{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:34:02Z","timestamp":1786120442889,"version":"build-2736575974"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":71,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"crossref","award":["2022D01C217"],"award-info":[{"award-number":["2022D01C217"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-55447-3","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:37:15Z","timestamp":1779925035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loganin alleviates oxidative stress-induced apoptosis by modulating mitochondrial function and STAT3 signaling in DSS-induced colitis and H2O2-injured Caco-2 cells"],"prefix":"10.1038","volume":"16","author":[{"given":"Guofeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"55447_CR1","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00281-019-00751-6","volume":"41","author":"MF Neurath","year":"2019","unstructured":"Neurath, M. F. & Leppkes, M. Resolution of Ulcerative Colitis. Semin Immunopathol. 41, 747\u2013756. https:\/\/doi.org\/10.1007\/s00281-019-00751-6 (2019).","journal-title":"Semin Immunopathol."},{"key":"55447_CR2","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng, S. C. et al. Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies. Lancet 390, 2769\u20132778. https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0 (2017).","journal-title":"Lancet"},{"key":"55447_CR3","doi-asserted-by":"publisher","first-page":"761981","DOI":"10.3389\/fimmu.2021.761981","volume":"12","author":"Y Chen","year":"2021","unstructured":"Chen, Y., Cui, W., Li, X. & Yang, H. Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease. Front. Immunol. 12, 761981. https:\/\/doi.org\/10.3389\/fimmu.2021.761981 (2021).","journal-title":"Front. Immunol."},{"key":"55447_CR4","doi-asserted-by":"publisher","first-page":"116879","DOI":"10.1016\/j.jep.2023.116879","volume":"318","author":"M Wang","year":"2024","unstructured":"Wang, M. et al. Traditional Chinese Medicine: A Promising Strategy to Regulate the Imbalance of Bacterial Flora, Impaired Intestinal Barrier and Immune Function Attributed to Ulcerative Colitis through Intestinal Microecology. J. Ethnopharmacol. 318, 116879. https:\/\/doi.org\/10.1016\/j.jep.2023.116879 (2024).","journal-title":"J. Ethnopharmacol."},{"key":"55447_CR5","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1146\/annurev-physiol-060821-083306","volume":"84","author":"GT Ho","year":"2022","unstructured":"Ho, G. T. & Theiss, A. L. Mitochondria and Inflammatory Bowel Diseases: Toward a Stratified Therapeutic Intervention. Annu. Rev. Physiol. 84, 435\u2013459. https:\/\/doi.org\/10.1146\/annurev-physiol-060821-083306 (2022).","journal-title":"Annu. Rev. Physiol."},{"key":"55447_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","volume":"51","author":"JN Peoples","year":"2019","unstructured":"Peoples, J. N., Saraf, A., Ghazal, N., Pham, T. T. & Kwong, J. Q. Mitochondrial Dysfunction and Oxidative Stress in Heart Disease. Exp. Mol. Med. 51, 1\u201313. https:\/\/doi.org\/10.1038\/s12276-019-0355-7 (2019).","journal-title":"Exp. Mol. Med."},{"key":"55447_CR7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fcell.2015.00062","volume":"3","author":"EA Novak","year":"2015","unstructured":"Novak, E. A. & Mollen, K. P. Mitochondrial Dysfunction in Inflammatory Bowel Disease. Front. Cell. Dev. Biol. 3, 62. https:\/\/doi.org\/10.3389\/fcell.2015.00062 (2015).","journal-title":"Front. Cell. Dev. Biol."},{"key":"55447_CR8","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1134\/S0026893323060043","volume":"57","author":"DA Chernyavskij","year":"2023","unstructured":"Chernyavskij, D. A., Galkin, I. I., Pavlyuchenkova, A. N., Fedorov, A. V. & Chelombitko, M. A. Role of Mitochondria in Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease. Mol. Biol. 57, 1024\u20131037. https:\/\/doi.org\/10.1134\/S0026893323060043 (2023).","journal-title":"Mol. Biol."