{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:47:36Z","timestamp":1785887256701,"version":"3.56.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":71,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ningxia Youth Top Talent Training Project"},{"name":"Leading Talent Development Program in Science and Technology of Ningxia"},{"name":"Ningxia Key Research and Development Program Project"},{"name":"Research Project of the Health System of Ningxia Hui Autonomous Region"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-55204-6","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:55:26Z","timestamp":1779803726000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["H. pylori-induced hsa_circ_0085465 promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-33b-3p"],"prefix":"10.1038","volume":"16","author":[{"given":"Jing","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"55204_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J. Clin. 74, 229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834 (2024).","journal-title":"Cancer J. Clin."},{"key":"55204_CR2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.trecan.2024.03.008","volume":"10","author":"T Yasuda","year":"2024","unstructured":"Yasuda, T. & Wang, Y. A. Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development. Trends cancer. 10, 627\u2013642. https:\/\/doi.org\/10.1016\/j.trecan.2024.03.008 (2024).","journal-title":"Trends cancer"},{"key":"55204_CR3","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1136\/gutjnl-2015-309168","volume":"64","author":"S Mocellin","year":"2015","unstructured":"Mocellin, S., Verdi, D., Pooley, K. A. & Nitti, D. Genetic variation and gastric cancer risk: a field synopsis and meta-analysis. Gut 64, 1209\u20131219. https:\/\/doi.org\/10.1136\/gutjnl-2015-309168 (2015).","journal-title":"Gut"},{"key":"55204_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01654-2","author":"Y Duan","year":"2025","unstructured":"Duan, Y., Xu, Y., Dou, Y. & Xu, D. Helicobacter pylori and gastric cancer: mechanisms and new perspectives. J. Hematol. Oncol. https:\/\/doi.org\/10.1186\/s13045-024-01654-2 (2025).","journal-title":"J. Hematol. Oncol."},{"key":"55204_CR5","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2174\/0109298665350654250111144722","volume":"32","author":"Q Suyila","year":"2025","unstructured":"Suyila, Q., Li, X. & Su, X. Anti-Cancer Bioactive Peptide Induces Apoptosis in Gastric Cancer Cells through TP53 Signaling Cascade. Protein Pept. Lett. 32, 194\u2013205. https:\/\/doi.org\/10.2174\/0109298665350654250111144722 (2025).","journal-title":"Protein Pept. Lett."},{"key":"55204_CR6","doi-asserted-by":"publisher","first-page":"380","DOI":"10.2174\/0113892029300694240612081006","volume":"25","author":"Q Li","year":"2024","unstructured":"Li, Q., Chu, Y., Yao, Y. & Song, Q. FAT4 Mutation is Related to Tumor Mutation Burden and Favorable Prognosis in Gastric Cancer. Curr. Genom. 25, 380\u2013389. https:\/\/doi.org\/10.2174\/0113892029300694240612081006 (2024).","journal-title":"Curr. Genom."},{"key":"55204_CR7","doi-asserted-by":"publisher","first-page":"e18761429318398","DOI":"10.2174\/0118761429318398240918063450","volume":"17","author":"X Zhang","year":"2024","unstructured":"Zhang, X. et al. Upregulation of LncRNA WT1-AS Inhibits Tumor Growth and Promotes Autophagy in Gastric Cancer via Suppression of PI3K\/Akt\/mTOR Pathway. Curr. Mol. Pharmacol. 17, e18761429318398. https:\/\/doi.org\/10.2174\/0118761429318398240918063450 (2024).","journal-title":"Curr. Mol. Pharmacol."},{"key":"55204_CR8","doi-asserted-by":"publisher","first-page":"e18761429322420","DOI":"10.2174\/0118761429322420241112051105","volume":"17","author":"S Fatima","year":"2024","unstructured":"Fatima, S. et al. Exploring the Pharmacological Mechanisms of P-hydroxylcinnamaldehyde for Treating Gastric Cancer: A Pharmacological Perspective with Experimental Confirmation. Curr. Mol. Pharmacol. 