{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:16:16Z","timestamp":1788869776332,"version":"build-2803163510"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":82,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["MAESTRIA: 965286"],"award-info":[{"award-number":["MAESTRIA: 965286"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["109371\/Z\/15\/Z"],"award-info":[{"award-number":["109371\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) increases energy demand in atrial myocytes, yet the mitochondrial mechanisms underlying this stress remain poorly defined. Using previously published proteomic data from left atrial tissue of AF and sham-operated goats, we performed organelle-specific bioinformatic analyses of the mitochondrial fraction. Over-representation and consensus pathway analyses consistently highlighted enrichment of oxidative phosphorylation (OXPHOS) subunits. Gene set enrichment and network analyses implicated Heat Shock Protein Family A Member 9 (HSPA9) as a potentially central regulatory hub coordinating the dysregulation of Complex I and III subunits, with 69% of regulatory relationships showing pathway concordance. These results indicate a coordinated, system-wide mitochondrial adaptation in AF, integrating energy production, proteostasis, and respiratory chain regulation.<\/jats:p>","DOI":"10.1038\/s41598-026-58413-1","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:41:07Z","timestamp":1781818867000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic signatures of mitochondrial dysfunction associated with atrial fibrillation in goats"],"prefix":"10.1038","volume":"16","author":[{"given":"Thamali","family":"Ayagama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Barrett-Jolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja S","family":"Hester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schotten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Verheule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca AB","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"issue":"3","key":"58413_CR1","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1093\/europace\/euac237","volume":"25","author":"XJ Dong","year":"2023","unstructured":"Dong, X. J. et al. Global burden of atrial fibrillation\/atrial flutter and its attributable risk factors from 1990 to 2019. Europace 25 (3), 793\u2013803 (2023).","journal-title":"Europace"},{"issue":"35","key":"58413_CR2","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1093\/eurheartj\/eht280","volume":"34","author":"BP Krijthe","year":"2013","unstructured":"Krijthe, B. P. et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur. Heart J. 34 (35), 2746\u20132751 (2013).","journal-title":"Eur. Heart J."},{"issue":"4","key":"58413_CR3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jacep.2022.11.032","volume":"9","author":"RM Inciardi","year":"2023","unstructured":"Inciardi, R. M. et al. Risks of Heart Failure, Stroke, and Bleeding in Atrial Fibrillation According to Heart Failure Phenotypes. JACC Clin. Electrophysiol. 9 (4), 569\u2013580 (2023).","journal-title":"JACC Clin. Electrophysiol."},{"issue":"1","key":"58413_CR4","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s11033-025-10914-4","volume":"52","author":"F Pan","year":"2025","unstructured":"Pan, F. et al. HSPA9\/HMGB1 regulates myocardial fibrosis in atrial fibrillation via TGF-\u03b21\/Smad pathway and autophagy. Mol. Biol. Rep. 52 (1), 815 (2025).","journal-title":"Mol. Biol. Rep."},{"issue":"6","key":"58413_CR5","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1161\/CIRCEP.109.910125","volume":"3","author":"MA Allessie","year":"2010","unstructured":"Allessie, M. A. et al. Electropathological substrate of long-standing persistent atrial fibrillation in patients with structural heart disease: longitudinal dissociation. Circ. Arrhythm. Electrophysiol. 