{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:27:35Z","timestamp":1786494455081,"version":"build-2736575974"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":80,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"ake-off Program","award":["No. TF2024YZZY03"],"award-info":[{"award-number":["No. TF2024YZZY03"]}]},{"name":"Clinical Research Cultivation Programa","award":["No.2023LC004"],"award-info":[{"award-number":["No.2023LC004"]}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Science and Technology plan","doi-asserted-by":"crossref","award":["2025A04J3674"],"award-info":[{"award-number":["2025A04J3674"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-54523-y","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T13:54:33Z","timestamp":1779630873000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["m6A modification-mediated lncRNA UNC5B-AS1 enhances HCC progression through miR-760\/IL6 axis"],"prefix":"10.1038","volume":"16","author":[{"given":"Li-ping","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-sheng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou-feng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"issue":"10","key":"54523_CR1","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","volume":"16","author":"JD Yang","year":"2019","unstructured":"Yang, J. D. et al. A global view of hepatocellular carcinoma: Trends, risk, prevention and management. Nat. Rev. Gastroenterol. Hepatol. 16(10), 589\u2013604 (2019).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"15","key":"54523_CR2","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJMra1713263","volume":"380","author":"A Villanueva","year":"2019","unstructured":"Villanueva, A. Hepatocellular carcinoma. N Engl. J. Med. 380 (15), 1450\u20131462 (2019).","journal-title":"N Engl. J. Med."},{"issue":"9","key":"54523_CR3","doi-asserted-by":"publisher","first-page":"706","DOI":"10.2174\/0109298665330781240830042601","volume":"31","author":"W Ye","year":"2024","unstructured":"Ye, W. et al. Association between higher expression of Vav1 in hepatocellular carcinoma and unfavourable clinicopathological features and prognosis. Protein Pept. Lett. 31(9), 706\u2013713 (2024).","journal-title":"Protein Pept. Lett."},{"issue":"1","key":"54523_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/cr.2010.183","volume":"21","author":"G He","year":"2011","unstructured":"He, G. & Karin, M. NF-\u03baB and STAT3 - key players in liver inflammation and cancer. Cell. Res. 21 (1), 159\u2013168 (2011).","journal-title":"Cell. Res."},{"issue":"4","key":"54523_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1055\/s-0041-1730926","volume":"41","author":"N Li","year":"2021","unstructured":"Li, N., Yamamoto, G., Fuji, H. & Kisseleva, T. Interleukin-17 in liver disease pathogenesis. Semin. Liver Dis. 41(4), 507\u2013515 (2021).","journal-title":"Semin. Liver Dis."},{"key":"54523_CR6","doi-asserted-by":"publisher","first-page":"37070","DOI":"10.1038\/srep37070","volume":"6","author":"H Zheng","year":"2016","unstructured":"Zheng, H. et al. TMED3 promotes hepatocellular carcinoma progression via IL-11\/STAT3 signaling. Sci. Rep. 6, 37070 (2016).","journal-title":"Sci. Rep."},{"key":"54523_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.903117","volume":"13","author":"D Shao","year":"2022","unstructured":"Shao, D. et al. An m6A\/m5C\/m1A\/m7G-related long non-coding: RNA signature to predict prognosis and immune features of glioma. Front. Genet. 13, 903117 (2022).","journal-title":"Front. Genet."},{"key":"54523_CR8","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","volume":"71","author":"R Desrosiers","year":"1974","unstructured":"Desrosiers, R., Friderici, K. & Rottman, F. Identification of methylated nucleosides in messenger RNA from novikoff hepatoma cells. Proc. Natl. Acad. Sci. U S A. 71, 3971\u20133975 (1974).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"54523_CR9","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.7150\/ijbs.60115","volume":"17","author":"J Li","year":"2021","unstructured":"Li, J., Wang, F., Liu, Y., Wang, H. & Ni, B. N6-methyladenosine (m6A) in pancreatic cancer: Regulatory mechanisms and future direction. Int. J. Biol. Sci. 17, 2323\u20132335 (2021).","journal-title":"Int. J. Biol. Sci."},{"key":"54523_CR10","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","volume":"149","author":"KD Meyer","year":"2012","unstructured":"Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2019 UTRs and near stop codons. Cell 149, 1635\u201346 (2012).","journal-title":"Cell"},{"key":"54523_CR11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrg3724","volume":"15","author":"Y Fu","year":"2014","unstructured":"Fu, Y., Dominissini, D., Rechavi, G. & He, C. Gene expression regulation mediated through reversible m6A RNA methylation. Nat. Rev. Genet. 