{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:09:37Z","timestamp":1789085377900,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":81,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Henan Province Young and Middle-Aged Health Science and Technology Innovation Leading Talent Training Project","award":["YXKC2021022"],"award-info":[{"award-number":["YXKC2021022"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-58150-5","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:15:13Z","timestamp":1782105313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation analysis of blood metabolites and periventricular leukomalacia in preterm infants two weeks postnatally"],"prefix":"10.1038","volume":"16","author":[{"given":"Caiyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muchun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"58150_CR1","doi-asserted-by":"publisher","first-page":"809248","DOI":"10.3389\/fped.2022.809248","volume":"10","author":"AL Schwab","year":"2022","unstructured":"Schwab, A. L. et al. Cerebral oxygenation in preterm infants developing cerebral lesions. Front Pediatr. 10, 809248. https:\/\/doi.org\/10.3389\/fped.2022.809248 (2022).","journal-title":"Front Pediatr."},{"key":"58150_CR2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fped.2017.00064","volume":"5","author":"ZA Vesoulis","year":"2017","unstructured":"Vesoulis, Z. A. & Mathur, A. M. Cerebral autoregulation, brain injury, and the transitioning premature infant. Front. Pediatr. 5, 64. https:\/\/doi.org\/10.3389\/fped.2017.00064 (2017).","journal-title":"Front. Pediatr."},{"issue":"2","key":"58150_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.mjafi.2020.05.013","volume":"77","author":"R Khurana","year":"2021","unstructured":"Khurana, R. et al. Periventricular leukomalacia: An ophthalmic perspective. Med J Armed Forces India. 77(2), 147\u2013153. https:\/\/doi.org\/10.1016\/j.mjafi.2020.05.013 (2021).","journal-title":"Med J Armed Forces India."},{"issue":"2","key":"58150_CR4","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1523\/jneurosci.22-02-00455.2002","volume":"22","author":"SA Back","year":"2002","unstructured":"Back, S. A. et al. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. J Neurosci. 22(2), 455\u2013463. https:\/\/doi.org\/10.1523\/jneurosci.22-02-00455.2002 (2002).","journal-title":"J Neurosci."},{"issue":"5","key":"58150_CR5","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00418-012-0941-4","volume":"137","author":"M Islinger","year":"2012","unstructured":"Islinger, M. et al. The peroxisome: an update on mysteries. Histochem Cell Biol. 137(5), 547\u2013574. https:\/\/doi.org\/10.1007\/s00418-012-0941-4 (2012).","journal-title":"Histochem Cell Biol."},{"issue":"9","key":"58150_CR6","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.bbadis.2012.05.008","volume":"1822","author":"NE Braverman","year":"2012","unstructured":"Braverman, N. E. & Moser, A. B. Functions of plasmalogen lipids in health and disease. Biochim Biophys Acta. 1822(9), 1442\u20131452. https:\/\/doi.org\/10.1016\/j.bbadis.2012.05.008 (2012).","journal-title":"Biochim Biophys Acta."},{"key":"58150_CR7","doi-asserted-by":"publisher","first-page":"141240","DOI":"10.1100\/2012\/141240","volume":"2012","author":"TL Rothhaar","year":"2012","unstructured":"Rothhaar, T. L. et al. Plasmalogens inhibit APP processing by directly affecting \u03b3-secretase activity in Alzheimer\u2019s disease. ScientificWorldJournal. 2012, 141240. https:\/\/doi.org\/10.1100\/2012\/141240 (2012).","journal-title":"ScientificWorldJournal."},{"key":"58150_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/nu14224725","author":"S Manninen","year":"2022","unstructured":"Manninen, S. et al. Carnitine intake and serum levels associate positively with postnatal growth and brain size at term in very preterm infants. Nutrients https:\/\/doi.org\/10.3390\/nu14224725 (2022).","journal-title":"Nutrients"},{"key":"58150_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25010182","author":"A Gnoni","year":"2020","unstructured":"Gnoni, A. et al. Carnitine in human muscle bioenergetics: Can carnitine supplementation improve physical exercise?. Molecules https:\/\/doi.org\/10.3390\/molecules25010182 (2020).","journal-title":"Molecules"},{"issue":"2","key":"58150_CR10","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s13760-020-01308-3","volume":"120","author":"P Greco","year":"2020","unstructured":"Greco, P. et al. Pathophysiology of hypoxic-ischemic encephalopathy: A review of the past and a view on the future. Acta Neurol. Belg. 120(2), 277\u2013288. https:\/\/doi.org\/10.1007\/s13760-020-01308-3 (2020).","journal-title":"Acta Neurol. Belg."