{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:48:44Z","timestamp":1792460924994,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Carl Gustav Carus Dresden an der Technischen Universit\u00e4t Dresden"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rapid coagulation assessment is essential in critical care to enable timely correction of coagulopathy. Viscoelastic testing (VET) supports this goal but may be affected by mechanical stress during transport by pneumatic tube systems (PTS). As PTS are widely used to expedite sample delivery, evaluating the robustness of next-generation VET and platelet function assays under these conditions is crucial for reliable, time-sensitive diagnostics in intensive care. This study investigated the impact of PTS transport on VET and platelet function testing in healthy individuals and septic patients, including quantitative analysis of acceleration forces. This randomized trial applied a non-systematic sample-level allocation of paired blood samples from 46 healthy volunteers and 45 septic patients to manual and PTS transport. Acceleration was quantified via three-axis accelerometry. Samples were analyzed using ClotPro, ROTEM, TEG PlateletMapping, and Multiplate. Primary objective was the difference in test results following both transport modes. Analyses were performed on paired datasets (manual vs. PTS) per participant and assay. As pre-specified in the protocol, logistic regression modeled the probability of a clinically relevant EX-test clotting time (CT) change (\u2265\u200910\u00a0s) within each cohort. Given the absence of associations, secondary equivalence analyses (TOST [two one-sided tests] and bootstrap) assessed whether observed effects were within pre-specified bounds. Neither logistic regression nor correlation analysis indicated an effect of mechanical stress on variable changes (all \u03c1\u2009&lt;\u20090.5;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.01). Across platforms, most viscoelastic and platelet function variables remained within predefined equivalence margins after PTS transport. Exceptions were TEG PlateletMapping HKH-R and, by bootstrap, ADP\/AA-inhibition. In healthy volunteers, equivalence was confirmed for all variables (TOST\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In septic patients, minor shifts remained within clinically acceptable limits, with equivalence confirmed for ClotPro IN-test CT (\u00b1\u200916s, p\n                    <jats:sub>lower<\/jats:sub>\n                    = 0.036; p\n                    <jats:sub>upper<\/jats:sub>\n                    &lt; 0.001), EX-test MCF (\u00b1\u20092\u00a0mm, both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), ROTEM INTEM CT (\u00b1\u200916s, both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), Multiplate TRAP (\u00b1\u200910U, p\n                    <jats:sub>lower<\/jats:sub>\n                    = 0.001; p\n                    <jats:sub>upper<\/jats:sub>\n                    &lt; 0.001), and TEG PlateletMapping ADP\/AA inhibition (\u00b1\u20095%, both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Most next-generation viscoelastic and platelet assays are robust to PTS-induced stress. Coagulation diagnostics can include PTS transport without compromising validity. Only selected TEG PlateletMapping variables exhibited variability, indicating limited robustness. Trial registration: The study is retrospectively registered with the German Clinical Trials Register (DRKS00036231;\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/search\/de\/trial\/DRKS00036231\/details\" ext-link-type=\"uri\">https:\/\/drks.de\/search\/de\/trial\/DRKS00036231\/details<\/jats:ext-link>\n                    on 20.02.2025).