{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:19:47Z","timestamp":1787789987044,"version":"build-2784847793"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":75,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-58288-2","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:24:10Z","timestamp":1781303050000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term outcomes after endoscopic resection of gastric adenocarcinoma of the fundic gland type and oxyntic gland adenoma: a retrospective cohort study"],"prefix":"10.1038","volume":"16","author":[{"given":"Tomoki","family":"Yoshikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-5754","authenticated-orcid":false,"given":"Masaya","family":"Iwamuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Matsueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Toyokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"58288_CR1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0034-1364955","volume":"46","author":"H Ueyama","year":"2014","unstructured":"Ueyama, H. et al. Gastric adenocarcinoma of the fundic gland type (chief cell predominant type). Endoscopy 46, 153\u2013157 (2014).","journal-title":"Endoscopy"},{"key":"58288_CR2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/ajcp\/aqy019","volume":"149","author":"MA Benedict","year":"2018","unstructured":"Benedict, M. A., Lauwers, G. Y. & Jain, D. Gastric adenocarcinoma of the fundic gland type: update and literature review. Am. J. Clin. Pathol. 149, 461\u2013473 (2018).","journal-title":"Am. J. Clin. Pathol."},{"key":"58288_CR3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41379-019-0338-1","volume":"33","author":"T Ushiku","year":"2020","unstructured":"Ushiku, T. et al. Oxyntic gland neoplasm of the stomach: expanding the spectrum and proposal of terminology. Mod. Pathol. 33, 206\u2013216 (2020).","journal-title":"Mod. Pathol."},{"key":"58288_CR4","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s00535-021-01813-z","volume":"56","author":"H Ueyama","year":"2021","unstructured":"Ueyama, H. et al. Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of the fundic gland type. J. Gastroenterol. 56, 814\u2013828 (2021).","journal-title":"J. Gastroenterol."},{"key":"58288_CR5","unstructured":"WHO Classification of Tumours Editorial Board. Digestive system tumours 5th edn (IARC, 2019)."},{"key":"58288_CR6","doi-asserted-by":"publisher","first-page":"7375","DOI":"10.1038\/s41598-021-86893-w","volume":"11","author":"M Iwamuro","year":"2021","unstructured":"Iwamuro, M. et al. Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type. Sci. Rep. 11, 7375 (2021).","journal-title":"Sci. Rep."},{"key":"58288_CR7","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s12876-022-02368-w","volume":"22","author":"M Iwamuro","year":"2022","unstructured":"Iwamuro, M. et al. Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type differ between patients with and without Helicobacter pylori infection: a retrospective observational study. BMC Gastroenterol. 22, 294 (2022).","journal-title":"BMC Gastroenterol."},{"key":"58288_CR8","doi-asserted-by":"publisher","first-page":"554","DOI":"10.21037\/jgo-22-870","volume":"14","author":"M Iwamuro","year":"2023","unstructured":"Iwamuro, M. et al. Lesion size, elevated morphology, and non- or closed-type atrophy are predictive factors for gastric adenocarcinoma of the fundic gland type rather than oxyntic gland adenoma. J. Gastrointest. Oncol. 14, 554\u2013562 (2023).","journal-title":"J. Gastrointest. Oncol."},{"key":"58288_CR9","doi-asserted-by":"publisher","first-page":"378","DOI":"10.5230\/jgc.2024.24.e30","volume":"24","author":"GH Kim","year":"2024","unstructured":"Kim, G. H. et al. Oxyntic gland neoplasms\u2014from adenoma to advanced gastric cancer: a review of 29 cases. J. Gastric Cancer. 24, 378\u2013390 (2024).","journal-title":"J. Gastric Cancer"},{"key":"58288_CR10","doi-asserted-by":"publisher","first-page":"e28469","DOI":"10.1097\/MD.0000000000028469","volume":"101","author":"H Zhang","year":"2022","unstructured":"Zhang, H. et al. Clinicopathological features of early-stage gastric adenocarcinoma of fundic gland type: case series. Med. (Baltim). 101, e28469 (2022).","journal-title":"Med. (Baltim)."},{"key":"58288_CR11","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/1751-2980.13149","volume":"23","author":"MJ He","year":"2022","unstructured":"He, M. J. et al. Endoscopic submucosal dissection for gastric adenocarcinoma of the fundic gland type (chief cell predominant type): four years\u2019 experience from a tertiary hospital. J. Dig. Dis. 23, 620\u2013627 (2022).","journal-title":"J. Dig. Dis."