{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:23:31Z","timestamp":1787703811534,"version":"build-2784847793"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":76,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100009402","name":"Mekelle University","doi-asserted-by":"publisher","award":["(ERC) of 1494\/2020"],"award-info":[{"award-number":["(ERC) of 1494\/2020"]}],"id":[{"id":"10.13039\/501100009402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-56470-0","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:06:38Z","timestamp":1781201198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life experiences of breast cancer patients undergoing chemotherapy: a descriptive qualitative study from Ayder Comprehensive Specialized Hospital, Ethiopia"],"prefix":"10.1038","volume":"16","author":[{"given":"Desta","family":"Hailu Aregawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haftu","family":"Berhe Gebru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailemariam","family":"Berhe Kahsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalayu","family":"Kidanu Berhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibrah","family":"Berhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senait","family":"Abrha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerezgiher","family":"Buruh Abera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"issue":"4","key":"56470_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/028418600750013384","volume":"39","author":"H Michelson","year":"2000","unstructured":"Michelson, H., Bolund, C., Nilsson, B. & Brandberg, Y. Health related quality of life measured by the EORTC QLQ-C30: reference values from a large sample of the Swedish population. Acta Oncologia 39(4):477\u2013484 (2000).","journal-title":"Acta Oncologia"},{"issue":"10","key":"56470_CR2","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.ejso.2004.07.003","volume":"30","author":"AFW Van der Steeg","year":"2004","unstructured":"Van der Steeg, A. F. W., De Vries, J. & Roukema, J. A. Quality of life and health status in breast carcinoma. Eur. J. Surg. Oncol. (EJSO). 30(10), 1051\u20131057 (2004).","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"56470_CR3","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1586\/14737140.7.8.1123","volume":"7","author":"PSM Grimison","year":"2007","unstructured":"Grimison, P. S. M. Quality of life and adjuvant systemic therapy for early-stage breast cancer. Expert Rev. Anticancer Ther. 7, 1123\u20131134 (2007).","journal-title":"Expert Rev. Anticancer Ther."},{"key":"56470_CR4","unstructured":"Stewart, B. W. P. K. P. World Cancer Report (International Agency Research on Cancer, Lyon, France, 2003)."},{"key":"56470_CR5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1207\/S15324796ABM2303_7","volume":"23","author":"DKSC Corle","year":"2001","unstructured":"Corle, D. K. S. C. & Mateski, D. J. Self-rated quality of life measures: effect of change to a low-fat, high-fiber, fruit and vegetable enriched diet. Ann. Behav. Med. 23, 198\u2013207 (2001).","journal-title":"Ann. Behav. Med."},{"key":"56470_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1188\/06.ONF.S1.5-12","volume":"33","author":"CR K","year":"2006","unstructured":"CR K. Advances in how clinical nurses can evaluate and improve quality of life for Individuals with cancer. Oncol. Nurs. Forum. 33, 5\u201312 (2006).","journal-title":"Oncol. Nurs. Forum"},{"key":"56470_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1477-7525-5-24","volume":"5","author":"SHKT Perry","year":"2007","unstructured":"Perry, S. H. K. T. & Chang, C. H. Quality of life assessment in women with breast cancer: benefits, acceptability and utilization. Health Qual. Life Outcomes. 5, 24\u201338 (2007).","journal-title":"Health Qual. Life Outcomes"},{"issue":"1","key":"56470_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3322\/caac.21834","volume":"74","author":"H Sung","year":"2024","unstructured":"Sung, H. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide. CA Cancer J. Clin. 74 (1), 1\u201320. https:\/\/doi.org\/10.3322\/caac.21834 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"56470_CR9","unstructured":"International Agency for Research on Cancer (IARC). Global Cancer Observatory: Cancer Today (GLOBOCAN 2022 estimates) (World Health Organization, Lyon, 2024). Available from: https:\/\/gco.iarc.who.int\/today."