{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:14:34Z","timestamp":1789038874031,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":82,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20243007"],"award-info":[{"award-number":["BK20243007"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province International Joint Laboratory For Regeneration Medicine Fund"},{"name":"National Center for International Research-Cambridge-Su Genomic Research Center","award":["2017B01012"],"award-info":[{"award-number":["2017B01012"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0807300"],"award-info":[{"award-number":["2022YFA0807300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0807300"],"award-info":[{"award-number":["2022YFA0807300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32222025"],"award-info":[{"award-number":["32222025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-56289-9","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T08:33:07Z","timestamp":1781944387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adipocyte-derived CRAMP\u2013neutrophil serine protease interaction axis regulates innate cutaneous defense against Staphylococcus aureus"],"prefix":"10.1038","volume":"16","author":[{"given":"Minghui","family":"Ou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peishan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"issue":"12","key":"56289_CR1","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","volume":"17","author":"E Proksch","year":"2008","unstructured":"Proksch, E., Brandner, J. M. & Jensen, J. M. The skin: an indispensable barrier. Exp. Dermatol. 17 (12), 1063\u20131072 (2008).","journal-title":"Exp. Dermatol."},{"issue":"9","key":"56289_CR2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/exd.12450","volume":"23","author":"RR Driskell","year":"2014","unstructured":"Driskell, R. R., Jahoda, C. A. B., Chuong, C. M., Watt, F. M. & Horsley, V. Defining dermal adipose tissue. Exp. Dermatol. 23 (9), 629\u2013631 (2014).","journal-title":"Exp. Dermatol."},{"issue":"6870","key":"56289_CR3","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/415389a","volume":"415","author":"M Zasloff","year":"2002","unstructured":"Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 415 (6870), 389\u2013395 (2002).","journal-title":"Nature"},{"issue":"1","key":"56289_CR4","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S0014-5793(96)01199-4","volume":"398","author":"JW Larrick","year":"1996","unstructured":"Larrick, J. W. et al. Structural, functional analysis and localization of the human CAP18 gene. FEBS Lett. 398 (1), 74\u201380 (1996).","journal-title":"FEBS Lett."},{"issue":"2","key":"56289_CR5","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1432-1033.1996.0325z.x","volume":"238","author":"GH Gudmundsson","year":"1996","unstructured":"Gudmundsson, G. H. et al. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur. J. Biochem. 238 (2), 325\u2013332 (1996).","journal-title":"Eur. J. Biochem."},{"issue":"20","key":"56289_CR6","doi-asserted-by":"publisher","first-page":"13088","DOI":"10.1074\/jbc.272.20.13088","volume":"272","author":"RL Gallo","year":"1997","unstructured":"Gallo, R. L. et al. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J. Biol. Chem. 272 (20), 13088\u201313093 (1997).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"56289_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1046\/j.1523-1747.2001.01340.x","volume":"117","author":"RA Dorschner","year":"2001","unstructured":"Dorschner, R. A. et al. Cutaneous injury induces the release of cathelicidin antimicrobial peptides active against group A Streptococcus. J. Invest. Dermatol. 117 (1), 91\u201397 (2001).","journal-title":"J. Invest. Dermatol."},{"issue":"8","key":"56289_CR8","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/NEJM199808203390806","volume":"339","author":"FD Lowy","year":"1998","unstructured":"Lowy, F. D. Staphylococcus aureus infections. N Engl. J. Med. 339 (8), 520\u2013532 (1998).","journal-title":"N Engl. J. Med."},{"key":"56289_CR9","doi-asserted-by":"crossref","unstructured":"Balasubramanian, D., Harper, L., Shopsin, B. & Torres, V. J. Staphylococcus aureus pathogenesis in diverse host environments. Pathog. Dis. 75, 1  (2017).","DOI":"10.1093\/femspd\/ftx005"},{"issue":"6217","key":"56289_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1126\/science.1260972","volume":"347","author":"LJ Zhang","year":"2015","unstructured":"Zhang, L. J. et al. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science 347 (6217), 67\u201371 (2015).","journal-title":"Science"},{"key":"56289_CR11","doi-asserted-by":"publisher","first-page":"996863","DOI":"10.3389\/fendo.2022.996863","volume":"13","author":"H Hu","year":"2022","unstructured":"Hu, H. et al. The causal relationship between obesity and skin and soft tissue infections: a two-sample Mendelian randomization study. Front. Endocrinol. (Lausanne). 13, 996863 (2022).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"56289_CR12","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-pathmechdis-051222-015009","volume":"19","author":"A Aroca-Crevill\u00e9n","year":"2024","unstructured":"Aroca-Crevill\u00e9n, A., Hidalgo, A. & Ballesteros, I. Neutrophils in physiology and pathology. Annu. Rev. Pathol. 19, 227\u2013259 (2024).","journal-title":"Annu. Rev. Pathol."},{"issue":"12","key":"56289_CR13","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1182\/blood.V97.12.3951","volume":"97","author":"OE S\u00f8rensen","year":"2001","unstructured":"S\u00f8rensen, O. E. et al. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97 (12), 3951\u20133959 (2001).","journal-title":"Blood"},{"issue":"12","key":"56289_CR14","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1128\/AAC.48.12.4673-4679.2004","volume":"48","author":"M Sieprawska-Lupa","year":"2004","unstructured":"Sieprawska-Lupa, M. et al. Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob. Agents Chemother. 48 (12), 4673\u20134679 (2004).","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"56289_CR15","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41580-018-0093-z","volume":"20","author":"AL Ghaben","year":"2019","unstructured":"Ghaben, A. L. & Scherer, P. E. Adipogenesis and metabolic health. Nat. Rev. Mol. Cell. Biol. 20 (4), 242\u2013258 (2019).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"7","key":"56289_CR16","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.3390\/jcm8070953","volume":"8","author":"HS Cheong","year":"2019","unstructured":"Cheong, H. S. et al. Metabolic obesity phenotypes and risk of cellulitis: a cohort study. J. Clin. Med. 8 (7), 1036 (2019).","journal-title":"J. Clin. Med."},{"key":"56289_CR17","doi-asserted-by":"publisher","first-page":"e54302","DOI":"10.2196\/54302","volume":"7","author":"KG Taira","year":"2024","unstructured":"Taira, K. G., Kim, R., Ma, F., Menzies, A. M. & Drucker, A. M. Association of cellulitis with obesity: systematic review and meta-analysis. JMIR Dermatol. 7, e54302 (2024).","journal-title":"JMIR Dermatol."},{"issue":"7","key":"56289_CR18","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/s41564-021-00912-0","volume":"6","author":"Y Liu","year":"2021","unstructured":"Liu, Y. et al. Gut microbiome alterations in high-fat-diet-fed mice are associated with antibiotic tolerance. Nat. Microbiol. 6 (7), 874\u2013884 (2021).","journal-title":"Nat. Microbiol."},{"issue":"577","key":"56289_CR19","doi-asserted-by":"publisher","first-page":"eabb5280","DOI":"10.1126\/scitranslmed.abb5280","volume":"13","author":"LJ Zhang","year":"2021","unstructured":"Zhang, L. J. et al. Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors. Sci. Transl Med. 13 (577), eabb5280 (2021).","journal-title":"Sci. Transl Med."},{"issue":"4","key":"56289_CR20","doi-asserted-by":"publisher","first-page":"e20231671","DOI":"10.1084\/jem.20231425","volume":"221","author":"KJ Cavagnero","year":"2024","unstructured":"Cavagnero, K. J. et al. CXCL12\u207a dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17. J. Exp. Med. 221 (4), e20231671 (2024).","journal-title":"J. Exp. Med."},{"key":"56289_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mib.2014.11.002","volume":"23","author":"DA Stapels","year":"2015","unstructured":"Stapels, D. A., Geisbrecht, B. V. & Rooijakkers, S. H. Neutrophil serine proteases in antibacterial defense. Curr. Opin. Microbiol. 23, 42\u201348 (2015).","journal-title":"Curr. Opin. Microbiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56289-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56289-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56289-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:03:38Z","timestamp":1789038218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56289-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["56289"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-56289-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]},"assertion":[{"value":"24 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"28281"}}