{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:57:09Z","timestamp":1790485029958,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["43009367"],"award-info":[{"award-number":["43009367"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-59888-8","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T19:25:50Z","timestamp":1782674750000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of magnesium supplementation on inflammatory factors and clinical outcomes of allogeneic hematopoietic stem cell transplantation in patients with acute leukemia receiving a neutropenic diet: a randomized clinical trial"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-0045","authenticated-orcid":false,"given":"Mohammad-Javad","family":"Abdolkarimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8603-5674","authenticated-orcid":false,"given":"Mohammad-Reza","family":"Jowshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-3222","authenticated-orcid":false,"given":"Sahar","family":"Parkhideh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-7593","authenticated-orcid":false,"given":"Bahareh","family":"Nikooyeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-0594","authenticated-orcid":false,"given":"Abbas","family":"Hajifathali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5200-8915","authenticated-orcid":false,"given":"Sayeh","family":"Parkhideh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-5495","authenticated-orcid":false,"given":"Mahshid","family":"Mehdizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-5191","authenticated-orcid":false,"given":"Mohammad","family":"Hassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-7459","authenticated-orcid":false,"given":"Hoda","family":"Zahedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"59888_CR1","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1056\/NEJMra1406184","volume":"373","author":"H D\u00f6hner","year":"2015","unstructured":"D\u00f6hner, H., Weisdorf, D. J. & Bloomfield, C. D. Acute Myeloid Leukemia. N Engl. J. Med. 373, 1136\u20131152. https:\/\/doi.org\/10.1056\/NEJMra1406184 (2015).","journal-title":"N Engl. J. Med."},{"key":"59888_CR2","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1038\/s41409-021-01227-8","volume":"56","author":"JR Passweg","year":"2021","unstructured":"Passweg, J. R. et al. Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years. Bone Marrow Transpl. 56, 1651\u20131664. https:\/\/doi.org\/10.1038\/s41409-021-01227-8 (2021).","journal-title":"Bone Marrow Transpl."},{"key":"59888_CR3","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMra052638","volume":"354","author":"EA Copelan","year":"2006","unstructured":"Copelan, E. A. Hematopoietic stem-cell transplantation. N Engl. J. Med. 354, 1813\u20131826. https:\/\/doi.org\/10.1056\/NEJMra052638 (2006).","journal-title":"N Engl. J. Med."},{"key":"59888_CR4","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1056\/NEJMra1703472","volume":"377","author":"R Zeiser","year":"2017","unstructured":"Zeiser, R. & Blazar, B. R. Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets. N Engl. J. Med. 377, 2565\u20132579. https:\/\/doi.org\/10.1056\/NEJMra1703472 (2017).","journal-title":"N Engl. J. Med."},{"key":"59888_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fimmu.2017.00079","volume":"8","author":"S Ghimire","year":"2017","unstructured":"Ghimire, S. et al. Pathophysiology of GvHD and Other HSCT-Related Major Complications. Front. Immunol. 8, 79. https:\/\/doi.org\/10.3389\/fimmu.2017.00079 (2017).","journal-title":"Front. Immunol."},{"key":"59888_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/oncolo\/oyac076","volume":"27","author":"DJ Martini","year":"2022","unstructured":"Martini, D. J., Chen, Y. B. & DeFilipp, Z. Recent FDA Approvals in the Treatment of Graft-Versus-Host Disease. Oncologist 27, 685\u2013693. https:\/\/doi.org\/10.1093\/oncolo\/oyac076 (2022).","journal-title":"Oncologist"},{"key":"59888_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1188\/15.Cjon.19-03ap","volume":"19","author":"M Lassiter","year":"2015","unstructured":"Lassiter, M. & Schneider, S. M. A pilot study comparing the neutropenic diet to a non-neutropenic diet in the allogeneic hematopoietic stem cell transplantation population. Clin. J. Oncol. Nurs. 19, 273\u2013278. https:\/\/doi.org\/10.1188\/15.Cjon.19-03ap (2015).","journal-title":"Clin. J. Oncol. Nurs."