},{"key":"56470_CR10","unstructured":"World Health Organization (WHO). Cancer fact sheet (WHO, Geneva, 2024). Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer."},{"key":"56470_CR11","doi-asserted-by":"publisher","first-page":"12736","DOI":"10.1038\/s41598-022-17128-9","volume":"12","author":"AF Awedew","year":"2022","unstructured":"Awedew, A. F., Asefa, Z. & Belay, W. B. National burden and trend of cancer in Ethiopia, 2010\u20132019: A systematic analysis for the Global Burden of Disease study. Sci. Rep. 12, 12736. https:\/\/doi.org\/10.1038\/s41598-022-17128-9 (2022).","journal-title":"Sci. Rep."},{"key":"56470_CR12","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/1099-1611(200005\/06)9:3<221::AID-PON456>3.0.CO;2-T","volume":"9","author":"M Hanson Frost","year":"2000","unstructured":"Hanson Frost, M. et al. Physical, psychological and social wellbeing of women with breast cancer: The influence of disease phase. Psychooncology 9, 221\u2013231 (2000).","journal-title":"Psychooncology"},{"key":"56470_CR13","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1200\/JCO.2001.19.15.3581","volume":"19","author":"HH Schnipper","year":"2001","unstructured":"Schnipper, H. H. Life after breast cancer. J. Clin. Oncol. 19, 3581\u20133584 (2001).","journal-title":"J. Clin. Oncol."},{"key":"56470_CR14","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/j.1524-4741.2007.00512.x","volume":"13","author":"LCWW Richardson","year":"2007","unstructured":"Richardson, L. C. W. W., Hartzema, A. G. & Wagner, S. The role of health-related quality of life in early discontinuation of chemotherapy for breast cancer. Breast J. 13, 581\u2013587 (2007).","journal-title":"Breast J."},{"key":"56470_CR15","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1038\/sj.bjc.6604091","volume":"97","author":"ESLS Costanzo","year":"2007","unstructured":"Costanzo, E. S. L. S. et al. Adjusting to life after treatment: distress and quality of life following treatment for breast cancer. Br. J. Cancer. 97, 1625\u20131631 (2007).","journal-title":"Br. J. Cancer"},{"key":"56470_CR16","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/00006199-199211000-00008","volume":"41","author":"SEVG Ward","year":"1992","unstructured":"Ward, S. E. V. G. et al. Patients\u2019 reactions to completion of adjuvant breast cancer therapy. Nurs. Res. 41, 362\u2013366 (1992).","journal-title":"Nurs. Res."},{"issue":"330","key":"56470_CR17","first-page":"6","volume":"8","author":"AVM Montazeri","year":"2008","unstructured":"Montazeri, A. V. M., Harirchi, I., Ebrahimi, M., Khaleghi, F. & Jarvandi, S. Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study. BMC 8 (330), 6 (2008).","journal-title":"BMC"},{"issue":"2-3","key":"56470_CR18","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.phymed.2010.06.013","volume":"18","author":"J Eisenbraun","year":"2011","unstructured":"Eisenbraun, J., Scheer, R., Kr\u00f6z, M., Schad, F. & Huber, R. Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract. Phytomedicine 18(2-3), 151\u2013157 (2011).","journal-title":"Phytomedicine"},{"issue":"30","key":"56470_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.7748\/ns.23.30.42.s51","volume":"23","author":"N Davies","year":"2009","unstructured":"Davies, N. Measuring health-related quality of life in cancer patients. Nurs. Stand. 23(30), 42 (2009).","journal-title":"Nurs. Stand."},{"issue":"10","key":"56470_CR20","first-page":"41","volume":"4","author":"BDM Grabsch","year":"2006","unstructured":"Grabsch, B. D. M. et al. Psychological morbidity and quality of life in women with advanced breast cancer. Palliat. Suppor. Care Ther. 4(10), 41\u201356 (2006).","journal-title":"Palliat. Support. Care Ther."},{"issue":"24","key":"56470_CR21","first-page":"14","volume":"5","author":"SKT Perry","year":"2007","unstructured":"Perry, S. K. T. & Chang, C. Quality of life assessment in women with breast cancer: benefits, acceptability and utilization. BMC 5(24), 14 (2007).","journal-title":"BMC"},{"issue":"6","key":"56470_CR22","first-page":"1671","volume":"19","author":"A Daldoul","year":"2018","unstructured":"Daldoul, A. et al. Factors predictive of quality of life among breast cancer patients. Asian Pac. J. Cancer Prev.: APJCP. 