},{"issue":"5","key":"58150_CR11","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1203\/01.Pdr.0000085036.07561.9c","volume":"54","author":"MS Wainwright","year":"2003","unstructured":"Wainwright, M. S. et al. L-carnitine reduces brain injury after hypoxia-ischemia in newborn rats. Pediatr Res. 54(5), 688\u2013695. https:\/\/doi.org\/10.1203\/01.Pdr.0000085036.07561.9c (2003).","journal-title":"Pediatr Res."},{"key":"58150_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12050467","author":"AM Dave","year":"2022","unstructured":"Dave, A. M. et al. Neonatal hypoxic-ischemic brain injury alters brain acylcarnitine levels in a mouse model. Metabolites https:\/\/doi.org\/10.3390\/metabo12050467 (2022).","journal-title":"Metabolites"},{"issue":"10","key":"58150_CR13","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1016\/j.bbamcr.2016.01.023","volume":"1863","author":"N Longo","year":"2016","unstructured":"Longo, N., Frigeni, M. & Pasquali, M. Carnitine transport and fatty acid oxidation. Biochim Biophys Acta. 1863(10), 2422\u20132435. https:\/\/doi.org\/10.1016\/j.bbamcr.2016.01.023 (2016).","journal-title":"Biochim Biophys Acta."},{"issue":"6","key":"58150_CR14","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1007\/s11064-017-2288-7","volume":"42","author":"GC Ferreira","year":"2017","unstructured":"Ferreira, G. C. & McKenna, M. C. L-Carnitine and acetyl-L-carnitine roles and neuroprotection in developing brain. Neurochem Res 42(6), 1661\u20131675. https:\/\/doi.org\/10.1007\/s11064-017-2288-7 (2017).","journal-title":"Neurochem Res"},{"issue":"8","key":"58150_CR15","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1016\/j.clnu.2019.10.025","volume":"39","author":"PD Manta-Vogli","year":"2020","unstructured":"Manta-Vogli, P. D. et al. The significant role of carnitine and fatty acids during pregnancy, lactation and perinatal period. Nutritional support in specific groups of pregnant women. Clin. Nutr. 39(8), 2337\u20132346. https:\/\/doi.org\/10.1016\/j.clnu.2019.10.025 (2020).","journal-title":"Clin. Nutr."},{"issue":"4","key":"58150_CR16","first-page":"417","volume":"18","author":"A K\u0119pka","year":"2014","unstructured":"K\u0119pka, A. et al. The role of carnitine in the perinatal period. Dev. Period Med. 18(4), 417\u2013425 (2014).","journal-title":"Dev. Period Med."},{"issue":"4","key":"58150_CR17","doi-asserted-by":"publisher","first-page":"101480","DOI":"10.1016\/j.xcrm.2024.101480","volume":"5","author":"M Pristner","year":"2024","unstructured":"Pristner, M. et al. Neuroactive metabolites and bile acids are altered in extremely premature infants with brain injury. Cell Reports Medicine 5(4), 101480. https:\/\/doi.org\/10.1016\/j.xcrm.2024.101480 (2024).","journal-title":"Cell Reports Medicine"},{"key":"58150_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fmolb.2018.00029","volume":"5","author":"A Parthasarathy","year":"2018","unstructured":"Parthasarathy, A. et al. A three-ring circus: Metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals. Front. Mol. Biosci. 5, 29. https:\/\/doi.org\/10.3389\/fmolb.2018.00029 (2018).","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"58150_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1203\/00006450-197901000-00051","volume":"13","author":"SM Andersson","year":"1979","unstructured":"Andersson, S. M., Ohisalo, J. J. & R\u00e4ih\u00e4, N. C. R. Tyrosine aminotransferase in human Liver; development, properties and substate induction in organ culture. Pediatr. Res. 13(1), 78. https:\/\/doi.org\/10.1203\/00006450-197901000-00051 (1979).","journal-title":"Pediatr. Res."},{"issue":"1","key":"58150_CR20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s13244-025-02030-5","volume":"16","author":"NL C","year":"2025","unstructured":"C, N. L. et al. Paediatric cranial ultrasound: Assessment of the preterm brain. Insights Imaging 16(1), 158. https:\/\/doi.org\/10.1186\/s13244-025-02030-5 (2025).","journal-title":"Insights Imaging"},{"issue":"8","key":"58150_CR21","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1007\/s00431-024-05627-y","volume":"183","author":"F Miselli","year":"2024","unstructured":"Miselli, F. et al. Cranial ultrasound in preterm infants\u2009\u2264\u200932 weeks gestation-novel insights from the use of very high-frequency (18-5 MHz) transducers: A case series. Eur J Pediatr 183(8), 3589\u20133598. https:\/\/doi.org\/10.1007\/s00431-024-05627-y (2024).","journal-title":"Eur J Pediatr"},{"issue":"5","key":"58150_CR22","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1177\/0883073815604229","volume":"31","author":"JY Choi","year":"2016","unstructured":"Choi, J. Y., Rha, D. W. & Park, E. S. The effects of the severity of periventricular leukomalacia on the neuropsychological outcomes of preterm children. J Child Neurol 31(5), 603\u2013612. https:\/\/doi.org\/10.1177\/0883073815604229 (2016).","journal-title":"J