},{"key":"59888_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1136\/bmjspcare-2018-001742","volume":"9","author":"MB Sonbol","year":"2019","unstructured":"Sonbol, M. B. et al. Neutropenic diets to prevent cancer infections: updated systematic review and meta-analysis. BMJ Support Palliat. Care. 9, 425\u2013433. https:\/\/doi.org\/10.1136\/bmjspcare-2018-001742 (2019).","journal-title":"BMJ Support Palliat. Care"},{"key":"59888_CR9","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.3390\/nu15143171","volume":"15","author":"S Matteucci","year":"2023","unstructured":"Matteucci, S. et al. Low-bacterial diet in cancer patients: a systematic review. Nutrients 15, 3171 (2023).","journal-title":"Nutrients"},{"key":"59888_CR10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0002-8223(21)20502-6","volume":"48","author":"AO Reimer","year":"1966","unstructured":"Reimer, A. O. & Tillotson, J. L. Food service procedures for reverse isolation. Journal of the American Dietetic Association 48, 381\u2013384 (1966).","journal-title":"Journal of the American Dietetic Association"},{"key":"59888_CR11","doi-asserted-by":"publisher","first-page":"e223","DOI":"10.1016\/j.bbmt.2019.05.011","volume":"25","author":"K Moody","year":"2019","unstructured":"Moody, K. Neutropenic dietary restrictions for hematopoietic stem cell patients: Time for a change. Biol Blood Marrow Transplant 25, e223\u2013e225. https:\/\/doi.org\/10.1016\/j.bbmt.2019.05.011 (2019).","journal-title":"Biol Blood Marrow Transplant"},{"key":"59888_CR12","doi-asserted-by":"publisher","first-page":"5996","DOI":"10.1182\/bloodadvances.2023010348","volume":"7","author":"F Stella","year":"2023","unstructured":"Stella, F. et al. Nonrestrictive diet does not increase infections during post-HSCT neutropenia: Data from a multicenter randomized trial. Blood Advances 7, 5996\u20136004 (2023).","journal-title":"Blood Advances"},{"key":"59888_CR13","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.clnesp.2024.07.002","volume":"63","author":"A Paviglianiti","year":"2024","unstructured":"Paviglianiti, A. et al. Modern views of nutritional support in patients undergoing allogeneic stem cell transplantation. Clinical Nutrition ESPEN 63, 400\u2013408 (2024).","journal-title":"Clinical Nutrition ESPEN"},{"key":"59888_CR14","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1097\/01.tp.0000174340.40585.d4","volume":"80","author":"Y Aisa","year":"2005","unstructured":"Aisa, Y. et al. Effects of immunosuppressive agents on magnesium metabolism early after allogeneic hematopoietic stem cell transplantation. Transplantation 80, 1046\u20131050. https:\/\/doi.org\/10.1097\/01.tp.0000174340.40585.d4 (2005).","journal-title":"Transplantation"},{"key":"59888_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4103\/jesnt.jesnt_30_22","volume":"23","author":"MM Elsayed","year":"2023","unstructured":"Elsayed, M. M., Elgohary, I. E., Abouelnaga, S. F., Elian, F. A. S. & Zeid, M. M. Hypomagnesemia and its association with calcineurin inhibitor use in renal transplant recipients. J. Egypt. Soc. Nephrol. Transplantation. 23, 106\u2013110. https:\/\/doi.org\/10.4103\/jesnt.jesnt_30_22 (2023).","journal-title":"J. Egypt. Soc. Nephrol. Transplantation"},{"issue":"2","key":"59888_CR16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1684\/mrh.2013.0338","volume":"26","author":"HS Chung","year":"2013","unstructured":"Chung, H. S. et al. Effects of magnesium pretreatment on the levels of T helper cytokines and on the severity of reperfusion syndrome in patients undergoing living donor liver transplantation. Magnesium research 26(2), 46\u201355 (2013).","journal-title":"Magnesium research"},{"key":"59888_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.semcdb.2020.11.002","volume":"115","author":"JA Maier","year":"2021","unstructured":"Maier, J. A., Castiglioni, S., Locatelli, L., Zocchi, M. & Mazur, A. Magnesium and inflammation: Advances and perspectives. Semin. Cell Dev. Biol. 115, 37\u201344. https:\/\/doi.org\/10.1016\/j.semcdb.2020.11.002 (2021).","journal-title":"Semin. Cell Dev. Biol."