{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:11:52Z","timestamp":1793293912772,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":59,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U54 CA242639"],"award-info":[{"award-number":["U54 CA242639"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CRP-23-1010710-06-COUN"],"award-info":[{"award-number":["CRP-23-1010710-06-COUN"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","award":["P30-CA076292"],"award-info":[{"award-number":["P30-CA076292"]}],"id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-55676-6","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:16:49Z","timestamp":1780046209000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alcohol consumption and oral human papillomavirus infection among men living with HIV: a cross-sectional study from the ULACNet 201 trial"],"prefix":"10.1038","volume":"16","author":[{"given":"Anna","family":"Beltrame","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa L.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Lazcano-Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Santana-Bagur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betania","family":"Allen-Leigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra J.","family":"Portillo-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant V.","family":"Sahasrabuddhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret G.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Brofsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenice Galan","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Carvalho","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Schell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Rathwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Isaacs-Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caique","family":"Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant B.","family":"Ellsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Wilkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"55676_CR1","unstructured":"U.S. Surgeon General. (ed US Department of Health and Human Services) (2024)."},{"key":"55676_CR2","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/s1470-2045(21)00279-5","volume":"22","author":"H Rumgay","year":"2021","unstructured":"Rumgay, H. et al. Global burden of cancer in 2020 attributable to alcohol consumption: A population-based study. Lancet Oncol. 22, 1071\u20131080. https:\/\/doi.org\/10.1016\/s1470-2045(21)00279-5 (2021).","journal-title":"Lancet Oncol."},{"key":"55676_CR3","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/s1470-2045(14)70471-1","volume":"15","author":"C Ndiaye","year":"2014","unstructured":"Ndiaye, C. et al. HPV DNA, E6\/E7 mRNA, and p16INK4a detection in head and neck cancers: A systematic review and meta-analysis. Lancet Oncol. 15, 1319\u20131331. https:\/\/doi.org\/10.1016\/s1470-2045(14)70471-1 (2014).","journal-title":"Lancet Oncol."},{"key":"55676_CR4","unstructured":"(IARC), I. A. f. R. o. C. Oral Cancer Prevention. Vol. 19. International Agency for Research on Cancer, (2023)."},{"key":"55676_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2026.101464","author":"A Beltrame","year":"2026","unstructured":"Beltrame, A. Association of alcohol consumption with oral high-risk human papillomavirus infection: A cross-sectional study within the multinational HPV infection in men (HIM) cohort. Lancet. Reg. Health. Am. https:\/\/doi.org\/10.1016\/j.lana.2026.101464 (2026).","journal-title":"Lancet. Reg. Health. Am."},{"key":"55676_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-019-0240-3","volume":"14","author":"B Duko","year":"2019","unstructured":"Duko, B., Ayalew, M. & Ayano, G. The prevalence of alcohol use disorders among people living with HIV\/AIDS: A systematic review and meta-analysis. Subst. Abuse Treat. Prev. Policy 14, 52. https:\/\/doi.org\/10.1186\/s13011-019-0240-3 (2019).","journal-title":"Subst. Abuse Treat. Prev. Policy"},{"key":"55676_CR7","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/jrh.12326","volume":"35","author":"KM Bensley","year":"2019","unstructured":"Bensley, K. M. et al. Patterns of alcohol use among patients living with HIV in urban, large rural, and small rural areas. J. Rural Health 35, 330\u2013340. https:\/\/doi.org\/10.1111\/jrh.12326 (2019).","journal-title":"J. Rural Health"},{"key":"55676_CR8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.15288\/jsa.2002.63.179","volume":"63","author":"FH Galvan","year":"2002","unstructured":"Galvan, F. H. et al. The prevalence of alcohol consumption and heavy