{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:23:15Z","timestamp":1787664195603,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":75,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez (FALP) Cancer Center","award":["LMT-2020 & LMT-2021"],"award-info":[{"award-number":["LMT-2020 & LMT-2021"]}]},{"name":"ANID-FONDECYT","award":["1221415"],"award-info":[{"award-number":["1221415"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-57417-1","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:56:30Z","timestamp":1781178990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiome profiles in Chilean participants with colorectal adenomas: an exploratory 16S rRNA sequencing study"],"prefix":"10.1038","volume":"16","author":[{"given":"Roxana","family":"Gonz\u00e1lez-Stegmaier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Ejsmentewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Podesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roddy","family":"Jorquera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Lagos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Barrientos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmundo","family":"Aravena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Larrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pablo","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Silva-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Villarroel-Esp\u00edndola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"57417_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"57417_CR2","unstructured":"Ferlay, J. et al. Global cancer observatory: Cancer today. Lyon, France: International Agency for Research on Cancer. https:\/\/gco.iarc.who.int\/today , accessed [02 December 2024]."},{"key":"57417_CR3","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/cncr.24760","volume":"116","author":"BK Edwards","year":"2010","unstructured":"Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975\u20132006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544\u2013573. https:\/\/doi.org\/10.1002\/cncr.24760 (2010).","journal-title":"Cancer"},{"key":"57417_CR4","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/S0140-6736(13)61649-9","volume":"383","author":"H Brenner","year":"2014","unstructured":"Brenner, H., Kloor, M. & Pox, C. P. Colorectal cancer. Lancet 383, 1490\u20131502. https:\/\/doi.org\/10.1016\/S0140-6736(13)61649-9 (2014).","journal-title":"Lancet"},{"key":"57417_CR5","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.chom.2023.04.007","volume":"31","author":"JWJ Lee","year":"2023","unstructured":"Lee, J. W. J. et al. Association of distinct microbial signatures with premalignant colorectal adenomas. Cell. Host Microbe. 31, 827\u2013838. https:\/\/doi.org\/10.1016\/j.chom.2023.04.007 (2023). .e3.","journal-title":"Cell. Host Microbe"},{"key":"57417_CR6","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.3748\/wjg.v30.i27.3336","volume":"30","author":"T Intarajak","year":"2024","unstructured":"Intarajak, T. et al. Distinct gut microbiomes in Thai patients with colorectal polyps. World J. Gastroenterol. 30, 3336\u20133355. https:\/\/doi.org\/10.3748\/wjg.v30.i27.3336 (2024).","journal-title":"World J. Gastroenterol."},{"key":"57417_CR7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/ijms18010197","volume":"18","author":"I M\u00e1rmol","year":"2017","unstructured":"M\u00e1rmol, I., S\u00e1nchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E. & Rodriguez Yoldi, M. J. Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. Int. J. Mol. Sci. 18, 197. https:\/\/doi.org\/10.3390\/ijms18010197 (2017).","journal-title":"Int. J. Mol. Sci."},{"key":"57417_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4251\/wjgo.v10.i3.71","volume":"10","author":"FM Shang","year":"2018","unstructured":"Shang, F. M. & Liu, H. L. Fusobacterium nucleatum and colorectal cancer: A review. World J. Gastrointest. Oncol. 10, 71\u201381. https:\/\/doi.org\/10.4251\/wjgo.v10.i3.71 (2018).","journal-title":"World J. Gastrointest. Oncol."