3 (6), 606\u2013615 (2010).","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"17","key":"58413_CR6","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1161\/CIRCULATIONAHA.109.910901","volume":"122","author":"NM de Groot","year":"2010","unstructured":"de Groot, N. M. et al. Electropathological substrate of longstanding persistent atrial fibrillation in patients with structural heart disease: epicardial breakthrough. Circulation 122 (17), 1674\u20131682 (2010).","journal-title":"Circulation"},{"issue":"4","key":"58413_CR7","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1093\/cvr\/cvw007","volume":"109","author":"D Opacic","year":"2016","unstructured":"Opacic, D. et al. Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation. Cardiovascular. Res. 109 (4), 527\u2013541 (2016).","journal-title":"Cardiovascular. Res."},{"issue":"1","key":"58413_CR8","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","volume":"10","author":"X Xu","year":"2025","unstructured":"Xu, X., Pang, Y. & Fan, X. Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances. Signal. Transduct. Target. Therapy. 10 (1), 190 (2025).","journal-title":"Signal. Transduct. Target. Therapy"},{"key":"58413_CR9","doi-asserted-by":"publisher","first-page":"1235188","DOI":"10.3389\/fmmed.2023.1235188","volume":"3","author":"TA Popoiu","year":"2023","unstructured":"Popoiu, T. A., Maack, C. & Bertero, E. Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease. Front. Mol. Med. 3, 1235188 (2023).","journal-title":"Front. Mol. Med."},{"issue":"5","key":"58413_CR10","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/cvr\/cvac134","volume":"119","author":"E Murphy","year":"2023","unstructured":"Murphy, E. & Liu, J. C. Mitochondrial calcium and reactive oxygen species in cardiovascular disease. Cardiovasc. Res. 119 (5), 1105\u20131116 (2023).","journal-title":"Cardiovasc. Res."},{"issue":"22","key":"58413_CR11","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1093\/eurheartj\/ehae031","volume":"45","author":"ZD Reis","year":"2024","unstructured":"Reis, Z. D. Mitochondria and the heart. Eur. Heart J. 45 (22), 1963\u20131964 (2024).","journal-title":"Eur. Heart J."},{"issue":"8","key":"58413_CR12","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1161\/CIRCRESAHA.111.246140","volume":"110","author":"DF Dai","year":"2012","unstructured":"Dai, D. F., Rabinovitch, P. S. & Ungvari, Z. Mitochondria and cardiovascular aging. Circ. Res. 110 (8), 1109\u20131124 (2012).","journal-title":"Circ. Res."},{"issue":"7527","key":"58413_CR13","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani, E. T. et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515 (7527), 431\u2013435 (2014).","journal-title":"Nature"},{"issue":"12","key":"58413_CR14","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1161\/RES.0000000000000104","volume":"118","author":"E Murphy","year":"2016","unstructured":"Murphy, E. et al. Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. Circ. Res. 118 (12), 1960\u20131991 (2016).","journal-title":"Circ. Res."},{"key":"58413_CR15","doi-asserted-by":"publisher","first-page":"107258","DOI":"10.1016\/j.phrs.2024.107258","volume":"206","author":"D Liu","year":"2024","unstructured":"Liu, D. et al. Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation. Pharmacol. Res. 206, 107258 (2024).","journal-title":"Pharmacol. Res."},{"issue":"4","key":"58413_CR16","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00395-024-01060-2","volume":"119","author":"E Bertero","year":"2024","unstructured":"Bertero, E., Popoiu, T. A. & Maack, C. Mitochondrial calcium in cardiac ischemia\/reperfusion injury and cardioprotection. Basic. Res. Cardiol. 119 (4), 569\u2013585 (2024).","journal-title":"Basic. Res. Cardiol."},{"issue":"11","key":"58413_CR17","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","volume":"17","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig, H. K. & Eckle, T. Ischemia and reperfusion\u2013from mechanism to translation. Nat. Med. 17 (11), 1391\u20131401 (2011).","journal-title":"Nat. Med."},{"issue":"3","key":"58413_CR18","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00424-021-02514-5","volume":"473","author":"JH Rennison","year":"2021","unstructured":"Rennison, J. H. et al. Atrial fibrillation rhythm is associated with marked changes in metabolic and myofibrillar protein expression in left atrial appendage. Pflugers Arch. 473 (3), 461\u2013475 (2021).","journal-title":"Pflugers Arch."