid derived suppressor cells in musculoskeletal disorders. Front. Immunol. 14, 1139683. https:\/\/doi.org\/10.3389\/fimmu.2023.1139683 (2023).","journal-title":"Front. Immunol."},{"key":"53555_CR10","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/mt.2015.66","volume":"23","author":"J Tonkin","year":"2015","unstructured":"Tonkin, J. et al. Monocyte\/macrophage-derived IGF-1 orchestrates murine skeletal muscle regeneration and modulates autocrine polarization. Mol. Ther. 23, 1189\u20131200. https:\/\/doi.org\/10.1038\/mt.2015.66 (2015).","journal-title":"Mol. Ther."},{"key":"53555_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-359","volume":"14","author":"CH Cote","year":"2013","unstructured":"Cote, C. H., Bouchard, P., van Rooijen, N., Marsolais, D. & Duchesne, E. Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury. BMC Musculoskelet. Disord. 14, 359. https:\/\/doi.org\/10.1186\/1471-2474-14-359 (2013).","journal-title":"BMC Musculoskelet. Disord."},{"key":"53555_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.imlet.2018.10.004","volume":"204","author":"C Zhang","year":"2018","unstructured":"Zhang, C. et al. Regulatory T cells were recruited by CCL3 to promote cryo-injured muscle repair. Immunol. Lett. 204, 29\u201337. https:\/\/doi.org\/10.1016\/j.imlet.2018.10.004 (2018).","journal-title":"Immunol. Lett."},{"key":"53555_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05142-8","volume":"13","author":"J Wu","year":"2022","unstructured":"Wu, J., Ren, B., Wang, D. & Lin, H. Regulatory T cells in skeletal muscle repair and regeneration: Recent insights. Cell Death Dis. 13, 680. https:\/\/doi.org\/10.1038\/s41419-022-05142-8 (2022).","journal-title":"Cell Death Dis."},{"key":"53555_CR14","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.cell.2013.10.054","volume":"155","author":"D Burzyn","year":"2013","unstructured":"Burzyn, D. et al. A special population of regulatory T cells potentiates muscle repair. Cell 155, 1282\u20131295. https:\/\/doi.org\/10.1016\/j.cell.2013.10.054 (2013).","journal-title":"Cell"},{"key":"53555_CR15","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1177\/1753425914527326","volume":"21","author":"J Nicholas","year":"2015","unstructured":"Nicholas, J. et al. Time course of chemokine expression and leukocyte infiltration after acute skeletal muscle injury in mice. Innate Immun. 21, 266\u2013274. https:\/\/doi.org\/10.1177\/1753425914527326 (2015).","journal-title":"Innate Immun."},{"key":"53555_CR16","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1469-7580.2006.00543.x","volume":"208","author":"H Toumi","year":"2006","unstructured":"Toumi, H., F\u2019Guyer, S. & Best, T. M. The role of neutrophils in injury and repair following muscle stretch. J. Anat. 208, 459\u2013470. https:\/\/doi.org\/10.1111\/j.1469-7580.2006.00543.x (2006).","journal-title":"J. Anat."},{"key":"53555_CR17","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e27","volume":"18","author":"JS Roh","year":"2018","unstructured":"Roh, J. S. & Sohn, D. H. Damage-associated molecular patterns in inflammatory diseases. Immune Netw. 18, e27. https:\/\/doi.org\/10.4110\/in.2018.18.e27 (2018).","journal-title":"Immune Netw."},{"key":"53555_CR18","doi-asserted-by":"publisher","first-page":"C1031","DOI":"10.1152\/ajpcell.00467.2003","volume":"286","author":"GL Warren","year":"2004","unstructured":"Warren, G. L. et al. Role of CC chemokines in skeletal muscle functional restoration after injury. Am. J. Physiol. Cell Physiol. 286, C1031-1036. https:\/\/doi.org\/10.1152\/ajpcell.00467.2003 (2004).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"53555_CR19","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1113\/jphysiol.2008.152090","volume":"586","author":"L Yahiaoui","year":"2008","unstructured":"Yahiaoui, L., Gvozdic, D., Danialou, G., Mack, M. & Petrof, B. J. CC family chemokines directly regulate myoblast responses to skeletal muscle injury. J. Physiol. 