},{"key":"59888_CR18","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1684\/mrh.2010.0220","volume":"23","author":"FH Nielsen","year":"2010","unstructured":"Nielsen, F. H., Johnson, L. K. & Zeng, H. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res. 23, 158\u2013168. https:\/\/doi.org\/10.1684\/mrh.2010.0220 (2010).","journal-title":"Magnes Res."},{"key":"59888_CR19","doi-asserted-by":"publisher","first-page":"8199","DOI":"10.3390\/nu7095388","volume":"7","author":"U Gr\u00f6ber","year":"2015","unstructured":"Gr\u00f6ber, U., Schmidt, J. & Kisters, K. Magnesium in Prevention and Therapy. Nutrients 7, 8199\u20138226. https:\/\/doi.org\/10.3390\/nu7095388 (2015).","journal-title":"Nutrients"},{"key":"59888_CR20","doi-asserted-by":"publisher","unstructured":"Liu, M. & Dudley, S. C. Jr. Magnesium, oxidative stress, inflammation, and cardiovascular disease. Antioxidants (Basel) https:\/\/doi.org\/10.3390\/antiox9100907 (2020).","DOI":"10.3390\/antiox9100907"},{"key":"59888_CR21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1186\/s13063-025-09201-1","volume":"26","author":"MJ Abdolkarimi","year":"2025","unstructured":"Abdolkarimi, M. J. et al. Effect of neutropenic diet with or without magnesium supplementation on inflammatory factors and outcomes of allogeneic hematopoietic stem cell transplantation in patients with acute leukemia: study protocol for a randomized clinical trial. Trials 26, 459. https:\/\/doi.org\/10.1186\/s13063-025-09201-1 (2025).","journal-title":"Trials"},{"key":"59888_CR22","doi-asserted-by":"publisher","first-page":"e7586","DOI":"10.1136\/bmj.e7586","volume":"346","author":"AW Chan","year":"2013","unstructured":"Chan, A. W. et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. Bmj 346, e7586. https:\/\/doi.org\/10.1136\/bmj.e7586 (2013).","journal-title":"Bmj"},{"key":"59888_CR23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.intimp.2017.02.022","volume":"46","author":"J Lv","year":"2017","unstructured":"Lv, J. et al. Effects of magnesium isoglycyrrhizinate on AST, ALT, and serum levels of Th1 cytokines in patients with allo-HSCT. Int. Immunopharmacol. 46, 56\u201361. https:\/\/doi.org\/10.1016\/j.intimp.2017.02.022 (2017).","journal-title":"Int. Immunopharmacol."},{"key":"59888_CR24","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110362768","author":"F Bozzetti","year":"2010","unstructured":"Bozzetti, F. Re: A.S.P.E.N. clinical guidelines: Nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation. JPEN J Parenter Enteral Nutr https:\/\/doi.org\/10.1177\/0148607110362768 (2010).","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"59888_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/ijlh.12278","volume":"37","author":"IV Morkis","year":"2015","unstructured":"Morkis, I. V. et al. Assessment of immature platelet fraction and immature reticulocyte fraction as predictors of engraftment after hematopoietic stem cell transplantation. Int. J. Lab. Hematol. 37, 259\u2013264. https:\/\/doi.org\/10.1111\/ijlh.12278 (2015).","journal-title":"Int. J. Lab. Hematol."},{"key":"59888_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","volume":"18","author":"H Glucksberg","year":"1974","unstructured":"Glucksberg, H. et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18, 295\u2013304. https:\/\/doi.org\/10.1097\/00007890-197410000-00001 (1974).","journal-title":"Transplantation"},{"key":"59888_CR27","doi-asserted-by":"publisher","first-page":"e079697","DOI":"10.1136\/bmjopen-2023-079697","volume":"14","author":"J Harooni","year":"2024","unstructured":"Harooni, J. et al. Cohort profile: the PERSIAN Dena Cohort Study (PDCS) of non-communicable diseases in Southwest Iran. BMJ Open. 14, e079697. https:\/\/doi.org\/10.1136\/bmjopen-2023-079697 (2024).","journal-title":"BMJ Open."},{"key":"59888_CR28","doi-asserted-by":"publisher","first-page":"421","DOI":"10.17219\/acem\/62120","volume":"26","author":"Y Ma","year":"2017","unstructured":"Ma, Y. et al. IL-6, IL-8 and TNF-\u03b1 levels correlate with disease stage in breast cancer patients. Adv. Clin. Exp. Med. 26, 421\u2013426. https:\/\/doi.org\/10.17219\/acem\/62120 (2017).","journal-title":"Adv. Clin. Exp. Med."