{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:11:47Z","timestamp":1793423507477,"version":"4.5.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":103,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Poznan University of Physical Education","award":["The Development of Young Scientists Program (Grant Number) 7\/NSN\/W\/2022, awarded on March 4, 2022"],"award-info":[{"award-number":["The Development of Young Scientists Program (Grant Number) 7\/NSN\/W\/2022, awarded on March 4, 2022"]}],"id":[{"id":"https:\/\/ror.org\/01zh80k81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Evidence supporting the effectiveness of non-pharmacological exercise interventions to mitigate the side effects of aromatase inhibitor (AI) therapy among breast cancer (BC) patients remains limited. Given that AI-related adverse effects are associated with reduced quality of life, there is a clear need to address these symptoms. Thus, this study investigated the effects of the Pilates Method (PM) intervention on thoracic spine extensor myofascial stiffness (M-FS), pain sensation, and quality of life (QoL). A randomized, two-arm, parallel-group supportive care trial with blinded outcome assessment compared an exercise intervention group (experimental group;\u00a0EG) and a usual-care group (U-CG) pre- and post-intervention (per-protocol analysis). Eligible BC patients receiving AI therapy were randomized to either group. The EG completed a 12-week Pilates mat intervention (two supervised group sessions per week, 60\u00a0min each). Primary outcomes included measurement M-FS of thoracic spine extensor muscles (MyotonPro\u00ae) at Th3, Th7, and Th12 spine levels, alongside assessments of pain sensation (The Brief Pain Inventory), and QoL (EORTC QLQ-C30, EORTC QLQ-BR23). Between-group and within-group differences were analyzed using a two-way repeated-measures ANOVA, followed by Bonferroni post hoc tests. 42 BC women were randomized to the EG (n\u2009=\u200928) and the U-CG (n\u2009=\u200914); 22 and 14 participants, respectively, were included in the final analysis. Significant time\u2009\u00d7\u2009group interaction effects for M-FS were observed at the Th3 (F\u2009=\u200917.04, \u03b7\n                    <jats:sub>p<\/jats:sub>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.33, p\u2009&lt;\u20090.001), Th7 (F\u2009=\u200920.13, \u03b7\n                    <jats:sub>p<\/jats:sub>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.37, p\u2009&lt;\u20090.001), whereas the interaction at Th12 was not statistically significant (F\u2009=\u20091.15, \u03b7\n                    <jats:sub>p<\/jats:sub>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.03, p\u2009&gt;\u20090.01). Significant time\u2009\u00d7\u2009group interaction effects with large effect sizes were found for pain severity, physical interference, and affective interference (all p\u2009&lt;\u20090.001), whereas pain indicators increased in the U-CG. QoL improved in the EG, reflected by higher global health status (GHS) (F\u2009=\u200918.69, \u03b7\n                    <jats:sub>p<\/jats:sub>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.36, p\u2009&lt;\u20090.001), with significant improvements in systemic therapy side effects, arm symptoms (both p\u2009&lt;\u20090.001). Clinically meaningful changes were observed in GHS and BC-specific symptom scales in the EG. No serious adverse events were observed. A supervised PM-based intervention may improve selected treatment-related musculoskeletal outcomes in BC women receiving AI. The observed reductions in thoracic extensor M-FS (Th3, Th7), accompanied by enhancements in quality of life, substantiate the potential clinical significance of Pilates-based physiotherapy as an adjunctive rehabilitation approach within this population. Given its observed analgesic effects, the PM may represent a complementary supportive strategy alongside guideline-recommended aerobic and resistance training interventions in oncology rehabilitation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration:<\/jats:bold>\n                    Clinicaltrials.gov (No: NCT06419023;\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT06419023\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/study\/NCT06419023<\/jats:ext-link>\n                    ). May 20, 2024. Retrospectively registered.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-58461-7","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:25:08Z","timestamp":1782397508000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pilates Method as a complementary activity reduces myofascial stiffness and pain in women with breast cancer undergoing aromatase inhibitor therapy: a randomized controlled trial"],"prefix":"10.1038","volume":"16","author":[{"given":"Maria","family":"Tarnas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Stemplewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Ciekot-So\u0142tysiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pospieszna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kufel-Grabowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Marsza\u0142ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Zieli\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Ziemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"58461_CR1","doi-asserted-by":"publisher","DOI":"10.61409\/A05240316","author":"EM Torpe","year":"2024","unstructured":"Torpe, E. 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