586, 3991\u20134004. https:\/\/doi.org\/10.1113\/jphysiol.2008.152090 (2008).","journal-title":"J. Physiol."},{"key":"53555_CR20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.it.2020.04.006","volume":"41","author":"B Chazaud","year":"2020","unstructured":"Chazaud, B. Inflammation and skeletal muscle regeneration: Leave it to the macrophages!. Trends Immunol. 41, 481\u2013492. https:\/\/doi.org\/10.1016\/j.it.2020.04.006 (2020).","journal-title":"Trends Immunol."},{"key":"53555_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00127","volume":"9","author":"S Gordon","year":"2018","unstructured":"Gordon, S. & Pluddemann, A. Macrophage clearance of apoptotic cells: A critical assessment. Front. Immunol. 9, 127. https:\/\/doi.org\/10.3389\/fimmu.2018.00127 (2018).","journal-title":"Front. Immunol."},{"key":"53555_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1083\/jcb.201104053","volume":"195","author":"E Perdiguero","year":"2011","unstructured":"Perdiguero, E. et al. p38\/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair. J. Cell Biol. 195, 307\u2013322. https:\/\/doi.org\/10.1083\/jcb.201104053 (2011).","journal-title":"J. Cell Biol."},{"key":"53555_CR23","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1084\/jem.20070075","volume":"204","author":"L Arnold","year":"2007","unstructured":"Arnold, L. et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 204, 1057\u20131069. https:\/\/doi.org\/10.1084\/jem.20070075 (2007).","journal-title":"J. Exp. Med."},{"key":"53555_CR24","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4761427","volume":"2019","author":"J Dort","year":"2019","unstructured":"Dort, J., Fabre, P., Molina, T. & Dumont, N. A. Macrophages are key regulators of stem cells during skeletal muscle regeneration and diseases. Stem Cells Int. 2019, 4761427. https:\/\/doi.org\/10.1155\/2019\/4761427 (2019).","journal-title":"Stem Cells Int."},{"key":"53555_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00585","volume":"9","author":"J Li","year":"2018","unstructured":"Li, J., Tan, J., Martino, M. M. & Lui, K. O. Regulatory T-cells: Potential regulator of tissue repair and regeneration. Front. Immunol. 9, 585. https:\/\/doi.org\/10.3389\/fimmu.2018.00585 (2018).","journal-title":"Front. Immunol."},{"key":"53555_CR26","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/gene.2014.45","volume":"15","author":"O Palomares","year":"2014","unstructured":"Palomares, O. et al. Regulatory T cells and immune regulation of allergic diseases: Roles of IL-10 and TGF-beta. Genes Immun. 15, 511\u2013520. https:\/\/doi.org\/10.1038\/gene.2014.45 (2014).","journal-title":"Genes Immun."},{"key":"53555_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00268","volume":"3","author":"T Hofer","year":"2012","unstructured":"Hofer, T., Krichevsky, O. & Altan-Bonnet, G. Competition for IL-2 between regulatory and effector T cells to chisel immune responses. Front. Immunol. 3, 268. https:\/\/doi.org\/10.3389\/fimmu.2012.00268 (2012).","journal-title":"Front. Immunol."},{"key":"53555_CR28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2023739118","author":"M Tekguc","year":"2021","unstructured":"Tekguc, M., Wing, J. B., Osaki, M., Long, J. & Sakaguchi, S. Treg-expressed CTLA-4 depletes CD80\/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells. Proc. Natl. Acad. Sci. U. S. A. https:\/\/doi.org\/10.1073\/pnas.2023739118 (2021).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"53555_CR29","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1016\/j.jid.2022.03.009","volume":"142","author":"SY Cheon","year":"2022","unstructured":"Cheon, S. Y. et al. IL-33\/regulatory T-cell axis suppresses skin fibrosis. J. Invest. Dermatol. 