{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:08:33Z","timestamp":1780672113842,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005690","name":"Universit\u00e4t des Saarlandes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005690","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Drug-coated balloon (DCB) therapy promotes beneficial vascular remodeling after percutaneous coronary intervention. However, its mechanisms remain elusive. Given paclitaxel\u2019s neurotoxicity, the effects of paclitaxel (PTX)-DCB treatment on periarterial innervation are unknown. This study assessed the impact of PTX-DCB on periarterial innervation in porcine coronary arteries. Coronary arteries from twelve pigs were treated with balloon catheters across four groups: (1) uncoated balloon (POBA), (2) balloon with 3 \u00b5g PTX\/mm\n                    <jats:sup>2<\/jats:sup>\n                    (1\u2009\u00d7\u20093), (3) balloon with 6 \u00b5g PTX\/mm\n                    <jats:sup>2<\/jats:sup>\n                    (1\u2009\u00d7\u20096) and (4) two balloons each with 6 \u00b5g PTX\/mm\n                    <jats:sup>2<\/jats:sup>\n                    (2\u2009\u00d7\u20096). Quantitative coronary angiography was performed before, during, and after balloon angioplasty, and at day 28 prior to sacrifice. Following sacrifice, tissue samples were taken for histological examination of periarterial nerve fibres. High-dose PTX treatment resulted in late lumen enlargement (+\u20090.29\u2009\u00b1\u20090.60 mm) in the control angiography after 28d compared to POBA treatment (POBA vs. 2\u2009\u00d7\u20096-PTX group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0236). Sympathetic nerve fiber density did not differ between the untreated and balloon-treated segments in the POBA group (untreated: 386.5\u2009\u00b1\u2009169.1 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , balloon: 328.5\u2009\u00b1\u2009289.9 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.6439) but was significantly reduced in the PTX-treated animals (1\u2009\u00d7\u20093-PTX: untreated: 540.9\u2009\u00b1\u2009216.2 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , balloon: 177.0\u2009\u00b1\u2009130.5 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0020; 1\u2009\u00d7\u20096-PTX: untreated: 546.5\u2009\u00b1\u2009226.8 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , balloon: 142.4\u2009\u00b1\u200961.7 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0003; 2\u2009\u00d7\u20096-PTX: untreated: 498.6\u2009\u00b1\u2009404.0 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , balloon: 176.5\u2009\u00b1\u2009103.4 nerves\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0478). PTX-DCB treatment significantly reduced the proportion of periarterial nerve fibers\u2009&lt;\u2009500 \u00b5m\n                    <jats:sup>2<\/jats:sup>\n                    in the balloon-treated segment (\n                    <jats:italic>p<\/jats:italic>\n                    vs. untreated segment: POBA\u2009=\u20090.0267; 1\u2009\u00d7\u20093-PTX\u2009=\u20090.0680; 1\u2009\u00d7\u20096-PTX\u2009=\u20090.0028; 2\u2009\u00d7\u20096-PTX\u2009=\u20090.0391). PTX-DCB therapy exerts previously unrecognized pleiotropic effects by reducing perivascular nerve fiber density, resulting in coronary denervation that may contribute to the luminal gain beyond antiproliferative effects.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-54572-3","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:16:54Z","timestamp":1780553814000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paclitaxel-coated balloon treatment is associated with sympathetic coronary denervation in a porcine model"],"prefix":"10.1038","volume":"16","author":[{"given":"Mert","family":"Tokcan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Bettink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Gemeinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saarraaken","family":"Kulenthiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Scheller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"54572_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","volume":"40","author":"F-J Neumann","year":"2019","unstructured":"Neumann, F.-J. et al. 2018 ESC\/EACTS guidelines on myocardial revascularization. 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SB and SK report no relationships relevant to the contents of this paper to disclose. OG is coinventor of a patent application, applicants Charit\u00e9-Universit\u00e4tsmedizin Berlin and InnoRa GmbH, Berlin, Germany. MB is supported by the Deutsche Forschungsgemeinschaft (German Research Foundation; TTR 219, project number 322900939) and reports personal fees from Abbott, Amgen, Astra Zeneca, Bayer, Boehringer Ingelheim, Cytokinetics, Edwards, Medtronic, Novartis, ReCor, Servier and Vifor. FM has been supported by Deutsche Forschungsgemeinschaft (SFB TRR219, Project-ID 322900939), and Deutsche Herzstiftung. Saarland University has received scientific support from Ablative Solutions, Medtronic and ReCor Medical. Until May 2024, FM has received speaker honoraria\/consulting fees from Ablative Solutions, Astra-Zeneca, Inari, Medtronic, Merck, Novartis, Philips and ReCor Medical. BS is a shareholder of InnoRa GmbH (Berlin, Germany) and has received lecture fees from B.Braun and Medtronic.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17518"}}