{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:50:10Z","timestamp":1791982210192,"version":"4.4.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"University of Medical Sciences, Arak, Iran","award":["IR.ARAKMU.AEC.1403.019"],"award-info":[{"award-number":["IR.ARAKMU.AEC.1403.019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-61855-2","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:13:40Z","timestamp":1784002420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cCell-free extracts from probiotics modulate miR-21 and miR-155 and tumor suppressors PDCD4 and PTEN in breast cancer\u201d"],"prefix":"10.1038","volume":"16","author":[{"given":"Sara","family":"Soheili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekufe Rezghi","family":"Barez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Davar","family":"Siadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Hejazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Abtahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"issue":"1130","key":"61855_CR1","doi-asserted-by":"publisher","first-page":"20211033","DOI":"10.1259\/bjr.20211033","volume":"95","author":"L Wilkinson","year":"2022","unstructured":"Wilkinson, L. & Gathani, T. Understanding breast cancer as a global health concern. Br. J. Radiol. 95 (1130), 20211033 (2022).","journal-title":"Br. J. Radiol."},{"key":"61855_CR2","doi-asserted-by":"crossref","unstructured":"\u0141ukasiewicz, S. et al. Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers (Basel) 13(17). (2021).","DOI":"10.3390\/cancers13174287"},{"issue":"1","key":"61855_CR3","doi-asserted-by":"publisher","first-page":"2240084","DOI":"10.1080\/15384047.2023.2240084","volume":"24","author":"S Kandalai","year":"2023","unstructured":"Kandalai, S., Li, H., Zhang, N., Peng, H. & Zheng, Q. The human microbiome and cancer: a diagnostic and therapeutic perspective. Cancer Biol. Ther. 24 (1), 2240084 (2023).","journal-title":"Cancer Biol. Ther."},{"issue":"1","key":"61855_CR4","doi-asserted-by":"publisher","first-page":"5518835","DOI":"10.1155\/sci5\/5518835","volume":"2024","author":"F Javed","year":"2024","unstructured":"Javed, F. et al. Relevance of the Human Microbiome in Breast Cancer: A Global Bibliometric and Visual Analysis. Scientifica 2024 (1), 5518835 (2024).","journal-title":"Scientifica"},{"issue":"2","key":"61855_CR5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s10549-020-05702-6","volume":"182","author":"AH Wu","year":"2020","unstructured":"Wu, A. H. et al. Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study. Breast Cancer Res. Treat. 182 (2), 451\u2013463 (2020).","journal-title":"Breast Cancer Res. Treat."},{"key":"61855_CR6","doi-asserted-by":"crossref","unstructured":"\u015ali\u017cewska, K., Markowiak-Kope\u0107, P. & \u015ali\u017cewska, W. The Role of Probiotics in Cancer Prevention. Cancers (Basel) 13(1). (2020).","DOI":"10.3390\/cancers13010020"},{"key":"61855_CR7","doi-asserted-by":"publisher","first-page":"100111","DOI":"10.1016\/j.medmic.2024.100111","volume":"22","author":"S Mukherjee","year":"2024","unstructured":"Mukherjee, S., Kumar, D. & Guha, D. Insights of probiotics as an alternative medicine for cancer therapy, mechanism, and applications. Med. Microecol. 22, 100111 (2024).","journal-title":"Med. Microecology"},{"issue":"1","key":"61855_CR8","first-page":"6632209","volume":"2024","author":"H Naeem","year":"2024","unstructured":"Naeem, H. et al. Role of Probiotics against Human Cancers, Inflammatory Diseases, and Other Complex Malignancies. J. Food Biochem. 2024 (1), 6632209 (2024).","journal-title":"J. Food Biochem."},{"issue":"10","key":"61855_CR9","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1093\/annonc\/mdu106","volume":"25","author":"MG Redman","year":"2014","unstructured":"Redman, M. G., Ward, E. J. & Phillips, R. S. The efficacy and safety of probiotics in people with cancer: a systematic review. Ann. Oncol. 25 (10), 1919\u20131929 (2014).","journal-title":"Ann. Oncol."},{"key":"61855_CR10","doi-asserted-by":"publisher","first-page":"1216674","DOI":"10.3389\/fmicb.2023.1216674","volume":"14","author":"A Latif","year":"2023","unstructured":"Latif, A. et al. Probiotics: mechanism of action, health benefits and their application in food industries. Front. Microbiol. 14, 1216674 (2023).","journal-title":"Front. Microbiol."},{"key":"61855_CR11","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3389\/fped.2017.00178","volume":"5","author":"F Indrio","year":"2017","unstructured":"Indrio, F. et al. Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development. Front. Pediatr. 