142, 2668-2676 e2664. https:\/\/doi.org\/10.1016\/j.jid.2022.03.009 (2022).","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"53555_CR30","doi-asserted-by":"publisher","first-page":"ziae101","DOI":"10.1093\/jbmrpl\/ziae101","volume":"8","author":"SK Kaushal","year":"2024","unstructured":"Kaushal, S. K. et al. IL-33 prevents age-related bone loss and memory impairment by suppression of Th17 response: evidence in a d-galactose-induced aging mouse model. JBMR Plus 8(10), ziae101. https:\/\/doi.org\/10.1093\/jbmrpl\/ziae101 (2024).","journal-title":"JBMR Plus"},{"key":"53555_CR31","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nature13577","volume":"513","author":"C Schiering","year":"2014","unstructured":"Schiering, C. et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature 513, 564\u2013568. https:\/\/doi.org\/10.1038\/nature13577 (2014).","journal-title":"Nature"},{"key":"53555_CR32","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1172\/JCI36498","volume":"119","author":"FR D\u2019Alessio","year":"2009","unstructured":"D\u2019Alessio, F. R. et al. CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J. Clin. Invest. 119, 2898\u20132913. https:\/\/doi.org\/10.1172\/JCI36498 (2009).","journal-title":"J. Clin. Invest."},{"issue":"6","key":"53555_CR33","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123919","volume":"4","author":"Q Liu","year":"2019","unstructured":"Liu, Q. et al. IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury. JCI Insight 4(6), e123919. https:\/\/doi.org\/10.1172\/jci.insight.123919 (2019).","journal-title":"JCI Insight"},{"key":"53555_CR34","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.bcp.2017.04.022","volume":"138","author":"PT Veeraveedu","year":"2017","unstructured":"Veeraveedu, P. T. et al. Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress. Biochem. Pharmacol. 138, 73\u201380. https:\/\/doi.org\/10.1016\/j.bcp.2017.04.022 (2017).","journal-title":"Biochem. Pharmacol."},{"key":"53555_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006345","volume":"13","author":"B Popovic","year":"2017","unstructured":"Popovic, B. et al. IL-33\/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon Cytomegalovirus infection. PLoS Pathog. 13, e1006345. https:\/\/doi.org\/10.1371\/journal.ppat.1006345 (2017).","journal-title":"PLoS Pathog."},{"key":"53555_CR36","doi-asserted-by":"publisher","first-page":"7151","DOI":"10.4049\/jimmunol.151.12.7151","volume":"151","author":"TM Doherty","year":"1993","unstructured":"Doherty, T. M., Kastelein, R., Menon, S., Andrade, S. & Coffman, R. L. Modulation of murine macrophage function by IL-13. J. Immunol. 151, 7151\u20137160. https:\/\/doi.org\/10.4049\/jimmunol.151.12.7151 (1993).","journal-title":"J. Immunol."},{"key":"53555_CR37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1146\/annurev-immunol-101320-124243","volume":"40","author":"GK Dwyer","year":"2022","unstructured":"Dwyer, G. K., D\u2019Cruz, L. M. & Turnquist, H. R. Emerging functions of IL-33 in homeostasis and immunity. Annu. Rev. Immunol. 40, 15\u201343. https:\/\/doi.org\/10.1146\/annurev-immunol-101320-124243 (2022).","journal-title":"Annu. Rev. Immunol."},{"key":"53555_CR38","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.immuni.2016.01.009","volume":"44","author":"W Kuswanto","year":"2016","unstructured":"Kuswanto, W. et al. Poor repair of skeletal muscle in aging mice reflects a defect in local, Interleukin-33-dependent accumulation of regulatory T cells. Immunity 44, 355\u2013367. https:\/\/doi.org\/10.1016\/j.immuni.2016.01.009 (2016).","journal-title":"Immunity"},{"key":"53555_CR39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI173593","author":"JJ Warunek","year":"2024","unstructured":"Warunek, J. J. et al. Dysregulated Treg repair responses lead to chronic rejection after heart transplantation. J. Clin. Invest. https:\/\/doi.org\/10.1172\/JCI173593 (2024).","journal-title":"J. Clin. Invest."},{"key":"53555_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.968453","volume":"9","author":"GP Dobson","year":"2022","unstructured":"Dobson, G. P., Morris, J. L. & Letson, H. L. Immune dysfunction following severe trauma: A systems failure from the central nervous system to mitochondria. Front. Med. 9, 968453. https:\/\/doi.org\/10.3389\/fmed.2022.968453 (2022).","journal-title":"Front. Med."