{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:19:50Z","timestamp":1787620790176,"version":"build-2736575974"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":75,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-57345-0","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:34:24Z","timestamp":1781177664000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phosphoproteomic profiling reveals reversal of dysregulated kinase signaling by nitric oxide inhibition in the Shank3 mouse model of autism"],"prefix":"10.1038","volume":"16","author":[{"given":"Shelly","family":"Ginzburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Khaliulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Kartawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajeha","family":"Hamoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham","family":"Amal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"57345_CR1","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1001\/jamapediatrics.2022.1846","volume":"176","author":"Q Li","year":"2022","unstructured":"Li, Q. et al. Prevalence of autism spectrum disorder among children and adolescents in the United States from 2019 to 2020. JAMA Pediatr. 176, 943\u2013945 (2022).","journal-title":"JAMA Pediatr."},{"key":"57345_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.ss7402a1","volume":"74","author":"KA Shaw","year":"2025","unstructured":"Shaw, K. A. et al. Prevalence and early identification of autism spectrum disorder among children aged 4 and 8 years - Autism and developmental disabilities monitoring network, 16 sites, United States, 2022. MMWR Surveill Summ. 74, 1\u201322 (2025).","journal-title":"MMWR Surveill Summ."},{"key":"57345_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41398-018-0155-1","volume":"8","author":"J Horder","year":"2018","unstructured":"Horder, J. et al. Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models. Transl Psychiatry. 8, 106 (2018).","journal-title":"Transl Psychiatry"},{"key":"57345_CR4","doi-asserted-by":"publisher","first-page":"6282","DOI":"10.1074\/jbc.M117.817700","volume":"293","author":"JJ Bruegger","year":"2018","unstructured":"Bruegger, J. J., Smith, B. C., Wynia-Smith, S. L. & Marletta, M. A. Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes. J. Biol. Chem. 293, 6282\u20136296 (2018).","journal-title":"J. Biol. Chem."},{"key":"57345_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.nbd.2015.03.017","volume":"84","author":"T Nakamura","year":"2015","unstructured":"Nakamura, T. et al. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases. Neurobiol. Dis. 84, 99\u2013108 (2015).","journal-title":"Neurobiol. Dis."},{"key":"57345_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.molcel.2017.12.025","volume":"69","author":"D Seth","year":"2018","unstructured":"Seth, D. et al. A multiplex enzymatic machinery for cellular protein S-nitrosylation. Mol. Cell. 69, 451\u2013464e456 (2018).","journal-title":"Mol. Cell."},{"key":"57345_CR7","doi-asserted-by":"publisher","first-page":"H505","DOI":"10.1152\/ajpheart.00681.2015","volume":"310","author":"Q Shao","year":"2016","unstructured":"Shao, Q. et al. Characterization of the sex-dependent myocardial S-nitrosothiol proteome. Am. J. Physiol. Heart Circ. Physiol. 310, H505\u2013515 (2016).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"57345_CR8","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.neuron.2013.05.005","volume":"78","author":"T Nakamura","year":"2013","unstructured":"Nakamura, T. et al. Aberrant protein s-nitrosylation in neurodegenerative diseases. Neuron 78, 596\u2013614 (2013).","journal-title":"Neuron"},{"key":"57345_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fnmol.2014.00086","volume":"7","author":"T Rosenberg","year":"2014","unstructured":"Rosenberg, T. et al. The roles of protein expression in synaptic plasticity and memory consolidation. Front. Mol. Neurosci. 7, 86 (2014).","journal-title":"Front. Mol. Neurosci."},{"key":"57345_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms10020","volume":"7","author":"M Lenz","year":"2016","unstructured":"Lenz, M. et al. Repetitive magnetic stimulation induces plasticity of inhibitory synapses. Nat. Commun. 7, 1\u201313 (2016).","journal-title":"Nat. Commun."},{"issue":"121ps123-121ps","key":"57345_CR11","first-page":"123","volume":"4","author":"M Deleidi","year":"2012","unstructured":"Deleidi, M. & Isacson, O. Viral and inflammatory triggers of neurodegenerative diseases. Sci. Transl Med. 4 (121ps123-121ps), 123 (2012).","journal-title":"Sci. Transl Med."},{"key":"57345_CR12","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s12035-014-8672-2","volume":"51","author":"QF Zhao","year":"2015","unstructured":"Zhao, Q. F., Yu, J. T. & Tan, L. S-nitrosylation in Alzheimer\u2019s disease. Mol. Neurobiol. 51, 268\u2013280 (2015).","journal-title":"Mol. Neurobiol."},{"key":"57345_CR13","doi-asserted-by":"crossref","unstructured":"Khaliulin, I., Hamoudi, W. & Amal, H. The multifaceted role of mitochondria in autism spectrum disorder. Mol. Psychiatr. (2024).","DOI":"10.1038\/s41380-024-02725-z"},{"key":"57345_CR14","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.1046\/j.0014-2956.2001.02473.x","volume":"268","author":"P Cohen","year":"2001","unstructured":"Cohen, P. The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. Eur. J. Biochem. 