{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:37:38Z","timestamp":1790469458937,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In Egypt, approximately 134,000 new cancer cases and over 30,000 deaths are recorded annually. Unfortunately, a considerable proportion of patients present with an advanced stage. This patient population often faces a misconception that if they understand their disease stage and treatment goals, it will increase their anxiety. This study assessed Egyptian patients\u2019 perceptions of their treatment objectives and the factors influencing their understanding. A survey-based study was conducted involving 487 Stage IV solid malignancy patients receiving palliative care at four Egyptian cancer centers. The survey assessed the patients\u2019 awareness of their cancer diagnosis, stage, and treatment goals. Demographic data were collected. Responses were compared with medical records, and a total knowledge score (TKS) was calculated. A cutoff of \u2265\u200975% was set for satisfactory knowledge. Of the 487 patients, 46 (9.4%) denied having cancer and were excluded. Among the remaining 441 patients, despite 85.5% accurately knowing their tumor site, only 20.4% defined their exact tumor stage, and only 12% understood that the treatment was palliative rather than curative, while 28.9% thought that their tumors were benign. Collectively, 12% demonstrated a satisfactory knowledge level. The most significant factor that correlated positively with TKS was the education level (r\n                    <jats:sub>s<\/jats:sub>\n                    = 0.311,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Illiterate\/primary-level education patients were 2.28 times more likely to have misconceptions. A substantial percentage of cancer patients demonstrated insufficient knowledge about their disease nature and treatment goals, especially those with lower education levels. These findings highlight the importance of improving patient education and physician-patient communication to help improve the process of shared decision-making.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-55911-0","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:16:35Z","timestamp":1780532195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Awareness of disease extent and perceived palliative treatment goals among oncology patients: a multicenter study"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3595-4333","authenticated-orcid":false,"given":"Manar","family":"Hamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend M. Hamdy Rashed","family":"Elkalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waled","family":"Bahaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aalaa M.","family":"Abdou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Horya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma Rezk","family":"Farouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab M.","family":"Farghaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman Mahmoud","family":"Shoaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaa Saber Abd","family":"El-raheem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Abdelfattah","family":"Elkhamisy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayada Fawzy","family":"Sedik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada Mohamed Ahmad","family":"Zahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Mahmoud","family":"El Zayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeel Gamal","family":"Elghamery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Roshdy Mohamed","family":"Al Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Hegazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"55911_CR1","doi-asserted-by":"publisher","first-page":"839835","DOI":"10.3389\/fpubh.2022.839835","volume":"10","author":"S Rajesh","year":"2022","unstructured":"Rajesh, S. et al. Mapping cancer in Africa: A comprehensive and comparable characterization of 34 cancer types using estimates from GLOBOCAN 2020. Front. Public. Health. 10, 839835 (2022).","journal-title":"Front. Public. Health"},{"issue":"1","key":"55911_CR2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.ejcdt.2015.08.008","volume":"65","author":"E Khalil","year":"2016","unstructured":"Khalil, E., Anwar, M. & AbdelFattah, S. Pattern of treatment and clinic-epidemiological analysis of 804 lung and pleura cancer patients treated in the radiation oncology department, NCI-Egypt. Egypt. J. Chest Dis. Tuberc. 65 (1), 271\u2013278 (2016).","journal-title":"Egypt. J. Chest Dis. Tuberc"},{"issue":"6","key":"55911_CR3","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.12816\/0040139","volume":"69","author":"R Regeai","year":"2017","unstructured":"Regeai, R., Faraj, A., Tawfik, A. & Mosalam, N. Clinicoepidemiological study and survival analysis of right versus left sided colon cancer patients. Egypt. J. Hosp. Med. 69 (6), 1723\u20131737 (2017).","journal-title":"Egypt. J. Hosp. Med."},{"issue":"Suppl 1","key":"55911_CR4","first-page":"S118","volume":"72","author":"NM Gado","year":"2017","unstructured":"Gado, N. M., Mosalam, N. A., Atef, D. & Hawi, M. Clinicoepidemiological study of breast cancer patients at Ain Shams University: A five-year retrospective study. Eur. J. Cancer. 72 (Suppl 1), S118 (2017).","journal-title":"Eur. J. Cancer"},{"issue":"2","key":"55911_CR5","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1200\/OP.20.00517","volume":"17","author":"R Patell","year":"2021","unstructured":"Patell, R. et al. Patient perceptions of treatment benefit and toxicity in advanced cancer: A prospective cross-sectional study. JCO Oncol. Pract. 17 (2), e119\u2013e129 (2021).","journal-title":"JCO Oncol. 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Pract."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55911-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55911-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55911-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:29:39Z","timestamp":1780532979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-55911-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["55911"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-55911-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"14 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was conducted according to the principles of the Declaration of Helsinki. The study protocol was approved by the institutional research board (IRB) of the faculty of Medicine, Mansoura University (R.21.06.1366.R1), and the Research Ethics Committee (REC) of the Egyptian Ministry of Health and population (7-2022\/06). Confidentiality and personal privacy were respected at all levels of the study. Collected data was not used for any other purpose. Informed written consent was taken from each patient who participated in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Informed written consent was taken from each patient to publish the study with their names totally hidden.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"17320"}}