},{"key":"53555_CR41","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/cei\/uxac076","volume":"211","author":"BS Hanna","year":"2023","unstructured":"Hanna, B. S., Yaghi, O. K., Langston, P. K. & Mathis, D. The potential for Treg-enhancing therapies in tissue, in particular skeletal muscle, regeneration. Clin. Exp. Immunol. 211, 138\u2013148. https:\/\/doi.org\/10.1093\/cei\/uxac076 (2023).","journal-title":"Clin. Exp. Immunol."},{"key":"53555_CR42","doi-asserted-by":"publisher","first-page":"4735","DOI":"10.1002\/adma.201202513","volume":"24","author":"S Jhunjhunwala","year":"2012","unstructured":"Jhunjhunwala, S. et al. Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo. Adv. Mater. 24, 4735\u20134738. https:\/\/doi.org\/10.1002\/adma.201202513 (2012).","journal-title":"Adv. Mater."},{"key":"53555_CR43","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1158\/0008-5472.CAN-08-2360","volume":"69","author":"M Gobert","year":"2009","unstructured":"Gobert, M. et al. Regulatory T cells recruited through CCL22\/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res. 69, 2000\u20132009. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-2360 (2009).","journal-title":"Cancer Res."},{"key":"53555_CR44","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000764","author":"LA Marshall","year":"2020","unstructured":"Marshall, L. A. et al. Tumors establish resistance to immunotherapy by regulating T(reg) recruitment via CCR4. J. Immunother. Cancer https:\/\/doi.org\/10.1136\/jitc-2020-000764 (2020).","journal-title":"J. Immunother. Cancer"},{"key":"53555_CR45","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/eji.200324429","volume":"34","author":"M Mariani","year":"2004","unstructured":"Mariani, M., Lang, R., Binda, E., Panina-Bordignon, P. & D\u2019Ambrosio, D. Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells. Eur. J. Immunol. 34, 231\u2013240. https:\/\/doi.org\/10.1002\/eji.200324429 (2004).","journal-title":"Eur. J. Immunol."},{"key":"53555_CR46","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1002\/ijc.27966","volume":"132","author":"T Tsujikawa","year":"2013","unstructured":"Tsujikawa, T. et al. Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4\/CCL22 in head and neck squamous cell carcinoma. Int. J. Cancer 132, 2755\u20132766. https:\/\/doi.org\/10.1002\/ijc.27966 (2013).","journal-title":"Int. J. Cancer"},{"key":"53555_CR47","doi-asserted-by":"publisher","first-page":"9739","DOI":"10.18632\/oncotarget.14185","volume":"8","author":"A Maolake","year":"2017","unstructured":"Maolake, A. et al. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis. Oncotarget 8, 9739\u20139751. https:\/\/doi.org\/10.18632\/oncotarget.14185 (2017).","journal-title":"Oncotarget"},{"key":"53555_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132027","author":"Q Wang","year":"2022","unstructured":"Wang, Q. et al. CCL22-polarized TAMs to M2a macrophages in cervical cancer in vitro model. Cells https:\/\/doi.org\/10.3390\/cells11132027 (2022).","journal-title":"Cells"},{"key":"53555_CR49","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax8429","volume":"6","author":"JD Fisher","year":"2020","unstructured":"Fisher, J. D. et al. In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation. Sci. Adv. 6, eaax8429. https:\/\/doi.org\/10.1126\/sciadv.aax8429 (2020).","journal-title":"Sci. Adv."},{"key":"53555_CR50","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.3727\/096368914X685249","volume":"24","author":"J Montane","year":"2015","unstructured":"Montane, J. et al. CCL22 prevents rejection of mouse islet allografts and induces donor-specific tolerance. Cell Transplant. 24, 2143\u20132154. https:\/\/doi.org\/10.3727\/096368914X685249 (2015).","journal-title":"Cell Transplant."},{"key":"53555_CR51","doi-asserted-by":"publisher","first-page":"18525","DOI":"10.1073\/pnas.1302829110","volume":"110","author":"AJ Glowacki","year":"2013","unstructured":"Glowacki, A. J. et al. Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 110, 18525\u201318530. https:\/\/doi.org\/10.1073\/pnas.1302829110 (2013).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"53555_CR52","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jconrel.2017.05.007","volume":"258","author":"ML Ratay","year":"2017","unstructured":"Ratay, M. L. et al. Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease. J. Control. Release 258, 208\u2013217. https:\/\/doi.org\/10.1016\/j.jconrel.2017.05.007 (2017).","journal-title":"J. Control. Release"},{"key":"53555_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113380","author":"Y Wang","year":"2022","unstructured":"Wang, Y., Lu, J. & Liu, Y. Skeletal muscle regeneration in cardiotoxin-induced muscle injury models. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms232113380 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"53555_CR54","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s10974-020-09584-5","volume":"41","author":"S Dalle","year":"2020","unstructured":"Dalle, S. et al. Cardiotoxin-induced skeletal muscle injury elicits profound changes in anabolic and stress signaling, and muscle fiber type composition. J. Muscle Res. Cell Motil. 41, 375\u2013387. https:\/\/doi.org\/10.1007\/s10974-020-09584-5 (2020).","journal-title":"J. Muscle Res. Cell Motil."},{"key":"53555_CR55","doi-asserted-by":"publisher","first-page":"19446","DOI":"10.1073\/pnas.0706832104","volume":"104","author":"MM Tiemessen","year":"2007","unstructured":"Tiemessen, M. M. et al. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes\/macrophages. Proc. Natl. Acad. Sci. U. S. A. 104, 19446\u201319451. https:\/\/doi.org\/10.1073\/pnas.0706832104 (2007).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"53555_CR56","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","volume":"44","author":"TA Wynn","year":"2016","unstructured":"Wynn, T. A. & Vannella, K. M. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44, 450\u2013462. https:\/\/doi.org\/10.1016\/j.immuni.2016.02.015 (2016).","journal-title":"Immunity"},{"key":"53555_CR57","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.4049\/jimmunol.0801124","volume":"182","author":"AW Mailloux","year":"2009","unstructured":"Mailloux, A. W. & Young, M. R. NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment. J. Immunol. 182, 2753\u20132765. https:\/\/doi.org\/10.4049\/jimmunol.0801124 (2009).","journal-title":"J. Immunol."},{"key":"53555_CR58","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.3390\/polym3031377","volume":"3","author":"HK Makadia","year":"2011","unstructured":"Makadia, H. K. & Siegel, S. J. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 3, 1377\u20131397. https:\/\/doi.org\/10.3390\/polym3031377 (2011).","journal-title":"Polymers"},{"key":"53555_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/nano12030354","author":"MM El-Hammadi","year":"2022","unstructured":"El-Hammadi, M. M. & Arias, J. L. Recent advances in the surface functionalization of PLGA-based nanomedicines. Nanomaterials https:\/\/doi.org\/10.3390\/nano12030354 (2022).","journal-title":"Nanomaterials"},{"key":"53555_CR60","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.biomaterials.2006.09.047","volume":"28","author":"J Cheng","year":"2007","unstructured":"Cheng, J. et al. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 28, 869\u2013876. https:\/\/doi.org\/10.1016\/j.biomaterials.2006.09.047 (2007).","journal-title":"Biomaterials"},{"key":"53555_CR61","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.colsurfb.2017.12.001","volume":"162","author":"A Badkas","year":"2018","unstructured":"Badkas, A. et al. Modulation of in vitro phagocytic uptake and immunogenicity potential of modified Herceptin((R))-conjugated PLGA-PEG nanoparticles for drug delivery. Colloids Surf. B. Biointerfaces 162, 271\u2013278. https:\/\/doi.org\/10.1016\/j.colsurfb.2017.12.001 (2018).","journal-title":"Colloids Surf. B. Biointerfaces"},{"key":"53555_CR62","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2165\/00137696-200402030-00002","volume":"2","author":"VR Sinha","year":"2004","unstructured":"Sinha, V. R., Aggarwal, A. & Trehan, A. Biodegradable PEGylated microspheres and nanospheres. Am. J. Drug Deliv. 