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This study aimed to evaluate the suitability of 7.5% icodextrin for all PD patients with UFF. We enrolled 19 patients with UFF and 24 non-UFF PD controls. All participants underwent standard, modified, Mini-, and Double-Mini peritoneal equilibrium tests (PET). Key parameters assessed included sodium sieving (\u2206DNa60, \u2206D\/PNa60), osmotic conductance to glucose, small-pore ultrafiltration (UFSP), free water transport (FWT), and net ultrafiltration. Correlation analyses were conducted between icodextrin-induced UF and these metrics. Descriptive analysis revealed variations in icodextrin UF, \u2206D\/PNa60, and FWT were identified across the four UFF types. Numerically, icodextrin UF was highest in type 1 and type 2 UFF, while FWT appeared lower in type 2. Net icodextrin UF correlated positively with \u2206D\/PNa60, \u2206DNa60, and UFSP. Our findings indicate that 7.5% icodextrin may be suitable for PD patients with type 1 and 2 UFF, but appears perhaps less effective in those with type 3 and 4 UFF.Moreover, icodextrin ultrafiltration may be predictable through UFSP measurement, offering a potential clinical tool for patient management.<\/jats:p>","DOI":"10.1038\/s41598-026-56076-6","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:32:37Z","timestamp":1780777957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An exploratory assessment of icodextrin for ultrafiltration failure subtypes in peritoneal dialysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Chuishun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingli","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"56076_CR1","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1038\/sj.ki.5001912","volume":"103","author":"S Mujais","year":"2006","unstructured":"Mujais, S. & Story, K. 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