{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:08:12Z","timestamp":1789135692236,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100020410","name":"T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131","doi-asserted-by":"crossref","award":["22897\/28589"],"award-info":[{"award-number":["22897\/28589"]}],"id":[{"id":"10.13039\/100020410","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-59094-6","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:24:34Z","timestamp":1789133074000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual-antigen AdV5 vaccines against Crimean-Congo hemorrhagic fever virus induce superior humoral and Th1-biased cellular immunity"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-3455","authenticated-orcid":false,"given":"Alireza","family":"Hanifehnezhad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5653-6080","authenticated-orcid":false,"given":"Sidika","family":"Oztop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3344-468X","authenticated-orcid":false,"given":"Ece","family":"Tavukcuoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-259X","authenticated-orcid":false,"given":"Yigit","family":"Tanyeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3333-8932","authenticated-orcid":false,"given":"Ekimcan","family":"Yoyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-2826","authenticated-orcid":false,"given":"Gokcen","family":"Gokce Tepeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-1187","authenticated-orcid":false,"given":"Nilay","family":"Unal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-3280","authenticated-orcid":false,"given":"Asuman","family":"Bozkir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9968-0813","authenticated-orcid":false,"given":"M. Taner","family":"Karaoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-2377","authenticated-orcid":false,"given":"Gunes","family":"Esendagli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-3232","authenticated-orcid":false,"given":"Ates","family":"Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-2372","authenticated-orcid":false,"given":"Hakan","family":"Gurdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-9443","authenticated-orcid":false,"given":"Aykut","family":"Ozkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"59094_CR1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3201\/eid3005.231646","volume":"30","author":"MG Frank","year":"2024","unstructured":"Frank, M. G., Weaver, G., Raabe, V., State of the Clinical Science Working Group of the National Emerging Pathogens, T. E. C. s. S. P. R., Network. Crimean Congo hemorrhagic fever virus for clinicians-virology, pathogenesis, and pathology. Emerg. Infect. Dis. 30, 847\u2013853. https:\/\/doi.org\/10.3201\/eid3005.231646 (2024).","journal-title":"Emerg. Infect. Dis."},{"key":"59094_CR2","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3201\/eid3005.231647","volume":"30","author":"MG Frank","year":"2024","unstructured":"Frank, M. G., Weaver, G., Raabe, V., State of the Clinical Science Working Group of the National Emerging Pathogens, T. E. C. s. S. P. R., Network. Crimean-Congo hemorrhagic fever virus for clinicians-epidemiology, clinical manifestations, and prevention. Emerg. Infect. Dis. 30, 854\u2013863. https:\/\/doi.org\/10.3201\/eid3005.231647 (2024).","journal-title":"Emerg. Infect. Dis."},{"key":"59094_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9091907","author":"N Shahhosseini","year":"2021","unstructured":"Shahhosseini, N. et al. Crimean-congo hemorrhagic fever virus in Asia, Africa and Europe. Microorganisms https:\/\/doi.org\/10.3390\/microorganisms9091907 (2021).","journal-title":"Microorganisms"},{"key":"59094_CR4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3201\/eid2902.220677","volume":"29","author":"HM Lorenzo Juanes","year":"2023","unstructured":"Lorenzo Juanes, H. M. et al. Crimean-Congo hemorrhagic fever, Spain, 2013-2021. Emerg. Infect. Dis. 29, 252\u2013259. https:\/\/doi.org\/10.3201\/eid2902.220677 (2023).","journal-title":"Emerg. Infect. Dis."