268, 5001\u20135010 (2001).","journal-title":"Eur. J. Biochem."},{"key":"57345_CR15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3892\/ijmm.2017.3036","volume":"40","author":"F Ardito","year":"2017","unstructured":"Ardito, F., Giuliani, M., Perrone, D. & Troiano, G. Lo Muzio, L. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review). Int. J. Mol. Med. 40, 271\u2013280 (2017).","journal-title":"Int. J. Mol. Med."},{"key":"57345_CR16","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.molonc.2010.09.004","volume":"4","author":"HC Harsha","year":"2010","unstructured":"Harsha, H. C. & Pandey, A. Phosphoproteomics in cancer. Mol. Oncol. 4, 482\u2013495 (2010).","journal-title":"Mol. Oncol."},{"key":"57345_CR17","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.cell.2007.02.046","volume":"129","author":"EJ Whalen","year":"2007","unstructured":"Whalen, E. J. et al. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 129, 511\u2013522 (2007).","journal-title":"Cell"},{"key":"57345_CR18","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1161\/CIRCRESAHA.118.313109","volume":"122","author":"HL Zhou","year":"2018","unstructured":"Zhou, H. L., Stomberski, C. T. & Stamler, J. S. Cross talk between S-nitrosylation and phosphorylation involving kinases and nitrosylases. Circ. Res. 122, 1485\u20131487 (2018).","journal-title":"Circ. Res."},{"key":"57345_CR19","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1038\/s41380-018-0113-6","volume":"25","author":"H Amal","year":"2020","unstructured":"Amal, H. et al. Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function. Mol. Psychiatry. 25, 1835\u20131848 (2020).","journal-title":"Mol. Psychiatry"},{"key":"57345_CR20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.niox.2023.09.003","volume":"140\u2013141","author":"M Abdel-Haq","year":"2023","unstructured":"Abdel-Haq, M. et al. Effects of extended-release 7-nitroindazole gel formulation treatment on the behavior of Shank3 mouse model of autism. Nitric Oxide. 140\u2013141, 41\u201349 (2023).","journal-title":"Nitric Oxide"},{"key":"57345_CR21","doi-asserted-by":"crossref","unstructured":"Kartawy, M., Khaliulin, I. & Amal, H. Systems biology reveals S-nitrosylation-dependent regulation of mitochondrial functions in mice with Shank3 mutation associated with autism spectrum disorder. Brain Sci 11 (2021).","DOI":"10.3390\/brainsci11060677"},{"key":"57345_CR22","doi-asserted-by":"publisher","first-page":"e2205783","DOI":"10.1002\/advs.202205783","volume":"10","author":"MK Tripathi","year":"2023","unstructured":"Tripathi, M. K. et al. The NO answer for autism spectrum disorder. Adv. Sci. (Weinh). 10, e2205783 (2023).","journal-title":"Adv. Sci. (Weinh)"},{"key":"57345_CR23","doi-asserted-by":"publisher","first-page":"10878","DOI":"10.1038\/s41598-025-95860-8","volume":"15","author":"E Deri","year":"2025","unstructured":"Deri, E., Kumar Ojha, S., Kartawy, M., Khaliulin, I. & Amal, H. Multi-omics study reveals differential expression and phosphorylation of autophagy-related proteins in autism spectrum disorder. Sci. Rep. 15, 10878 (2025).","journal-title":"Sci. Rep."},{"key":"57345_CR24","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12031-024-02270-y","volume":"74","author":"W Bazbaz","year":"2024","unstructured":"Bazbaz, W. et al. The role of thioredoxin system in Shank3 mouse model of autism. J. Mol. Neurosci. 74, 90 (2024).","journal-title":"J. Mol. Neurosci."},{"key":"57345_CR25","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.freeradbiomed.2022.06.007","volume":"188","author":"W Hamoudi","year":"2022","unstructured":"Hamoudi, W., Tripathi, M. K., Ojha, S. K. & Amal, H. A cross-talk between nitric oxide and the glutamatergic system in a Shank3 mouse model of autism. Free Radic Biol. Med. 188, 83\u201391 (2022).","journal-title":"Free Radic Biol. Med."},{"key":"57345_CR26","doi-asserted-by":"crossref","unstructured":"Tripathi, M. K., Kartawy, M. & Amal, H. The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders. Redox Biol., 101567 (2020).","DOI":"10.1016\/j.redox.2020.101567"},{"key":"57345_CR27","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1089\/ars.2019.7916","volume":"32","author":"T Nakamura","year":"2020","unstructured":"Nakamura, T. & Lipton, S. A. Nitric oxide-dependent protein post-translational modifications impair mitochondrial function and metabolism to contribute to neurodegenerative diseases. Antioxid. Redox Signal. 32, 817\u2013833 (2020).","journal-title":"Antioxid. Redox Signal."},{"key":"57345_CR28","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1080\/00207454.2020.1713776","volume":"130","author":"M Bandookwala","year":"2020","unstructured":"Bandookwala, M. & Sengupta, P. 3-Nitrotyrosine: A versatile oxidative stress biomarker for major neurodegenerative diseases. Int. J. Neurosci. 130, 1047\u20131062 (2020).","journal-title":"Int. J. Neurosci."},{"key":"57345_CR29","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/aur.1966","volume":"11","author":"D Dong","year":"2018","unstructured":"Dong, D., Zielke, H. R., Yeh, D. & Yang, P. Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder. Autism Res. 11, 1076\u20131090 (2018).","journal-title":"Autism Res."},{"key":"57345_CR30","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41380-018-0056-y","volume":"24","author":"E Courchesne","year":"2019","unstructured":"Courchesne, E. et al. The ASD living biology: from cell proliferation to clinical phenotype. Mol. Psychiatry. 