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In this study, we propose SLIC-Former, a superpixel-guided transformer framework for automatic liver segmentation in abdominal CT scans. The method replaces fixed square image patches with adaptive superpixels generated by the Simple Linear Iterative Clustering (SLIC) algorithm, so that each token follows anatomical boundaries and reduces redundant computation. Quantitative evaluation on the Liver Tumor Segmentation (LiTS) dataset demonstrated strong segmentation performance, achieving a Dice coefficient of 0.93, an IoU of 0.87, and a VOE of 13.5%, indicating high overlap with expert annotations. Qualitative results confirm that the model produces smooth and coherent liver masks. Overall, SLIC-Former offers an accurate and computationally efficient tool for automatic liver segmentation and provides a promising basis for future extensions to more organs, larger datasets, and clinical decision-support systems.<\/jats:p>","DOI":"10.1038\/s41598-026-60656-x","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:05:45Z","timestamp":1783685145000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SLIC-Former: a superpixel-guided transformer framework for automatic liver segmentation in CT images"],"prefix":"10.1038","volume":"16","author":[{"given":"Sarah F.","family":"Elqersh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira Y.","family":"Haikal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Saafan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha A.","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"60656_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.compbiomed.2017.12.024","volume":"94","author":"UR Acharya","year":"2018","unstructured":"Acharya, U. 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