2, 157\u2013171. https:\/\/doi.org\/10.2165\/00137696-200402030-00002 (2004).","journal-title":"Am. J. Drug Deliv."},{"key":"53555_CR63","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1046\/j.1471-4159.2002.01160.x","volume":"83","author":"J Luo","year":"2002","unstructured":"Luo, J., Borgens, R. & Shi, R. Polyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injury. J. Neurochem. 83, 471\u2013480. https:\/\/doi.org\/10.1046\/j.1471-4159.2002.01160.x (2002).","journal-title":"J. Neurochem."},{"key":"53555_CR64","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainres.2007.03.091","volume":"1155","author":"J Luo","year":"2007","unstructured":"Luo, J. & Shi, R. Polyethylene glycol inhibits apoptotic cell death following traumatic spinal cord injury. Brain Res. 1155, 10\u201316. https:\/\/doi.org\/10.1016\/j.brainres.2007.03.091 (2007).","journal-title":"Brain Res."},{"key":"53555_CR65","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.immuni.2012.09.023","volume":"38","author":"DM Zaiss","year":"2013","unstructured":"Zaiss, D. M. et al. Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity 38, 275\u2013284. https:\/\/doi.org\/10.1016\/j.immuni.2012.09.023 (2013).","journal-title":"Immunity"},{"key":"53555_CR66","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","volume":"162","author":"N Arpaia","year":"2015","unstructured":"Arpaia, N. et al. A distinct function of regulatory T Cells in tissue protection. Cell 162, 1078\u20131089. https:\/\/doi.org\/10.1016\/j.cell.2015.08.021 (2015).","journal-title":"Cell"},{"key":"53555_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612545","author":"FX Pizza","year":"2023","unstructured":"Pizza, F. X. & Buckley, K. H. Regenerating myofibers after an acute muscle injury: What do we really know about them?. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms241612545 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"53555_CR68","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-1-4939-3810-0_6","volume-title":"Skeletal Muscle Regeneration in the Mouse: Methods and Protocols","author":"GA Garry","year":"2016","unstructured":"Garry, G. A., Antony, M. L. & Garry, D. J. Cardiotoxin induced injury and skeletal muscle regeneration. In Skeletal Muscle Regeneration in the Mouse: Methods and Protocols (ed. Kyba, M.) 61\u201371 (Springer New York, 2016)."},{"key":"53555_CR69","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.mod.2016.11.003","volume":"144","author":"SB Lemke","year":"2017","unstructured":"Lemke, S. B. & Schnorrer, F. Mechanical forces during muscle development. Mech. Dev. 144, 92\u2013101. https:\/\/doi.org\/10.1016\/j.mod.2016.11.003 (2017).","journal-title":"Mech. Dev."},{"key":"53555_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114079","volume":"180","author":"D Shi","year":"2022","unstructured":"Shi, D. et al. To PEGylate or not to PEGylate: Immunological properties of nanomedicine\u2019s most popular component, polyethylene glycol and its alternatives. Adv. Drug Deliv. Rev. 180, 114079. https:\/\/doi.org\/10.1016\/j.addr.2021.114079 (2022).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"53555_CR71","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.4049\/jimmunol.2100014","volume":"206","author":"W Jiang","year":"2021","unstructured":"Jiang, W. et al. Extracellular acidity reprograms macrophage metabolism and innate responsiveness. J. Immunol. 206, 3021\u20133031. https:\/\/doi.org\/10.4049\/jimmunol.2100014 (2021).","journal-title":"J. Immunol."