17, e18761429322420. https:\/\/doi.org\/10.2174\/0118761429322420241112051105 (2024).","journal-title":"Curr. Mol. Pharmacol."},{"key":"55204_CR9","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/ejhg.2017.138","volume":"25","author":"IP Vogelaar","year":"2017","unstructured":"Vogelaar, I. P. et al. Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing. Eur. J. Hum. genetics: EJHG. 25, 1246\u20131252. https:\/\/doi.org\/10.1038\/ejhg.2017.138 (2017).","journal-title":"Eur. J. Hum. genetics: EJHG"},{"key":"55204_CR10","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.cmi.2015.06.004","volume":"21","author":"F M\u00e9graud","year":"2015","unstructured":"M\u00e9graud, F., Bess\u00e8de, E. & Varon, C. Helicobacter pylori infection and gastric carcinoma. Clin. Microbiol. infection: official publication Eur. Soc. Clin. Microbiol. Infect. Dis. 21, 984\u2013990. https:\/\/doi.org\/10.1016\/j.cmi.2015.06.004 (2015).","journal-title":"Clin. Microbiol. infection: official publication Eur. Soc. Clin. Microbiol. Infect. Dis."},{"key":"55204_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9122502","author":"YY Cheok","year":"2021","unstructured":"Cheok, Y. Y. et al. An Overview of Helicobacter pylori Survival Tactics in the Hostile Human Stomach Environment. Microorganisms. https:\/\/doi.org\/10.3390\/microorganisms9122502 (2021).","journal-title":"Microorganisms"},{"key":"55204_CR12","doi-asserted-by":"publisher","first-page":"6221","DOI":"10.3892\/ol.2019.10976","volume":"18","author":"F Zhang","year":"2019","unstructured":"Zhang, F. et al. Molecular mechanism of Helicobacter pylori-induced autophagy in gastric cancer. Oncol. Lett. 18, 6221\u20136227. https:\/\/doi.org\/10.3892\/ol.2019.10976 (2019).","journal-title":"Oncol. Lett."},{"key":"55204_CR13","doi-asserted-by":"publisher","first-page":"103016","DOI":"10.1016\/j.tice.2025.103016","volume":"96","author":"Z Feng","year":"2025","unstructured":"Feng, Z. et al. Helicobacter pylori infection induces STAT3\/MYBL2\/NF-\u03baB axis to promote gastric cancer progression. Tissue cell. 96, 103016. https:\/\/doi.org\/10.1016\/j.tice.2025.103016 (2025).","journal-title":"Tissue cell."},{"key":"55204_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042168","author":"J Korbecki","year":"2022","unstructured":"Korbecki, J. et al. CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms23042168 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"55204_CR15","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s12935-023-03177-1","volume":"23","author":"W Cheng","year":"2023","unstructured":"Cheng, W. et al. Helicobacter pylori-induced fibroblast-derived Serpin E1 promotes gastric cancer growth and peritoneal dissemination through p38 MAPK\/VEGFA-mediated angiogenesis. Cancer Cell Int. 23, 326. https:\/\/doi.org\/10.1186\/s12935-023-03177-1 (2023).","journal-title":"Cancer Cell Int."},{"key":"55204_CR16","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.3892\/mmr.2018.9405","volume":"18","author":"L Liu","year":"2018","unstructured":"Liu, L., Shuai, T., Li, B., Zhu, L. & Li, X. Long non\u2013coding RNA lnc\u2013GNAT1\u20131 inhibits gastric cancer cell proliferation and invasion through the Wnt\/\u03b2\u2013catenin pathway in Helicobacter pylori infection. Mol. Med. Rep. 18, 4009\u20134015. https:\/\/doi.org\/10.3892\/mmr.2018.9405 (2018).","journal-title":"Mol. Med. Rep."},{"key":"55204_CR17","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/gutjnl-2016-312141","volume":"66","author":"S Zhu","year":"2017","unstructured":"Zhu, S. et al. Helicobacter pylori-induced cell death is counteracted by NF-\u03baB-mediated transcription of DARPP-32. Gut 66, 761\u2013762. https:\/\/doi.org\/10.1136\/gutjnl-2016-312141 (2017).","journal-title":"Gut"},{"key":"55204_CR18","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1096\/fj.201701456RR","volume":"33","author":"L Shao","year":"2019","unstructured":"Shao, L. et al. Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer. FASEB journal: official publication Federation Am. Soc. Experimental Biology. 