{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T19:44:18Z","timestamp":1782675858054,"version":"3.54.5"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide, with surgical resection as the cornerstone of curative therapy for localized disease. Surgery triggers a profound systemic inflammatory response that influences recovery, complications, and oncologic outcomes. While elevated NLR, PLR, and SII pre- or postoperatively predict adverse events like anastomotic leakage and poor survival, their normal temporal trajectories in uncomplicated cases remain poorly defined, hindering clinical interpretation. This preliminary study was conducted at two tertiary centers, screening 88 consecutive adults (\u2265\u200918 years) undergoing elective curative (R0) CRC resection (stages I\u2013III, open\/laparoscopic). Inclusion required Clavien-Dindo grade\u2009\u2264\u2009I recovery (no intervention beyond symptomatic treatment; ERAS discharge criteria met) and complete blood counts (preop baseline\u2009\u2264\u20097 days, POD1\/15\/30). Exclusions: emergencies, immunosuppression, severe comorbidities (e.g., eGFR\u2009&lt;\u200930, HbA1c\u2009&gt;\u200910), neoadjuvant\u2009&lt;\u20094 weeks prior, grade\u2009\u2265\u2009II complications (e.g., leak, sepsis, readmission). Only the uncomplicated cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200947; median age 50 years; 62% female) was finally analyzed. EDTA-blood analyzed via automated hematology (neutrophils\/lymphocytes\/platelets); markers calculated; trajectories via Friedman test; 5th\u201395th percentile intervals. All markers declined significantly (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). NLR medians: POD1 12.5 (IQR 5.6\u201326.1), POD15 3.4 (2.5\u20136.4), POD30 2.6 (1.7\u20135.1); 95th percentiles 49.0 to 11.9. PLR: POD1 366.1 (223\u2013682), POD15 244.9 (173\u2013330), POD30 194.5 (129\u2013319); 95th 1455 to 658.5. SII: POD1 3520 (1473\u20138806), POD15 1244 (757\u20132223), POD30 789 (470\u20131389); 95th 17,063 to 3311. Neutrophils fell (8.99 to 4.4\u2009\u00d7\u200910^9\/L), lymphocytes rose (0.71 to 1.25\u2009\u00d7\u200910^9\/L). Uncomplicated CRC resection recovery features rapid normalization of NLR, PLR, and SII over 30 days, providing preliminary time-specific percentile-based benchmarks for describing expected postoperative inflammatory trajectories. These findings should be interpreted as exploratory and require validation in larger multicenter cohorts before clinical application.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-59229-9","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T18:44:49Z","timestamp":1782672289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative dynamics of inflammatory markers in patients with uncomplicated recovery after colorectal cancer surgery: a preliminary inflammatory benchmarks study"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-2901","authenticated-orcid":false,"given":"Mohammed. N.","family":"Abdelaziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed. Y.","family":"Eldomyaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"issue":"9","key":"59229_CR1","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.3390\/medicina60091481","volume":"60","author":"I Shevchenko","year":"2024","unstructured":"Shevchenko, I. et al. The Value of Systemic Inflammatory Indices for Predicting Early Postoperative Complications in Colorectal Cancer. Med. (Kaunas). 