},{"key":"55447_CR9","doi-asserted-by":"publisher","first-page":"1309963","DOI":"10.3389\/fnut.2023.1309963","volume":"10","author":"W Deng","year":"2024","unstructured":"Deng, W. et al. A Comprehensive Review of Cornus Officinalis: Health Benefits, Phytochemistry, and Pharmacological Effects for Functional Drug and Food Development. Front. Nutr. 10, 1309963. https:\/\/doi.org\/10.3389\/fnut.2023.1309963 (2024).","journal-title":"Front. Nutr."},{"key":"55447_CR10","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.3390\/cells10102688","volume":"10","author":"YC Cheng","year":"2021","unstructured":"Cheng, Y. C., Chiu, Y. M., Dai, Z. K. & Wu, B. N. Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats. Cells 10, 2688. https:\/\/doi.org\/10.3390\/cells10102688 (2021).","journal-title":"Cells"},{"key":"55447_CR11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4062\/biomolther.2022.077","volume":"31","author":"JH Jang","year":"2023","unstructured":"Jang, J. H. et al. Loganin Prevents Hepatic Steatosis by Blocking NLRP3 Inflammasome Activation. Biomol. Ther. (Seoul). 31, 40\u201347. https:\/\/doi.org\/10.4062\/biomolther.2022.077 (2023).","journal-title":"Biomol. Ther. (Seoul)"},{"key":"55447_CR12","doi-asserted-by":"publisher","first-page":"110640","DOI":"10.1016\/j.cbi.2023.110640","volume":"382","author":"X Kong","year":"2023","unstructured":"Kong, X. et al. Loganin Reduces Diabetic Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome-Mediated Pyroptosis. Chem. Biol. Interact. 382, 110640. https:\/\/doi.org\/10.1016\/j.cbi.2023.110640 (2023).","journal-title":"Chem. Biol. Interact."},{"key":"55447_CR13","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1080\/21655979.2020.1774992","volume":"11","author":"S Liu","year":"2020","unstructured":"Liu, S. et al. Loganin Inhibits Macrophage M1 Polarization and Modulates Sirt1\/NF-\u03baB Signaling Pathway to Attenuate Ulcerative Colitis. Bioengineered 11, 628\u2013639. https:\/\/doi.org\/10.1080\/21655979.2020.1774992 (2020).","journal-title":"Bioengineered"},{"key":"55447_CR14","doi-asserted-by":"publisher","first-page":"106240","DOI":"10.1016\/j.intimp.2020.106240","volume":"81","author":"J Yuan","year":"2020","unstructured":"Yuan, J. et al. Protective Effects of Iridoid Glycosides on Acute Colitis via Inhibition of the Inflammatory Response Mediated by the STAT3\/NF-\u043aB Pathway. Int. Immunopharmacol. 81, 106240. https:\/\/doi.org\/10.1016\/j.intimp.2020.106240 (2020).","journal-title":"Int. Immunopharmacol."},{"key":"55447_CR15","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/kjm2.12160","volume":"36","author":"JW Wang","year":"2020","unstructured":"Wang, J. W. et al. Loganin Alleviates LPS-Activated Intestinal Epithelial Inflammation by Regulating TLR4\/NF-\u03baB and JAK\/STAT3 Signaling Pathways. Kaohsiung J. Med. Sci. 36, 257\u2013264. https:\/\/doi.org\/10.1002\/kjm2.12160 (2020).","journal-title":"Kaohsiung J. Med. Sci."},{"key":"55447_CR16","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3390\/molecules26041071","volume":"26","author":"N Choi","year":"2021","unstructured":"Choi, N. et al. Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage. Molecules 26, 1071. https:\/\/doi.org\/10.3390\/molecules26041071 (2021).","journal-title":"Molecules"},{"key":"55447_CR17","doi-asserted-by":"publisher","first-page":"116455","DOI":"10.1016\/j.jep.2023.116455","volume":"312","author":"Y Zhou","year":"2023","unstructured":"Zhou, Y. et al. Loganin Alleviated Cognitive Impairment in 3\u00d7Tg-AD Mice through Promoting Mitophagy Mediated by Optineurin. J. Ethnopharmacol. 312, 116455. https:\/\/doi.org\/10.1016\/j.jep.2023.116455 (2023).","journal-title":"J. Ethnopharmacol."},{"key":"55447_CR18","doi-asserted-by":"publisher","unstructured":"Garcia-Hernandez, V. et al. Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model. J. Vis. Exp. 10 (3791\/62135). https:\/\/doi.org\/10.3791\/62135 (2021).","DOI":"10.3791\/62135"},{"key":"55447_CR19","doi-asserted-by":"publisher","unstructured":"Alhendi, A. & Naser, S. A. In Vitro Neutralization of IL-6 Receptor Exacerbates Damage to Intestinal Epithelial Cells during Mycobacterium Avium Paratuberculosis Infection. Front. Immunol. 