},{"issue":"22","key":"58413_CR19","doi-asserted-by":"publisher","first-page":"5626","DOI":"10.1111\/febs.12502","volume":"280","author":"R Drissi","year":"2013","unstructured":"Drissi, R., Dubois, M. L. & Boisvert, F. M. Proteomics methods for subcellular proteome analysis. Febs j. 280 (22), 5626\u20135634 (2013).","journal-title":"Febs j."},{"key":"58413_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-4939-6533-5_2","volume":"1511","author":"SJ Mueller","year":"2017","unstructured":"Mueller, S. J., Hoernstein, S. N. & Reski, R. Approaches to Characterize Organelle, Compartment, or Structure Purity. Methods Mol. Biol. 1511, 13\u201328 (2017).","journal-title":"Methods Mol. Biol."},{"key":"58413_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-1-61779-148-2_8","volume":"753","author":"S Duclos","year":"2011","unstructured":"Duclos, S. & Desjardins, M. Organelle proteomics. Methods Mol. Biol. 753, 117\u2013128 (2011).","journal-title":"Methods Mol. Biol."},{"key":"58413_CR22","doi-asserted-by":"crossref","unstructured":"Yates, J. R. 3 et al. Proteomics of organelles and large cellular structures. Nat. Rev. Mol. Cell. Biol. 6 (9), 702\u2013714 (2005).","DOI":"10.1038\/nrm1711"},{"key":"58413_CR23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mito.2016.07.006","volume":"33","author":"J Palmfeldt","year":"2017","unstructured":"Palmfeldt, J. & Bross, P. Proteomics of human mitochondria. Mitochondrion 33, 2\u201314 (2017).","journal-title":"Mitochondrion"},{"issue":"4","key":"58413_CR24","doi-asserted-by":"publisher","first-page":"104248","DOI":"10.1016\/j.xpro.2025.104248","volume":"6","author":"T Ayagama","year":"2025","unstructured":"Ayagama, T. et al. Protocol for endolysosomal proteomics in goat atrial tissue using a refined density-gradient approach. STAR. Protoc. 6 (4), 104248 (2025).","journal-title":"STAR. Protoc."},{"key":"58413_CR25","doi-asserted-by":"crossref","unstructured":"Pirrotta, S., Bonora, M. & Calura, E. Dissect mitochondrial activity by transcriptome data with mitology R package. bioRxiv, : p. 2024.11.27.625451. (2024).","DOI":"10.1101\/2024.11.27.625451"},{"issue":"6","key":"58413_CR26","doi-asserted-by":"publisher","first-page":"109609","DOI":"10.1016\/j.isci.2024.109609","volume":"27","author":"T Ayagama","year":"2024","unstructured":"Ayagama, T. et al. Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation. iScience 27 (6), 109609 (2024).","journal-title":"iScience"},{"issue":"1","key":"58413_CR27","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1161\/CIRCEP.112.975144","volume":"6","author":"S Verheule","year":"2013","unstructured":"Verheule, S. et al. Loss of continuity in the thin epicardial layer because of endomysial fibrosis increases the complexity of atrial fibrillatory conduction. Circ. Arrhythm. Electrophysiol. 6 (1), 202\u2013211 (2013).","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"5","key":"58413_CR28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G. et al. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16 (5), 284\u2013287 (2012).","journal-title":"OMICS"},{"issue":"3","key":"58413_CR29","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu, T. et al. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov. (Camb). 2 (3), 100141 (2021).","journal-title":"Innov. (Camb)"},{"key":"58413_CR30","unstructured":"Ligtenberg, W. reactome.db: A set of annotation maps for Reactome (R package version 1.92.0). Bioconductor. (2025)."},{"issue":"2","key":"58413_CR31","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1039\/C5MB00663E","volume":"12","author":"G Yu","year":"2016","unstructured":"Yu, G. & He, Q. Y. ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization. Mol. Biosyst. 12 (2), 477\u2013479 (2016).","journal-title":"Mol. Biosyst"},{"issue":"D1","key":"58413_CR32","doi-asserted-by":"publisher","first-page":"D661","DOI":"10.1093\/nar\/gkx1064","volume":"46","author":"DN Slenter","year":"2018","unstructured":"Slenter, D. N. et al. WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research. Nucleic Acids Res. 46 (D1), D661\u2013D667 (2018).","journal-title":"Nucleic Acids Res."},{"key":"58413_CR33","unstructured":"Yu, G. enrichplot: Visualization of Functional Enrichment Result. R package version 1.30.2. (2025)."