},{"key":"59094_CR5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41579-023-00871-9","volume":"21","author":"DW Hawman","year":"2023","unstructured":"Hawman, D. W. & Feldmann, H. Crimean-Congo haemorrhagic fever virus. Nat. Rev. Microbiol. 21, 463\u2013477. https:\/\/doi.org\/10.1038\/s41579-023-00871-9 (2023).","journal-title":"Nat. Rev. Microbiol."},{"key":"59094_CR6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41541-024-00970-5","volume":"9","author":"J de la Fuente","year":"2024","unstructured":"de la Fuente, J. et al. Interventions for the control of Crimean-Congo hemorrhagic fever and tick vectors. NPJ Vaccines 9, 181. https:\/\/doi.org\/10.1038\/s41541-024-00970-5 (2024).","journal-title":"NPJ Vaccines"},{"key":"59094_CR7","doi-asserted-by":"publisher","first-page":"1238882","DOI":"10.3389\/fimmu.2023.1238882","volume":"14","author":"B Ahata","year":"2023","unstructured":"Ahata, B. & Akcapinar, G. B. CCHFV vaccine development, current challenges, limitations, and future directions. Front. Immunol. 14, 1238882. https:\/\/doi.org\/10.3389\/fimmu.2023.1238882 (2023).","journal-title":"Front. Immunol."},{"key":"59094_CR8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.antiviral.2018.09.009","volume":"159","author":"MS Mehand","year":"2018","unstructured":"Mehand, M. S., Al-Shorbaji, F., Millett, P. & Murgue, B. The WHO R&D blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts. Antiviral Res. 159, 63\u201367. https:\/\/doi.org\/10.1016\/j.antiviral.2018.09.009 (2018).","journal-title":"Antiviral Res."},{"key":"59094_CR9","doi-asserted-by":"publisher","first-page":"e223","DOI":"10.1016\/S1473-3099(24)00656-X","volume":"25","author":"AE Semper","year":"2025","unstructured":"Semper, A. E. et al. Research and product development for Crimean-Congo haemorrhagic fever: Priorities for 2024-30. Lancet Infect. Dis. 25, e223\u2013e234. https:\/\/doi.org\/10.1016\/S1473-3099(24)00656-X (2025).","journal-title":"Lancet Infect. Dis."},{"key":"59094_CR10","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/v8040106","volume":"8","author":"M Zivcec","year":"2016","unstructured":"Zivcec, M., Scholte, F., Spiropoulou, C., Spengler, J. & Bergeron, \u00c9. Molecular insights into Crimean-Congo hemorrhagic fever virus. Viruses 8, 106. https:\/\/doi.org\/10.3390\/v8040106 (2016).","journal-title":"Viruses"},{"key":"59094_CR11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1089\/biores.2019.0057","volume":"9","author":"T Tipih","year":"2020","unstructured":"Tipih, T. & Burt, F. J. Crimean-Congo hemorrhagic fever virus: Advances in vaccine development. BioRes. Open Access 9, 137\u2013150. https:\/\/doi.org\/10.1089\/biores.2019.0057 (2020).","journal-title":"BioRes. Open Access"},{"key":"59094_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines7030115","author":"TA Farzani","year":"2019","unstructured":"Farzani, T. A. et al. Immunological analysis of a CCHFV mRNA vaccine candidate in mouse models. Vaccines https:\/\/doi.org\/10.3390\/vaccines7030115 (2019).","journal-title":"Vaccines"},{"key":"59094_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/v11030237","author":"TA Farzani","year":"2019","unstructured":"Farzani, T. A. et al. Bovine herpesvirus type 4 (BoHV-4) vector delivering nucleocapsid protein of Crimean-Congo hemorrhagic fever virus induces comparable protective immunity against lethal challenge in IFN\u03b1\/\u03b2\/\u03b3R\u2212\/\u2212 mice models. Viruses https:\/\/doi.org\/10.3390\/v11030237 (2019).","journal-title":"Viruses"},{"key":"59094_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/v14030521","author":"M Santak","year":"2022","unstructured":"Santak, M. & Matic, Z. The role of nucleoprotein in immunity to human negative-stranded RNA viruses-not just another brick in the viral nucleocapsid. Viruses https:\/\/doi.org\/10.3390\/v14030521 (2022).","journal-title":"Viruses"},{"key":"59094_CR15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.antiviral.2017.08.014","volume":"146","author":"M Zivcec","year":"2017","unstructured":"Zivcec, M. et al. Identification of broadly neutralizing monoclonal antibodies against Crimean-Congo hemorrhagic fever virus. Antiviral Res. 146, 112\u2013120. https:\/\/doi.org\/10.1016\/j.antiviral.2017.08.014 (2017).","journal-title":"Antiviral Res."},{"key":"59094_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13040406","author":"MST Murala","year":"2025","unstructured":"Murala, M. S. T., Gairola, V., Sayedahmed, E. E. & Mittal, S. K. Next-generation adenoviral vector-based vaccines for severe acute respiratory syndrome coronavirus-2. Vaccines (Basel) https:\/\/doi.org\/10.3390\/vaccines13040406 (2025).","journal-title":"Vaccines (Basel)"},{"key":"59094_CR17","doi-asserted-by":"publisher","first-page":"104523","DOI":"10.1016\/j.ebiom.2023.104523","volume":"90","author":"JE Saunders","year":"2023","unstructured":"Saunders, J. E. et al. Adenoviral vectored vaccination protects against Crimean-Congo haemorrhagic fever disease in a lethal challenge model. EBioMedicine 90, 104523. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104523 (2023).","journal-title":"EBioMedicine"},{"key":"59094_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/v11010075","author":"TA Farzani","year":"2019","unstructured":"Farzani, T. A. et al. Co-delivery effect of CD24 on the immunogenicity and lethal challenge protection of a DNA vector expressing nucleocapsid protein of Crimean Congo hemorrhagic fever virus. Viruses https:\/\/doi.org\/10.3390\/v11010075 (2019).","journal-title":"Viruses"},{"key":"59094_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41541-020-00243-x","volume":"5","author":"R Bos","year":"2020","unstructured":"Bos, R. et al. Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 spike immunogen induces potent humoral and cellular immune responses. NPJ Vaccines 5, 91. https:\/\/doi.org\/10.1038\/s41541-020-00243-x (2020).","journal-title":"NPJ Vaccines"},{"key":"59094_CR20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41591-020-01194-5","volume":"27","author":"KJ Ewer","year":"2021","unstructured":"Ewer, K. J. et al. T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1\/2 clinical trial. Nat. Med. 27, 270\u2013278. https:\/\/doi.org\/10.1038\/s41591-020-01194-5 (2021).","journal-title":"Nat. Med."},{"key":"59094_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/v15010204","author":"E Sallard","year":"2023","unstructured":"Sallard, E., Zhang, W., Aydin, M., Schroer, K. & Ehrhardt, A. The adenovirus vector platform: Novel insights into rational vector design and lessons learned from the COVID-19 vaccine. Viruses https:\/\/doi.org\/10.3390\/v15010204 (2023).","journal-title":"Viruses"},{"key":"59094_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41541-021-00356-x","volume":"6","author":"SA Mendonca","year":"2021","unstructured":"Mendonca, S. A., Lorincz, R., Boucher, P. & Curiel, D. T. Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic. NPJ Vaccines 6, 97. https:\/\/doi.org\/10.1038\/s41541-021-00356-x (2021).","journal-title":"NPJ Vaccines"},{"key":"59094_CR23","doi-asserted-by":"publisher","first-page":"eaaw9535","DOI":"10.1126\/sciadv.aaw9535","volume":"5","author":"JW Golden","year":"2019","unstructured":"Golden, J. W. et al. GP38-targeting monoclonal antibodies protect adult mice against lethal Crimean-Congo hemorrhagic fever virus infection. Sci. Adv. 5, eaaw9535. https:\/\/doi.org\/10.1126\/sciadv.aaw9535 (2019).","journal-title":"Sci. Adv."