},{"key":"53555_CR72","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040869","author":"Y Ohno","year":"2019","unstructured":"Ohno, Y. et al. Lactate stimulates a potential for hypertrophy and regeneration of mouse skeletal muscle. Nutrients https:\/\/doi.org\/10.3390\/nu11040869 (2019).","journal-title":"Nutrients"},{"key":"53555_CR73","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.immuni.2025.02.008","volume":"58","author":"A Llibre","year":"2025","unstructured":"Llibre, A., Kucuk, S., Gope, A., Certo, M. & Mauro, C. Lactate: A key regulator of the immune response. Immunity 58, 535\u2013554. https:\/\/doi.org\/10.1016\/j.immuni.2025.02.008 (2025).","journal-title":"Immunity"},{"key":"53555_CR74","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1175563","volume":"13","author":"M Hosonuma","year":"2023","unstructured":"Hosonuma, M. & Yoshimura, K. Association between pH regulation of the tumor microenvironment and immunological state. Front. Oncol. 13, 1175563. https:\/\/doi.org\/10.3389\/fonc.2023.1175563 (2023).","journal-title":"Front. Oncol."},{"key":"53555_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104998","volume":"25","author":"S Spath","year":"2022","unstructured":"Spath, S., Roan, F., Presnell, S. R., Hollbacher, B. & Ziegler, S. F. Profiling of Tregs across tissues reveals plasticity in ST2 expression and hierarchies in tissue-specific phenotypes. iScience 25, 104998. https:\/\/doi.org\/10.1016\/j.isci.2022.104998 (2022).","journal-title":"iScience"},{"key":"53555_CR76","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/cea.13313","volume":"49","author":"H Hirata","year":"2019","unstructured":"Hirata, H. et al. Th2 cell differentiation from naive CD4(+) T cells is enhanced by autocrine CC chemokines in atopic diseases. Clin. Exp. Allergy 49, 474\u2013483. https:\/\/doi.org\/10.1111\/cea.13313 (2019).","journal-title":"Clin. Exp. Allergy"},{"key":"53555_CR77","doi-asserted-by":"publisher","first-page":"335","DOI":"10.22203\/ecm.v028a23","volume":"28","author":"J Zandstra","year":"2014","unstructured":"Zandstra, J. et al. Microsphere size influences the foreign body reaction. Eur. Cells. Mater. 28, 335\u2013347. https:\/\/doi.org\/10.22203\/ecm.v028a23 (2014).","journal-title":"Eur. Cells. Mater."},{"issue":"Pt 4","key":"53555_CR78","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1242\/jcs.101.4.907","volume":"101","author":"GJ Cannon","year":"1992","unstructured":"Cannon, G. J. & Swanson, J. A. The macrophage capacity for phagocytosis. J. Cell Sci. 101(Pt 4), 907\u2013913. https:\/\/doi.org\/10.1242\/jcs.101.4.907 (1992).","journal-title":"J. Cell Sci."},{"key":"53555_CR79","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.4049\/jimmunol.181.5.3549","volume":"181","author":"M Rosas","year":"2008","unstructured":"Rosas, M. et al. The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. J. Immunol. 181, 3549\u20133557. https:\/\/doi.org\/10.4049\/jimmunol.181.5.3549 (2008).","journal-title":"J. Immunol."},{"key":"53555_CR80","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.intimp.2011.05.014","volume":"11","author":"R Nicolete","year":"2011","unstructured":"Nicolete, R., dos Santos, D. F. & Faccioli, L. H. The uptake of PLGA micro or nanoparticles by macrophages provokes distinct in vitro inflammatory response. Int. Immunopharmacol. 11, 1557\u20131563. https:\/\/doi.org\/10.1016\/j.intimp.2011.05.014 (2011).","journal-title":"Int. Immunopharmacol."},{"key":"53555_CR81","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.humimm.2004.12.006","volume":"66","author":"LS Taams","year":"2005","unstructured":"Taams, L. S. et al. Modulation of monocyte\/macrophage function by human CD4+CD25+ regulatory T cells. Hum. Immunol. 66, 222\u2013230. https:\/\/doi.org\/10.1016\/j.humimm.2004.12.006 (2005).","journal-title":"Hum. Immunol."},{"key":"53555_CR82","doi-asserted-by":"publisher","first-page":"8053","DOI":"10.4049\/jimmunol.181.11.8053","volume":"181","author":"D Hartl","year":"2008","unstructured":"Hartl, D. et al. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J. Immunol. 181, 8053\u20138067. https:\/\/doi.org\/10.4049\/jimmunol.181.11.8053 (2008).","journal-title":"J. Immunol."