15, 293\u2013306 (2014).","journal-title":"Nat. Rev. Genet."},{"key":"54523_CR12","doi-asserted-by":"publisher","first-page":"11356","DOI":"10.1093\/nar\/gkx778","volume":"45","author":"M Bartosovic","year":"2017","unstructured":"Bartosovic, M. et al. N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3\u2019-end processing. Nucleic Acids Res. 45, 11356\u201311370 (2017).","journal-title":"Nucleic Acids Res."},{"key":"54523_CR13","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/ni1217-1361a","volume":"18","author":"Q Zheng","year":"2017","unstructured":"Zheng, Q., Hou, J., Zhou, Y., Li, Z. & Cao, X. Corrigendum: The RNA helicase DDX46 inhibits innate immunity by entrapping m(6)A-demethylated antiviral transcripts in the nucleus. Nat. Immunol. 18, 1361 (2017).","journal-title":"Nat. Immunol."},{"issue":"1","key":"54523_CR14","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12943-019-1109-9","volume":"18","author":"L He","year":"2019","unstructured":"He, L. et al. Functions of N6-methyladenosine and its role in cancer. Mol. Cancer 18176. (2019).","journal-title":"Mol. Cancer"},{"issue":"3","key":"54523_CR15","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nrd.2016.117","volume":"16","author":"M Matsui","year":"2017","unstructured":"Matsui, M. & Corey, D. R. Non-coding RNAs as drug targets. Nat. Rev. Drug Discov. 16 (3), 167\u2013179 (2017).","journal-title":"Nat. Rev. Drug Discov"},{"issue":"15","key":"54523_CR16","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","volume":"77","author":"A Bhan","year":"2017","unstructured":"Bhan, A., Soleimani, M. & Mandal, S. S. Long noncoding RNA and cancer: a new paradigm. Cancer Res. 77 (15), 3965\u20133981 (2017).","journal-title":"Cancer Res."},{"issue":"Pt B","key":"54523_CR17","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.ijbiomac.2022.09.209","volume":"222","author":"YK El Fattah Abd","year":"2022","unstructured":"El Fattah Abd, Y. K. et al. Interactome battling of lncRNA CCDC144NL-AS1: its role in the emergence and ferocity of cancer and beyond. Int. J. Biol. Macromol. 222 (Pt B), 1676\u20131687 (2022).","journal-title":"Int. J. Biol. Macromol."},{"issue":"20","key":"54523_CR18","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1080\/15384101.2021.1962632","volume":"20","author":"X Huang","year":"2021","unstructured":"Huang, X. et al. UNC5B-AS1 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells via regulating miR-4306\/KDM2A axis. Cell. Cycle. 20 (20), 2114\u20132124 (2021).","journal-title":"Cell. Cycle"},{"issue":"1","key":"54523_CR19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s13018-023-03754-0","volume":"18","author":"Y Yan","year":"2023","unstructured":"Yan, Y. et al. EPB41L4A-AS1 and UNC5B-AS1 have diagnostic and prognostic significance in osteosarcoma. J. Orthop. Surg. Res. 18 (1), 261 (2023).","journal-title":"J. Orthop. Surg. Res."},{"issue":"4","key":"54523_CR20","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1002\/cbin.11300","volume":"44","author":"H Wang","year":"2020","unstructured":"Wang, H., Su, H. & Tan, Y. UNC5B-AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2. Cell. Biol. Int. 44 (4), 1028\u20131036 (2020).","journal-title":"Cell. Biol. Int."},{"issue":"5","key":"54523_CR21","first-page":"2271","volume":"24","author":"SF Tan","year":"2020","unstructured":"Tan, S. F., Ni, J. X. & Xiong, H. LncRNA UNC5B-AS1 promotes malignant progression of prostate cancer by competitive binding to caspase-9. Eur. Rev. Med. Pharmacol. Sci. 24 (5), 2271\u20132280 (2020).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"3","key":"54523_CR22","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s13577-019-00242-8","volume":"32","author":"Y Wang","year":"2019","unstructured":"Wang, Y. et al. The lncRNA UNC5B-AS1 promotes proliferation, migration, and invasion in papillary thyroid cancer cell lines. Hum. Cell. 32 (3), 334\u2013342 (2019).","journal-title":"Hum. Cell"},{"issue":"1","key":"54523_CR23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12920-024-01851-5","volume":"17","author":"Y Song","year":"2024","unstructured":"Song, Y., Chen, B., Jiao, H. & Yi, L. Long noncoding RNA UNC5B-AS1 suppresses cell proliferation by sponging miR-24-3p in glioblastoma multiforme. BMC Med. Genomics. 