24, 88\u2013107 (2019).","journal-title":"Mol. Psychiatry"},{"key":"57345_CR31","doi-asserted-by":"crossref","unstructured":"Drapeau, E., Riad, M., Kajiwara, Y. & Buxbaum, J. D. Behavioral phenotyping of an improved mouse model of Phelan\u2013McDermid syndrome with a complete deletion of the Shank3 gene. eNeuro 5 (2018).","DOI":"10.1101\/278622"},{"key":"57345_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11689-021-09397-8","volume":"13","author":"JP Delling","year":"2021","unstructured":"Delling, J. P. & Boeckers, T. M. Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications. J. Neurodev Disord. 13, 1\u201337 (2021).","journal-title":"J. Neurodev Disord"},{"key":"57345_CR33","doi-asserted-by":"crossref","unstructured":"Ojha, S. K. et al. Nitric oxide-mediated S-nitrosylation of TSC2 drives mTOR dysregulation across Shank3 and Cntnap2 models of autism spectrum disorder. Mol. Psychiatr. (2026).","DOI":"10.1038\/s41380-026-03514-6"},{"key":"57345_CR34","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","volume":"13","author":"J Cox","year":"2014","unstructured":"Cox, J. et al. Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ. Mol. Cell. Proteom. 13, 2513\u20132526 (2014).","journal-title":"Mol. Cell. Proteom."},{"key":"57345_CR35","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","volume":"13","author":"S Tyanova","year":"2016","unstructured":"Tyanova, S. et al. The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat. Methods. 13, 731\u2013740 (2016).","journal-title":"Nat. Methods"},{"key":"57345_CR36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","volume":"17","author":"V Demichev","year":"2020","unstructured":"Demichev, V., Messner, C. B., Vernardis, S. I., Lilley, K. S. & Ralser, M. DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput. Nat. Methods. 17, 41\u201344 (2020).","journal-title":"Nat. Methods"},{"key":"57345_CR37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13229-026-00716-1","volume":"17","author":"W Bazbaz","year":"2026","unstructured":"Bazbaz, W., Kartawy, M., Khaliulin, I. & Amal, H. Nitric oxide inhibition ameliorates cortical proteomic changes in the Cntnap2-\/- and Shank3\u22064\u201322 mouse models of autism spectrum disorder. Mol. Autism. 17, 21 (2026).","journal-title":"Mol. Autism"},{"key":"57345_CR38","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cell.2012.08.045","volume":"151","author":"JP Clement","year":"2012","unstructured":"Clement, J. P. et al. Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell 151, 709\u2013723 (2012).","journal-title":"Cell"},{"key":"57345_CR39","doi-asserted-by":"publisher","first-page":"13811","DOI":"10.3390\/cimb46120826","volume":"46","author":"A Kot","year":"2024","unstructured":"Kot, A., Koszewska, D., Ochman, B. & \u015awi\u0119tochowska, E. Clinical potential of Misshapen\/NIKs-related kinase (MINK) 1-A many-sided element of cell physiology and pathology. Curr. Issues Mol. Biol. 46, 13811\u201313845 (2024).","journal-title":"Curr. Issues Mol. Biol."},{"key":"57345_CR40","doi-asserted-by":"crossref","unstructured":"Eisfeldt, J. et al. Multi-omic investigations of a 17\u201319 translocation links MINK1 disruption to autism, epilepsy and osteoporosis. Int. J. Mol. Sci. 23 (2022).","DOI":"10.3390\/ijms23169392"},{"key":"57345_CR41","doi-asserted-by":"publisher","first-page":"11074","DOI":"10.1523\/JNEUROSCI.0905-17.2017","volume":"37","author":"M Larhammar","year":"2017","unstructured":"Larhammar, M., Huntwork-Rodriguez, S., Rudhard, Y., Sengupta-Ghosh, A. & Lewcock, J. W. The Ste20 family kinases MAP4K4, MINK1, and TNIK converge to regulate stress-induced JNK signaling in neurons. J. Neurosci. 37, 11074\u201311084 (2017).","journal-title":"J. Neurosci."},{"key":"57345_CR42","doi-asserted-by":"publisher","first-page":"25019","DOI":"10.1074\/jbc.M112.372342","volume":"287","author":"T Hyodo","year":"2012","unstructured":"Hyodo, T. et al. Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. J. Biol. Chem. 287, 25019\u201325029 (2012).","journal-title":"J. Biol. Chem."},{"key":"57345_CR43","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neuron.2014.12.023","volume":"85","author":"Y Araki","year":"2015","unstructured":"Araki, Y., Zeng, M., Zhang, M. & Huganir, R. L. Rapid Dispersion of SynGAP from Synaptic Spines Triggers AMPA Receptor Insertion and Spine Enlargement during LTP. Neuron 85, 173\u2013189 (2015).","journal-title":"Neuron"},{"key":"57345_CR44","doi-asserted-by":"publisher","first-page":"e71795","DOI":"10.1371\/journal.pone.0071795","volume":"8","author":"Y Yang","year":"2013","unstructured":"Yang, Y., Tao-Cheng, J. H., Bayer, K. U., Reese, T. S. & Dosemeci, A. Camkii-mediated phosphorylation regulates distributions of Syngap-\u03b11 and -\u03b12 at the postsynaptic density. PLoS One. 8, e71795 (2013).","journal-title":"PLoS One"},{"key":"57345_CR45","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1021\/cn500337u","volume":"6","author":"AJ Baucum","year":"2015","unstructured":"Baucum, A. J. 2, Shonesy, B. C., Rose, K. L., Colbran, R. J. & nd, & Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain. ACS Chem. Neurosci. 6, 615\u2013631 (2015).","journal-title":"ACS Chem. Neurosci."},{"key":"57345_CR46","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3892\/ijmm.2017.3036","volume":"40","author":"F Ardito","year":"2017","unstructured":"Ardito, F., Giuliani, M., Perrone, D. & Troiano, G. Lo Muzio, L. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy. Int. J. Mol. Med. 40, 271\u2013280 (2017).","journal-title":"Int. J. Mol. Med."},{"key":"57345_CR47","doi-asserted-by":"publisher","first-page":"15021","DOI":"10.1074\/jbc.M112451200","volume":"277","author":"Z Balafanova","year":"2002","unstructured":"Balafanova, Z. et al. Nitric Oxide (NO) Induces Nitration of Protein Kinase C\u03b5 (PKC\u03b5), Facilitating PKC\u03b5 Translocation via Enhanced PKC\u03b5-RACK2 Interactions: A Novel Mechanism of no-triggered activation of PKC\u03b5*. J. Biol. Chem. 277, 15021\u201315027 (2002).","journal-title":"J. Biol. Chem."},{"key":"57345_CR48","doi-asserted-by":"publisher","first-page":"8945","DOI":"10.1073\/pnas.0400588101","volume":"101","author":"NL Reynaert","year":"2004","unstructured":"Reynaert, N. L. et al. Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc. Natl. Acad. Sci. USA 101, 8945\u20138950 (2004).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"57345_CR49","doi-asserted-by":"publisher","first-page":"7511","DOI":"10.1074\/jbc.M411871200","volume":"280","author":"T Yasukawa","year":"2005","unstructured":"Yasukawa, T. et al. S-nitrosylation-dependent inactivation of Akt\/protein kinase B in insulin resistance. J. Biol. Chem. 280, 7511\u20137518 (2005).","journal-title":"J. Biol. Chem."},{"key":"57345_CR50","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/FJC.0b013e3181fef9cb","volume":"57","author":"H Choi","year":"2011","unstructured":"Choi, H., Tostes, R. C. & Webb, R. C. S-nitrosylation Inhibits protein kinase C-mediated contraction in mouse aorta. J. Cardiovasc. Pharmacol. 57, 65\u201371 (2011).","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"57345_CR51","doi-asserted-by":"publisher","first-page":"14453","DOI":"10.1074\/jbc.M411523200","volume":"280","author":"DM Barrett","year":"2005","unstructured":"Barrett, D. M. et al. Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. J. Biol. Chem. 280, 14453\u201314461 (2005).","journal-title":"J. Biol. Chem."},{"key":"57345_CR52","doi-asserted-by":"publisher","first-page":"10349","DOI":"10.1073\/pnas.1103503108","volume":"108","author":"N Numajiri","year":"2011","unstructured":"Numajiri, N. et al. On\u2013off system for PI3-kinase\u2013Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN). Proc. Natl. Acad. Sci. U S A. 108, 10349\u201310354 (2011).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"57345_CR53","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nature09965","volume":"472","author":"J Peca","year":"2011","unstructured":"Peca, J. et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472, 437\u2013442 (2011).","journal-title":"Nature"},{"key":"57345_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-18861-3","volume":"11","author":"H Sacai","year":"2020","unstructured":"Sacai, H. et al. Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex. Nat. Commun. 11, 1\u201315 (2020).","journal-title":"Nat. Commun."},{"key":"57345_CR55","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","volume":"2","author":"JLR Rubenstein","year":"2003","unstructured":"Rubenstein, J. L. R. & Merzenich, M. M. Model of autism: increased ratio of excitation\/inhibition in key neural systems. Genes Brain Behav. 2, 255\u2013267 (2003).","journal-title":"Genes Brain Behav."},{"key":"57345_CR56","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1126\/science.1146221","volume":"318","author":"K Tabuchi","year":"2007","unstructured":"Tabuchi, K. et al. A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. science 318, 71\u201376 (2007).","journal-title":"science"},{"key":"57345_CR57","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fped.2014.00061","volume":"2","author":"R Canitano","year":"2014","unstructured":"Canitano, R. New experimental treatments for core social domain in autism spectrum disorders. Front. Pediatr. 2, 61 (2014).","journal-title":"Front. Pediatr."},{"key":"57345_CR58","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev.ne.17.030194.000335","volume":"17","author":"M Hollmann","year":"1994","unstructured":"Hollmann, M. & Heinemann, S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31\u2013108 (1994).","journal-title":"Annu. Rev. Neurosci."},{"key":"57345_CR59","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1146\/annurev.neuro.25.112701.142758","volume":"25","author":"R Malinow","year":"2002","unstructured":"Malinow, R. & Malenka, R. C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25, 103\u2013126 (2002).","journal-title":"Annu. Rev. Neurosci."},{"key":"57345_CR60","doi-asserted-by":"publisher","first-page":"1304300","DOI":"10.3389\/fpsyt.2024.1304300","volume":"15","author":"A Jimenez-Gomez","year":"2024","unstructured":"Jimenez-Gomez, A., Nguyen, M. X. & Gill, J. S. Understanding the role of AMPA receptors in autism: insights from circuit and synapse dysfunction. Front. Psychiatry. 15, 1304300 (2024).","journal-title":"Front. Psychiatry"},{"key":"57345_CR61","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/nn.4589","volume":"20","author":"MR Geisheker","year":"2017","unstructured":"Geisheker, M. R. et al. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat. Neurosci. 20, 1043\u20131051 (2017).","journal-title":"Nat. Neurosci."},{"key":"57345_CR62","doi-asserted-by":"publisher","first-page":"18163","DOI":"10.1073\/pnas.0708699104","volume":"104","author":"Y Wu","year":"2007","unstructured":"Wu, Y. et al. Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. Proc. Natl. Acad. Sci. U S A. 104, 18163\u201318168 (2007).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"57345_CR63","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.neuroscience.2021.09.013","volume":"479","author":"RF Niescier","year":"2021","unstructured":"Niescier, R. F. & Lin, Y. C. The potential role of AMPA receptor trafficking in autism and other neurodevelopmental conditions. Neuroscience 479, 180\u2013191 (2021).","journal-title":"Neuroscience"},{"key":"57345_CR64","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S0896-6273(00)81008-9","volume":"20","author":"JH Kim","year":"1998","unstructured":"Kim, J. H., Liao, D., Lau, L. F. & Huganir, R. L. SynGAP: a synaptic RasGAP that associates with the PSD-95\/SAP90 protein family. Neuron 20, 683\u2013691 (1998).","journal-title":"Neuron"},{"key":"57345_CR65","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.neuron.2004.08.003","volume":"43","author":"G Krapivinsky","year":"2004","unstructured":"Krapivinsky, G., Medina, I., Krapivinsky, L., Gapon, S. & Clapham, D. E. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 43, 563\u2013574 (2004).","journal-title":"Neuron"},{"key":"57345_CR66","doi-asserted-by":"publisher","first-page":"eadk1291","DOI":"10.1126\/science.adk1291","volume":"383","author":"Y Araki","year":"2024","unstructured":"Araki, Y. et al. SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity. Science 383, eadk1291 (2024).","journal-title":"Science"},{"key":"57345_CR67","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ajhg.2020.11.011","volume":"108","author":"F Meili","year":"2021","unstructured":"Meili, F. et al. Multi-parametric analysis of 57 SYNGAP1 variants reveal impacts on GTPase signaling, localization, and protein stability. Am. J. Hum. Genet. 108, 148\u2013162 (2021).","journal-title":"Am. J. Hum. Genet."},{"key":"57345_CR68","doi-asserted-by":"publisher","first-page":"14786","DOI":"10.1523\/JNEUROSCI.4124-10.2010","volume":"30","author":"NK Hussain","year":"2010","unstructured":"Hussain, N. K., Hsin, H., Huganir, R. L. & Sheng, M. MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. J. Neurosci. 30, 14786\u201314794 (2010).","journal-title":"J. Neurosci."},{"key":"57345_CR69","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1016\/j.bbrc.2018.07.087","volume":"503","author":"WG Walkup","year":"2018","unstructured":"Walkup, W. G., Sweredoski, M. J., Graham, R. L., Hess, S. & Kennedy, M. B. Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases. Biochem. Biophys. Res. Commun. 503, 1599\u20131604 (2018).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"57345_CR70","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1523\/JNEUROSCI.10-02-00588.1990","volume":"10","author":"K Goslin","year":"1990","unstructured":"Goslin, K., Schreyer, D. J., Skene, J. H. & Banker, G. Changes in the distribution of GAP-43 during the development of neuronal polarity. J. Neurosci. 10, 588\u2013602 (1990).","journal-title":"J. Neurosci."},{"key":"57345_CR71","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1126\/science.3738509","volume":"233","author":"JHP Skene","year":"1986","unstructured":"Skene, J. H. P. et al. A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes. Science 233, 783\u2013786 (1986).","journal-title":"Science"},{"key":"57345_CR72","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.isci.2018.05.019","volume":"4","author":"A Kawasaki","year":"2018","unstructured":"Kawasaki, A. et al. Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a Marker of Axon growth and regeneration. iScience 4, 190\u2013203 (2018).","journal-title":"iScience"},{"key":"57345_CR73","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.1073\/pnas.85.10.3638","volume":"85","author":"RL Neve","year":"1988","unstructured":"Neve, R. L., Finch, E. A., Bird, E. D. & Benowitz, L. I. Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain. Proc. Natl. Acad. Sci. USA. 85, 3638\u20133642 (1988).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"57345_CR74","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1074\/mcp.M113.030676","volume":"12","author":"MH Han","year":"2013","unstructured":"Han, M. H. et al. The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression. Mol. Cell. Proteom. 12, 3719\u20133731 (2013).","journal-title":"Mol. Cell. Proteom."},{"key":"57345_CR75","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3389\/fnhum.2013.00609","volume":"7","author":"B Zikopoulos","year":"2013","unstructured":"Zikopoulos, B. & Barbas, H. Altered neural connectivity in excitatory and inhibitory cortical circuits in autism. Front. Hum. Neurosci. 7, 609 (2013).","journal-title":"Front. Hum. Neurosci."},{"key":"57345_CR76","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/s41398-021-01578-2","volume":"11","author":"S Mencer","year":"2021","unstructured":"Mencer, S. et al. Proteomics of autism and Alzheimer\u2019s mouse models reveal common alterations in mTOR signaling pathway. Transl. Psychiatr. 11, 480 (2021).","journal-title":"Transl Psychiatry"},{"key":"57345_CR77","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/emboj\/19.4.496","volume":"19","author":"DB Parekh","year":"2000","unstructured":"Parekh, D. B., Ziegler, W. & Parker, P. J. Multiple pathways control protein kinase C phosphorylation. EMBO J. 19, 496\u2013503 (2000).","journal-title":"EMBO J."