},{"key":"59094_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41564-020-00815-6","volume":"6","author":"DW Hawman","year":"2021","unstructured":"Hawman, D. W. et al. A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model. Nat. Microbiol. 6, 187\u2013195. https:\/\/doi.org\/10.1038\/s41564-020-00815-6 (2021).","journal-title":"Nat. Microbiol."},{"key":"59094_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41541-024-01045-1","volume":"9","author":"SS Leventhal","year":"2024","unstructured":"Leventhal, S. S. et al. Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice. NPJ Vaccines 9, 249. https:\/\/doi.org\/10.1038\/s41541-024-01045-1 (2024).","journal-title":"NPJ Vaccines"},{"key":"59094_CR26","doi-asserted-by":"publisher","first-page":"105017","DOI":"10.1016\/j.ebiom.2024.105017","volume":"101","author":"SS Leventhal","year":"2024","unstructured":"Leventhal, S. S. et al. Single dose, dual antigen RNA vaccines protect against lethal Crimean-Congo haemorrhagic fever virus infection in mice. EBioMedicine 101, 105017. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105017 (2024).","journal-title":"EBioMedicine"},{"key":"59094_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13030291","author":"E Calvo-Pinilla","year":"2025","unstructured":"Calvo-Pinilla, E. et al. Prime-boost vaccination based on nanospheres and MVA encoding the nucleoprotein of Crimean-Congo hemorrhagic fever virus elicits broad immune responses. Vaccines https:\/\/doi.org\/10.3390\/vaccines13030291 (2025).","journal-title":"Vaccines"},{"key":"59094_CR28","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12575-024-00244-3","volume":"26","author":"K Muzammil","year":"2024","unstructured":"Muzammil, K. et al. Recent advances in Crimean-Congo hemorrhagic fever virus detection, treatment, and vaccination: Overview of current status and challenges. Biol. Proced. 26, 20. https:\/\/doi.org\/10.1186\/s12575-024-00244-3 (2024).","journal-title":"Biol. Proced."},{"key":"59094_CR29","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41541-025-01164-3","volume":"10","author":"T Tipih","year":"2025","unstructured":"Tipih, T. et al. Single dose VSV-based vaccine protects mice against lethal heterologous Crimean-Congo hemorrhagic fever virus challenge. NPJ Vaccines 10, 109. https:\/\/doi.org\/10.1038\/s41541-025-01164-3 (2025).","journal-title":"NPJ Vaccines"},{"key":"59094_CR30","doi-asserted-by":"publisher","first-page":"7365","DOI":"10.1038\/s41467-023-43206-1","volume":"14","author":"S Dai","year":"2023","unstructured":"Dai, S. et al. Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins. Nat. Commun. 14, 7365. https:\/\/doi.org\/10.1038\/s41467-023-43206-1 (2023).","journal-title":"Nat. Commun."},{"key":"59094_CR31","doi-asserted-by":"publisher","first-page":"9236","DOI":"10.1038\/s41467-024-53362-7","volume":"15","author":"SS Leventhal","year":"2024","unstructured":"Leventhal, S. S. et al. Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21. Nat. Commun. 15, 9236. https:\/\/doi.org\/10.1038\/s41467-024-53362-7 (2024).","journal-title":"Nat. Commun."},{"key":"59094_CR32","doi-asserted-by":"publisher","first-page":"864","DOI":"10.3201\/eid3005.231648","volume":"30","author":"MG Frank","year":"2024","unstructured":"Frank, M. G., Weaver, G., Raabe, V., State of the Clinical Science Working Group of the National Emerging Pathogens, T. E. C. s. S. P. R., Network. Crimean-Congo hemorrhagic fever virus for clinicians-diagnosis, clinical management, and therapeutics. Emerg. Infect. Dis. 30, 864\u2013873. https:\/\/doi.org\/10.3201\/eid3005.231648 (2024).","journal-title":"Emerg. Infect. Dis."