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We combined diffusion-weighted imaging (DWI) and resting-state fMRI in female participants (14 patients with episodic migraine without aura; 15 matched healthy controls) to test how direct and indirect anatomical communication paths in the brain can predict brain function. We used a spectral mapping framework that isolates the contribution of communication paths of a specific length and evaluated how well brain structure predicts brain function within individuals. Analyses of individual path lengths revealed a non-monotonic dissociation: no difference at one-step (direct) paths, but higher mapping accuracy in patients at intermediate indirect scales (four and five steps). At longer scales, contributions attenuated in both groups. Spatial correspondence analyses localized patient-specific effects to default mode network subsystems across multiple atlases. These findings indicate that migraine-related dysfunction reflects altered mesoscale structure-function integration along indirect anatomical routes, and they provide a general approach to dissect structure-function coupling by communication scale in disease.<\/jats:p>","DOI":"10.1038\/s41598-026-53726-7","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:36:16Z","timestamp":1779244576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated anatomical and functional connectivity mapping in episodic migraine: a spectral graph theory approach"],"prefix":"10.1038","volume":"16","author":[{"given":"Gon\u00e7alo","family":"Gr\u00e1cio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Matoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Fouto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Ruiz-Tagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Gil-Gouveia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita G.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Pequito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"53726_CR1","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators","year":"2018","unstructured":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. 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