},{"key":"57417_CR9","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/s41564-023-01426-7","volume":"8","author":"AW Walker","year":"2023","unstructured":"Walker, A. W. & Hoyles, L. Human microbiome myths and misconceptions. Nat. Microbiol. 8, 1392\u20131396. https:\/\/doi.org\/10.1038\/s41564-023-01426-7 (2023).","journal-title":"Nat. Microbiol."},{"key":"57417_CR10","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1007\/s00018-019-03190-6","volume":"76","author":"G Wang","year":"2019","unstructured":"Wang, G. et al. Bridging intestinal immunity and gut microbiota by metabolites. Cell. Mol. Life Sci. 76, 3917\u20133937. https:\/\/doi.org\/10.1007\/s00018-019-03190-6 (2019).","journal-title":"Cell. Mol. Life Sci."},{"key":"57417_CR11","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","volume":"368","author":"D Nejman","year":"2020","unstructured":"Nejman, D. et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368, 973\u2013980. https:\/\/doi.org\/10.1126\/science.aay9189 (2020).","journal-title":"Science"},{"key":"57417_CR12","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.3390\/ijms20174146","volume":"20","author":"I Koliarakis","year":"2019","unstructured":"Koliarakis, I. et al. Oral Bacteria and Intestinal Dysbiosis in Colorectal Cancer. Int. J. Mol. Sci. 20, 4146. https:\/\/doi.org\/10.3390\/ijms20174146 (2019).","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"57417_CR13","doi-asserted-by":"publisher","first-page":"766","DOI":"10.15252\/msb.20145645","volume":"10","author":"G Zeller","year":"2014","unstructured":"Zeller, G. et al. Potential of fecal microbiota for early-stage detection of colorectal cancer. Mol. Syst. Biol. 10 (11), 766. https:\/\/doi.org\/10.15252\/msb.20145645 (2014).","journal-title":"Mol. Syst. Biol."},{"issue":"4","key":"57417_CR14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41591-019-0405-7","volume":"25","author":"AM Thomas","year":"2019","unstructured":"Thomas, A. M. et al. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nat. Med. 25 (4), 667\u2013678. https:\/\/doi.org\/10.1038\/s41591-019-0405-7 (2019).","journal-title":"Nat. Med."},{"issue":"4","key":"57417_CR15","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41591-019-0406-6","volume":"25","author":"J Wirbel","year":"2019","unstructured":"Wirbel, J. et al. Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat. Med. 25 (4), 679\u2013689. https:\/\/doi.org\/10.1038\/s41591-019-0406-6 (2019).","journal-title":"Nat. Med."},{"issue":"6","key":"57417_CR16","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41591-019-0458-7","volume":"25","author":"S Yachida","year":"2019","unstructured":"Yachida, S. et al. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat. Med. 25 (6), 968\u2013976. https:\/\/doi.org\/10.1038\/s41591-019-0458-7 (2019).","journal-title":"Nat. Med."},{"key":"57417_CR17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.micinf.2019.02.001","volume":"21","author":"C Ambrosi","year":"2019","unstructured":"Ambrosi, C. et al. Colonic adenoma-associated Escherichia coli express specific phenotypes. Microbes Infect. 21, 305\u2013312. https:\/\/doi.org\/10.1016\/j.micinf.2019.02.001 (2019).","journal-title":"Microbes Infect."},{"key":"57417_CR18","doi-asserted-by":"publisher","first-page":"e0171602","DOI":"10.1371\/journal.pone.0171602","volume":"12","author":"RV Purcell","year":"2017","unstructured":"Purcell, R. V. et al. Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia. PLoS One. 12, e0171602. https:\/\/doi.org\/10.1371\/journal.pone.0171602 (2017).","journal-title":"PLoS One"},{"key":"57417_CR19","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/cid\/ciu787","volume":"60","author":"A Boleij","year":"2015","unstructured":"Boleij, A. et al. The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients. Clin. Infect. Dis. 60, 208\u2013215. https:\/\/doi.org\/10.1093\/cid\/ciu787 (2015).","journal-title":"Clin. Infect. Dis."