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Ltd., Morinaga Co. Ltd., Miyarisan Pharma Co. Ltd, Morishita-Jintan Co. Ltd., Fujikko Co. Ltd., Mizkan Co. Ltd., Mykinso Co. Ltd. and KINS Co. Ltd.; a collaboration research fund from TOTO Ltd., Takeda Pharma. Co. Ltd. and Taiyo Kagaku Co., Ltd.; and received lecture fees by Takeda Pharma. Co. Ltd., Biofermin. Co. Ltd., Otsuka Pharma. Co. Ltd., and Miyarisan Pharma. Co. Ltd. The present research was partly supported by these funds including a collaboration research fund from TOTO Ltd. Neither the funding agency nor any outside organization has participated in the study design or have any competing interests. These companies have approved the final version of the manuscript.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"32898"}}