17 (1), 83 (2024).","journal-title":"BMC Med. Genomics"},{"issue":"1","key":"54523_CR24","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang, X. et al. The role of m6A modification in the biological functions and diseases. Signal. Transduct. Target. Ther. 6 (1), 74 (2021).","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"54523_CR25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12943-020-01258-7","volume":"19","author":"S Zou","year":"2020","unstructured":"Zou, S. et al. Targeting STAT3 in Cancer Immunotherapy. Mol. Cancer. 19 (1), 145 (2020).","journal-title":"Mol. Cancer"},{"key":"54523_CR26","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1172\/JCI84424","volume":"127","author":"BD Adams","year":"2017","unstructured":"Adams, B. D., Parsons, C., Walker, L., Zhang, W. C. & Slack, F. J. Targeting noncoding RNAs in disease. J. Clin. Invest. 127, 761\u2013771. https:\/\/doi.org\/10.1172\/JCI84424 (2017).","journal-title":"J. Clin. Invest."},{"key":"54523_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/srep24922","volume":"6","author":"A Ahadi","year":"2016","unstructured":"Ahadi, A., Brennan, S., Kennedy, P. J., Hutvagner, G. & Tran, N. Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes. Sci. Rep. 6, 24922. https:\/\/doi.org\/10.1038\/srep24922 (2016).","journal-title":"Sci. Rep."},{"key":"54523_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03556-7","volume":"9","author":"JH Ahn","year":"2018","unstructured":"Ahn, J. H. et al. nc886 is induced by TGF-\u03b2 and suppresses the microRNA pathway in ovarian cancer. Nat. Commun. 9, 1166. https:\/\/doi.org\/10.1038\/s41467-018-03556-7 (2018).","journal-title":"Nat. Commun."},{"key":"54523_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.903699","volume":"13","author":"W Liang","year":"2022","unstructured":"Liang, W. et al. Research progress of RNA methylation modification in colorectal cancer. Front. Pharmacol. 13, 903699 (2022).","journal-title":"Front. Pharmacol."},{"key":"54523_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02041-8","volume":"23","author":"Y Li","year":"2024","unstructured":"Li, Y. et al. The role of RNA methylation in tumor immunity and its potential in immunotherapy. Mol. Cancer. 23, 130 (2024).","journal-title":"Mol. Cancer."},{"key":"54523_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01385-w","volume":"21","author":"T Wen","year":"2023","unstructured":"Wen, T. et al. The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing. Cell Commun. Signal. 21, 355 (2023).","journal-title":"Cell Commun. Signal."},{"key":"54523_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01500-4","volume":"21","author":"Y An","year":"2022","unstructured":"An, Y. & Duan, H. The role of m6A RNA methylation in cancer metabolism. Mol. Cancer. 21, 14 (2022).","journal-title":"Mol. Cancer."},{"key":"54523_CR33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.gendis.2021.12.017","volume":"10","author":"Q Zhang","year":"2023","unstructured":"Zhang, Q. & Xu, K. The role of regulators of RNA m6A methylation in lung cancer. Genes Dis. 10, 495\u2013504 (2023).","journal-title":"Genes Dis."},{"key":"54523_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116365","volume":"173","author":"H Ma","year":"2024","unstructured":"Ma, H. et al. N6-methyladenosine (m6A) modification in hepatocellular carcinoma. Biomed. Pharmacother. 173, 116365 (2024).","journal-title":"Biomed. Pharmacother."},{"key":"54523_CR35","doi-asserted-by":"crossref","unstructured":"Qu, Y. et al. Role of N6-methyladenosine RNA modification in cancer. MedComm 2024; 5:e715. (2020).","DOI":"10.1002\/mco2.715"},{"issue":"30","key":"54523_CR36","doi-asserted-by":"publisher","first-page":"e43476","DOI":"10.1097\/MD.0000000000043476","volume":"104","author":"L Zhang","year":"2025","unstructured":"Zhang, L. et al. Advances in research on unphosphorylated STAT3: A review. Med. (Baltim). 104 (30), e43476 (2025).","journal-title":"Med. (Baltim)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54523-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54523-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54523-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:37:18Z","timestamp":1786491438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54523-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["54523"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-54523-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]},"assertion":[{"value":"27 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors are fully accountable for all aspects of the study and ensure the resolution of integrity and accuracy issues; the study complied with ARRIVE guidelines.","order":2,"name":"Ethics","label":"Ethics statement","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"25021"}}