},{"key":"57417_CR20","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3390\/gidisord1040031","volume":"1","author":"DHW Little","year":"2019","unstructured":"Little, D. H. W., Onizuka, K. M. & Khan, K. J. Referral for Colonoscopy in Patients with Streptococcus bovis Bacteremia and the Association with Colorectal Cancer and Adenomatous Polyps: A Quality Assurance Study. Gastrointest. Disorders. 1, 385\u2013390. https:\/\/doi.org\/10.3390\/gidisord1040031 (2019).","journal-title":"Gastrointest. Disorders"},{"key":"57417_CR21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1158\/1055-9965.EPI-16-0337","volume":"26","author":"VL Hale","year":"2017","unstructured":"Hale, V. L. et al. Shifts in the Fecal Microbiota Associated with Adenomatous Polyps. Cancer Epidemiol. Biomarkers Prev. 26, 85\u201394. https:\/\/doi.org\/10.1158\/1055-9965.EPI-16-0337 (2017).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"57417_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.7150\/ijbs.37399","volume":"16","author":"S Liang","year":"2020","unstructured":"Liang, S. et al. Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps. Int. J. Biol. Sci. 16, 135\u2013146. https:\/\/doi.org\/10.7150\/ijbs.37399 (2020).","journal-title":"Int. J. Biol. Sci."},{"issue":"18","key":"57417_CR23","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1093\/nar\/23.18.3800","volume":"23","author":"R Deuter","year":"1995","unstructured":"Deuter, R., Pietsch, S., Hertel, S. & M\u00fcller, O. A method for preparation of fecal DNA suitable for PCR. Nucleic Acids Res. 23 (18), 3800\u20133801. https:\/\/doi.org\/10.1093\/nar\/23.18.3800 (1995).","journal-title":"Nucleic Acids Res."},{"key":"57417_CR24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.4174\/astr.2021.101.5.281","volume":"101","author":"H Kwon","year":"2021","unstructured":"Kwon, H. et al. The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study. Ann. Surg. Treat. Res. 101, 281\u2013290. https:\/\/doi.org\/10.4174\/astr.2021.101.5.281 (2021).","journal-title":"Ann. Surg. Treat. Res."},{"issue":"1","key":"57417_CR25","doi-asserted-by":"publisher","first-page":"e00016","DOI":"10.1128\/mSystems.00016-19","volume":"4","author":"C Martino","year":"2019","unstructured":"Martino, C. et al. A Novel Sparse Compositional Technique Reveals Microbial Perturbations. mSystems 4 (1), e00016\u201319. https:\/\/doi.org\/10.1128\/mSystems.00016-19 (2019).","journal-title":"mSystems"},{"key":"57417_CR26","doi-asserted-by":"publisher","unstructured":"Lin, H. & Peddada, S. D. Analysis of compositions of microbiomes with bias correction. Nat Commun. 11, 3514. https:\/\/doi.org\/10.1038\/s41467-020-17041-7 (2020).","DOI":"10.1038\/s41467-020-17041-7"},{"key":"57417_CR27","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen, E. et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat. Biotechnol. 37, 852\u2013857. https:\/\/doi.org\/10.1038\/s41587-019-0209-9 (2019).","journal-title":"Nat. Biotechnol."},{"key":"57417_CR28","doi-asserted-by":"publisher","unstructured":"Rinninella, E. et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms 7 (14). https:\/\/doi.org\/10.3390\/microorganisms7010014 (2019).","DOI":"10.3390\/microorganisms7010014"},{"key":"57417_CR29","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/s41598-019-56561-1","volume":"10","author":"W Li","year":"2020","unstructured":"Li, W., Ma, Z. S. F. B. A. & Ecological Guild Trio of Firmicutes-Bacteroidetes Alliance against Actinobacteria in Human Oral Microbiome. Sci. Rep. 10, 287. https:\/\/doi.org\/10.1038\/s41598-019-56561-1 (2020).","journal-title":"Sci. Rep."},{"key":"57417_CR30","doi-asserted-by":"publisher","unstructured":"Kara\u010di\u0107, A., Renko, I., Krznari\u0107, \u017d., Klobu\u010dar, S. & Liberati Pr\u0161o, A. M. The association between the firmicutes\/bacteroidetes ratio and body mass among european population with the highest proportion of adults with obesity: An observational follow-up study from croatia. Biomedicines. 12, 2263. https:\/\/doi.org\/10.3390\/biomedicines12102263 (2024).","DOI":"10.3390\/biomedicines12102263"},{"key":"57417_CR31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1471-2180-9-123","volume":"9","author":"D Mariat","year":"2009","unstructured":"Mariat, D. et al. The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol. 9, 123. https:\/\/doi.org\/10.1186\/1471-2180-9-123 (2009).","journal-title":"BMC Microbiol."