\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-54938-7","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T15:25:42Z","timestamp":1779981942000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of pneumatic tube systems on next-generation viscoelastic coagulation test devices in septic patients and healthy individuals: Results of the randomized controlled VETaPT trial"],"prefix":"10.1038","volume":"16","author":[{"given":"Martin","family":"Mirus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Buehrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Tiebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schnabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Beyer-Westendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Thielecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Markus","family":"Spieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Heubner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"issue":"7","key":"54938_CR1","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/anae.14670","volume":"74","author":"J Gratz","year":"2019","unstructured":"Gratz, J. et al. Protocolised thromboelastometric-guided haemostatic management in patients with traumatic brain injury: A pilot study. Anaesthesia 74(7), 883\u201390. https:\/\/doi.org\/10.1111\/anae.14670 (2019).","journal-title":"Anaesthesia"},{"issue":"6","key":"54938_CR2","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1097\/TA.0000000000002944","volume":"89","author":"N Bugaev","year":"2020","unstructured":"Bugaev, N. et al. Thromboelastography and rotational thromboelastometry in bleeding patients with coagulopathy: Practice management guideline from the Eastern Association for the Surgery of Trauma. J. Trauma Acute Care Surg. 89(6), 999\u20131017. https:\/\/doi.org\/10.1097\/TA.0000000000002944 (2020).","journal-title":"J. Trauma Acute Care Surg."},{"issue":"1","key":"54938_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13054-019-2347-3","volume":"23","author":"DR Spahn","year":"2019","unstructured":"Spahn, D. R. et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit. Care. 23 (1), 98. https:\/\/doi.org\/10.1186\/s13054-019-2347-3 (2019). PubMed PMID: 30917843; PubMed Central PMCID: PMC6436241.","journal-title":"Crit. Care"},{"issue":"5","key":"54938_CR4","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s00101-025-01524-7","volume":"74","author":"M Mirus","year":"2025","unstructured":"Mirus, M. et al. Point-of-care-Gerinnungsdiagnostik \u2013 zwingend notwendig oder nur eine sinnvolle Erg\u00e4nzung?. Anaesthesiologie 74(5), 264\u201374. https:\/\/doi.org\/10.1007\/s00101-025-01524-7 (2025).","journal-title":"Anaesthesiologie"},{"issue":"1","key":"54938_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-015-0036-2","volume":"13","author":"N Tynng\u00e5rd","year":"2015","unstructured":"Tynng\u00e5rd, N., Lindahl, T. L. & Ramstr\u00f6m, S. Assays of different aspects of haemostasis \u2013 What do they measure?. Thrombosis J 13(1), 8. https:\/\/doi.org\/10.1186\/s12959-015-0036-2 (2015).","journal-title":"Thrombosis J"},{"key":"54938_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.23736\/S0375-9393.22.16380-7","volume":"88","author":"L Heubner","year":"2022","unstructured":"Heubner, L. et al. Point of care coagulation management in anesthesiology and critical care. Minerva Anestesiol. 88, 7\u20138. https:\/\/doi.org\/10.23736\/S0375-9393.22.16380-7 (2022).","journal-title":"Minerva Anestesiol"},{"issue":"5","key":"54938_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051407","volume":"11","author":"V Pavoni","year":"2022","unstructured":"Pavoni, V. et al. \u201cIn less than no time\u201d: Feasibility of rotational thromboelastometry to detect anticoagulant drugs activity and to guide reversal therapy. JCM 11(5), 1407. https:\/\/doi.org\/10.3390\/jcm11051407 (2022).","journal-title":"JCM"},{"issue":"1","key":"54938_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-022-00403-0","volume":"20","author":"L Heubner","year":"2022","unstructured":"Heubner, L. et al. Predictive ability of viscoelastic testing using ClotPro\u00ae for short-term outcome in patients with severe Covid-19 ARDS with or without ECMO therapy: A retrospective study. Thrombosis J 20(1), 48. https:\/\/doi.org\/10.1186\/s12959-022-00403-0 (2022).","journal-title":"Thrombosis J"},{"issue":"3","key":"54938_CR9","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.bja.2020.12.010","volume":"126","author":"M Bachler","year":"2021","unstructured":"Bachler, M. et al. Impaired fibrinolysis in critically ill COVID-19 patients. Br. J. Anaesth. 126(3), 590\u20138. https:\/\/doi.org\/10.1016\/j.bja.2020.12.010 (2021).","journal-title":"Br. J. Anaesth."