{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:07:06Z","timestamp":1784801226961,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Department of Health Research and Indian Council of Medical Research","award":["5\/13\/92\/2020\/NCD-III"],"award-info":[{"award-number":["5\/13\/92\/2020\/NCD-III"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-55515-8","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:38:16Z","timestamp":1782131896000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase"],"prefix":"10.1038","volume":"16","author":[{"given":"Sajib Kumar","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Nayek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Minocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet Singh","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om Saswat","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasenjit","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar Ranjan","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Kurdia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhibroto","family":"Karmakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-6554","authenticated-orcid":false,"given":"Ruby","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-8729","authenticated-orcid":false,"given":"Subhradip","family":"Karmakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"55515_CR1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/j.1440-1746.2011.07048.x","volume":"27","author":"U Dutta","year":"2012","unstructured":"Dutta, U. Gallbladder cancer: Can newer insights improve the outcome? J. Gastroenterol. Hepatol. 27, 642\u2013653 (2012).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"55515_CR2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/jso.23476","volume":"109","author":"C Ramos-Font","year":"2014","unstructured":"Ramos-Font, C. et al. Ability of FDG\u2010PET\/CT in the detection of gallbladder cancer. J. Surg. Oncol. 109, 218\u2013224 (2014).","journal-title":"J. Surg. Oncol."},{"key":"55515_CR3","doi-asserted-by":"publisher","first-page":"699","DOI":"10.4103\/ijmr.IJMR_201_19","volume":"154","author":"K Mishra","year":"2021","unstructured":"Mishra, K. et al. Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case\u2013control study. Indian J. Med. Res. 154, 699\u2013706 (2021).","journal-title":"Indian J. Med. Res."},{"key":"55515_CR4","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8694","author":"J Xu","year":"2018","unstructured":"Xu, J., Chang, W., Fu, H., Yuan, T. & Chen, P. The mRNA, miRNA and lncRNA networks in hepatocellular carcinoma: An integrative transcriptomic analysis from Gene Expression Omnibus. Mol. Med. Rep. https:\/\/doi.org\/10.3892\/mmr.2018.8694 (2018).","journal-title":"Mol. Med. Rep."},{"key":"55515_CR5","first-page":"1","volume":"2018","author":"Q Yang","year":"2018","unstructured":"Yang, Q. et al. Candidate Biomarkers and Molecular Mechanism Investigation for Glioblastoma Multiforme Utilizing WGCNA. Biomed. Res. Int. 2018, 1\u201310 (2018).","journal-title":"Biomed. Res. Int."},{"key":"55515_CR6","doi-asserted-by":"publisher","first-page":"102451","DOI":"10.1016\/j.isci.2021.102451","volume":"24","author":"CD Dill","year":"2021","unstructured":"Dill, C. D., Dammer, E. B., Griffen, T. L., Seyfried, N. T. & Lillard, J. W. A network approach reveals driver genes associated with survival of patients with triple-negative breast cancer. iScience 24, 102451 (2021).","journal-title":"iScience"},{"key":"55515_CR7","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013D677 (2025).","journal-title":"Nucleic Acids Res."},{"key":"55515_CR8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1101\/gad.949802","volume":"16","author":"B Ren","year":"2002","unstructured":"Ren, B. et al. E2F integrates cell cycle progression with DNA repair, replication, and G 2 \/M checkpoints. Genes Dev. 16, 245\u2013256 (2002).","journal-title":"Genes Dev."},{"key":"55515_CR9","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.surg.2023.04.030","volume":"174","author":"K Chida","year":"2023","unstructured":"Chida, K. et al. E2F target score is associated with cell proliferation and survival of patients with hepatocellular carcinoma. Surgery 174, 307\u2013314 (2023).","journal-title":"Surgery"},{"key":"55515_CR10","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3390\/cells9071643","volume":"9","author":"M Oshi","year":"2020","unstructured":"Oshi, M. et al. The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+\/HER2\u2009\u2013\u2009Breast Cancer. Cells 9, 1643 (2020).","journal-title":"Cells"},{"key":"55515_CR11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/cells7110208","volume":"7","author":"IN Sari","year":"2018","unstructured":"Sari, I. N. et al. Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells. Cells 7, 208 (2018).","journal-title":"Cells"},{"key":"55515_CR12","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3390\/cells8040375","volume":"8","author":"N Riobo-Del Galdo","year":"2019","unstructured":"Riobo-Del Galdo, N., Lara Montero, \u00c1. & Wertheimer, E. Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics. Cells 8, 375 (2019).","journal-title":"Cells"},{"key":"55515_CR13","doi-asserted-by":"publisher","first-page":"115253","DOI":"10.1016\/j.bcp.2022.115253","volume":"205","author":"W Li","year":"2022","unstructured":"Li, W. et al. Lithocholic acid inhibits gallbladder cancer proliferation through interfering glutaminase-mediated glutamine metabolism. Biochem. Pharmacol. 205, 115253 (2022).","journal-title":"Biochem. Pharmacol."},{"key":"55515_CR14","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3390\/cells13161397","volume":"13","author":"F Polverino","year":"2024","unstructured":"Polverino, F., Mastrangelo, A. & Guarguaglini, G. Contribution of AurkA\/TPX2 Overexpression to Chromosomal Imbalances and Cancer. Cells 13, 1397 (2024).","journal-title":"Cells"},{"key":"55515_CR15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4103\/jcar.JCar_3_21","volume":"20","author":"A Gupta","year":"2021","unstructured":"Gupta, A. et al. Demographic and clinicopathological profile of gall bladder cancer patients: Study from a tertiary care center of the sub-himalayan region in indo-gangetic belt. J. Carcinog. 20, 6 (2021).","journal-title":"J. Carcinog."},{"key":"55515_CR16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/hep.22627","volume":"49","author":"K Song","year":"2009","unstructured":"Song, K., Li, T., Owsley, E., Strom, S. & Chiang, J. Y. L. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7\u03b1-hydroxylase gene expression\u2020. Hepatology 49, 297\u2013305 (2009).","journal-title":"Hepatology"},{"key":"55515_CR17","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/hep.24702","volume":"55","author":"SJLB Zweers","year":"2012","unstructured":"Zweers, S. J. L. B. et al. The Human Gallbladder Secretes Fibroblast Growth Factor 19 Into Bile: Towards Defining the Role of Fibroblast Growth Factor 19 in the Enterobiliary Tract. Hepatology 55, 575\u2013583 (2012).","journal-title":"Hepatology"},{"key":"55515_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02754","author":"MS Pereira","year":"2018","unstructured":"Pereira, M. S. et al. Glycans as Key Checkpoints of T Cell Activity and Function. Front. Immunol. https:\/\/doi.org\/10.3389\/fimmu.2018.02754 (2018).","journal-title":"Front. Immunol."},{"key":"55515_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.554331","author":"L Zhang","year":"2020","unstructured":"Zhang, L. et al. Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors. Front. Oncol. https:\/\/doi.org\/10.3389\/fonc.2020.554331 (2020).","journal-title":"Front. Oncol."},{"key":"55515_CR20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.11613\/BM.2023.030503","volume":"33","author":"G Begolli","year":"2023","unstructured":"Begolli, G., Markovi\u0107, I., Kne\u017eevi\u0107, J. & Debeljak, \u017d. Carbohydrate sulfotransferases. Biochem. Med. (Zagreb). 33, 255\u2013265 (2023).","journal-title":"Biochem. Med. (Zagreb)"},{"key":"55515_CR21","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.3934\/mbe.2020073","volume":"17","author":"S Gu","year":"2020","unstructured":"Gu, S., Luo, J. & Yao, W. The regulation of miR-139-5p on the biological characteristics of breast cancer cells by targeting COL11A1. Math. Biosci. Eng. 17, 1428\u20131441 (2020).","journal-title":"Math. Biosci. Eng."},{"key":"55515_CR22","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.7150\/jca.47032","volume":"12","author":"H Wang","year":"2021","unstructured":"Wang, H. et al. The COL11A1\/Akt\/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX\/BCL-2 function. J. Cancer. 12, 1406\u20131420 (2021).","journal-title":"J. Cancer"},{"key":"55515_CR23","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1186\/1471-2407-14-867","volume":"14","author":"JA Galv\u00e1n","year":"2014","unstructured":"Galv\u00e1n, J. A. et al. Validation of COL11A1\/procollagen 11A1 expression in TGF-\u03b21-activated immortalised human mesenchymal cells and in stromal cells of human colon adenocarcinoma. BMC Cancer. 14, 867 (2014).","journal-title":"BMC Cancer"},{"key":"55515_CR24","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3892\/or.2016.4869","volume":"36","author":"L Shen","year":"2016","unstructured":"Shen, L. et al. COL11A1 is overexpressed in recurrent non-small cell lung cancer and promotes cell proliferation, migration, invasion and drug resistance. Oncol. Rep. 36, 877\u2013885 (2016).","journal-title":"Oncol. Rep."},{"key":"55515_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.925165","author":"Y-H Wu","year":"2022","unstructured":"Wu, Y-H. & Chou, C-Y. Collagen XI Alpha 1 Chain, a Novel Therapeutic Target for Cancer Treatment. Front. Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.925165 (2022).","journal-title":"Front. Oncol."},{"key":"55515_CR26","unstructured":"Kleinert R, Prenzel K, Stoecklein N, Alakus H, Bollschweiler E, H\u00f6lscher A, Warnecke-eberz Ute. Gene expression of Col11A1 is a marker not only for pancreas carcinoma but also for adenocarcinoma of the papilla of vater, discriminating between carcinoma and chronic pancreatitis. Anticancer Res. 35 6153. (2015)."},{"key":"55515_CR27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13046-017-0559-4","volume":"36","author":"H Huan","year":"2017","unstructured":"Huan, H. et al. HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition. J. Experimental Clin. Cancer Res. 36, 86 (2017).","journal-title":"J. Experimental Clin. Cancer Res."},{"key":"55515_CR28","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41374-018-0150-4","volume":"99","author":"L Dai","year":"2019","unstructured":"Dai, L. et al. Upregulated expression of HOXB7 in intrahepatic cholangiocarcinoma is associated with tumor cell metastasis and poor prognosis. Lab. Invest. 99, 736\u2013748 (2019).","journal-title":"Lab. Invest."},{"key":"55515_CR29","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41374-018-0150-4","volume":"99","author":"L Dai","year":"2019","unstructured":"Dai, L. et al. Upregulated expression of HOXB7 in intrahepatic cholangiocarcinoma is associated with tumor cell metastasis and poor prognosis. Lab. Invest. 99, 736\u2013748 (2019).","journal-title":"Lab. Invest."},{"key":"55515_CR30","first-page":"2767","volume":"36","author":"H Komatsu","year":"2016","unstructured":"Komatsu, H. et al. HOXB7 Expression is a Novel Biomarker for Long-term Prognosis After Resection of Hepatocellular Carcinoma. Anticancer Res. 36, 2767\u20132773 (2016).","journal-title":"Anticancer Res."},{"key":"55515_CR31","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/s12885-023-10840-3","volume":"23","author":"V Jain","year":"2023","unstructured":"Jain, V. et al. Tissue proteome analysis for profiling proteins associated with lymph node metastasis in gallbladder cancer. BMC Cancer. 23, 402 (2023).","journal-title":"BMC Cancer"},{"key":"55515_CR32","first-page":"1","volume":"2022","author":"J Wang","year":"2022","unstructured":"Wang, J., Lan, L., Ma, B., Ren, G. & Yin, C. KRT17 Accelerates Cell Proliferative and Invasive Potential of Laryngeal Squamous Cell Carcinoma (LSCC) through Regulating AKT\/mTOR and Wnt\/\u03b2-Catenin Pathways. Evidence-Based Complement. Altern. Med. 2022, 1\u201311 (2022).","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"55515_CR33","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.2147\/CMAR.S243129","volume":"12","author":"D Li","year":"2020","unstructured":"Li, D. et al. <\u2009p>KRT17 Functions as a Tumor Promoter and Regulates Proliferation, Migration and Invasion in Pancreatic Cancer via mTOR\/S6k1 Pathway. Cancer Manag Res.. 12, 2087\u20132095 (2020).","journal-title":"Cancer Manag Res. Volume"},{"key":"55515_CR34","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41568-019-0143-7","volume":"19","author":"LN Kent","year":"2019","unstructured":"Kent, L. N. & Leone, G. The broken cycle: E2F dysfunction in cancer. Nat. Rev. Cancer. 19, 326\u2013338 (2019).","journal-title":"Nat. Rev. Cancer"},{"key":"55515_CR35","doi-asserted-by":"publisher","first-page":"5624","DOI":"10.3390\/ijms23105624","volume":"23","author":"K-M Lai","year":"2022","unstructured":"Lai, K-M. et al. Crassolide Induces G2\/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways. Int. J. Mol. Sci. 23, 5624 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"55515_CR36","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","volume":"149","author":"CV Dang","year":"2012","unstructured":"Dang, C. V. MYC on the Path to Cancer. Cell 149, 22\u201335 (2012).","journal-title":"Cell"},{"key":"55515_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/boc.201800050","volume":"111","author":"E Madden","year":"2019","unstructured":"Madden, E., Logue, S. E., Healy, S. J., Manie, S. & Samali, A. The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance. Biol. Cell. 111, 1\u201317 (2019).","journal-title":"Biol. Cell."},{"key":"55515_CR38","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1172\/JCI62973","volume":"122","author":"LS Hart","year":"2012","unstructured":"Hart, L. S. et al. ER stress\u2013mediated autophagy promotes Myc-dependent transformation and tumor growth. J. Clin. Invest. 122, 4621\u20134634 (2012).","journal-title":"J. Clin. Invest."},{"key":"55515_CR39","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1186\/s12885-024-12842-1","volume":"24","author":"J Huang","year":"2024","unstructured":"Huang, J. et al. Clinical pathological significance and biological function of PLIN1 in hepatocellular carcinoma: bioinformatics analysis and in vitro experiments. BMC Cancer. 