15 https:\/\/doi.org\/10.3389\/fimmu.2024.1412800 (2024).","DOI":"10.3389\/fimmu.2024.1412800"},{"key":"55447_CR20","first-page":"238","volume":"69","author":"HS Cooper","year":"1993","unstructured":"Cooper, H. S., Murthy, S. N., Shah, R. S. & Sedergran, D. J. Clinicopathologic Study of Dextran Sulfate Sodium Experimental Murine Colitis. Lab. Invest. 69, 238\u2013249 (1993).","journal-title":"Lab. Invest."},{"key":"55447_CR21","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","volume":"389","author":"R Ungaro","year":"2017","unstructured":"Ungaro, R., Mehandru, S., Allen, P. B., Peyrin-Biroulet, L. & Colombel, J. F. Ulcerative Colitis Lancet 389, 1756\u20131770, doi:https:\/\/doi.org\/10.1016\/S0140-6736(16)32126-2. (2017).","journal-title":"Ulcerative Colitis Lancet"},{"key":"55447_CR22","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrgastro.2016.208","volume":"14","author":"MF Neurath","year":"2017","unstructured":"Neurath, M. F. Current and Emerging Therapeutic Targets for IBD. Nat. Rev. Gastroenterol. Hepatol. 14, 269\u2013278. https:\/\/doi.org\/10.1038\/nrgastro.2016.208 (2017).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"55447_CR23","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1002\/ptr.7347","volume":"36","author":"F Zhang","year":"2022","unstructured":"Zhang, F. et al. Phytochemistry, Synthesis, Analytical Methods, Pharmacological Activity, and Pharmacokinetics of Loganin: A Comprehensive Review. Phytother Res. 36, 2272\u20132299. https:\/\/doi.org\/10.1002\/ptr.7347 (2022).","journal-title":"Phytother Res."},{"key":"55447_CR24","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1089\/ars.2012.4530","volume":"19","author":"F Biasi","year":"2013","unstructured":"Biasi, F., Leonarduzzi, G., Oteiza, P. I. & Poli, G. Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets. Antioxid. Redox Signal. 19, 1711\u20131747. https:\/\/doi.org\/10.1089\/ars.2012.4530 (2013).","journal-title":"Antioxid. Redox Signal."},{"key":"55447_CR25","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1196\/annals.1326.027","volume":"1072","author":"JD Schulzke","year":"2006","unstructured":"Schulzke, J. D. et al. Disrupted Barrier Function through Epithelial Cell Apoptosis. Ann. N Y Acad. Sci. 1072, 288\u2013299. https:\/\/doi.org\/10.1196\/annals.1326.027 (2006).","journal-title":"Ann. N Y Acad. Sci."},{"key":"55447_CR26","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1093\/ibd\/izab277","volume":"28","author":"Y Wan","year":"2022","unstructured":"Wan, Y., Yang, L., Jiang, S., Qian, D. & Duan, J. Excessive Apoptosis in Ulcerative Colitis: Crosstalk Between Apoptosis, ROS, ER Stress, and Intestinal Homeostasis. Inflamm. Bowel Dis. 28, 639\u2013648. https:\/\/doi.org\/10.1093\/ibd\/izab277 (2022).","journal-title":"Inflamm. Bowel Dis."},{"key":"55447_CR27","doi-asserted-by":"publisher","first-page":"4139","DOI":"10.3390\/molecules27134139","volume":"27","author":"M Shahid","year":"2022","unstructured":"Shahid, M. et al. Sinapic Acid Ameliorates Acetic Acid-Induced Ulcerative Colitis in Rats by Suppressing Inflammation, Oxidative Stress, and Apoptosis. Molecules 27, 4139. https:\/\/doi.org\/10.3390\/molecules27134139 (2022).","journal-title":"Molecules"},{"key":"55447_CR28","doi-asserted-by":"publisher","first-page":"110937","DOI":"10.1016\/j.biopha.2020.110937","volume":"133","author":"H Wu","year":"2021","unstructured":"Wu, H. et al. Compound Sophorae Decoction Enhances Intestinal Barrier Function of Dextran Sodium Sulfate Induced Colitis via Regulating Notch Signaling Pathway in Mice. Biomed. Pharmacother. 