},{"key":"57345_CR78","doi-asserted-by":"publisher","first-page":"6368","DOI":"10.1021\/pr100666c","volume":"9","author":"JH Herskowitz","year":"2010","unstructured":"Herskowitz, J. H. et al. Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. J. Proteome Res. 9, 6368\u20136379 (2010).","journal-title":"J. Proteome Res."},{"key":"57345_CR79","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s12035-020-02135-6","volume":"58","author":"M Gomis-Gonz\u00e1lez","year":"2021","unstructured":"Gomis-Gonz\u00e1lez, M. et al. Protein kinase C-gamma knockout mice show impaired hippocampal short-term memory while preserved long-term memory. Mol. Neurobiol. 58, 617\u2013630 (2021).","journal-title":"Mol. Neurobiol."},{"key":"57345_CR80","doi-asserted-by":"publisher","first-page":"6307","DOI":"10.1074\/jbc.M205587200","volume":"278","author":"SS Correia","year":"2003","unstructured":"Correia, S. S., Duarte, C. B., Faro, C. J., Pires, E. V. & Carvalho, A. L. Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation. J. Biol. Chem. 278, 6307\u20136313 (2003).","journal-title":"J. Biol. Chem."},{"key":"57345_CR81","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/mp.2008.21","volume":"14","author":"C Lintas","year":"2009","unstructured":"Lintas, C. et al. Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression. Mol. Psychiatry. 14, 705\u2013718 (2009).","journal-title":"Mol. Psychiatry"},{"key":"57345_CR82","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/sj.mp.4001704","volume":"10","author":"A Philippi","year":"2005","unstructured":"Philippi, A. et al. Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism. Mol. Psychiatry. 10, 950\u2013960 (2005).","journal-title":"Mol. Psychiatry"},{"key":"57345_CR83","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41398-018-0285-5","volume":"8","author":"T Liu","year":"2018","unstructured":"Liu, T. et al. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry. 8, 232 (2018).","journal-title":"Transl Psychiatry"},{"key":"57345_CR84","doi-asserted-by":"publisher","first-page":"e83941","DOI":"10.1371\/journal.pone.0083941","volume":"8","author":"CC Wang","year":"2013","unstructured":"Wang, C. C., Held, R. G. & Hall, B. J. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One. 8, e83941 (2013).","journal-title":"PLoS One"},{"key":"57345_CR85","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1093\/brain\/awac398","volume":"146","author":"K Chalkiadaki","year":"2023","unstructured":"Chalkiadaki, K. et al. Mnk1\/2 kinases regulate memory and autism-related behaviours via Syngap1. Brain 146, 2175\u20132190 (2023).","journal-title":"Brain"},{"key":"57345_CR86","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1111\/bjd.13523","volume":"172","author":"A Andreoli","year":"2015","unstructured":"Andreoli, A., Ruf, M. T., Itin, P., Pluschke, G. & Schmid, P. Phosphorylation of the ribosomal protein S6, a marker of mTOR (mammalian target of rapamycin) pathway activation, is strongly increased in hypertrophic scars and keloids. Br. J. Dermatol. 172, 1415\u20131417 (2015).","journal-title":"Br. J. Dermatol."},{"key":"57345_CR87","doi-asserted-by":"publisher","first-page":"8688","DOI":"10.1074\/jbc.M110.141754","volume":"286","author":"JA Hutchinson","year":"2011","unstructured":"Hutchinson, J. A., Shanware, N. P., Chang, H. & Tibbetts, R. S. Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. J. Biol. Chem. 286, 8688\u20138696 (2011).","journal-title":"J. Biol. Chem."},{"key":"57345_CR88","doi-asserted-by":"publisher","first-page":"14056","DOI":"10.1074\/jbc.M700906200","volume":"282","author":"PP Roux","year":"2007","unstructured":"Roux, P. P. et al. RAS\/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J. Biol. Chem. 282, 14056\u201314064 (2007).","journal-title":"J. Biol. Chem."},{"key":"57345_CR89","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuroscience.2024.10.050","volume":"563","author":"I Drehmer","year":"2024","unstructured":"Drehmer, I., Santos-Terra, J., Gottfried, C. & Deckmann, I. mTOR signaling pathway as a pathophysiologic mechanism in preclinical models of autism spectrum disorder. Neuroscience 563, 33\u201342 (2024).","journal-title":"Neuroscience"},{"key":"57345_CR90","doi-asserted-by":"crossref","unstructured":"Geoffray, M. M. et al. Autism spectrum disorder symptom profile across the RASopathies. Front. Psychiatr. 11\u20132020 (2021).","DOI":"10.3389\/fpsyt.2020.585700"},{"key":"57345_CR91","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fncel.2016.00032","volume":"10","author":"N Jeyabalan","year":"2016","unstructured":"Jeyabalan, N. & Clement, J. P. SYNGAP1: Mind the gap. Front. Cell. Neurosci. 10, 32 (2016).","journal-title":"Front. Cell. Neurosci."},{"key":"57345_CR92","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1002\/j.1460-2075.1994.tb06599.x","volume":"13","author":"G Pag\u00e8s","year":"1994","unstructured":"Pag\u00e8s, G., Brunet, A., L\u2019Allemain, G. & Pouyss\u00e9gur, J. Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). EMBO J. 13, 3003\u20133010 (1994).","journal-title":"EMBO J."},{"key":"57345_CR93","doi-asserted-by":"publisher","first-page":"33759","DOI":"10.1074\/jbc.M402055200","volume":"279","author":"S Sato","year":"2004","unstructured":"Sato, S., Fujita, N. & Tsuruo, T. Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK\/MAPK signal transduction pathway. J. Biol. Chem. 279, 33759\u201333767 (2004).","journal-title":"J. Biol. Chem."},{"key":"57345_CR94","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/dmcn.13394","volume":"59","author":"S Garg","year":"2017","unstructured":"Garg, S. et al. Autism spectrum disorder and other neurobehavioural comorbidities in rare disorders of the Ras\/MAPK pathway. Dev. Med. Child. Neurol. 59, 544\u2013549 (2017).","journal-title":"Dev. Med. Child. Neurol."},{"key":"57345_CR95","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.21037\/atm.2016.10.19","volume":"4","author":"EJ de Ruiter","year":"2016","unstructured":"de Ruiter, E. J. & Willems, S. M. PTK2\/FAK: a new predictive biomarker for response to radiotherapy in head and neck squamous cell carcinoma. Ann. Transl Med. 4, S44 (2016).","journal-title":"Ann. Transl Med."},{"key":"57345_CR96","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.tig.2016.01.001","volume":"32","author":"JN Crawley","year":"2016","unstructured":"Crawley, J. N., Heyer, W. D. & LaSalle, J. M. Autism and cancer share risk genes, pathways, and drug targets. Trends Genet. 32, 139\u2013146 (2016).","journal-title":"Trends Genet."},{"key":"57345_CR97","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","volume":"36","author":"MC Mendoza","year":"2011","unstructured":"Mendoza, M. C., Er, E. E. & Blenis, J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem. Sci. 36, 320\u2013328 (2011).","journal-title":"Trends Biochem. Sci."},{"key":"57345_CR98","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1042\/BJ20070058","volume":"408","author":"E Villa-Moruzzi","year":"2007","unstructured":"Villa-Moruzzi, E. Targeting of FAK Ser910 by ERK5 and PP1\u03b4 in non-stimulated and phorbol ester-stimulated cells. Biochem. J. 408, 7\u201318 (2007).","journal-title":"Biochem. J."},{"key":"57345_CR99","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/cvr\/cvr247","volume":"92","author":"M Chu","year":"2011","unstructured":"Chu, M. et al. Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy. Cardiovasc. Res. 92, 409\u2013419 (2011).","journal-title":"Cardiovasc. Res."},{"key":"57345_CR100","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.molcel.2009.06.013","volume":"35","author":"Y Zheng","year":"2009","unstructured":"Zheng, Y. et al. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol. Cell. 35, 11\u201325 (2009).","journal-title":"Mol. Cell."},{"key":"57345_CR101","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/jnc.15135","volume":"157","author":"A John","year":"2021","unstructured":"John, A., Ng-Cordell, E., Hanna, N., Brkic, D. & Baker, K. The neurodevelopmental spectrum of synaptic vesicle cycling disorders. J. Neurochem. 157, 208\u2013228 (2021).","journal-title":"J. Neurochem"},{"key":"57345_CR102","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1006\/bbrc.1993.1036","volume":"190","author":"FM Heemskerk","year":"1993","unstructured":"Heemskerk, F. M., Chen, H. C. & Huang, F. L. Protein kinase C phosphorylates Ser152, Ser156 and Ser163 but not Ser160 of MARCKS in rat brain. Biochem. Biophys. Res. Commun. 190, 236\u2013241 (1993).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"57345_CR103","doi-asserted-by":"publisher","first-page":"F800","DOI":"10.1152\/ajprenal.00703.2011","volume":"303","author":"AA Alli","year":"2012","unstructured":"Alli, A. A. et al. Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein. Am. J. Physiol. Ren. Physiol. 303, F800\u2013811 (2012).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"57345_CR104","doi-asserted-by":"publisher","first-page":"L374","DOI":"10.1152\/ajplung.00040.2014","volume":"307","author":"AF Eaton","year":"2014","unstructured":"Eaton, A. F., Yue, Q., Eaton, D. C. & Bao, H. F. ENaC activity and expression is decreased in the lungs of protein kinase C-\u03b1 knockout mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 307, L374\u2013385 (2014).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"57345_CR105","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40364-021-00286-9","volume":"9","author":"DN Iyer","year":"2021","unstructured":"Iyer, D. N. et al. Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies. Biomark. Res. 9, 34 (2021).","journal-title":"Biomark. Res."},{"key":"57345_CR106","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neubiorev.2014.09.013","volume":"50","author":"RO Solomonia","year":"2015","unstructured":"Solomonia, R. O. & McCabe, B. J. Molecular mechanisms of memory in imprinting. Neurosci. Biobehav Rev. 50, 56\u201369 (2015).","journal-title":"Neurosci. Biobehav Rev."},{"key":"57345_CR107","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/326704a0","volume":"326","author":"M B\u00e4hler","year":"1987","unstructured":"B\u00e4hler, M. & Greengard, P. Synapsin I bundles F-actin in a phosphorylation-dependent manner. Nature 326, 704\u2013707 (1987).","journal-title":"Nature"},{"key":"57345_CR108","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1083\/jcb.105.3.1355","volume":"105","author":"TC Petrucci","year":"1987","unstructured":"Petrucci, T. C. & Morrow, J. S. Synapsin I: an actin-bundling protein under phosphorylation control. J. Cell. Biol. 105, 1355\u20131363 (1987).","journal-title":"J. Cell. Biol."