19(6), 1671 (2018).","journal-title":"Asian Pac. J. Cancer Prev.: APJCP"},{"issue":"10","key":"56470_CR23","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1038\/bjc.2014.208","volume":"110","author":"DCC Ediebah","year":"2014","unstructured":"Ediebah, D. C. C. et al. Does change in health-related quality of life score predict survival? Analysis of EORTC 08975. lung cancer trial. Br. J. Cancer 110(10), 2427\u20132433 (2014).","journal-title":"Br. J. Cancer"},{"key":"56470_CR24","first-page":"269510","volume":"6","author":"AWL Sharma","year":"2013","unstructured":"Sharma, A. W. L. & Monson, J. Baseline quality of life factors predict long term survival after elective resection for colorectal cancer. Int. J. Surg. Oncol. 6, 269510 (2013).","journal-title":"Int. J. Surg. Oncol."},{"key":"56470_CR25","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/jjco\/hys158","volume":"42","author":"KM Hirai","year":"2012","unstructured":"Hirai, K. M. et al. Problem-solving therapy for psychological distress in Japanese early-stage breast cancer patients. Jpn J. Clin. Oncol. 42, 1168\u20131174 (2012).","journal-title":"Jpn J. Clin. Oncol."},{"key":"56470_CR26","unstructured":"University, M. Ayder comprehensive specialized hospital profile (2018)."},{"issue":"3","key":"56470_CR27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1017\/S1478951508000382","volume":"6","author":"Press: qCU","year":"2008","unstructured":"Press: qCU. A qualitative study of the experiences of women with metastatic breast cancer. Palliat. Support. Care. 6 (3), 249\u2013258 (2008).","journal-title":"Palliat. Support. Care"},{"issue":"10","key":"56470_CR28","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/pon.788","volume":"13","author":"ML Luoma","year":"2004","unstructured":"Luoma, M. L. & Hakamies\u2010Blomqvist, L. The meaning of quality of life in patients being treated for advanced breast cancer: A qualitative study. Psychooncology 13(10), 729\u2013739 (2004).","journal-title":"Psychooncology"},{"key":"56470_CR29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12888-020-02760-4","volume":"20","author":"LAFD Merri Iddrisu","year":"2020","unstructured":"Merri Iddrisu, L. A. F. D. Psychological and physical effects of breast cancer diagnosis and treatment on young Ghanaian women: a qualitative study. BMC Psychiatry 20, 353 (2020).","journal-title":"BMC Psychiatry"},{"issue":"2","key":"56470_CR30","first-page":"521","volume":"19","author":"D Suwankhong","year":"2018","unstructured":"Suwankhong, D. & Liamputtong, P. Physical and emotional experiences of chemotherapy: A qualitative study among women with breast cancer in southern Thailand. Asian Pac. J. Cancer Prev. 19(2), 521\u2013528 (2018).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"56470_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40359-021-00515-8","volume":"9","author":"J-Y-W Ruo-Yu Hu","year":"2021","unstructured":"Ruo-Yu Hu, J-Y-W., Chen, W. L., Zhao, J., Shao, C. H. & Wang, J. W. Xiao-Min Wei & Jin-Ming Yu Stress, coping strategies and expectations among breast cancer survivors in China: a qualitative study. BMC Psychol. 9, 26 (2021).","journal-title":"BMC Psychol."},{"issue":"1","key":"56470_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/01.gco.0000192996.20040.24","volume":"18","author":"AE Kayl","year":"2006","unstructured":"Kayl, A. E. & Meyers, C. A. Side-effects of chemotherapy and quality of life in ovarian and breast cancer patients. Curr. Opin. Obstet. Gynecol. 18(1), 24\u201328 (2006).","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"56470_CR33","doi-asserted-by":"publisher","unstructured":"Montazeri, A. Quality of life in breast cancer patients: an overview of the literature. in Handbook of Disease Burdens and Quality of Life Measures (eds Preedy V.R., Watson R. R.) (Springer, New York, NY, 2010). https:\/\/doi.org\/10.1007\/978-0-387-78665-0_165.","DOI":"10.1007\/978-0-387-78665-0_165"},{"issue":"4","key":"56470_CR34","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/j.1369-7625.2008.00512.x","volume":"11","author":"L Beatty","year":"2008","unstructured":"Beatty, L., Oxlad, M., Koczwara, B. & Wade, T. D. The psychosocial concerns and needs of women recently diagnosed with breast cancer: A qualitative study of patient, nurse and volunteer perspectives. Health Expect. 11(4), 331\u2013342 (2008).","journal-title":"Health Expect."