},{"key":"59094_CR33","doi-asserted-by":"publisher","first-page":"1216225","DOI":"10.3389\/fimmu.2023.1216225","volume":"14","author":"TP Monath","year":"2023","unstructured":"Monath, T. P. et al. Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease. Front. Immunol. 14, 1216225. https:\/\/doi.org\/10.3389\/fimmu.2023.1216225 (2023).","journal-title":"Front. Immunol."},{"key":"59094_CR34","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41541-023-00737-4","volume":"8","author":"SE Vinzon","year":"2023","unstructured":"Vinzon, S. E. et al. Cross-protection and cross-neutralization capacity of ancestral and VOC-matched SARS-CoV-2 adenoviral vector-based vaccines. NPJ Vaccines 8, 149. https:\/\/doi.org\/10.1038\/s41541-023-00737-4 (2023).","journal-title":"NPJ Vaccines"},{"key":"59094_CR35","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.ymthe.2022.09.016","volume":"31","author":"DW Hawman","year":"2023","unstructured":"Hawman, D. W. et al. Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model. Mol. Ther. 31, 387\u2013397. https:\/\/doi.org\/10.1016\/j.ymthe.2022.09.016 (2023).","journal-title":"Mol. Ther."},{"key":"59094_CR36","doi-asserted-by":"publisher","first-page":"100432","DOI":"10.1016\/j.dmpk.2021.100432","volume":"42","author":"F Sakurai","year":"2022","unstructured":"Sakurai, F., Tachibana, M. & Mizuguchi, H. Adenovirus vector-based vaccine for infectious diseases. Drug Metab. Pharmacokinet 42, 100432. https:\/\/doi.org\/10.1016\/j.dmpk.2021.100432 (2022).","journal-title":"Drug Metab. Pharmacokinet"},{"key":"59094_CR37","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.ymthe.2004.07.013","volume":"10","author":"N Tatsis","year":"2004","unstructured":"Tatsis, N. & Ertl, H. C. Adenoviruses as vaccine vectors. Mol. Ther. 10, 616\u2013629. https:\/\/doi.org\/10.1016\/j.ymthe.2004.07.013 (2004).","journal-title":"Mol. Ther."},{"key":"59094_CR38","doi-asserted-by":"publisher","first-page":"e2250022","DOI":"10.1002\/eji.202250022","volume":"53","author":"NM Provine","year":"2023","unstructured":"Provine, N. M. & Klenerman, P. Adenovirus vector and mRNA vaccines: Mechanisms regulating their immunogenicity. Eur. J. Immunol. 53, e2250022. https:\/\/doi.org\/10.1002\/eji.202250022 (2023).","journal-title":"Eur. J. Immunol."},{"key":"59094_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/v13081493","author":"M Alhashimi","year":"2021","unstructured":"Alhashimi, M., Elkashif, A., Sayedahmed, E. E. & Mittal, S. K. Nonhuman adenoviral vector-based platforms and their utility in designing next generation of vaccines for infectious diseases. Viruses https:\/\/doi.org\/10.3390\/v13081493 (2021).","journal-title":"Viruses"},{"key":"59094_CR40","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41541-022-00567-w","volume":"7","author":"S Khan","year":"2022","unstructured":"Khan, S. et al. Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets. NPJ Vaccines 7, 146. https:\/\/doi.org\/10.1038\/s41541-022-00567-w (2022).","journal-title":"NPJ Vaccines"},{"key":"59094_CR41","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01155-19","author":"CP Hrycak","year":"2019","unstructured":"Hrycak, C. P., Windmann, S. & Bayer, W. Comparative evaluation of the vaccine efficacies of three adenovirus-based vector types in the Friend retrovirus infection model. J. Virol. https:\/\/doi.org\/10.1128\/jvi.01155-19 (2019).","journal-title":"J. Virol."},{"key":"59094_CR42","doi-asserted-by":"publisher","first-page":"6744","DOI":"10.1016\/j.vaccine.2018.09.031","volume":"36","author":"EE Sayedahmed","year":"2018","unstructured":"Sayedahmed, E. E. et al. Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy. Vaccine 36, 6744\u20136751. https:\/\/doi.org\/10.1016\/j.vaccine.2018.09.031 (2018).","journal-title":"Vaccine"},{"key":"59094_CR43","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1186\/s13071-024-06517-w","volume":"17","author":"J de la Fuente","year":"2024","unstructured":"de la Fuente, J., Sobrino, I. & Villar, M. Design and evaluation of vaccines for the control of the etiological agent of East Coast fever. Parasites Vectors 17, 479. https:\/\/doi.org\/10.1186\/s13071-024-06517-w (2024).","journal-title":"Parasites Vectors"},{"key":"59094_CR44","doi-asserted-by":"publisher","DOI":"10.3201\/eid2409.171427","author":"MS Mehand","year":"2018","unstructured":"Mehand, M. S. et al. World Health Organization methodology to prioritize emerging infectious diseases in need of research and development. Emerg. Infect. Dis. https:\/\/doi.org\/10.3201\/eid2409.171427 (2018).","journal-title":"Emerg. Infect. Dis."},{"key":"59094_CR45","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75537","author":"DW Hawman","year":"2022","unstructured":"Hawman, D. W. et al. SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern. Elife https:\/\/doi.org\/10.7554\/eLife.75537 (2022).","journal-title":"Elife"},{"key":"59094_CR46","unstructured":"Hanifehnezhad, A. Production and Characterization of Monoclonal Antibody against Crimean-Congo Hemorrhagic Fever Virus PhD thesis, Ankara University, Graduate School for Health Sciences, (2022)."},{"key":"59094_CR47","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1080\/21645515.2015.1078045","volume":"12","author":"SD Dowall","year":"2016","unstructured":"Dowall, S. D. et al. A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease. Hum. Vaccin. Immunother. 12, 519\u2013527. https:\/\/doi.org\/10.1080\/21645515.2015.1078045 (2016).","journal-title":"Hum. Vaccin. Immunother."},{"key":"59094_CR48","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s41421-021-00360-4","volume":"7","author":"J Liu","year":"2021","unstructured":"Liu, J. et al. Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection. Cell Discov. 7, 123. https:\/\/doi.org\/10.1038\/s41421-021-00360-4 (2021).","journal-title":"Cell Discov."},{"key":"59094_CR49","doi-asserted-by":"publisher","first-page":"e0012011","DOI":"10.1371\/journal.pntd.0012011","volume":"18","author":"B Borrego","year":"2024","unstructured":"Borrego, B. et al. The Rift Valley fever (RVF) vaccine candidate 40Fp8 shows an extreme attenuation in IFNARKO mice following intranasal inoculation. PLoS Negl. Trop. Dis. 18, e0012011. https:\/\/doi.org\/10.1371\/journal.pntd.0012011 (2024).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"59094_CR50","doi-asserted-by":"publisher","first-page":"104188","DOI":"10.1016\/j.ebiom.2022.104188","volume":"82","author":"SS Leventhal","year":"2022","unstructured":"Leventhal, S. S. et al. Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge. EBioMedicine 82, 104188. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104188 (2022).","journal-title":"EBioMedicine"},{"key":"59094_CR51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41541-022-00551-4","volume":"7","author":"JD Doyle","year":"2022","unstructured":"Doyle, J. D., Barbeau, D. J., Cartwright, H. N. & McElroy, A. K. Immune correlates of protection following Rift Valley fever virus vaccination. NPJ Vaccines 7, 129. https:\/\/doi.org\/10.1038\/s41541-022-00551-4 (2022).","journal-title":"NPJ Vaccines"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59094-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:24:35Z","timestamp":1789133075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59094-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["59094"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-59094-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"12 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"28482"}}