24, 1073 (2024).","journal-title":"BMC Cancer"},{"key":"55515_CR40","doi-asserted-by":"publisher","first-page":"13750","DOI":"10.1038\/srep13750","volume":"5","author":"J Zhang","year":"2015","unstructured":"Zhang, J. et al. Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma. Sci. Rep. 5, 13750 (2015).","journal-title":"Sci. Rep."},{"key":"55515_CR41","doi-asserted-by":"publisher","first-page":"104113","DOI":"10.18632\/oncotarget.22020","volume":"8","author":"L-W Qu","year":"2017","unstructured":"Qu, L-W., Zhou, B., Wang, G-Z., Chen, Y. & Zhou, G-B. Genomic variations in paired normal controls for lung adenocarcinomas. Oncotarget 8, 104113\u2013104122 (2017).","journal-title":"Oncotarget"},{"key":"55515_CR42","first-page":"4450","volume":"13","author":"X Zhang","year":"2021","unstructured":"Zhang, X., Su, L. & Sun, K. Expression status and prognostic value of the perilipin family of genes in breast cancer. Am. J. Transl Res. 13, 4450\u20134463 (2021).","journal-title":"Am. J. Transl Res."},{"key":"55515_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246103","author":"Q Sun","year":"2022","unstructured":"Sun, Q. et al. Systematic Investigation of the Multifaceted Role of SOX11 in Cancer. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers14246103 (2022).","journal-title":"Cancers (Basel)"},{"key":"55515_CR44","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1186\/s12885-015-1987-1","volume":"15","author":"X Sun","year":"2015","unstructured":"Sun, X. et al. Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma. BMC Cancer. 15, 961 (2015).","journal-title":"BMC Cancer"},{"key":"55515_CR45","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s10142-023-01088-y","volume":"23","author":"Q Xu","year":"2023","unstructured":"Xu, Q., Li, X., Li, Y., Yu, J. & Yang, A. Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt\/\u03b2-catenin pathway. Funct. Integr. Genomics. 23, 154 (2023).","journal-title":"Funct. Integr. Genomics"},{"key":"55515_CR46","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s13046-022-02373-7","volume":"41","author":"Z Li","year":"2022","unstructured":"Li, Z. et al. Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt\/\u03b2-catenin pathway. J. Experimental Clin. Cancer Res. 41, 168 (2022).","journal-title":"J. Experimental Clin. Cancer Res."},{"key":"55515_CR47","doi-asserted-by":"publisher","first-page":"14570","DOI":"10.1038\/s41598-024-61762-4","volume":"14","author":"RK Gupta","year":"2024","unstructured":"Gupta, R. K., Bhushan, R., Kumar, S. & Prasad, S. B. In silico analysis unveiling potential biomarkers in gallbladder carcinogenesis. Sci. Rep. 14, 14570 (2024).","journal-title":"Sci. Rep."},{"key":"55515_CR48","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S1097-2765(03)00392-7","volume":"12","author":"R Bayliss","year":"2003","unstructured":"Bayliss, R., Sardon, T., Vernos, I. & Conti, E. Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle. Mol. Cell. 12, 851\u2013862 (2003).","journal-title":"Mol. Cell."},{"key":"55515_CR49","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1242\/jcs.112.21.3591","volume":"112","author":"R Giet","year":"1999","unstructured":"Giet, R. & Prigent, C. Aurora\/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J. Cell. Sci. 112, 3591\u20133601 (1999).","journal-title":"J. Cell. Sci."},{"key":"55515_CR50","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41388-018-0470-2","volume":"38","author":"SE van Gijn","year":"2019","unstructured":"van Gijn SE, et al. TPX2\/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells. Oncogene 38, 852\u2013867 (2019).","journal-title":"Oncogene"},{"key":"55515_CR51","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s12672-025-02878-5","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang Y, Liu J, Xu J, Ji Z. The expression and prognosis for Aurora kinases in human non-small cell lung cancer. Discov. Oncol. 16, 1021 (2025).","journal-title":"Discover Oncology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55515-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55515-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55515-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:50:38Z","timestamp":1784800238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55515-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["55515"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-55515-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"15 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by Institute Ethics Committee of AIIMS, New Delhi. Informed consents were obtained from all the participants. The study was conducted in accordance with the Declarations of Helsinki.","order":2,"name":"Ethics","label":"Ethics statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors consented for publication.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"23080"}}