},{"issue":"1","key":"56470_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12905-021-01212-9","volume":"21","author":"M Maleki","year":"2021","unstructured":"Maleki, M., Mardani, A., Ghafourifard, M. & Vaismoradi, M. Qualitative exploration of sexual life among breast cancer survivors at reproductive age. BMC Women\u2019s Health 21(1), 56 (2021).","journal-title":"BMC Women\u2019s Health"},{"issue":"2","key":"56470_CR36","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jpainsymman.2006.10.014","volume":"34","author":"B Bennett","year":"2007","unstructured":"Bennett, B., Goldstein, D., Friedlander, M., Hickie, I. & Lloyd, A. The experience of cancer-related fatigue and chronic fatigue syndrome: A qualitative and comparative study. J. Pain Symptom Manag. 34(2), 126\u2013135 (2007).","journal-title":"J. Pain Symptom Manag."},{"issue":"2","key":"56470_CR37","first-page":"98","volume":"15","author":"AA Redhwan","year":"2009","unstructured":"Redhwan, A. A., Idris, M. N., Fuad, I., Robert, C. & Hairol, O. The differences between the quality of life of malays and nonmalays breast cancer survivors women from a Teaching Hospital, Kuala Lumpur: A qualitative study. J. Kesihatan Masyarakat 15(2), 98\u2013105 (2009).","journal-title":"Jurnal Kesihatan Masyarakat"},{"issue":"3","key":"56470_CR38","doi-asserted-by":"publisher","first-page":"744","DOI":"10.4314\/ahs.v16i3.14","volume":"16","author":"B Peter","year":"2016","unstructured":"Peter, B. & Wampaalu, L. E. E. 2,3,4 Allen Naamala,5 Rose C Nabirye,1, and Lena Wettergren6. Experiences of patients undergoing chemotherapy - a qualitative study of adults attending Uganda Cancer Institute. Afr. Health Sci. 16 (3), 744\u2013749 (2016).","journal-title":"Afr. Health Sci."},{"key":"56470_CR39","first-page":"215","volume":"18","author":"S Hajian","year":"2017","unstructured":"Hajian, S., Mehrabi, E., Simbar, M. & Houshyari, M. Coping strategies and experiences in women with a primary breast cancer diagnosis. Asian Pac. J. Cancer Prev. 18, 215\u2013224 (2017).","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"4","key":"56470_CR40","doi-asserted-by":"publisher","first-page":"e020512","DOI":"10.1136\/bmjopen-2017-020512","volume":"8","author":"PJ Ho","year":"2018","unstructured":"Ho, P. J. et al. Health-related quality of life in Asian patients with breast cancer: A systematic review. BMJ Open 8(4), e020512 (2018).","journal-title":"BMJ Open"},{"issue":"3","key":"56470_CR41","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4103\/0019-509X.44066","volume":"45","author":"A Safaee","year":"2008","unstructured":"Safaee, A. et al. Predictors of quality of life in breast cancer patients under chemotherapy. Indian J. Cancer. 45(3), 107\u2013111 (2008).","journal-title":"Indian J. Cancer"},{"issue":"7","key":"56470_CR42","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3109\/0284186X.2011.577446","volume":"50","author":"M H\u00f8yer","year":"2011","unstructured":"H\u00f8yer, M. et al. Health-related quality of life among women with breast cancer\u2013a population-based study. Acta Oncol. 50(7), 1015\u20131026 (2011).","journal-title":"Acta Oncol."},{"issue":"6","key":"56470_CR43","first-page":"6","volume":"27","author":"SFA L\u00f4bo","year":"2014","unstructured":"L\u00f4bo, S. F. A., Almeida, P., Carvalho, C. & Sawada, N. Quality of life in women with breast cancer undergoing chemotherapy. Acta Paul Enferm. 27(6), 6 (2014).","journal-title":"Acta Paul Enferm"},{"key":"56470_CR44","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.2147\/PPA.S168638","volume":"12","author":"YH Nies","year":"2018","unstructured":"Nies, Y. H. et al. A qualitative study among breast cancer patients on chemotherapy: Experiences and side-effects. Patient Prefer. Adher. 12, 1955\u20131964 (2018).","journal-title":"Patient Prefer. Adher."},{"key":"56470_CR45","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1186\/s12885-018-4868-6","volume":"18","author":"J. Sibeoni","year":"2018","unstructured":"Sibeoni, J. et al. Patients\u2019 quality of life during active cancer treatment: A qualitative study. J. BMC Cancer 18, 951 (2018).","journal-title":"J. BMC Cancer"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56470-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56470-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56470-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:18:12Z","timestamp":1787699892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-56470-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["56470"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-56470-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"23 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"26743"}}