60 (9), 1481. https:\/\/doi.org\/10.3390\/medicina60091481 (2024).","journal-title":"Med. (Kaunas)"},{"issue":"2","key":"59229_CR2","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","volume":"72","author":"E Morgan","year":"2023","unstructured":"Morgan, E. et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 72 (2), 338\u2013344. https:\/\/doi.org\/10.1136\/gutjnl-2022-327736 (2023).","journal-title":"Gut"},{"issue":"5","key":"59229_CR3","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.21037\/jgo-22-716","volume":"13","author":"L Feng","year":"2022","unstructured":"Feng, L., Xu, R., Lin, L. & Liao, X. Effect of the systemic immune-inflammation index on postoperative complications and the long-term prognosis of patients with colorectal cancer: a retrospective cohort study. J. Gastrointest. Oncol. 13 (5), 2333\u20132339. https:\/\/doi.org\/10.21037\/jgo-22-716 (2022).","journal-title":"J. Gastrointest. Oncol."},{"issue":"1","key":"59229_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ijsu.2006.05.013","volume":"5","author":"EJ Cook","year":"2007","unstructured":"Cook, E. J. et al. Post-operative neutrophil-lymphocyte ratio predicts complications following colorectal surgery. Int. J. Surg. 5 (1), 27\u201330. https:\/\/doi.org\/10.1016\/j.ijsu.2006.05.013 (2007).","journal-title":"Int. J. Surg."},{"issue":"15","key":"59229_CR5","doi-asserted-by":"publisher","first-page":"8441","DOI":"10.3390\/ijms25158441","volume":"25","author":"O Menyhart","year":"2024","unstructured":"Menyhart, O., Fekete, J. T. & Gy\u0151rffy, B. Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI). Int. J. Mol. Sci. 25 (15), 8441. https:\/\/doi.org\/10.3390\/ijms25158441 (2024).","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"59229_CR6","doi-asserted-by":"publisher","first-page":"e0163523","DOI":"10.1371\/journal.pone.0163523","volume":"11","author":"X Gu","year":"2016","unstructured":"Gu, X. et al. Elevated Platelet to Lymphocyte Ratio Is Associated with Poor Survival Outcomes in Patients with Colorectal Cancer. PLoS One. 11 (9), e0163523. https:\/\/doi.org\/10.1371\/journal.pone.0163523 (2016).","journal-title":"PLoS One"},{"key":"59229_CR7","doi-asserted-by":"publisher","unstructured":"Tan, D., Fu, Y., Su, Q. & Wang, H. Prognostic role of platelet-lymphocyte ratio in colorectal cancer: A systematic review and meta-analysis. Medicine (Baltimore). ;95(24):e3837. doi: 10.1097\/MD.0000000000003837. Erratum in: Medicine (Baltimore). 2016;95(31):e5074. (2016). https:\/\/doi.org\/10.1097\/01.md.0000490009.39850.74","DOI":"10.1097\/01.md.0000490009.39850.74"},{"issue":"6","key":"59229_CR8","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s13304-021-01082-8","volume":"73","author":"M Baeza-Murcia","year":"2021","unstructured":"Baeza-Murcia, M. et al. Early diagnosis of anastomotic leakage in colorectal surgery: prospective observational study of the utility of inflammatory markers and determination of pathological levels. Updates Surg. 73 (6), 2103\u20132111. https:\/\/doi.org\/10.1007\/s13304-021-01082-8 (2021).","journal-title":"Updates Surg."},{"issue":"1","key":"59229_CR9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.21037\/tcr-23-1289","volume":"13","author":"J Sun","year":"2024","unstructured":"Sun, J., Yang, R., Wu, H., Li, L. & Gu, Y. Prognostic value of preoperative combined with postoperative systemic immune-inflammation index for disease-free survival after radical rectal cancer surgery: a retrospective cohort study. Transl Cancer Res. 13 (1), 371\u2013380. https:\/\/doi.org\/10.21037\/tcr-23-1289 (2024).","journal-title":"Transl Cancer Res."},{"issue":"19","key":"59229_CR10","doi-asserted-by":"publisher","first-page":"6338","DOI":"10.3390\/jcm12196338","volume":"12","author":"A Firut","year":"2023","unstructured":"Firut, A. et al. Preoperative Immunocyte-Derived Ratios Predict Postoperative Recovery of Gastrointestinal Motility after Colorectal Cancer Surgery. J. Clin. 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Before commencing, all study participants provided written informed consent after the purpose and nature of the study were explained to them. Every study was conducted in accordance with the Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"19636"}}