},{"key":"59888_CR29","doi-asserted-by":"publisher","unstructured":"Noh, S. et al. Recent Advances in CRP Biosensor Based on Electrical, Electrochemical and Optical Methods. Sens. (Basel). 21 https:\/\/doi.org\/10.3390\/s21093024 (2021).","DOI":"10.3390\/s21093024"},{"key":"59888_CR30","unstructured":"Tishkowski, K. & Zubair, M. in StatPearls (StatPearls Publishing Copyright \u00a9 2025 (StatPearls Publishing LLC., 2025)."},{"key":"59888_CR31","first-page":"213","volume":"7","author":"M Ghaffarpour","year":"1999","unstructured":"Ghaffarpour, M., Houshiar-Rad, A. & Kianfar, H. The manual for household measures, cooking yields factors and edible portion of foods. Tehran: Nashre Olume Keshavarzy. 7, 213 (1999).","journal-title":"Tehran: Nashre Olume Keshavarzy"},{"key":"59888_CR32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12937-020-00624-x","volume":"19","author":"M Aghayan","year":"2020","unstructured":"Aghayan, M. et al. Secular trend in dietary patterns of Iranian adults from 2006 to 2017: Tehran lipid and glucose study. Nutr. J. 19, 110. https:\/\/doi.org\/10.1186\/s12937-020-00624-x (2020).","journal-title":"Nutr. J."},{"key":"59888_CR33","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1177\/0748730419892105","volume":"34","author":"ENC Manoogian","year":"2019","unstructured":"Manoogian, E. N. C., Chaix, A. & Panda, S. When to Eat: The Importance of Eating Patterns in Health and Disease. J. Biol. Rhythms. 34, 579\u2013581. https:\/\/doi.org\/10.1177\/0748730419892105 (2019).","journal-title":"J. Biol. Rhythms"},{"key":"59888_CR34","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/ajcn\/nqx027","volume":"107","author":"C Schwedhelm","year":"2018","unstructured":"Schwedhelm, C., Iqbal, K., Kn\u00fcppel, S., Schwingshackl, L. & Boeing, H. Contribution to the understanding of how principal component analysis-derived dietary patterns emerge from habitual data on food consumption. Am. J. Clin. Nutr. 107, 227\u2013235. https:\/\/doi.org\/10.1093\/ajcn\/nqx027 (2018).","journal-title":"Am. J. Clin. Nutr."},{"key":"59888_CR35","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1017\/S0007114521002543","volume":"127","author":"Z Akbarzade","year":"2022","unstructured":"Akbarzade, Z. et al. The association between lunch composition and obesity in Iranian adults. Br. J. Nutr. 127, 1517\u20131527. https:\/\/doi.org\/10.1017\/S0007114521002543 (2022).","journal-title":"Br. J. Nutr."},{"key":"59888_CR36","doi-asserted-by":"publisher","first-page":"102100","DOI":"10.1016\/j.trim.2024.102100","volume":"86","author":"Q Fan","year":"2024","unstructured":"Fan, Q., Hui, X., Zhang, Y. & Wang, Y. Effect of magnesium level before allogeneic hematopoietic cell transplantation on outcome in acute leukemia. Transpl. Immunol. 86, 102100. https:\/\/doi.org\/10.1016\/j.trim.2024.102100 (2024).","journal-title":"Transpl. Immunol."},{"key":"59888_CR37","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s00277-020-04382-y","volume":"100","author":"L Angenendt","year":"2021","unstructured":"Angenendt, L. et al. Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia. Ann. Hematol. 100, 1871\u20131878. https:\/\/doi.org\/10.1007\/s00277-020-04382-y (2021).","journal-title":"Ann. Hematol."},{"key":"59888_CR38","doi-asserted-by":"publisher","first-page":"1692937","DOI":"10.3389\/fnut.2025.1692937","volume":"12","author":"W Wang","year":"2025","unstructured":"Wang, W., Wang, J., Yang, Y. & Shi, Y. The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Front. Nutr. 12, 1692937. https:\/\/doi.org\/10.3389\/fnut.2025.1692937 (2025).","journal-title":"Front. Nutr."},{"key":"59888_CR39","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/bjh.17151","volume":"191","author":"J Barrett","year":"2020","unstructured":"Barrett, J. & Craddock, C. Bone marrow transplantation in the United Kingdom - past, present and future. Br. J. Haematol. 191, 612\u2013616. https:\/\/doi.org\/10.1111\/bjh.17151 (2020).","journal-title":"Br. J. Haematol."