133, 110937. https:\/\/doi.org\/10.1016\/j.biopha.2020.110937 (2021).","journal-title":"Biomed. Pharmacother"},{"key":"55447_CR29","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1111\/jcmm.15198","volume":"24","author":"Y Chen","year":"2020","unstructured":"Chen, Y. et al. Loganin Alleviates Testicular Damage and Germ Cell Apoptosis Induced by AGEs upon Diabetes Mellitus by Suppressing the RAGE\/p38MAPK\/NF-\u03baB Pathway. J. Cell. Mol. Med. 24, 6083\u20136095. https:\/\/doi.org\/10.1111\/jcmm.15198 (2020).","journal-title":"J. Cell. Mol. Med."},{"key":"55447_CR30","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.neuint.2011.01.012","volume":"58","author":"SH Kwon","year":"2011","unstructured":"Kwon, S. H. et al. Loganin Protects against Hydrogen Peroxide-Induced Apoptosis by Inhibiting Phosphorylation of JNK, P38, and ERK 1\/2 MAPKs in SH-SY5Y Cells. Neurochem Int. 58, 533\u2013541. https:\/\/doi.org\/10.1016\/j.neuint.2011.01.012 (2011).","journal-title":"Neurochem Int."},{"key":"55447_CR31","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/s41575-024-00931-2","volume":"21","author":"PS Haque","year":"2024","unstructured":"Haque, P. S., Kapur, N., Barrett, T. A. & Theiss, A. L. Mitochondrial Function and Gastrointestinal Diseases. Nat. Rev. Gastroenterol. Hepatol. 21, 537\u2013555. https:\/\/doi.org\/10.1038\/s41575-024-00931-2 (2024).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"55447_CR32","doi-asserted-by":"publisher","unstructured":"Chuang, Y. F. et al. Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence. Kaohsiung J. Med. Sci. e70117. https:\/\/doi.org\/10.1002\/kjm2.70117 (2025).","DOI":"10.1002\/kjm2.70117"},{"key":"55447_CR33","doi-asserted-by":"publisher","first-page":"291","DOI":"10.5582\/bst.2022.01116","volume":"16","author":"C Park","year":"2022","unstructured":"Park, C. et al. The Preventive Effect of Loganin on Oxidative Stress-Induced Cellular Damage in Human Keratinocyte HaCaT Cells. Biosci. Trends. 16, 291\u2013300. https:\/\/doi.org\/10.5582\/bst.2022.01116 (2022).","journal-title":"Biosci. Trends"},{"key":"55447_CR34","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ccr.2009.01.001","volume":"15","author":"S Grivennikov","year":"2009","unstructured":"Grivennikov, S. et al. IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer. Cancer Cell. 15, 103\u2013113. https:\/\/doi.org\/10.1016\/j.ccr.2009.01.001 (2009).","journal-title":"Cancer Cell."},{"key":"55447_CR35","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3892\/etm.2021.10322","volume":"22","author":"Y Li","year":"2021","unstructured":"Li, Y., Jia, Y., Cui, T. & Zhang, J. IL-6\/STAT3 Signaling Pathway Regulates the Proliferation and Damage of Intestinal Epithelial Cells in Patients with Ulcerative Colitis via H3K27ac. Exp. Ther. Med. 22, 890. https:\/\/doi.org\/10.3892\/etm.2021.10322 (2021).","journal-title":"Exp. Ther. Med."},{"key":"55447_CR36","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3390\/biomedicines9020187","volume":"9","author":"L Pang","year":"2021","unstructured":"Pang, L. et al. STAT3 Signalling via the IL-6ST\/Gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis. Biomedicines 9, 187. https:\/\/doi.org\/10.3390\/biomedicines9020187 (2021).","journal-title":"Biomedicines"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55447-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55447-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55447-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T22:54:00Z","timestamp":1786056840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55447-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["55447"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-55447-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"26 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Animal Care and Use Committee (IACUC) of Xinjiang Medical University (Approval No. K202307-21) and conducted in accordance with the ethical standards outlined in the 8th edition of the Guide for the Care and Use of Laboratory Animals (National Research Council, USA, 2011). Additionally, we confirm that the study is reported in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"24371"}}