{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:29:07Z","timestamp":1786663747573,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":72,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004421","name":"The World Bank Group","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004421","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Timely diagnosis is critical for improving breast cancer outcomes, especially in resource-limited health systems. This study provides the first real-world evidence from Bosnia and Herzegovina on diagnostic and treatment intervals, adherence, and survival in women with breast cancer. We conducted a retrospective analysis of breast cancer cases diagnosed between 2019 and 2023 at the Clinical Centre University of Sarajevo, the largest cancer center in the country, managing approximately 60% of cases in the Federation of Bosnia and Herzegovina. Most patients (78.1%; 95% CI: 73.8\u201382.3) were diagnosed through self-referral due to symptoms, with 62.4% of cancers detected at stages 1 and 2. The mean patient and system diagnostic intervals were 38.1 days (95% CI: 23.4\u201352.8) and 38.6 days (95% CI: 29.9\u201347.3), respectively, with a total diagnostic interval of 70 days (95% CI: 58.9\u201382.5). Almost all diagnostic procedures had a waiting time of less than ten days. Among all women undergoing surgery, radical mastectomy was performed in 61% (95% CI: 55\u201366), while among women with stage 1\u20132 disease, 55% (95% CI: 48\u201362) underwent radical mastectomy. Treatment duration averaged 3.7 months for chemotherapy (95% CI: 3.4\u20134.1) and 0.48 months for radiotherapy (95% CI: 0.26\u20130.69), with higher compliance for radiotherapy (99.5%; 95% CI: 98\u2013100) than chemotherapy (78%; 95% CI: 72\u201384). Three-year progression-free survival was 85.7%, and overall three-year survival was 86%. Early breast cancer detection and favorable survival can be achieved even in resource-constrained settings.<\/jats:p>","DOI":"10.1038\/s41598-026-54863-9","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:52:25Z","timestamp":1780509145000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Breast cancer in Bosnia and Herzegovina: real-world patterns of diagnosis, treatment, and survival outcomes"],"prefix":"10.1038","volume":"16","author":[{"given":"Semir","family":"Be\u0161lija","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Sokolovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Ceri\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anes","family":"Pa\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azra","family":"Grebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Alji\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layan","family":"Mattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Doroshenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Mandrik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"54863_CR1","unstructured":"European Commission JRC (JRC). 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The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding organisation.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"25379"}}