5, 178 (2017).","journal-title":"Front. Pediatr."},{"issue":"2","key":"61855_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.tim.2020.04.008","volume":"29","author":"W Morovic","year":"2021","unstructured":"Morovic, W., Budinoff, C. R. & Epigenetics A New Frontier in Probiotic Research. Trends Microbiol. 29 (2), 117\u2013126 (2021).","journal-title":"Trends Microbiol."},{"key":"61855_CR13","doi-asserted-by":"crossref","unstructured":"Reva, K., Laranjinha, J. & Rocha, B. S. Epigenetic Modifications Induced by the Gut Microbiota May Result from What We Eat: Should We Talk about Precision Diet in Health and Disease? Metabolites 13(3). (2023).","DOI":"10.3390\/metabo13030375"},{"key":"61855_CR14","doi-asserted-by":"crossref","unstructured":"Vitetta, L., Bambling, M. & Strodl, E. Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions. Microorganisms 11(5). (2023).","DOI":"10.3390\/microorganisms11051334"},{"issue":"3","key":"61855_CR15","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1007\/s12029-019-00338-2","volume":"51","author":"A Salek Farrokhi","year":"2020","unstructured":"Salek Farrokhi, A., Mohammadlou, M., Abdollahi, M., Eslami, M. & Yousefi, B. Histone deacetylase modifications by probiotics in colorectal cancer. J. Gastrointest. Cancer. 51 (3), 754\u2013764 (2020).","journal-title":"J. Gastrointest. Cancer"},{"issue":"5","key":"61855_CR16","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1093\/nutrit\/nux001","volume":"75","author":"MI Bhat","year":"2017","unstructured":"Bhat, M. I. & Kapila, R. Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr. Rev. 75 (5), 374\u2013389 (2017).","journal-title":"Nutr. Rev."},{"issue":"2","key":"61855_CR17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s12602-024-10443-9","volume":"17","author":"W Li","year":"2025","unstructured":"Li, W. et al. Probiotics exert gut immunomodulatory effects by regulating the expression of host miRNAs. Probiotics Antimicrob. Proteins. 17 (2), 557\u2013568 (2025).","journal-title":"Probiotics Antimicrob. Proteins"},{"issue":"9","key":"61855_CR18","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.3390\/cancers12092465","volume":"12","author":"A Laborda-Illanes","year":"2020","unstructured":"Laborda-Illanes, A. et al. Breast and gut microbiota action mechanisms in breast cancer pathogenesis and treatment. Cancers 12 (9), 2465 (2020).","journal-title":"Cancers"},{"issue":"21","key":"61855_CR19","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1080\/10408398.2018.1494539","volume":"59","author":"A Nowak","year":"2019","unstructured":"Nowak, A., Paliwoda, A. & B\u0142asiak, J. Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives. Crit. Rev. Food Sci. Nutr. 59 (21), 3456\u20133467 (2019).","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"144","key":"61855_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.30699\/jambs.31.144.64","volume":"31","author":"M Ghorbani","year":"2023","unstructured":"Ghorbani, M., Mahmoudian, A., Abtahi Froushani, S. M., Ownagh, A. & Tokmahchi, A. Lactobacillus acidophilus regulates the expression of microRNAs and ameliorates the symptoms of acid-induced ulcerative colitis in rats. J. Adv. Med. Biomed. Res. 31 (144), 64\u201372 (2023).","journal-title":"J. Adv. Med. Biomedical Res."},{"key":"61855_CR21","doi-asserted-by":"publisher","first-page":"108353","DOI":"10.1016\/j.jnutbio.2020.108353","volume":"79","author":"AU Din","year":"2020","unstructured":"Din, A. U. et al. Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism. J. Nutr. Biochem. 79, 108353 (2020).","journal-title":"J. Nutr. Biochem."},{"issue":"11","key":"61855_CR22","doi-asserted-by":"publisher","first-page":"1700144","DOI":"10.1002\/mnfr.201700144","volume":"61","author":"A Rodr\u00edguez-Nogales","year":"2017","unstructured":"Rodr\u00edguez-Nogales, A. et al. Differential intestinal anti\u2010inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition. Mol. Nutr. Food Res. 61 (11), 1700144 (2017).","journal-title":"Mol. Nutr. Food Res."},{"issue":"4","key":"61855_CR23","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s12602-018-9478-8","volume":"11","author":"Z Heydari","year":"2019","unstructured":"Heydari, Z. et al. Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the expression of microRNAs 135b, 26b, 18a and 155, and their involving genes in mice colon cancer. Probiotics Antimicrob. proteins. 11 (4), 1155\u20131162 (2019).","journal-title":"Probiotics Antimicrob. proteins"},{"issue":"3","key":"61855_CR24","first-page":"1043","volume":"54","author":"M Jiang","year":"2019","unstructured":"Jiang, M. et al. Long non-coding RNA FOXD2-AS1\/miR-150-5p\/PFN2 axis regulates breast cancer malignancy and tumorigenesis. Int. J. Oncol. 