},{"issue":"15","key":"54938_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/s20154254","volume":"20","author":"SD Sahli","year":"2020","unstructured":"Sahli, S. D. et al. Point-of-care diagnostics in coagulation management. Sensors 20(15), 4254. https:\/\/doi.org\/10.3390\/s20154254 (2020).","journal-title":"Sensors"},{"issue":"3","key":"54938_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030860","volume":"11","author":"O Volod","year":"2022","unstructured":"Volod, O. et al. Viscoelastic hemostatic assays: A primer on legacy and new generation devices. JCM 11(3), 860. https:\/\/doi.org\/10.3390\/jcm11030860 (2022).","journal-title":"JCM"},{"issue":"10","key":"54938_CR12","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1111\/j.1365-2044.2012.07231.x","volume":"67","author":"NS Weitzel","year":"2012","unstructured":"Weitzel, N. S. et al. Platelet mapping as part of modified thromboelastography (TEG\u00ae ) in patients undergoing cardiac surgery and cardiopulmonary bypass. Anaesthesia 67(10), 1158\u201365. https:\/\/doi.org\/10.1111\/j.1365-2044.2012.07231.x (2012).","journal-title":"Anaesthesia"},{"issue":"1","key":"54938_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4103\/ajts.AJTS_52_18","volume":"13","author":"JJ Kok","year":"2019","unstructured":"Kok, J. J., Lam, C. L. & Lee, M. J. Reducing delivery times of emergency blood products through pneumatic tube systems. Asian J. Transfus. Sci. 13 (1), 3. https:\/\/doi.org\/10.4103\/ajts.AJTS_52_18 (2019).","journal-title":"Asian J. Transfus. Sci."},{"key":"54938_CR14","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.288","author":"O Wallin","year":"2008","unstructured":"Wallin, O., S\u00f6derberg, J., Grankvist, K., Jonsson, P. A. & Hultdin, J. Preanalytical effects of pneumatic tube transport on routine haematology, coagulation parameters, platelet function and global coagulation. Clin. Chem. Lab. Med. https:\/\/doi.org\/10.1515\/CCLM.2008.288 (2008).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"4","key":"54938_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1751-553X.2011.01303.x","volume":"33","author":"G Colucci","year":"2011","unstructured":"Colucci, G., Giabbani, E., Barizzi, G., Urwyler, N. & Alberio, L. Laboratory-based ROTEM\u00ae analysis: Implementing pneumatic tube transport and real-time graphic transmission: Laboratory-based ROTEM analysis. Int. J. Lab. Hematol. 33(4), 441\u20136. https:\/\/doi.org\/10.1111\/j.1751-553X.2011.01303.x (2011).","journal-title":"Int. J. Lab. Hematol."},{"issue":"4","key":"54938_CR16","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/bja\/aes213","volume":"109","author":"J Martin","year":"2012","unstructured":"Martin, J., Schuster, T., Moessmer, G., Kochs, E. F. & Wagner, K. J. Alterations in rotation thromboelastometry (ROTEM \u00ae) parameters: point-of-care testing vs analysis after pneumatic tube system transport. Br. J. Anaesth. 109 (4), 540\u2013545. https:\/\/doi.org\/10.1093\/bja\/aes213 (2012).","journal-title":"Br. J. Anaesth."},{"issue":"5","key":"54938_CR17","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1111\/ijlh.13470","volume":"43","author":"H Lorenzen","year":"2021","unstructured":"Lorenzen, H. et al. Pneumatic tube transport of blood samples affects global hemostasis and platelet function assays. Int J Lab Hematology 43(5), 1207\u201315. https:\/\/doi.org\/10.1111\/ijlh.13470 (2021).","journal-title":"Int J Lab Hematology"},{"issue":"3","key":"54938_CR18","doi-asserted-by":"publisher","first-page":"e147","DOI":"10.1016\/j.thromres.2012.05.002","volume":"130","author":"MD Lanc\u00e9","year":"2012","unstructured":"Lanc\u00e9, M. D. et al. The effects of pneumatic tube system transport on ROTEM analysis and contact activation assessed by thrombin generation test. Thromb. Res. 130(3), e147-50. https:\/\/doi.org\/10.1016\/j.thromres.2012.05.002 (2012).","journal-title":"Thromb. Res."