drinking among people with HIV in the United States: Results from the HIV Cost and Services Utilization Study. J. Stud. Alcohol 63, 179\u2013186. https:\/\/doi.org\/10.15288\/jsa.2002.63.179 (2002).","journal-title":"J. Stud. Alcohol"},{"key":"55676_CR9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/acer.15522","volume":"49","author":"SM Ingle","year":"2025","unstructured":"Ingle, S. M. et al. Harmonization of alcohol use data and mortality across a multi-national HIV cohort collaboration. Alcohol Clin Exp Res (Hoboken) 49, 407\u2013417. https:\/\/doi.org\/10.1111\/acer.15522 (2025).","journal-title":"Alcohol Clin Exp Res (Hoboken)"},{"key":"55676_CR10","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1080\/09540121.2021.1874274","volume":"33","author":"HM Crane","year":"2021","unstructured":"Crane, H. M. et al. Drug and alcohol use among people living with HIV in care in the United States by geographic region. AIDS Care 33, 1569\u20131576. https:\/\/doi.org\/10.1080\/09540121.2021.1874274 (2021).","journal-title":"AIDS Care"},{"key":"55676_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2024.112523","volume":"266","author":"NE Chichetto","year":"2025","unstructured":"Chichetto, N. E. et al. Impact of syndemic heavy drinking, smoking, and depression on mortality among MSM with and without HIV: A longitudinal study. Drug Alcohol Depend. 266, 112523. https:\/\/doi.org\/10.1016\/j.drugalcdep.2024.112523 (2025).","journal-title":"Drug Alcohol Depend."},{"key":"55676_CR12","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/QAI.0b013e3181b18b6e","volume":"52","author":"CS Hendershot","year":"2009","unstructured":"Hendershot, C. S., Stoner, S. A., Pantalone, D. W. & Simoni, J. M. Alcohol use and antiretroviral adherence: review and meta-analysis. J. Acquir. Immune Defic. Syndr. 52, 180\u2013202. https:\/\/doi.org\/10.1097\/QAI.0b013e3181b18b6e (2009).","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"55676_CR13","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1007\/s10461-016-1474-y","volume":"21","author":"CW Kahler","year":"2017","unstructured":"Kahler, C. W. et al. Direct and indirect effects of heavy alcohol use on clinical outcomes in a longitudinal study of HIV patients on ART. AIDS Behav. 21, 1825\u20131835. https:\/\/doi.org\/10.1007\/s10461-016-1474-y (2017).","journal-title":"AIDS Behav."},{"key":"55676_CR14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1093\/alcalc\/agy016","volume":"53","author":"PE Molina","year":"2018","unstructured":"Molina, P. E., Simon, L., Amedee, A. M., Welsh, D. A. & Ferguson, T. F. Impact of alcohol on HIV disease pathogenesis, comorbidities and aging: Integrating preclinical and clinical findings. Alcohol Alcohol. 53, 439\u2013447. https:\/\/doi.org\/10.1093\/alcalc\/agy016 (2018).","journal-title":"Alcohol Alcohol."},{"key":"55676_CR15","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000004329","author":"DD Satre","year":"2025","unstructured":"Satre, D. D. et al. The relationship of smoking and unhealthy alcohol use to HIV care retention and viral suppression: Findings from a multi-site cohort study. AIDS https:\/\/doi.org\/10.1097\/qad.0000000000004329 (2025).","journal-title":"AIDS"},{"key":"55676_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/aje\/kwu247","volume":"181","author":"DC Beachler","year":"2015","unstructured":"Beachler, D. C. et al. Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. Am. J. Epidemiol. 181, 40\u201353. https:\/\/doi.org\/10.1093\/aje\/kwu247 (2015).","journal-title":"Am. J. Epidemiol."},{"key":"55676_CR17","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1086\/381504","volume":"189","author":"AR Kreimer","year":"2004","unstructured":"Kreimer, A. R. et al. Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J. Infect. Dis. 189, 686\u2013698. https:\/\/doi.org\/10.1086\/381504 (2004).","journal-title":"J. Infect. Dis."},{"key":"55676_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvr.2022.200237","volume":"13","author":"J Riddell","year":"2022","unstructured":"Riddell, J. et al. Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults. Tumour Virus Res. 13, 200237. https:\/\/doi.org\/10.1016\/j.tvr.2022.200237 (2022).","journal-title":"Tumour Virus Res."