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Participants provided informed consent when able, while those who could not provided assent, and their caregiver gave consent.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr Nicolson reported receiving grants from Brain Canada, Hoffman La Roche, Otsuka Pharmaceuticals, and Maplight Therapeutics outside the submitted work.Dr. Penner has received consulting fee from Addis & Associates\/Roche, and MedCounsel.Dr Anagnostou reported receiving grants from Roche and Anavex; receiving nonfinancial support from AMO Pharma and CRA-Simons Foundation; and receiving personal fees from Roche, Impel, Ono, and Quadrant outside the submitted work; in addition, Dr Anagnostou has a patent for Anxiety Meter issued 14\/755\/084 (United States) and a patent for Anxiety Meter pending 2,895,954 (Canada) as well as receiving royalties from APPI and Springer. Dr Kushki has a patent for Anxiety Meter with potential future revenues from commercialization. . Dr Kushki is the inventor of a software called holly (formerly \u201cAnxiety Meter\u201d). She is involved in commercialising the holly (patents US 9,844,332 B2) and will financially benefit from its commercialization. Dr Kushki served on the board of advisors for Shaftesbury, a media company developing virtual reality products for autistic children, from February 2020 to February 2021, and was compensated financially for this role. She has also received consulting fees from DNAStack and donations of hardware for her research program from Samsung Canada.\u00a0Dr. Kushki serves as an advisor to Attune. The remaining authors have no conflicts to report.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"31747"}}