},{"key":"59888_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.605726","volume":"12","author":"M Gooptu","year":"2021","unstructured":"Gooptu, M. & Antin, J. H. GVHD prophylaxis 2020. Front Immunol 12, 605726. https:\/\/doi.org\/10.3389\/fimmu.2021.605726 (2021).","journal-title":"Front Immunol"},{"key":"59888_CR41","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s41043-023-00423-0","volume":"42","author":"S Ashique","year":"2023","unstructured":"Ashique, S. et al. A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer. J. Health Popul. Nutr. 42, 74. https:\/\/doi.org\/10.1186\/s41043-023-00423-0 (2023).","journal-title":"J. Health Popul. Nutr."},{"key":"59888_CR42","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1093\/jn\/nxab138","volume":"151","author":"L Fan","year":"2021","unstructured":"Fan, L. et al. Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults. J. Nutr. 151, 2226\u20132235. https:\/\/doi.org\/10.1093\/jn\/nxab138 (2021).","journal-title":"J. Nutr."},{"key":"59888_CR43","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s12011-017-1198-5","volume":"184","author":"F Afshar Ebrahimi","year":"2018","unstructured":"Afshar Ebrahimi, F., Foroozanfard, F., Aghadavod, E., Bahmani, F. & Asemi, Z. The Effects of Magnesium and Zinc Co-Supplementation on Biomarkers of Inflammation and Oxidative Stress, and Gene Expression Related to Inflammation in Polycystic Ovary Syndrome: a Randomized Controlled Clinical Trial. Biol. Trace Elem. Res. 184, 300\u2013307. https:\/\/doi.org\/10.1007\/s12011-017-1198-5 (2018).","journal-title":"Biol. Trace Elem. Res."},{"key":"59888_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010180","author":"LJ Dominguez","year":"2021","unstructured":"Dominguez, L. J., Veronese, N., Guerrero-Romero, F. & Barbagallo, M. Magnesium in infectious diseases in older people. Nutrients https:\/\/doi.org\/10.3390\/nu13010180 (2021).","journal-title":"Nutrients"},{"key":"59888_CR45","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3945\/jn.109.117374","volume":"140","author":"BD Pachikian","year":"2010","unstructured":"Pachikian, B. D. et al. Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. J. Nutr. 140, 509\u2013514 (2010).","journal-title":"J. Nutr."},{"key":"59888_CR46","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1017\/jns.2024.61","volume":"13","author":"T Gulliver","year":"2024","unstructured":"Gulliver, T., Hewett, M., Konstantopoulos, P., Tran, L. & Mantzioris, E. The neutropenic diet and its impacts on clinical, nutritional, and lifestyle outcomes for people with cancer: a scoping review. J. Nutr. Sci. 13, e60. https:\/\/doi.org\/10.1017\/jns.2024.61 (2024).","journal-title":"J. Nutr. Sci."},{"key":"59888_CR47","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/sj.ejcn.1601689","volume":"57","author":"M Tam","year":"2003","unstructured":"Tam, M., Gomez, S., Gonzalez-Gross, M. & Marcos, A. Possible roles of magnesium on the immune system. European journal of clinical nutrition 57, 1193\u20131197 (2003).","journal-title":"European journal of clinical nutrition"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59888-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59888-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59888-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:01:59Z","timestamp":1790481719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-59888-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["59888"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-59888-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"18 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study received ethical approval from the Ethics Committee of Shahid Beheshti University of Medical Sciences on 21 July 2024 (approval code: IR.SBMU.NNFTRI.REC.1403.035). All research activities adhered to the principles outlined in the Declaration of Helsinki. Before enrollment, each participant provided written informed consent after receiving detailed explanations regarding the study\u2019s purpose, methodology, and associated risks and benefits. To ensure confidentiality, participants were assigned unique identification codes, and no personal identifiers were used during data collection or analysis. Members of the research team who were trained in ethical research practices were responsible for obtaining consent. All participants continued to receive standard medical care throughout and after their involvement in the trial.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"29670"}}