},{"key":"55676_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1360-0443.2011.03621.x","volume":"107","author":"J Rehm","year":"2012","unstructured":"Rehm, J., Shield, K. D., Joharchi, N. & Shuper, P. A. Alcohol consumption and the intention to engage in unprotected sex: systematic review and meta-analysis of experimental studies. Addiction 107, 51\u201359. https:\/\/doi.org\/10.1111\/j.1360-0443.2011.03621.x (2012).","journal-title":"Addiction"},{"key":"55676_CR20","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/01.olq.0000151418.03899.97","volume":"32","author":"RL Cook","year":"2005","unstructured":"Cook, R. L. & Clark, D. B. Is there an association between alcohol consumption and sexually transmitted diseases? A systematic review. Sex. Transm Dis. 32, 156\u2013164. https:\/\/doi.org\/10.1097\/01.olq.0000151418.03899.97 (2005).","journal-title":"Sex. Transm Dis."},{"key":"55676_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/23744235.2020.1811373","volume":"53","author":"HM Goncalves","year":"2021","unstructured":"Goncalves, H. M. et al. The prevalence and risk-factors of oral HPV DNA detection among HIV-infected men between men who have sex with men and heterosexual men. Infect. Dis. 53, 19\u201330. https:\/\/doi.org\/10.1080\/23744235.2020.1811373 (2021). https:\/\/doi.org\/https:","journal-title":"Infect. Dis."},{"key":"55676_CR22","doi-asserted-by":"publisher","first-page":"107249","DOI":"10.1016\/j.oraloncology.2025.107249","volume":"163","author":"DS G","year":"2025","unstructured":"G, D. S. et al. Oral HPV incidence and risk factors for acquisition. Oral Oncol. 163, 107249. https:\/\/doi.org\/10.1016\/j.oraloncology.2025.107249 (2025).","journal-title":"Oral Oncol."},{"key":"55676_CR23","doi-asserted-by":"publisher","first-page":"6592","DOI":"10.1038\/srep06592","volume":"4","author":"K Gaester","year":"2014","unstructured":"Gaester, K. et al. Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors. Sci. Rep. 4, 6592. https:\/\/doi.org\/10.1038\/srep06592 (2014).","journal-title":"Sci. Rep."},{"key":"55676_CR24","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1186\/s12879-021-06301-6","volume":"21","author":"AL Hernandez","year":"2021","unstructured":"Hernandez, A. L. et al. Prevalence of oral human papillomavirus infection among Indian HIV-positive men who have sex with men: a cross-sectional study. BMC Infect. Dis. 21, 675. https:\/\/doi.org\/10.1186\/s12879-021-06301-6 (2021).","journal-title":"BMC Infect. Dis."},{"key":"55676_CR25","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1093\/infdis\/jiv080","volume":"212","author":"K Muller","year":"2015","unstructured":"Muller, K. et al. Oral Human Papillomavirus Infection and Oral Lesions in HIV-Positive and HIV-Negative Dental Patients. J. Infect. Dis. 212, 760\u2013768. https:\/\/doi.org\/10.1093\/infdis\/jiv080 (2015).","journal-title":"J. Infect. Dis."},{"key":"55676_CR26","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4407","volume":"6","author":"LMS Vianna","year":"2018","unstructured":"Vianna, L. M. S. et al. Oropharynx HPV status and its relation to HIV infection. PeerJ 6, e4407. https:\/\/doi.org\/10.7717\/peerj.4407 (2018).","journal-title":"PeerJ"},{"key":"55676_CR27","doi-asserted-by":"publisher","first-page":"ofaf577","DOI":"10.1093\/ofid\/ofaf577","volume":"12","author":"N Wongkalasin","year":"2025","unstructured":"Wongkalasin, N. et al. Global Estimates of the HPV-related, Noncervical Cancer Burden in People With HIV and AIDS and the Potential Effect of Improved HPV Vaccine Coverage in This Population: A Systematic Review, Meta-analysis and Modeling Study. Open. Forum Infect. Dis. 12, ofaf577. https:\/\/doi.org\/10.1093\/ofid\/ofaf577 (2025).","journal-title":"Open. Forum Infect. Dis."},{"key":"55676_CR28","doi-asserted-by":"publisher","first-page":"105830","DOI":"10.1016\/j.archoralbio.2023.105830","volume":"157","author":"M Cui","year":"2024","unstructured":"Cui, M. et al. Characteristics of human papillomavirus infection among oropharyngeal cancer patients: A systematic review and meta-analysis. Arch. Oral Biol. 157, 105830. https:\/\/doi.org\/10.1016\/j.archoralbio.2023.105830 (2024).","journal-title":"Arch. Oral Biol."},{"key":"55676_CR29","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41571-022-00603-7","volume":"19","author":"M Lechner","year":"2022","unstructured":"Lechner, M., Liu, J., Masterson, L. & Fenton, T. R. HPV-associated oropharyngeal cancer: Epidemiology, molecular biology and clinical management. Nat. Rev. Clin. Oncol. 19, 306\u2013327. https:\/\/doi.org\/10.1038\/s41571-022-00603-7 (2022).