Child Neurol"},{"issue":"8-9","key":"58150_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1177\/08830738231185688","volume":"38","author":"AA Garvey","year":"2023","unstructured":"Garvey, A. A. et al. Acute diffusion-weighted imaging signaling severe periventricular leukomalacia in preterm infants: Case report and review of literature. J Child Neurol 38(8\u20139), 489\u2013497. https:\/\/doi.org\/10.1177\/08830738231185688 (2023).","journal-title":"J Child Neurol"},{"key":"58150_CR24","doi-asserted-by":"publisher","first-page":"1172290","DOI":"10.3389\/fendo.2023.1172290","volume":"14","author":"ZP Wu","year":"2023","unstructured":"Wu, Z. P. et al. Altered adolescents obesity metabolism is associated with hypertension: A UPLC-MS-based untargeted metabolomics study. Front Endocrinol (Lausanne) 14, 1172290. https:\/\/doi.org\/10.3389\/fendo.2023.1172290 (2023).","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"58150_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/jms.3780","volume":"51","author":"S Barnes","year":"2016","unstructured":"Barnes, S. et al. Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future. J. Mass Spectrom. 51(8), 535\u2013548. https:\/\/doi.org\/10.1002\/jms.3780 (2016).","journal-title":"J. Mass Spectrom."},{"issue":"9-10","key":"58150_CR26","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cca.2012.01.026","volume":"413","author":"T Zhang","year":"2012","unstructured":"Zhang, T. et al. Discrimination between malignant and benign ovarian tumors by plasma metabolomic profiling using ultra performance liquid chromatography\/mass spectrometry. Clin Chim Acta 413(9\u201310), 861\u2013868. https:\/\/doi.org\/10.1016\/j.cca.2012.01.026 (2012).","journal-title":"Clin Chim Acta"},{"issue":"1","key":"58150_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1), 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"58150_CR28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/ppul.1950200307","volume":"20","author":"AK Iafolla","year":"1995","unstructured":"Iafolla, A. K., Browning, I. B. 3rd. & Roe, C. R. Familial infantile apnea and immature beta oxidation. Pediatr Pulmonol. 20(3), 167\u2013171. https:\/\/doi.org\/10.1002\/ppul.1950200307 (1995).","journal-title":"Pediatr Pulmonol."},{"key":"58150_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12020178","author":"ST Teoh","year":"2022","unstructured":"Teoh, S. T. et al. Combined plasma and urinary metabolomics uncover metabolic perturbations associated with severe respiratory syncytial viral infection and future development of asthma in infant patients. Metabolites https:\/\/doi.org\/10.3390\/metabo12020178 (2022).","journal-title":"Metabolites"},{"key":"58150_CR30","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3389\/fgene.2018.00405","volume":"9","author":"M Maher","year":"2018","unstructured":"Maher, M. et al. Epigenetic-transcriptional regulation of fatty acid metabolism and its alterations in leukaemia. Front Genet. 9, 405. https:\/\/doi.org\/10.3389\/fgene.2018.00405 (2018).","journal-title":"Front Genet."},{"issue":"12","key":"58150_CR31","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1002\/1873-3468.12691","volume":"591","author":"YH Kwon","year":"2017","unstructured":"Kwon, Y. H. et al. Hypothalamic lipid-laden astrocytes induce microglia migration and activation. FEBS Lett. 591(12), 1742\u20131751. https:\/\/doi.org\/10.1002\/1873-3468.12691 (2017).","journal-title":"FEBS Lett."},{"issue":"2","key":"58150_CR32","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","volume":"23","author":"J Marschallinger","year":"2020","unstructured":"Marschallinger, J. et al. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat Neurosci. 23(2), 194\u2013208. https:\/\/doi.org\/10.1038\/s41593-019-0566-1 (2020).","journal-title":"Nat Neurosci."},{"issue":"3","key":"58150_CR33","doi-asserted-by":"publisher","first-page":"254","DOI":"10.2174\/092986710790149783","volume":"17","author":"J Westra","year":"2010","unstructured":"Westra, J., Molema, G. & Kallenberg, C. G. Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis\u2014Therapeutic implications. Curr Med Chem. 17(3), 254\u2013263. https:\/\/doi.org\/10.2174\/092986710790149783 (2010).","journal-title":"Curr Med Chem."},{"issue":"3","key":"58150_CR34","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","volume":"169","author":"BD Manning","year":"2017","unstructured":"Manning, B. D. & Toker, A. AKT\/PKB signaling: Navigating the network. Cell 169(3), 381\u2013405. https:\/\/doi.org\/10.1016\/j.cell.2017.04.001 (2017).","journal-title":"Cell"},{"issue":"2","key":"58150_CR35","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ceb.2009.02.002","volume":"21","author":"L Bozulic","year":"2009","unstructured":"Bozulic, L. & Hemmings, B. A. PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr Opin Cell Biol. 21(2), 256\u2013261. https:\/\/doi.org\/10.1016\/j.ceb.2009.02.002 (2009).","journal-title":"Curr Opin Cell Biol."