{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:55:55Z","timestamp":1793228155429,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":73,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Padjadjaran"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypertensive disorders of pregnancy, affecting 5\u201310% of pregnancies, pose significant risks to maternal and fetal health. Pregnant women with preeclampsia and proteinuria experience a gradual decrease in serum albumin due to increased protein requirements, urinary protein loss, and endothelial damage. This study aimed to investigate the correlation between hypoalbuminemia and the severity of preeclampsia. A retrospective cohort study was conducted from 2022 to 2024 at Dr. Hasan Sadikin General Hospital and Regional General Hospital Prof. Dr. Margono Soekarjo. The study included 245 pregnant women diagnosed with preeclampsia who met specific inclusion criteria. Data were collected on age, body mass index (BMI), parity status, and albumin levels. Chi-square tests, relative risk, and receiver operating characteristic (ROC) curve analyses were utilized to assess the correlation between hypoalbuminemia and preeclampsia severity. Hypoalbuminemia was predominantly identified in individuals aged 31\u201340 years with mild to moderate hypoalbuminemia. Most participants were multiparous, obese, and presented with preeclampsia without severe features. A significant correlation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.000) was observed between hypoalbuminemia and preeclampsia severity. Pregnant women with severe hypoalbuminemia had a 4.4 times higher risk of developing preeclampsia with severe features compared to those with mild to moderate hypoalbuminemia. ROC analysis identified an albumin cut-off value of 2.51\u00a0g\/dL as a predictor of preeclampsia with severe features. Hypoalbuminemia is significantly correlated with the severity of preeclampsia and may serve as a valuable predictor for identifying severe cases. Recognizing this relationship could improve the management of hypertensive disorders during pregnancy and potentially reduce maternal morbidity and mortality rates.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-55731-2","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:14:18Z","timestamp":1780942458000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypoalbuminemia as a severity predictor of preeclampsia in a multicenter study from Indonesia"],"prefix":"10.1038","volume":"16","author":[{"given":"Dina","family":"Marlina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budi","family":"Handono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Utomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putri Nadhira Adinda","family":"Adriansyah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Nadya Khairunissa","family":"Alamsyah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Sumawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Alamsyah","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megawati Al\u2019badly Ponco Dewi","family":"Poernomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"1","key":"55731_CR1","first-page":"77","volume":"39","author":"AM Khedagi","year":"2021","unstructured":"Khedagi, A. M. & Bello, N. A. Hypertensive Disorders Pregnancy Cardiol. Clin., 39(1): 77\u201390. (2021).","journal-title":"Hypertensive Disorders Pregnancy Cardiol. Clin."},{"key":"55731_CR2","unstructured":"Luger, R. K., Kight BP. Hypertension in pregnancy [Internet]. Last updated: October 3, (2022). Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430839"},{"issue":"1","key":"55731_CR3","doi-asserted-by":"publisher","first-page":"6227","DOI":"10.1038\/s41598-017-06606-0","volume":"7","author":"M Shen","year":"2017","unstructured":"Shen, M. et al. Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach. Sci. Rep. 7 (1), 6227 (2017).","journal-title":"Sci. Rep."},{"issue":"9","key":"55731_CR4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s11906-020-01070-0","volume":"22","author":"A Agrawal","year":"2020","unstructured":"Agrawal, A. & Wenger, N. K. Hypertension During Pregnancy. Curr. Hypertens. Rep. 22 (9), 64 (2020).","journal-title":"Curr. Hypertens. Rep."},{"key":"55731_CR5","unstructured":"Karrar, S. A., Martingano, D. J. & Hong, P. L. Preeclampsia [Internet]. Last updated: February 25, (2024). Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK570611\/"},{"key":"55731_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.placenta.2023.06.007","volume":"139","author":"AA Freedman","year":"2023","unstructured":"Freedman, A. A., Suresh, S. & Ernst, L. M. Patterns of placental pathology associated with preeclampsia. Placenta 139, 85\u201391 (2023).","journal-title":"Placenta"},{"key":"55731_CR7","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejogrb.2022.05.033","volume":"274","author":"P Tam\u00e1s","year":"2022","unstructured":"Tam\u00e1s, P. et al. Preeclampsia subtypes: Clinical aspects regarding pathogenesis, signs, and management with special attention to diuretic administration. Eur. J. Obstet. Gynecol. Reprod. Biol. 274, 175\u2013181 (2022).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"55731_CR8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.4103\/1735-1995.193170","volume":"21","author":"H Chen","year":"2016","unstructured":"Chen, H. et al. Association of hypoproteinemia in preeclampsia with maternal and perinatal outcomes: A retrospective analysis of high-risk women. J. Res. Med. Sci. 21, 98 (2016).","journal-title":"J. Res. Med. Sci."},{"key":"#cr-split#-55731_CR9.1","unstructured":"Gounden, V., Vashisht, R. & Jialal, I. Hypoalbuminemia. [Updated 2023 Aug 28]. In: statpearls [Internet]. Treasure island (FL): statpearls publishing"},{"key":"#cr-split#-55731_CR9.2","unstructured":"Jan.Available from: (2025). https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526080\/"},{"key":"55731_CR10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2147\/IJGM.S102819","volume":"9","author":"DG Levitt","year":"2016","unstructured":"Levitt, D. G. & Levitt, M. D. Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. Int. J. Gen. Med. 9, 229\u2013255 (2016).","journal-title":"Int. J. Gen. Med."},{"key":"55731_CR11","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.21608\/ejhm.2024.350103","volume":"95","author":"AM Mohamed Zakaria","year":"2024","unstructured":"Mohamed Zakaria, A. M. et al. Association of Hypoalbuminemia in preeclampsia with maternal and perinatal outcomes. Egypt J. Hosp. Med. 95, 1550\u20131558 (2024).","journal-title":"Egypt J. Hosp. Med."},{"issue":"4","key":"55731_CR12","first-page":"741","volume":"83","author":"T Saitou","year":"2021","unstructured":"Saitou, T. et al. Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia. Nagoya J. Med. Sci. 83 (4), 741\u2013748 (2021).","journal-title":"Nagoya J. Med. 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Relationship of maternal parity with pre-eclampsia.. International Journal of Health Sciences II, 4170\u20134176 (2022).","journal-title":"International Journal of Health Sciences"},{"issue":"1","key":"55731_CR19","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1186\/s12884-020-03284-1","volume":"20","author":"J Luo","year":"2020","unstructured":"Luo, J. et al. Pregnancy complications among nulliparous and multiparous women with advanced maternal age: a community-based prospective cohort study in China. BMC Pregnancy Childbirth. 20 (1), 581 (2020).","journal-title":"BMC Pregnancy Childbirth"},{"key":"55731_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030557","author":"G Sebastiani","year":"2019","unstructured":"Sebastiani, G. et al. The effects of vegetarian and vegan diet during pregnancy on the health of mothers and offspring.. 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(Greenwich)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55731-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55731-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55731-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:27:14Z","timestamp":1787182034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55731-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["55731"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-55731-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"30 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research has been according with guidelines aligned with the Declaration of Helsinki. Ethical clearance was obtained from Ethical Committee of Margono Hospital (Approval Number: 420 \/ 03289) and the Ethical Committee of Hasan Sadikin Hospital (Approval Number: DP.04.03\/D.XIV.6.5\/134\/2024).","order":2,"name":"Ethics","label":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Due to the retrospective nature of the study, the Ethical Committee of Margono Hospital and the Ethical Committee of Hasan Sadikin Hospital waived the need of obtaining informed consent.","order":3,"name":"Ethics","label":"Patient consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"26122"}}