},{"key":"53555_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218412","author":"J Korbecki","year":"2020","unstructured":"Korbecki, J. et al. CC chemokines in a tumor: A review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms21218412 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"53555_CR84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00183","volume":"7","author":"AE Proudfoot","year":"2016","unstructured":"Proudfoot, A. E. & Uguccioni, M. Modulation of chemokine responses: Synergy and cooperativity. Front. Immunol. 7, 183. https:\/\/doi.org\/10.3389\/fimmu.2016.00183 (2016).","journal-title":"Front. Immunol."},{"key":"53555_CR85","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/eji.200525800","volume":"35","author":"S Sebastiani","year":"2005","unstructured":"Sebastiani, S., Danelon, G., Gerber, B. & Uguccioni, M. CCL22\u2010induced responses are powerfully enhanced by synergy inducing chemokines via CCR4: Evidence for the involvement of first \u03b2\u2010strand of chemokine. Eur. J. Immunol. 35, 746\u2013756. https:\/\/doi.org\/10.1002\/eji.200525800 (2005).","journal-title":"Eur. J. Immunol."},{"key":"53555_CR86","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/thoraxjnl-2016-208597","volume":"72","author":"AE Williams","year":"2017","unstructured":"Williams, A. E. et al. Evidence for chemokine synergy during neutrophil migration in ARDS. Thorax 72, 66\u201373. https:\/\/doi.org\/10.1136\/thoraxjnl-2016-208597 (2017).","journal-title":"Thorax"},{"issue":"1","key":"53555_CR87","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jconrel.2012.01.013","volume":"159","author":"S Jhunjhunwala","year":"2012","unstructured":"Jhunjhunwala, S. et al. Controlled release formulations of IL-2, TGF-\u03b21 and rapamycin for the induction of regulatory T cells. J. Control. Release. 159(1), 78\u201384. https:\/\/doi.org\/10.1016\/j.jconrel.2012.01.013 (2012).","journal-title":"J. Control. Release."},{"key":"53555_CR88","doi-asserted-by":"publisher","DOI":"10.3791\/2610","author":"RM Deacon","year":"2013","unstructured":"Deacon, R. M. Measuring the strength of mice. J Vis Exp https:\/\/doi.org\/10.3791\/2610 (2013).","journal-title":"J Vis Exp"},{"key":"53555_CR89","doi-asserted-by":"publisher","DOI":"10.1371\/currents.md.1e2bec4e78697b7b0ff80ea25a1d38be","author":"E Hoffman","year":"2016","unstructured":"Hoffman, E. & Winder, S. J. A Modified Wire Hanging Apparatus for Small Animal Muscle Function Testing. PLoS Curr https:\/\/doi.org\/10.1371\/currents.md.1e2bec4e78697b7b0ff80ea25a1d38be (2016).","journal-title":"PLoS Curr"},{"key":"53555_CR90","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jneumeth.2011.10.001","volume":"203","author":"SM Klein","year":"2012","unstructured":"Klein, S. M. et al. Noninvasive in vivo assessment of muscle impairment in the mdx mouse model--A comparison of two common wire hanging methods with two different results. J. Neurosci. Methods 203, 292\u2013297. https:\/\/doi.org\/10.1016\/j.jneumeth.2011.10.001 (2012).","journal-title":"J. Neurosci. Methods"},{"key":"53555_CR91","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"P Bankhead","year":"2017","unstructured":"Bankhead, P. et al. QuPath: Open source software for digital pathology image analysis. Sci. Rep. 7, 16878. https:\/\/doi.org\/10.1038\/s41598-017-17204-5 (2017).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53555-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53555-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53555-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:17:04Z","timestamp":1784593024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-53555-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":91,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["53555"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-53555-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7237053\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"28 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"22808"}}