},{"key":"57417_CR32","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12866-020-01903-7","volume":"20","author":"A Vaiserman","year":"2020","unstructured":"Vaiserman, A. et al. Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population. BMC microbiol. 20, 221. https:\/\/doi.org\/10.1186\/s12866-020-01903-7 (2020).","journal-title":"BMC microbiol."},{"key":"57417_CR33","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.3390\/genes11111374","volume":"11","author":"PL Wei","year":"2020","unstructured":"Wei, P. L. et al. Classification of Changes in the Fecal Microbiota Associated with Colonic Adenomatous Polyps Using a Long-Read Sequencing Platform. Genes 11, 1374. https:\/\/doi.org\/10.3390\/genes11111374 (2020).","journal-title":"Genes"},{"key":"57417_CR34","doi-asserted-by":"publisher","first-page":"13974","DOI":"10.1038\/s41598-018-32413-2","volume":"8","author":"M Mangifesta","year":"2018","unstructured":"Mangifesta, M. et al. Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer. Sci. Rep. 8, 13974. https:\/\/doi.org\/10.1038\/s41598-018-32413-2 (2018).","journal-title":"Sci. Rep."},{"key":"57417_CR35","doi-asserted-by":"publisher","first-page":"e28028","DOI":"10.1097\/MD.0000000000028028","volume":"100","author":"X Zhou","year":"2021","unstructured":"Zhou, X. et al. The differences between fecal microbiota and intestinal fluid microbiota in colon polyps: An observational study. Medicine 100, e28028. https:\/\/doi.org\/10.1097\/MD.0000000000028028 (2021).","journal-title":"Medicine"},{"key":"57417_CR36","doi-asserted-by":"publisher","first-page":"10923","DOI":"10.1038\/s41598-019-45588-z","volume":"9","author":"TW Yang","year":"2019","unstructured":"Yang, T. W. et al. Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway. Sci. Rep. 9, 10923. https:\/\/doi.org\/10.1038\/s41598-019-45588-z (2019).","journal-title":"Sci. Rep."},{"key":"57417_CR37","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3389\/fmicb.2017.01221","volume":"8","author":"S Fujio-Vejar","year":"2017","unstructured":"Fujio-Vejar, S. et al. The Gut Microbiota of Healthy Chilean Subjects Reveals a High Abundance of the Phylum Verrucomicrobia. Front. Microbiol. 8, 1221. https:\/\/doi.org\/10.3389\/fmicb.2017.01221 (2017).","journal-title":"Front. Microbiol."},{"key":"57417_CR38","doi-asserted-by":"publisher","first-page":"223","DOI":"10.15698\/mic2021.09.760","volume":"8","author":"N Chamorro","year":"2021","unstructured":"Chamorro, N. et al. Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease. Microb. Cell. 8, 223\u2013238. https:\/\/doi.org\/10.15698\/mic2021.09.760 (2021).","journal-title":"Microb. Cell."},{"key":"57417_CR39","doi-asserted-by":"publisher","unstructured":"Liu, W. et al. Study of the Relationship between microbiome and colorectal cancer susceptibility using 16S rRNA sequencing. Biomed. Res. Int. 2020 (7828392). https:\/\/doi.org\/10.1155\/2020\/7828392 (2020).","DOI":"10.1155\/2020\/7828392"},{"key":"57417_CR40","doi-asserted-by":"publisher","first-page":"988","DOI":"10.3390\/nu10080988","volume":"10","author":"K Hiippala","year":"2018","unstructured":"Hiippala, K. et al. The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation. Nutrients 10, 988. https:\/\/doi.org\/10.3390\/nu10080988 (2018).","journal-title":"Nutrients"},{"issue":"Pt 5","key":"57417_CR41","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1099\/00207713-52-5-1615","volume":"52","author":"SH Duncan","year":"2002","unstructured":"Duncan, S. H., Hold, G. L., Barcenilla, A., Stewart, C. S. & Flint, H. J. Roseburia intestinalis sp. nov., a novel saccharolytic, butyrate-producing bacterium from human faeces. Int. J. Syst. Evol. Microbiol. 52 (Pt 5), 1615\u20131620. https:\/\/doi.org\/10.1099\/00207713-52-5-1615 (2002).