},{"key":"57345_CR109","doi-asserted-by":"publisher","first-page":"8383","DOI":"10.1016\/S0021-9258(19)83924-8","volume":"261","author":"W Schiebler","year":"1986","unstructured":"Schiebler, W., Jahn, R., Doucet, J. P., Rothlein, J. & Greengard, P. Characterization of synapsin I binding to small synaptic vesicles. J. Biol. Chem. 261, 8383\u20138390 (1986).","journal-title":"J. Biol. Chem."},{"key":"57345_CR110","doi-asserted-by":"publisher","first-page":"21108","DOI":"10.1074\/jbc.271.35.21108","volume":"271","author":"M Matsubara","year":"1996","unstructured":"Matsubara, M. et al. Site-specific phosphorylation of synapsin I by Mitogen-activated protein kinase and Cdk5 and its effects on physiological functions. J. Biol. Chem. 271, 21108\u201321113 (1996).","journal-title":"J. Biol. Chem."},{"key":"57345_CR111","doi-asserted-by":"publisher","first-page":"12168","DOI":"10.1073\/pnas.94.22.12168","volume":"94","author":"F Onofri","year":"1997","unstructured":"Onofri, F. et al. Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 94, 12168\u201312173 (1997).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"57345_CR112","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11068-007-9012-5","volume":"35","author":"JH Tao-Cheng","year":"2006","unstructured":"Tao-Cheng, J. H., Dosemeci, A., Winters, C. A. & Reese, T. S. Changes in the distribution of calcium calmodulin-dependent protein kinase II at the presynaptic bouton after depolarization. Brain Cell. Biol. 35, 117\u2013124 (2006).","journal-title":"Brain Cell. Biol."},{"key":"57345_CR113","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.tins.2017.03.003","volume":"40","author":"V Sytnyk","year":"2017","unstructured":"Sytnyk, V., Leshchyns\u2019ka, I. & Schachner, M. Neural cell adhesion molecules of the immunoglobulin superfamily regulate synapse formation, maintenance, and function. Trends Neurosci. 40, 295\u2013308 (2017).","journal-title":"Trends Neurosci."},{"key":"57345_CR114","doi-asserted-by":"publisher","first-page":"625340","DOI":"10.3389\/fcell.2021.625340","volume":"9","author":"BW Duncan","year":"2021","unstructured":"Duncan, B. W., Murphy, K. E. & Maness, P. F. Molecular mechanisms of L1 and NCAM adhesion molecules in synaptic pruning, plasticity, and stabilization. Front. Cell. Dev. Biol. 9, 625340 (2021).","journal-title":"Front. Cell. Dev. Biol."},{"key":"57345_CR115","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41398-020-00899-y","volume":"10","author":"V Vukojevic","year":"2020","unstructured":"Vukojevic, V. et al. Evolutionary conserved role of neural cell adhesion molecule-1 in memory. Transl. Psychiatr. 10, 217 (2020).","journal-title":"Transl Psychiatry"},{"key":"57345_CR116","doi-asserted-by":"publisher","first-page":"842755","DOI":"10.3389\/fpsyt.2022.842755","volume":"13","author":"M Eve","year":"2022","unstructured":"Eve, M., Gandawijaya, J. & Yang, L. Oguro-Ando, A. Neuronal cell adhesion molecules may mediate neuroinflammation in autism spectrum disorder. Front. Psychiatr. 13, 842755 (2022).","journal-title":"Front. Psychiatry"},{"key":"57345_CR117","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/YPG.0b013e328012d850","volume":"17","author":"ME Atz","year":"2007","unstructured":"Atz, M. E., Rollins, B. & Vawter, M. P. NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences. Psychiatr Genet. 17, 55\u201367 (2007).","journal-title":"Psychiatr Genet."},{"key":"57345_CR118","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.bbr.2018.11.012","volume":"359","author":"X Yang","year":"2019","unstructured":"Yang, X. et al. The association between NCAM1 levels and behavioral phenotypes in children with autism spectrum disorder. Behav. Brain Res. 359, 234\u2013238 (2019).","journal-title":"Behav. Brain Res."},{"key":"57345_CR119","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1002\/jnr.23038","volume":"90","author":"J Pollscheit","year":"2012","unstructured":"Pollscheit, J., Glaubitz, N., Haller, H., Horstkorte, R. & Bork, K. Phosphorylation of serine 774 of the neural cell adhesion molecule is necessary for cyclic adenosine monophosphate response element binding protein activation and neurite outgrowth. J. Neurosci. Res. 90, 1577\u20131582 (2012).","journal-title":"J. Neurosci. Res."},{"key":"57345_CR120","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s11064-013-0973-8","volume":"38","author":"Y Karbe","year":"2013","unstructured":"Karbe, Y., Pollscheit, J., Glaubitz, N., Horstkorte, R. & Bork, K. Phosphorylation of serine 774 of the neural cell adhesion molecule (NCAM) is involved in the interaction with collapsin response mediator protein-2. Neurochem Res. 38, 1229\u20131235 (2013).","journal-title":"Neurochem Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57345-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57345-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57345-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:02:35Z","timestamp":1787619755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57345-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":120,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["57345"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-57345-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"31 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"HA is a CSO of Point6 Bio and Neuro-NOS. No funds from both companies were received for this study. All other authors do not hold any competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"26624"}}