33, 264\u2013274. https:\/\/doi.org\/10.1096\/fj.201701456RR (2019).","journal-title":"FASEB journal: official publication Federation Am. Soc. Experimental Biology"},{"key":"55204_CR19","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s13046-023-02895-8","volume":"42","author":"N Li","year":"2023","unstructured":"Li, N. et al. Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway. J. experimental Clin. cancer research: CR. 42, 305. https:\/\/doi.org\/10.1186\/s13046-023-02895-8 (2023). Correction.","journal-title":"J. experimental Clin. cancer research: CR"},{"key":"55204_CR20","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41419-022-04811-y","volume":"13","author":"R Guo","year":"2022","unstructured":"Guo, R. et al. CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer. Cell Death Dis. 13, 409. https:\/\/doi.org\/10.1038\/s41419-022-04811-y (2022).","journal-title":"Cell Death Dis."},{"key":"55204_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-023-00402-9","author":"Y Liu","year":"2023","unstructured":"Liu, Y. et al. CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p\/ZCCHC14 axis. Biol. Direct. https:\/\/doi.org\/10.1186\/s13062-023-00402-9 (2023).","journal-title":"Biol. Direct"},{"key":"55204_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12282-017-0793-9","volume":"25","author":"HD Zhang","year":"2018","unstructured":"Zhang, H. D., Jiang, L. H., Sun, D. W., Hou, J. C. & Ji, Z. L. CircRNA: a novel type of biomarker for cancer. Breast cancer (Tokyo Japan). 25, 1\u20137. https:\/\/doi.org\/10.1007\/s12282-017-0793-9 (2018).","journal-title":"Breast cancer (Tokyo Japan)"},{"key":"55204_CR23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/hepr.12871","volume":"47","author":"T Yao","year":"2017","unstructured":"Yao, T., Chen, Q., Fu, L., Guo, J. & Circular RNAs Biogenesis, properties, roles, and their relationships with liver diseases. Hepatol. research: official J. Japan Soc. Hepatol. 47, 497\u2013504. https:\/\/doi.org\/10.1111\/hepr.12871 (2017).","journal-title":"Hepatol. research: official J. Japan Soc. Hepatol."},{"key":"55204_CR24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12943-019-1061-8","volume":"18","author":"C Wang","year":"2019","unstructured":"Wang, C. et al. RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma. Mol. Cancer. 18, 134. https:\/\/doi.org\/10.1186\/s12943-019-1061-8 (2019).","journal-title":"Mol. Cancer"},{"key":"55204_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12943-023-01883-y","volume":"22","author":"Z Miao","year":"2023","unstructured":"Miao, Z. et al. Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375\/PRKDC Axis and PD-L1 phosphorylation. Mol. Cancer. 22, 205. https:\/\/doi.org\/10.1186\/s12943-023-01883-y (2023).","journal-title":"Mol. Cancer"},{"key":"55204_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12943-024-01966-4","volume":"23","author":"C Deng","year":"2024","unstructured":"Deng, C. et al. Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p\/STAT6 axis to promote gastric cancer progression. Mol. Cancer. 23, 49. https:\/\/doi.org\/10.1186\/s12943-024-01966-4 (2024).","journal-title":"Mol. Cancer"},{"key":"55204_CR27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s13059-017-1368-y","volume":"18","author":"L Verduci","year":"2017","unstructured":"Verduci, L. et al. The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53\/YAP\/TEAD transcription-competent complex. Genome Biol. 18, 237. https:\/\/doi.org\/10.1186\/s13059-017-1368-y (2017).","journal-title":"Genome Biol."},{"key":"55204_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0888-8","author":"W Tang","year":"2018","unstructured":"Tang, W. et al. CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. Mol. Cancer. https:\/\/doi.org\/10.1186\/s12943-018-0888-8 (2018).","journal-title":"Mol. Cancer"},{"key":"55204_CR29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12943-017-0719-3","volume":"16","author":"J Zhang","year":"2017","unstructured":"Zhang, J. et al. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol. Cancer. 16, 151. https:\/\/doi.org\/10.1186\/s12943-017-0719-3 (2017).","journal-title":"Mol. Cancer"},{"key":"55204_CR30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13046-021-01905-x","volume":"40","author":"LJ Cao","year":"2021","unstructured":"Cao, L. J. et al. ATAD2 interacts with C\/EBP\u03b2 to promote esophageal squamous cell carcinoma metastasis via TGF-\u03b21\/Smad3 signaling. J. experimental Clin. cancer research: CR. 40, 109. https:\/\/doi.org\/10.1186\/s13046-021-01905-x (2021).","journal-title":"J. experimental Clin. cancer research: CR"},{"key":"55204_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-022-00345-5","author":"S Hao","year":"2022","unstructured":"Hao, S., Li, F., Jiang, P. & Gao, J. Effect of chronic intermittent hypoxia-induced HIF-1\u03b1\/ATAD2 expression on lung cancer stemness. Cell. Mol. Biol. Lett. https:\/\/doi.org\/10.1186\/s11658-022-00345-5 (2022).","journal-title":"Cell. Mol. Biol. Lett."},{"key":"55204_CR32","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1139\/bcb-2018-0081","volume":"96","author":"S Hong","year":"2018","unstructured":"Hong, S. et al. ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer. Biochem. cell. biology = Biochimie et Biol. cellulaire. 96, 761\u2013768. https:\/\/doi.org\/10.1139\/bcb-2018-0081 (2018).","journal-title":"Biochem. cell. biology = Biochimie et Biol. cellulaire"},{"key":"55204_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-107","author":"G Wu","year":"2014","unstructured":"Wu, G. et al. miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis. BMC cancer. https:\/\/doi.org\/10.1186\/1471-2407-14-107 (2014).","journal-title":"BMC cancer"},{"key":"55204_CR34","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.3892\/or.2015.3867","volume":"33","author":"L Zheng","year":"2015","unstructured":"Zheng, L. et al. Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer. Oncol. Rep. 33, 2337\u20132344. https:\/\/doi.org\/10.3892\/or.2015.3867 (2015).","journal-title":"Oncol. Rep."},{"key":"55204_CR35","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1158\/0008-5472.Can-08-3440","volume":"69","author":"JX Zou","year":"2009","unstructured":"Zou, J. X. et al. Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. Cancer Res. 69, 3339\u20133346. https:\/\/doi.org\/10.1158\/0008-5472.Can-08-3440 (2009).","journal-title":"Cancer Res."},{"key":"55204_CR36","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1002\/hep.29270","volume":"66","author":"D Han","year":"2017","unstructured":"Han, D. et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatol. (Baltimore Md). 66, 1151\u20131164. https:\/\/doi.org\/10.1002\/hep.29270 (2017).","journal-title":"Hepatol. (Baltimore Md)"},{"key":"55204_CR37","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.jhep.2018.01.012","volume":"68","author":"J Yu","year":"2018","unstructured":"Yu, J. et al. Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J. Hepatol. 68, 1214\u20131227. https:\/\/doi.org\/10.1016\/j.jhep.2018.01.012 (2018).","journal-title":"J. Hepatol."},{"key":"55204_CR38","doi-asserted-by":"publisher","first-page":"4854","DOI":"10.1097\/JS9.0000000000002464","volume":"111","author":"P Yang","year":"2025","unstructured":"Yang, P., Huang, W., Xu, Y., Teng, Y. & Shu, P. Trends and projections of the burden of gastric cancer in China and G20 countries: a comparative study based on the global burden of disease database 2021. Int. J. Surg. 111, 4854\u20134865. https:\/\/doi.org\/10.1097\/JS9.0000000000002464 (2025).","journal-title":"Int. J. Surg."