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"55676_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2025.127447","volume":"61","author":"AR Giuliano","year":"2025","unstructured":"Giuliano, A. R. et al. Design of a multicenter, randomized, double-blinded, placebo-controlled phase III trial evaluating the 9-valent human papillomavirus (HPV) vaccine to prevent persistent oral HPV infection in men living with human immunodeficiency virus: ULACNet trial 201. Vaccine 61, 127447. https:\/\/doi.org\/10.1016\/j.vaccine.2025.127447 (2025).","journal-title":"Vaccine"},{"key":"55676_CR31","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1016\/s1470-2045(15)70075-6","volume":"16","author":"DR Lowy","year":"2015","unstructured":"Lowy, D. R., Herrero, R. & Hildesheim, A. Primary endpoints for future prophylactic human papillomavirus vaccine trials: Towards infection and immunobridging. Lancet Oncol. 16, e226-233. https:\/\/doi.org\/10.1016\/s1470-2045(15)70075-6 (2015).","journal-title":"Lancet Oncol."},{"key":"55676_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-05774-0","volume":"25","author":"IN Zoschke","year":"2025","unstructured":"Zoschke, I. N. et al. The influence of tobacco use, hazardous drinking, and other risk factors on HPV-associated oropharyngeal cancer risk and screening perceptions among gay and bisexual men: A cross-sectional study. BMC Oral Health 25, 462. https:\/\/doi.org\/10.1186\/s12903-025-05774-0 (2025).","journal-title":"BMC Oral Health"},{"key":"55676_CR33","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1158\/1055-9965.Epi-11-0734","volume":"21","author":"DC Beachler","year":"2012","unstructured":"Beachler, D. C. et al. Risk factors for oral HPV infection among a high prevalence population of HIV-positive and at-risk HIV-negative adults. Cancer Epidemiol. Biomarkers Prev. 21, 122\u2013133. https:\/\/doi.org\/10.1158\/1055-9965.Epi-11-0734 (2012).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"55676_CR34","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/CCO.0b013e32836242b4","volume":"25","author":"DC Beachler","year":"2013","unstructured":"Beachler, D. C. & D\u02bcSouza, G. Oral human papillomavirus infection and head and neck cancers in HIV-infected individuals. Curr. Opin. Oncol. 25, 503\u2013510. https:\/\/doi.org\/10.1097\/CCO.0b013e32836242b4 (2013).","journal-title":"Curr. Opin. Oncol."},{"key":"55676_CR35","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1016\/S1470-2045(15)70075-6","volume":"16","author":"DR Lowy","year":"2015","unstructured":"Lowy, D. R., Herrero, R., Hildesheim, A., Participants in the, I. N. C. I. w. o. P. E. f. P. H. P. V. V. T. Primary endpoints for future prophylactic human papillomavirus vaccine trials: Towards infection and immunobridging. Lancet Oncol. 16, e226-233. https:\/\/doi.org\/10.1016\/S1470-2045(15)70075-6 (2015).","journal-title":"Lancet Oncol."},{"key":"55676_CR36","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1128\/jcm.36.11.3248-3254.1998","volume":"36","author":"CL Peyton","year":"1998","unstructured":"Peyton, C. L. et al. Comparison of PCR- and hybrid capture-based human papillomavirus detection systems using multiple cervical specimen collection strategies. J. Clin. Microbiol. 36, 3248\u20133254. https:\/\/doi.org\/10.1128\/jcm.36.11.3248-3254.1998 (1998).","journal-title":"J. Clin. Microbiol."},{"key":"55676_CR37","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/jama.2012.101","volume":"307","author":"ML Gillison","year":"2012","unstructured":"Gillison, M. L. et al. Prevalence of oral HPV infection in the United States, 2009\u20132010. JAMA 307, 693\u2013703. https:\/\/doi.org\/10.1001\/jama.2012.101 (2012).","journal-title":"JAMA"},{"key":"55676_CR38","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/ijc.22667","volume":"121","author":"G D'Souza","year":"2007","unstructured":"D\u2019Souza, G. et al. Six-month natural history of oral versus cervical Human Papillomavirus infection. Int. J. Cancer 121, 143\u2013150. https:\/\/doi.org\/10.1002\/ijc.22667 (2007).","journal-title":"Int. J. Cancer"},{"key":"55676_CR39","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1158\/1055-9965.Epi-08-0347","volume":"18","author":"M Hashibe","year":"2009","unstructured":"Hashibe, M. et al. Interaction between tobacco and alcohol use and the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol. Biomarkers Prev. 18, 541\u2013550. https:\/\/doi.org\/10.1158\/1055-9965.Epi-08-0347 (2009).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"55676_CR40","first-page":"193","volume":"29","author":"C Pelucchi","year":"2006","unstructured":"Pelucchi, C., Gallus, S., Garavello, W., Bosetti, C. & La Vecchia, C. Cancer risk associated with alcohol and tobacco use: Focus on upper aero-digestive tract and liver. Alcohol Res. Health 29, 193\u2013198 (2006).","journal-title":"Alcohol Res. Health"},{"key":"55676_CR41","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.amjoto.2011.02.001","volume":"33","author":"P Sinha","year":"2012","unstructured":"Sinha, P., Logan, H. L. & Mendenhall, W. M. Human Papillomavirus, smoking, and head and neck cancer. Am. J. Otolaryngol. 