{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T15:14:50Z","timestamp":1783264490949,"version":"3.54.6"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ambulatory inguinal hernia repair requires anesthetic techniques that provide reliable intraoperative analgesia while facilitating rapid recovery and timely discharge. Postoperative spontaneous voiding is a critical determinant of discharge readiness. This study compared unilateral intrathecal prilocaine\u2013fentanyl with bupivacaine\u2013fentanyl in male patients undergoing elective inguinal hernioplasty. In this randomized comparative trial, 70 male patients (ASA I\u2013II, aged 18\u201360 years) scheduled for elective unilateral inguinal hernia repair were allocated to receive either intrathecal prilocaine 40\u00a0mg plus fentanyl 25\u00a0\u00b5g (Pr\u2011F group, n\u2009=\u200935) or bupivacaine 7.5\u00a0mg plus fentanyl 25\u00a0\u00b5g (Bu\u2011F group, n\u2009=\u200935). Blocks were performed unilaterally with patients maintained in the lateral decubitus position for 15\u00a0min. The primary outcome was time to first spontaneous voiding. Secondary outcomes included block characteristics, recovery parameters, pain scores, rescue analgesia, discharge readiness (Modified Post-Anesthesia Discharge Scoring System\u2009\u2265\u20099), and adverse events. Baseline demographics and intraoperative hemodynamics were comparable between groups. The Pr\u2011F group demonstrated significantly shorter time to first spontaneous voiding (213\u2009\u00b1\u200927 vs. 307\u2009\u00b1\u200922\u00a0min, p\u2009&lt;\u20090.001). Motor and sensory regression times were also shorter with prilocaine (98\u2009\u00b1\u200911 vs. 187\u2009\u00b1\u200919\u00a0min; 120\u2009\u00b1\u200911 vs. 209\u2009\u00b1\u200923\u00a0min, respectively; p\u2009&lt;\u20090.001). Time to achieve Modified Post-Anesthesia Discharge Scoring System\u2009\u2265\u20099 was reduced in the Pr\u2011F group (97\u2009\u00b1\u200911 vs. 187\u2009\u00b1\u200919\u00a0min, p\u2009&lt;\u20090.001). Pain scores were higher with prilocaine, and rescue analgesia was required more frequently (34% vs. 11%, p\u2009=\u20090.023). Kaplan\u2013Meier analysis confirmed earlier voiding in the Pr\u2011F group (log\u2011rank \u03c7\u00b2=82.85, p\u2009&lt;\u20090.0001). Adverse events, including pruritus, shivering, urinary retention, and transient neurological symptoms, were infrequent and comparable between groups. Unilateral intrathecal prilocaine\u2013fentanyl provided faster recovery of sensory and motor function, earlier spontaneous voiding, and shorter discharge times compared with bupivacaine\u2013fentanyl in male patients undergoing ambulatory inguinal hernia repair. Both regimens were safe, but prilocaine\u2013fentanyl offers distinct advantages for fast\u2011track hernia surgery. Larger multicenter studies are warranted to confirm these findings across broader patient populations.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>Trial registration:<\/jats:italic>\n                    The study was registered retrospectively at ClinicalTrials.gov (Identifier: NCT07262398) on 14\/11\/2025.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-59157-8","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T14:24:19Z","timestamp":1783261459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of unilateral intrathecal prilocaine\u2013fentanyl versus bupivacaine\u2013fentanyl on postoperative spontaneous voiding in ambulatory male patients undergoing inguinal hernioplasty: a randomized double-blinded comparative study"],"prefix":"10.1038","volume":"16","author":[{"given":"Magdy Abdelmohsen Elsayed","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2831-1443","authenticated-orcid":false,"given":"Mina Adolf","family":"Helmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Mohamed Elsayed Abou","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Mounir","family":"Shash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad Sedik","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Ebrahim","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Mohamed Ramzy","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"issue":"7638","key":"59157_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1136\/bmj.39450.428275.AD","volume":"336","author":"JT Jenkins","year":"2008","unstructured":"Jenkins, J. T., O\u2019Dwyer, P. J. & Inguinal hernias BMJ ;336(7638):269\u2013272. doi:https:\/\/doi.org\/10.1136\/bmj.39450.428275.AD (2008).","journal-title":"BMJ"},{"key":"59157_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s44158-022-00034-x","author":"F Costa","year":"2022","unstructured":"Costa, F. et al. Selective spinal anesthesia with hyperbaric prilocaine provides better perioperative pain control than local anesthesia for ambulatory inguinal hernia repair without affecting discharging time: A randomized controlled trial. Journal of Anesthesia, Analgesia and Critical Care https:\/\/doi.org\/10.1186\/s44158-022-00034-x (2022).","journal-title":"Journal of Anesthesia, Analgesia and Critical Care"},{"key":"59157_CR3","doi-asserted-by":"publisher","unstructured":"Velioglu, O., Calis, A. S., Koca, H. & Velioglu, E. Bupivacaine vs. lidocaine: a comparison of local anesthetic efficacy in impacted third molar surgery. https:\/\/doi.org\/10.1007\/s00784-020-03224-5\/Published","DOI":"10.1007\/s00784-020-03224-5\/Published"},{"key":"59157_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s44158-023-00122-6","author":"AL Ambrosoli","year":"2023","unstructured":"Ambrosoli, A. L. et al. Safety and effectiveness of prilocaine for spinal anesthesia in day surgery setting: A retrospective study on a sample of 3291 patients. Journal of Anesthesia, Analgesia and Critical Care https:\/\/doi.org\/10.1186\/s44158-023-00122-6 (2023).","journal-title":"Journal of Anesthesia, Analgesia and Critical Care"},{"issue":"3","key":"59157_CR5","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.bjane.2013.06.014","volume":"64","author":"SM Moosavi Tekye","year":"2014","unstructured":"Moosavi Tekye, S. M. & ostafa, Alipour, M. Comparison of the effects and complications of unilateral spinal anesthesia versus standard spinal anesthesia in lower-limb orthopedic surgery. Braz J. Anesthesiol. 64 (3), 173\u2013176. https:\/\/doi.org\/10.1016\/j.bjane.2013.06.014 (2014).","journal-title":"Braz J. Anesthesiol"},{"issue":"1","key":"59157_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/bjs5.50114","volume":"3","author":"J Jackson","year":"2019","unstructured":"Jackson, J. et al. Systematic review of interventions for the prevention and treatment of postoperative urinary retention. BJS Open John Wiley Sons Inc. 3 (1), 11\u201323. https:\/\/doi.org\/10.1002\/bjs5.50114 (2019).","journal-title":"BJS Open John Wiley Sons Inc"},{"issue":"6","key":"59157_CR7","first-page":"685","volume":"80","author":"A Manassero","year":"2014","unstructured":"Manassero, A. et al. Comparison of unilateral and bilateral spinal anesthesia with 2% hyperbaric prilocaine in day-case inguinal herniorraphy: a randomized controlled trial. Minera Anesthesiol. 80 (6), 685\u2013691 (2014).","journal-title":"Minera Anesthesiol"},{"issue":"3","key":"59157_CR8","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1213\/ANE.0000000000007127","volume":"139","author":"GP Joshi","year":"2024","unstructured":"Joshi, G. P. & Vetter, T. R. Ambulatory anesthesia: Current state and future considerations. Anesth Analg 139(3), 453\u2013457. https:\/\/doi.org\/10.1213\/ANE.0000000000007127 (2024).","journal-title":"Anesth Analg"},{"issue":"3","key":"59157_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.18203\/2349-3259.ijct20162795","volume":"3","author":"MB Kotwani","year":"2016","unstructured":"Kotwani, M. B., Rupwate, K., Shivananda, P. & Magar, J. Comparison between high dose hyperbaric Bupivacaine (12.5\u00a0mg) alone versus low dose hyperbaric Bupivacaine (7.5\u00a0mg) with Fentanyl (25 \u00b5g) in spinal anaesthesia for inguinal hernia surgery. Int. J. Clin. Trials. 3 (3), 140. https:\/\/doi.org\/10.18203\/2349-3259.ijct20162795 (2016).","journal-title":"Int. J. Clin. Trials"},{"issue":"7","key":"59157_CR10","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12630-012-9717-5","volume":"59","author":"S Choi","year":"2012","unstructured":"Choi, S., Mahon, P. & Awad, I. T. Neuraxial anesthesia and bladder dysfunction in the perioperative period: A systematic review. Canadian J. Anesthesia Springer New. York LLC. 59 (7), 681\u2013703. https:\/\/doi.org\/10.1007\/s12630-012-9717-5 (2012).","journal-title":"Canadian J. Anesthesia Springer New. York LLC"},{"key":"59157_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2026.101835","author":"AMB Eldin","year":"2026","unstructured":"Eldin, A. M. B. Time to first void following knee arthroscopy: A randomized trial of three prilocaine doses. Anaesth. Crit. Care Pain Med. https:\/\/doi.org\/10.1016\/j.accpm.2026.101835 (2026).","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"59157_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/608372","author":"OG Kaban","year":"2014","unstructured":"Kaban, O. G. et al. Spinal anaesthesia with hyperbaric prilocaine in day-case perianal surgery: Randomised controlled trial. Scientific World Journal https:\/\/doi.org\/10.1155\/2014\/608372 (2014).","journal-title":"Scientific World Journal"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59157-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59157-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59157-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T14:36:17Z","timestamp":1783262177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59157-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,5]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["59157"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-59157-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,5]]},"assertion":[{"value":"4 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20569"}}