},{"key":"55204_CR39","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","volume":"153","author":"JKY Hooi","year":"2017","unstructured":"Hooi, J. K. Y. et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology 153, 420\u2013429. https:\/\/doi.org\/10.1053\/j.gastro.2017.04.022 (2017).","journal-title":"Gastroenterology"},{"key":"55204_CR40","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.dld.2021.03.007","volume":"53","author":"M Rugge","year":"2021","unstructured":"Rugge, M., Savarino, E., Sbaraglia, M., Bricca, L. & Malfertheiner, P. Gastritis: The clinico-pathological spectrum. Dig. liver disease: official J. Italian Soc. Gastroenterol. Italian Association Study Liver. 53, 1237\u20131246. https:\/\/doi.org\/10.1016\/j.dld.2021.03.007 (2021).","journal-title":"Dig. liver disease: official J. Italian Soc. Gastroenterol. Italian Association Study Liver"},{"key":"55204_CR41","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1002\/mc.22464","volume":"55","author":"HK Ngo","year":"2016","unstructured":"Ngo, H. K. et al. Helicobacter pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3\u03b2 in human gastric cancer cells. Mol. Carcinog. 55, 2236\u20132246. https:\/\/doi.org\/10.1002\/mc.22464 (2016).","journal-title":"Mol. Carcinog."},{"key":"55204_CR42","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.chom.2021.04.006","volume":"29","author":"S Imai","year":"2021","unstructured":"Imai, S. et al. Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis. Cell. host microbe. 29, 941\u2013958e910. https:\/\/doi.org\/10.1016\/j.chom.2021.04.006 (2021).","journal-title":"Cell. host microbe"},{"key":"55204_CR43","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/onc.2017.361","volume":"37","author":"LS Kristensen","year":"2018","unstructured":"Kristensen, L. S., Hansen, T. B., Ven\u00f8, M. T. & Kjems, J. Circular RNAs in cancer: opportunities and challenges in the field. Oncogene 37, 555\u2013565. https:\/\/doi.org\/10.1038\/onc.2017.361 (2018).","journal-title":"Oncogene"},{"key":"55204_CR44","doi-asserted-by":"publisher","first-page":"548","DOI":"10.4103\/jcrt.jcrt_1868_20","volume":"19","author":"C Zhou","year":"2023","unstructured":"Zhou, C., Zhu, D., Zhou, S., Wang, H. & Huang, M. Screening differential circular RNA expression profiles and the potential role of hsa_circ_0085465 in liver cancer. J. Cancer Res. Ther. 19, 548\u2013555. https:\/\/doi.org\/10.4103\/jcrt.jcrt_1868_20 (2023).","journal-title":"J. Cancer Res. Ther."},{"key":"55204_CR45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13578-022-00833-3","volume":"12","author":"Q Chen","year":"2022","unstructured":"Chen, Q. et al. Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star. Cell. bioscience. 12, 97. https:\/\/doi.org\/10.1186\/s13578-022-00833-3 (2022).","journal-title":"Cell. bioscience"},{"key":"55204_CR46","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jaci.2021.10.041","volume":"150","author":"X Wang","year":"2022","unstructured":"Wang, X. et al. CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p\/JAK2 signaling pathway in allergic airway epithelia. J. Allergy Clin. Immunol. 150, 192\u2013203. https:\/\/doi.org\/10.1016\/j.jaci.2021.10.041 (2022).","journal-title":"J. Allergy Clin. Immunol."},{"key":"55204_CR47","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013d677. https:\/\/doi.org\/10.1093\/nar\/gkae909 (2025).","journal-title":"Nucleic Acids Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55204-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55204-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55204-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:08:23Z","timestamp":1785884903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55204-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["55204"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-55204-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"4 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal Experiment Ethics Committee of Ningxia Medical University approved the animal study. The study was conducted in accordance with the local legislation and institutional requirements.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors read and approve the final manuscript.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"24080"}}