},{"key":"58413_CR34","unstructured":"Kolde, R. Pretty Heatmaps \u2018pheatmap\u2019. (2025)."},{"key":"58413_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 14, 7 (2013).","journal-title":"BMC Bioinform."},{"key":"58413_CR36","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1471-2105-13-20","volume":"13","author":"G Sales","year":"2012","unstructured":"Sales, G. et al. graphite - a Bioconductor package to convert pathway topology to gene network. BMC Bioinform. 13, 20 (2012).","journal-title":"BMC Bioinform."},{"key":"58413_CR37","unstructured":"G\u00e1bor Cs\u00e1rdi, T. N. The igraph software package for complex network research (InterJournal, Complex Systems, 2006)."},{"issue":"1","key":"58413_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.120.316366","volume":"127","author":"D Sch\u00fcttler","year":"2020","unstructured":"Sch\u00fcttler, D. et al. Animal Models of Atrial Fibrillation. Circ. Res. 127 (1), 91\u2013110 (2020).","journal-title":"Circ. Res."},{"issue":"10","key":"58413_CR39","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nrcardio.2016.118","volume":"13","author":"S Nattel","year":"2016","unstructured":"Nattel, S. & Dobrev, D. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nat. Rev. Cardiol. 13 (10), 575\u2013590 (2016).","journal-title":"Nat. Rev. Cardiol."},{"issue":"2","key":"58413_CR40","first-page":"193","volume":"7","author":"Y Xi","year":"2015","unstructured":"Xi, Y. & Cheng, J. Dysfunction of the autonomic nervous system in atrial fibrillation. J. Thorac. Dis. 7 (2), 193\u2013198 (2015).","journal-title":"J. Thorac. Dis."},{"issue":"6","key":"58413_CR41","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s00395-020-00827-7","volume":"115","author":"FE Mason","year":"2020","unstructured":"Mason, F. E. et al. Cellular and mitochondrial mechanisms of atrial fibrillation. Basic. Res. Cardiol. 115 (6), 72 (2020).","journal-title":"Basic. Res. Cardiol."},{"key":"58413_CR42","doi-asserted-by":"publisher","unstructured":"Muszy\u0144ski, P. & Bonda, T. A. Mitochondrial Dysfunction in Atrial Fibrillation-Mechanisms and Pharmacological Interventions. J. Clin. Med., 10(11), 2385 (2021). https:\/\/doi.org\/10.3390\/jcm10112385.","DOI":"10.3390\/jcm10112385"},{"issue":"9","key":"58413_CR43","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1161\/CIRCULATIONAHA.105.538108","volume":"112","author":"SC Dudley","year":"2005","unstructured":"Dudley, S. C. et al. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases. Circulation 112 (9), 1266\u20131273 (2005).","journal-title":"Circulation"},{"issue":"10","key":"58413_CR44","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1161\/CIRCULATIONAHA.111.029223","volume":"124","author":"SN Reilly","year":"2011","unstructured":"Reilly, S. N. et al. Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins. Circulation 124 (10), 1107\u20131117 (2011).","journal-title":"Circulation"},{"issue":"11","key":"58413_CR45","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1080\/15548627.2020.1712812","volume":"16","author":"DS Jo","year":"2020","unstructured":"Jo, D. S. et al. Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy. Autophagy 16 (11), 1989\u20132003 (2020).","journal-title":"Autophagy"},{"issue":"38","key":"58413_CR46","doi-asserted-by":"publisher","first-page":"36027","DOI":"10.1074\/jbc.M304854200","volume":"278","author":"Q Chen","year":"2003","unstructured":"Chen, Q. et al. Production of Reactive Oxygen Species by Mitochondria: CENTRAL ROLE OF COMPLEX III *. J. Biol. Chem. 278 (38), 36027\u201336031 (2003).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"58413_CR47","doi-asserted-by":"publisher","first-page":"e0117170","DOI":"10.1371\/journal.pone.0117170","volume":"10","author":"PR Dores-Silva","year":"2015","unstructured":"Dores-Silva, P. R. et al. Human mitochondrial Hsp70 (mortalin): shedding light on ATPase activity, interaction with adenosine nucleotides, solution structure and domain organization. PLoS One. 10 (1), e0117170 (2015).","journal-title":"PLoS One"},{"issue":"1","key":"58413_CR48","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13041-023-01029-7","volume":"16","author":"JE Bae","year":"2023","unstructured":"Bae, J. E. et al. Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9\/mortalin-depleted SH-SY5Y cells. Mol. Brain. 16 (1), 41 (2023).","journal-title":"Mol. Brain"},{"issue":"15","key":"58413_CR49","doi-asserted-by":"publisher","first-page":"8077","DOI":"10.3390\/ijms22158077","volume":"22","author":"H Havalov\u00e1","year":"2021","unstructured":"Havalov\u00e1, H. et al. Mitochondrial HSP70 Chaperone System\u2014The Influence of Post-Translational Modifications and Involvement in Human Diseases. Int. J. Mol. Sci. 22 (15), 8077 (2021).","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"58413_CR50","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1182\/blood-2013-06-508333","volume":"123","author":"I Tai-Nagara","year":"2014","unstructured":"Tai-Nagara, I. et al. Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress. Blood 123 (1), 41\u201350 (2014).","journal-title":"Blood"},{"key":"58413_CR51","doi-asserted-by":"publisher","first-page":"102164","DOI":"10.1016\/j.redox.2021.102164","volume":"47","author":"AD Read","year":"2021","unstructured":"Read, A. D. et al. Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology. Redox Biol. 47, 102164 (2021).","journal-title":"Redox Biol."},{"key":"58413_CR52","doi-asserted-by":"publisher","unstructured":"Sun, S. et al. NFS1 Plays a Critical Role in Regulating Ferroptosis Homeostasis. Biomolecules, 16(1), 32. https:\/\/doi.org\/10.3390\/biom16010032.","DOI":"10.3390\/biom16010032"},{"issue":"35","key":"58413_CR53","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1093\/eurheartj\/eht194","volume":"34","author":"H Kottkamp","year":"2013","unstructured":"Kottkamp, H. Human atrial fibrillation substrate: towards a specific fibrotic atrial cardiomyopathy. Eur. Heart J. 34 (35), 2731\u20132738 (2013).","journal-title":"Eur. Heart J."},{"issue":"3 Suppl","key":"58413_CR54","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1016\/j.hrthm.2006.12.040","volume":"4","author":"TH Everett","year":"2007","unstructured":"Everett, T. H. & Olgin, J. E. Atrial fibrosis and the mechanisms of atrial fibrillation. Heart Rhythm. 4 (3 Suppl), S24\u2013S27 (2007).","journal-title":"Heart Rhythm"},{"issue":"20","key":"58413_CR55","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1161\/CIRCULATIONAHA.118.035202","volume":"138","author":"C Yao","year":"2018","unstructured":"Yao, C. et al. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation 138 (20), 2227\u20132242 (2018).","journal-title":"Circulation"},{"key":"58413_CR56","doi-asserted-by":"publisher","unstructured":"Costa-Mattioli, M. & Walter, P. The integrated stress response: From mechanism to disease. Science, 368(6489), eaat5314 (2020). https:\/\/doi.org\/10.1126\/science.aat5314.","DOI":"10.1126\/science.aat5314"},{"key":"58413_CR57","doi-asserted-by":"publisher","unstructured":"Wiersma, M. et al. Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation. J. Am. Heart Assoc., 6(10), e006458 (2017). https:\/\/doi.org\/10.1161\/JAHA.117.006458.","DOI":"10.1161\/JAHA.117.006458"},{"issue":"11","key":"58413_CR58","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1161\/CIRCRESAHA.124.325658","volume":"137","author":"JRD Pronto","year":"2025","unstructured":"Pronto, J. R. D. et al. Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation. Circ. Res. 137 (11), 1333\u20131352 (2025).","journal-title":"Circ. Res."},{"issue":"10","key":"58413_CR59","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/s41569-024-01038-6","volume":"21","author":"D Bode","year":"2024","unstructured":"Bode, D. et al. Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications. Nat. Rev. Cardiol. 21 (10), 682\u2013700 (2024).","journal-title":"Nat. Rev. Cardiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58413-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58413-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58413-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:02:28Z","timestamp":1788868948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-58413-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["58413"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-58413-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"24 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"28023"}}