},{"key":"54938_CR19","unstructured":"German Clinical Trials Register [Internet]. [cited 2025 Jun 16]. German Clinical Trials Register. Available from: https:\/\/drks.de\/search\/de\/trial\/DRKS00036231"},{"key":"54938_CR20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-081123","volume":"389","author":"S Hopewell","year":"2025","unstructured":"Hopewell, S. et al. CONSORT 2025 statement: Updated guideline for reporting randomised trials. BMJ e081123. https:\/\/doi.org\/10.1136\/bmj-2024-081123 (2025).","journal-title":"BMJ"},{"key":"54938_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1613276","volume":"12","author":"M Mirus","year":"2025","unstructured":"Mirus, M. et al. Effects of pneumatic tube systems on viscoelastic coagulation tests in septic patients and healthy individuals: protocol of the randomized controlled VETaPT-trial. Front. Med. 12, 1613276. https:\/\/doi.org\/10.3389\/fmed.2025.1613276 (2025).","journal-title":"Front. Med."},{"issue":"8","key":"54938_CR22","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1001\/jama.2016.0288","volume":"315","author":"CW Seymour","year":"2016","unstructured":"Seymour, C. W. et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315(8), 762. https:\/\/doi.org\/10.1001\/jama.2016.0288 (2016).","journal-title":"JAMA"},{"issue":"10","key":"54938_CR23","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1373\/clinchem.2011.167932","volume":"57","author":"T Streichert","year":"2011","unstructured":"Streichert, T. et al. Determination of Hemolysis Thresholds by the Use of Data Loggers in Pneumatic Tube Systems. Clin. Chem. 57(10), 1390\u20137. https:\/\/doi.org\/10.1373\/clinchem.2011.167932 (2011).","journal-title":"Clin. Chem."},{"issue":"4","key":"54938_CR24","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","volume":"41","author":"F Faul","year":"2009","unstructured":"Faul, F., Erdfelder, E., Buchner, A. & Lang, A. G. Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav. Res. Methods 41(4), 1149\u201360. https:\/\/doi.org\/10.3758\/BRM.41.4.1149 (2009).","journal-title":"Behav. Res. Methods"},{"issue":"6","key":"54938_CR25","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/BF01068419","volume":"15","author":"DJ Schuirmann","year":"1987","unstructured":"Schuirmann, D. J. A comparison of the Two One-Sided Tests Procedure and the Power Approach for assessing the equivalence of average bioavailability. J. Pharmacokinet. Biopharm. 15(6), 657\u201380. https:\/\/doi.org\/10.1007\/BF01068419 (1987).","journal-title":"J. Pharmacokinet. Biopharm."},{"issue":"4","key":"54938_CR26","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1177\/1948550617697177","volume":"8","author":"D Lakens","year":"2017","unstructured":"Lakens, D. Equivalence Tests: A Practical Primer for t Tests, Correlations, and Meta-Analyses. Soc. Psychol. Personal. Sci. 8(4), 355\u201362. https:\/\/doi.org\/10.1177\/1948550617697177 (2017).","journal-title":"Soc. Psychol. Personal. Sci."},{"key":"54938_CR27","doi-asserted-by":"publisher","unstructured":"Caldwell, A. R. Exploring Equivalence Testing with the Updated TOSTER R Package [Internet]. 2022 [cited 2025 Jun 16]. Available from: https:\/\/osf.io\/ty8dehttps:\/\/doi.org\/10.31234\/osf.io\/ty8de","DOI":"10.31234\/osf.io\/ty8de"},{"key":"54938_CR28","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0800","author":"G Amann","year":"2012","unstructured":"Amann, G., Zehntner, C., Marti, F. & Colucci, G. Effect of acceleration forces during transport through a pneumatic tube system on ROTEM\u00ae analysis. Clin. Chem. Lab. Med. https:\/\/doi.org\/10.1515\/cclm-2011-0800 (2012).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"6","key":"54938_CR29","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3109\/09537104.2012.718383","volume":"24","author":"M Glas","year":"2013","unstructured":"Glas, M., Mauer, D., Kassas, H., Volk, T. & Kreuer, S. Sample transport by pneumatic tube system alters results of multiple electrode aggregometry but not rotational thromboelastometry. Platelets 24(6), 454\u201361. https:\/\/doi.org\/10.3109\/09537104.2012.718383 (2013).","journal-title":"Platelets"},{"issue":"4","key":"54938_CR30","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/09537104.2018.1430361","volume":"29","author":"PH Nissen","year":"2018","unstructured":"Nissen, P. H., Wulff, D. E., T\u00f8rring, N. & Hvas, A. M. The impact of pneumatic tube transport on whole blood coagulation and platelet function assays. Platelets 29 (4), 421\u2013424. https:\/\/doi.org\/10.1080\/09537104.2018.1430361 (2018).","journal-title":"Platelets"},{"key":"54938_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.thromres.2016.12.022","volume":"153","author":"S Le Quellec","year":"2017","unstructured":"Le Quellec, S. et al. Pre-analytical effects of pneumatic tube system transport on routine haematology and coagulation tests, global coagulation assays and platelet function assays. Thromb. Res. 153, 7\u201313. https:\/\/doi.org\/10.1016\/j.thromres.2016.12.022 (2017).","journal-title":"Thromb. Res."