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"issue":"10","key":"57417_CR42","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","volume":"9","author":"HJ Flint","year":"2012","unstructured":"Flint, H. J., Scott, K. P., Louis, P. & Duncan, S. H. The role of the gut microbiota in nutrition and health. Nat. Rev. Gastroenterol. Hepatol. 9 (10), 577\u2013589. https:\/\/doi.org\/10.1038\/nrgastro.2012.156 (2012).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"57417_CR43","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","volume":"63","author":"K Machiels","year":"2014","unstructured":"Machiels, K. et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut 63 (8), 1275\u20131283. https:\/\/doi.org\/10.1136\/gutjnl-2013-304833 (2014).","journal-title":"Gut"},{"issue":"12","key":"57417_CR44","doi-asserted-by":"publisher","first-page":"5558","DOI":"10.1128\/AEM.67.12.5558-5567.2001","volume":"67","author":"A Braune","year":"2001","unstructured":"Braune, A., G\u00fctschow, M., Engst, W. & Blaut, M. Degradation of quercetin and luteolin by Eubacterium ramulus. Appl. Environ. Microbiol. 67 (12), 5558\u20135567. https:\/\/doi.org\/10.1128\/AEM.67.12.5558-5567.2001 (2001).","journal-title":"Appl. Environ. Microbiol."},{"issue":"5","key":"57417_CR45","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1128\/AEM.72.5.3593-3599.2006","volume":"72","author":"A Belenguer","year":"2006","unstructured":"Belenguer, A. et al. Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut. Appl. Environ. Microbiol. 72 (5), 3593\u20133599. https:\/\/doi.org\/10.1128\/AEM.72.5.3593-3599.2006 (2006).","journal-title":"Appl. Environ. Microbiol."},{"issue":"5","key":"57417_CR46","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3945\/ajcn.112.046607","volume":"97","author":"HM Chen","year":"2013","unstructured":"Chen, H. M. et al. Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma. Am. J. Clin. Nutr. 97 (5), 1044\u20131052. https:\/\/doi.org\/10.3945\/ajcn.112.046607 (2013).","journal-title":"Am. J. Clin. Nutr."},{"key":"57417_CR47","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1128\/JCM.43.8.4041-4045.2005","volume":"43","author":"YA Warren","year":"2005","unstructured":"Warren, Y. A., Citron, D. M., Merriam, C. V. & Goldstein, E. J. Biochemical differentiation and comparison of Desulfovibrio species and other phenotypically similar genera. J. Clin. Microbiol. 43, 4041\u20134045. https:\/\/doi.org\/10.1128\/JCM.43.8.4041-4045.2005 (2005).","journal-title":"J. Clin. Microbiol."},{"key":"57417_CR48","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/em.20546","volume":"51","author":"MS Attene-Ramos","year":"2010","unstructured":"Attene-Ramos, M. S. et al. R. DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells. Environ. Mol. Mutagen. 51, 304\u2013314. https:\/\/doi.org\/10.1002\/em.20546 (2010).","journal-title":"Environ. Mol. Mutagen."},{"issue":"10","key":"57417_CR49","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1128\/AEM.02810-10","volume":"77","author":"PD Schloss","year":"2011","unstructured":"Schloss, P. D. & Westcott, S. L. Assessing and improving methods used in operational taxonomic unit-based approaches for 16S rRNA gene sequence analysis. Appl. Environ. Microbiol. 77 (10), 3219\u20133226. https:\/\/doi.org\/10.1128\/AEM.02810-10 (2011).","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57417-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57417-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57417-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:02:23Z","timestamp":1787662943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-57417-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["57417"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-57417-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"23 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The entire study was previously approved by the Scientific Ethics Committee (CEC) of the Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez, as the name \u201cPROTOCOLO 2020-009-RES-SIN-INT\u201d. Written informed consent was obtained from all participants.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"26631"}}