33, 130\u2013136. https:\/\/doi.org\/10.1016\/j.amjoto.2011.02.001 (2012).","journal-title":"Am. J. Otolaryngol."},{"key":"55676_CR42","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae479","author":"M Horberg","year":"2024","unstructured":"Horberg, M. et al. Primary Care Guidance for Providers of Care for Persons With Human Immunodeficiency Virus: 2024 Update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin. Infect. Dis. https:\/\/doi.org\/10.1093\/cid\/ciae479 (2024).","journal-title":"Clin. Infect. Dis."},{"key":"55676_CR43","unstructured":"Centers for Disease Control and Prevention. Alcohol use and your health., (2025). https:\/\/www.cdc.gov\/alcohol\/about-alcohol-use\/index.html"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55676-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55676-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55676-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:12:12Z","timestamp":1785517932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55676-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["55676"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-55676-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"9 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval for the ULACNet-201 trial was obtained by the Human Subjects Committees of the University of Puerto Rico, School of Medicine in Puerto Rico (IRB00000378, IRB00004408, IRB00004409; 02\/05\/2020), the University of Sa\u00f5 Paulo in Brazil (IRB00001650; 07\/11\/2020), Instituto Nacional de Salud P\u00fablica in Mexico (IRB00001022; 09\/25\/2020), Weill Cornell Medicine (IRB00009417-IRB00009421; 03\/17\/2020), and H. Lee Moffitt Cancer Center & Research Institute (IRB00000362, IRB00001786; 01\/07\/2020) before the start of participant enrollment. The study adheres to the principles outlined in the Declaration of Helsinki and Good Clinical Practice guidelines. Written informed consent was obtained from all participants after providing comprehensive information about the trial procedures and potential risks, prior to collecting study data or biospecimens. Oversight is provided by the Data and Safety Monitoring Board (DSMB) at Weill Cornell Medicine, which conducted pre-initiation protocol reviews, and conducts annual assessments, and ad hoc reviews as needed. The DSMB evaluates safety, trial conduct and the overall risk-benefit profile of participants, and provide recommendations on study continuation, modification, or termination; DSMB personnel are not directly related to the study team. A monitoring team reviews the documentation of informed consent, verification of key eligibility criteria, assessment of critical endpoints, and reporting of significant adverse events for a subset of participants. The trial is also audited by external personnel, in collaboration with the NCI.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare the following financial interests\/personal relationships, which may be considered as potential competing interests: Luisa L. Villa reports that financial support was provided by the National Cancer Institute. Luisa L. Villa reports a relationship with Merck & Co Inc. that includes fees for travel and talks. Michael J. Schell reports financial support was provided by National Cancer Institute. Betania Allen-Leigh reports financial support was provided by National Cancer Institute. Julie Rathwell reports a relationship with Merck Sharp & Dohme, LLC that includes: consulting or advisory. Moffitt Cancer Center reports financial support was provided by National Cancer Institute. Anna R Giuliano reports financial support was provided by National Cancer Institute. Anna R Giuliano, reports a relationship with Merck & Co Inc. that includes: consulting or advisory, funding grants, and speaking and lecture fees. Anna R Giuliano holds an American Cancer Society Clinical Research Professorship. Anna Beltrame reports financial support was provided by this award. Grant B Ellsworth reports financial support was provided by National Institutes of Health National Cancer Institute. Grant Ellsworth reports financial support was provided by Merck & Co Inc. Grant B Ellsworth reports a relationship with Northeast Caribbean AIDS Clinical Training Center that includes: speaking and lecture fees. Grant B Ellsworth reports a relationship with International AIDS Society USA that includes: speaking and lecture fees. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"23323"}}