},{"issue":"2","key":"58150_CR36","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/s0039-6257(02)00455-1","volume":"48","author":"JE Lee","year":"2001","unstructured":"Lee, J. E. Low IGF-1 suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity,. Surv. Ophthalmol. 48(2), 234\u2013235. https:\/\/doi.org\/10.1016\/s0039-6257(02)00455-1 (2001).","journal-title":"Surv. Ophthalmol."},{"issue":"5","key":"58150_CR37","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1073\/pnas.041359198","volume":"98","author":"D Fukumura","year":"2001","unstructured":"Fukumura, D. et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A. 98(5), 2604\u20132609. https:\/\/doi.org\/10.1073\/pnas.041359198 (2001).","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"58150_CR38","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.tem.2010.01.001","volume":"21","author":"JR Krycer","year":"2010","unstructured":"Krycer, J. R. et al. The Akt-SREBP nexus: Cell signaling meets lipid metabolism. Trends Endocrinol Metab. 21(5), 268\u2013276. https:\/\/doi.org\/10.1016\/j.tem.2010.01.001 (2010).","journal-title":"Trends Endocrinol Metab."},{"issue":"3\u20134","key":"58150_CR39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10555-009-9198-3","volume":"28","author":"MA Knowles","year":"2009","unstructured":"Knowles, M. A. et al. Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer. Cancer Metastasis Rev. 28(3\u20134), 305\u2013316. https:\/\/doi.org\/10.1007\/s10555-009-9198-3 (2009).","journal-title":"Cancer Metastasis Rev."},{"key":"58150_CR40","doi-asserted-by":"publisher","first-page":"117752","DOI":"10.1016\/j.jep.2024.117752","volume":"323","author":"W Ma","year":"2024","unstructured":"Ma, W. et al. Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation. J. Ethnopharmacol. 323, 117752. https:\/\/doi.org\/10.1016\/j.jep.2024.117752 (2024).","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"58150_CR41","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1021\/jacs.6b11013","volume":"139","author":"Y Liu","year":"2017","unstructured":"Liu, Y. et al. Comprehensive insights into the multi-antioxidative mechanisms of melanin nanoparticles and their application to protect brain from injury in ischemic stroke. J. Am. Chem. Soc. 139(2), 856\u2013862. https:\/\/doi.org\/10.1021\/jacs.6b11013 (2017).","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"58150_CR42","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1038\/s41467-020-15819-3","volume":"11","author":"J Cheng","year":"2020","unstructured":"Cheng, J. et al. TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K\/AKT pathway and PPP metabolism. Nat. Commun. 11(1), 1880. https:\/\/doi.org\/10.1038\/s41467-020-15819-3 (2020).","journal-title":"Nat. Commun."},{"issue":"6","key":"58150_CR43","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/s0022-3476(81)80609-9","volume":"98","author":"D Penn","year":"1981","unstructured":"Penn, D., Schmidt-Sommerfeld, E. & Pascu, F. Decreased tissue carnitine concentrations in newborn infants receiving total parenteral nutrition. J. Pediatr. 98(6), 976\u2013978. https:\/\/doi.org\/10.1016\/s0022-3476(81)80609-9 (1981).","journal-title":"J. Pediatr."},{"issue":"4","key":"58150_CR44","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/clinchem\/39.4.592","volume":"39","author":"P Harper","year":"1993","unstructured":"Harper, P., Wadstr\u00f6m, C. & Cederblad, G. Carnitine measurements in liver, muscle tissue, and blood in normal subjects. Clin. Chem. 39(4), 592\u2013599. https:\/\/doi.org\/10.1093\/clinchem\/39.4.592 (1993).","journal-title":"Clin. Chem."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58150-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58150-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58150-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:31:24Z","timestamp":1789083084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58150-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["58150"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-58150-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"25 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Henan Children\u2019s Hospital (approval number: 2024- KY- 0030) and followed the principles of the Declaration of Helsinki. The purpose and details of the study were explained to the families of all infants participating in the study, and written informed consent was signed.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors, parents or legal guardians of the child have consented to publication.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"28434"}}