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This cross-sectional study, conducted from December 2023 to May 2024 using printed surveys and convenience sampling, included 598 participants (412 medical students and 186 interns). The survey included the Connor-Davidson Resilience Scale (CD-RISC-10), the Toronto Alexithymia Scale (TAS-20), and the NEO Five-Factor Inventory (NEO-FFI). Pearson\u2019s correlation (\n                    <jats:italic>r<\/jats:italic>\n                    ), multivariable linear regression, and path analysis were conducted to examine factors associated with resilience. Resilience was negatively correlated with neuroticism and alexithymia (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009-0.41 and -0.32,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and positively correlated with extraversion and conscientiousness (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.29 and 0.36,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Regression identified neuroticism, externally-oriented thinking, agreeableness, and current psychiatric disorder as negative predictors (\u03b2\u2009=\u2009-0.32, -0.14, -0.10, and -0.45 respectively, p\u2009\u2264\u20090.012), while extraversion and conscientiousness were positive predictors (\u03b2\u2009=\u20090.14 and 0.24 respectively, p\u2009&lt;\u20090.001). On path analysis, externally-oriented thinking provided a significant indirect statistical link in the associations of conscientiousness (\u03b2\u2009=\u20090.02, p\u2009=\u20090.019) and openness (\u03b2\u2009=\u20090.03, p\u2009=\u20090.010) with resilience. Addressing neuroticism and alexithymia subcomponents may enhance resilience and support student well-being.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-59508-5","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:35:09Z","timestamp":1783013709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the pathways between personality traits, alexithymia, and resilience among medical students and interns: a cross-sectional study in Egypt"],"prefix":"10.1038","volume":"16","author":[{"given":"Hajer","family":"Azzam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusof Mohamed","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kariem","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed H.","family":"Ata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mennatullah","family":"Elagouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam H.","family":"Nabih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"ElKaffas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad A.","family":"Helaiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"R. 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