},{"issue":"1","key":"54938_CR32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.thromres.2013.04.020","volume":"132","author":"S Thal\u00e9n","year":"2013","unstructured":"Thal\u00e9n, S., Forsling, I., Eintrei, J., S\u00f6derblom, L. & Antovic, J. P. Pneumatic tube transport affects platelet function measured by multiplate electrode aggregometry. Thromb. Res. 132 (1), 77\u201380. https:\/\/doi.org\/10.1016\/j.thromres.2013.04.020 (2013).","journal-title":"Thromb. Res."},{"issue":"7","key":"54938_CR33","doi-asserted-by":"publisher","first-page":"458","DOI":"10.3109\/09537100903236462","volume":"20","author":"D Bolliger","year":"2009","unstructured":"Bolliger, D. et al. Pre-analytical effects of pneumatic tube transport on impedance platelet aggregometry. Platelets 20 (7), 458\u2013465. https:\/\/doi.org\/10.3109\/09537100903236462 (2009).","journal-title":"Platelets"},{"issue":"3","key":"54938_CR34","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1308\/rcsann.2025.0091","volume":"108","author":"JA Broomfield","year":"2026","unstructured":"Broomfield, J. A., Abidia, A. & Gopal, J. Thromboelastography and clinical outcomes in peripheral arterial disease: a systematic review and narrative synthesis. annals 108 (3), 170\u2013183. https:\/\/doi.org\/10.1308\/rcsann.2025.0091 (2026).","journal-title":"annals"},{"issue":"4","key":"54938_CR35","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1097\/TA.0000000000004894","volume":"100","author":"JR Killinger","year":"2026","unstructured":"Killinger, J. R. et al. Platelet function assays fail to detect differences between transfusion of cold or room temperature platelets in traumatic brain injury patients. J. Trauma. Acute Care Surg. 100 (4), 555\u2013561. https:\/\/doi.org\/10.1097\/TA.0000000000004894 (2026).","journal-title":"J. Trauma. Acute Care Surg."},{"issue":"6","key":"54938_CR36","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1080\/09537104.2016.1237626","volume":"28","author":"BH Kirmani","year":"2017","unstructured":"Kirmani, B. H., Johnson, R. I. & Agarwal, S. Platelet function testing in cardiac surgery: A comparative study of electrical impedance aggregometry and thromboelastography. Platelets 28 (6), 550\u2013554. https:\/\/doi.org\/10.1080\/09537104.2016.1237626 (2017).","journal-title":"Platelets"},{"issue":"1","key":"54938_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s11239-019-01971-1","volume":"50","author":"JD Dias","year":"2020","unstructured":"Dias, J. D. et al. Comparison of three common whole blood platelet function tests for in vitro P2Y12 induced platelet inhibition. J. Thromb. Thrombolysis. 50 (1), 135\u2013143. https:\/\/doi.org\/10.1007\/s11239-019-01971-1 (2020).","journal-title":"J. Thromb. Thrombolysis"},{"key":"54938_CR38","unstructured":"Research Data Repository of Saxon Universities [Internet]. Available from: https:\/\/opara.zih.tu-dresden.de\/home"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54938-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54938-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54938-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T15:35:28Z","timestamp":1779982528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-54938-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["54938"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-54938-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"15 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the responsible Ethics Committee of the Technical University of Dresden (BO-EK-12012024_1). Written informed consent was obtained from all participants or their legal representatives prior to enrollment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"16587"}}