},{"key":"58288_CR12","first-page":"e58467","volume":"16","author":"J Hayasaka","year":"2024","unstructured":"Hayasaka, J. et al. Comparison of prognosis and metachronous gastric tumor rates after endoscopic submucosal dissection between gastric neoplasms of fundic gland type and conventional gastric adenocarcinoma. Cureus 16, e58467 (2024).","journal-title":"Cureus"},{"key":"58288_CR13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10120-025-01595-w","volume":"28","author":"Y Miyaoka","year":"2025","unstructured":"Miyaoka, Y. et al. Multiple metachronous foveolar-type gastric adenomas in a Helicobacter pylori-na\u00efve patient with long-term use of a proton pump inhibitor: a case report. Gastric Cancer. 28, 537\u2013543 (2025).","journal-title":"Gastric Cancer"},{"key":"58288_CR14","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1177\/1066896920962574","volume":"29","author":"Y Sato","year":"2021","unstructured":"Sato, Y. et al. Histopathologic change of a case of gastric oxyntic neoplasm through 5 years with concurrent other oxyntic gland lesions. Int. J. Surg. Pathol. 29, 557\u2013564 (2021).","journal-title":"Int. J. Surg. Pathol."},{"key":"58288_CR15","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.humpath.2013.06.002","volume":"44","author":"Y Hidaka","year":"2013","unstructured":"Hidaka, Y. et al. Alteration in the Wnt\/\u03b2-catenin signaling pathway in gastric neoplasias of fundic gland type. Hum. Pathol. 44, 2438\u20132448 (2013).","journal-title":"Hum. Pathol."},{"key":"58288_CR16","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1016\/j.humpath.2014.08.016","volume":"45","author":"R Nomura","year":"2014","unstructured":"Nomura, R. et al. GNAS mutation as an alternative mechanism of activation of the Wnt\/\u03b2-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. Hum. Pathol. 45, 2488\u20132496 (2014).","journal-title":"Hum. Pathol."},{"key":"58288_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00428-015-1753-4","volume":"467","author":"SY Lee","year":"2015","unstructured":"Lee, S. Y. et al. Mutation spectrum in the Wnt\/\u03b2-catenin signaling pathway in gastric fundic gland-associated neoplasms\/polyps. Virchows Arch. 467, 27\u201338 (2015).","journal-title":"Virchows Arch."},{"key":"58288_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000478999","volume":"96","author":"Y Tajima","year":"2017","unstructured":"Tajima, Y. et al. Distinct involvement of the Sonic Hedgehog signaling pathway in gastric adenocarcinoma of fundic gland type and conventional gastric adenocarcinoma. Digestion 96, 81\u201391 (2017).","journal-title":"Digestion"},{"key":"58288_CR19","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1007\/s10620-009-0993-z","volume":"54","author":"MR Ally","year":"2009","unstructured":"Ally, M. R. et al. Chronic proton pump inhibitor therapy associated with increased development of fundic gland polyps. Dig. Dis. Sci. 54, 2617\u20132622 (2009).","journal-title":"Dig. Dis. Sci."},{"key":"58288_CR20","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1016\/j.cgh.2016.05.018","volume":"14","author":"A Tran-Duy","year":"2016","unstructured":"Tran-Duy, A. et al. Use of proton pump inhibitors and risks of fundic gland polyps and gastric cancer: systematic review and meta-analysis. Clin. Gastroenterol. Hepatol. 14, 1706\u20131719e5 (2016).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"58288_CR21","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.cgh.2016.12.007","volume":"15","author":"RH Palmer","year":"2017","unstructured":"Palmer, R. H. Use of proton pump inhibitors and risks of fundic gland polyps and gastric cancer: systematic review and meta-analysis. Clin. Gastroenterol. Hepatol. 15, 790 (2017).","journal-title":"Clin. Gastroenterol. Hepatol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58288-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:46:15Z","timestamp":1787787975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58288-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["58288"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-58288-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,13]]},"assertion":[{"value":"4 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"26914"}}