54 (3), 1043\u20131052 (2019).","journal-title":"Int. J. Oncol."},{"key":"61855_CR25","first-page":"922","volume":"20","author":"SR Barez","year":"2021","unstructured":"Barez, S. R., Attar, A. M. & Aghaei, M. MicroRNA-30c-2-3p regulates ER stress and induces apoptosis in ovarian cancer cells underlying ER stress. EXCLI J. 20, 922 (2021).","journal-title":"EXCLI J."},{"issue":"3","key":"61855_CR26","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.2353\/ajpath.2010.090664","volume":"176","author":"Z Yu","year":"2010","unstructured":"Yu, Z. et al. microRNA, cell cycle, and human breast cancer. Am. J. Pathol. 176 (3), 1058\u20131064 (2010).","journal-title":"Am. J. Pathol."},{"issue":"3","key":"61855_CR27","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3892\/ol.2024.14565","volume":"28","author":"S Yang","year":"2024","unstructured":"Yang, S. & Li, D. Role of microRNAs in triple\u2013negative breast cancer and new therapeutic concepts. Oncol. Lett. 28 (3), 431 (2024).","journal-title":"Oncol. Lett."},{"key":"61855_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15698\/cst2025.05.303","volume":"9","author":"EA Sharif-Askari","year":"2025","unstructured":"Sharif-Askari, E. A., Atoui, K. M., Mteyrek, A. K. & Fawaz, L. M. Probiotics and mediterranean diet for breast cancer management and prevention? Cell. Stress. 9, 1 (2025).","journal-title":"Cell. Stress"},{"issue":"02","key":"61855_CR29","first-page":"6","volume":"7","author":"M Nouman","year":"2025","unstructured":"Nouman, M. et al. Gut Microbiome-Host microRNA Interactions in Cancer Development and Immune Regulation: A Case of Colorectal and Breast Cancer. Am. J. Med. Sci. Pharm. Res. 7 (02), 6\u201320 (2025).","journal-title":"Am. J. Med. Sci. Pharm. Res."},{"issue":"13","key":"61855_CR30","doi-asserted-by":"publisher","first-page":"7091","DOI":"10.3390\/ijms25137091","volume":"25","author":"A Laborda-Illanes","year":"2024","unstructured":"Laborda-Illanes, A. et al. Exploring the relationship between microRNAs, intratumoral microbiota, and breast cancer progression in patients with and without metastasis. Int. J. Mol. Sci. 25 (13), 7091 (2024).","journal-title":"Int. J. Mol. Sci."},{"key":"61855_CR31","doi-asserted-by":"crossref","unstructured":"Avc\u0131, E. & Avc\u0131, G. A. Effect of new bioactive substances obtained from possible probiotic bacteria on miRNA expression by in vitro cocultivation in colorectal cancer cells. Int. J. Environ. Health Res. :1\u201310. (2025).","DOI":"10.1080\/09603123.2025.2495195"},{"issue":"4","key":"61855_CR32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s12079-020-00562-7","volume":"14","author":"SR Barez","year":"2020","unstructured":"Barez, S. R., Atar, A. M. & Aghaei, M. Mechanism of inositol-requiring enzyme 1-alpha inhibition in endoplasmic reticulum stress and apoptosis in ovarian cancer cells. J. Cell. Commun. Signal. 14 (4), 403\u2013415 (2020).","journal-title":"J. Cell. Commun. Signal."},{"issue":"8","key":"61855_CR33","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s00210-023-02426-4","volume":"396","author":"MK Shahrestanaki","year":"2023","unstructured":"Shahrestanaki, M. K., Mirjani, A., Ghanadian, M. & Aghaei, M. Cycloartane triterpenoid from Euphorbia macrostegia modulates ER stress signaling pathways to induce apoptosis in MDA-MB231 and MCF-7 breast cancer cell lines. Naunyn Schmiedebergs Arch. Pharmacol. 396 (8), 1749\u20131758 (2023).","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"10","key":"61855_CR34","first-page":"692","volume":"92","author":"P Ning","year":"2012","unstructured":"Ning, P. et al. [Differential expression profile of microRNA between hyperplastic scar and normal skin]. Zhonghua Yi Xue Za Zhi. 92 (10), 692\u2013694 (2012).","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"61855_CR35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ebiom.2016.09.012","volume":"12","author":"S Wu","year":"2016","unstructured":"Wu, S. et al. MicroRNA-137 Inhibits\u2009<\u2009em>EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients. eBioMedicine 12, 133\u2013142 (2016).","journal-title":"eBioMedicine"},{"issue":"6","key":"61855_CR36","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1007\/s00414-019-02125-x","volume":"133","author":"S Scrivano","year":"2019","unstructured":"Scrivano, S., Sanavio, M., Tozzo, P. & Caenazzo, L. Analysis of RNA in the estimation of post-mortem interval: a review of current evidence. Int. J. Legal Med. 133 (6), 1629\u20131640 (2019).","journal-title":"Int. J. Legal Med."},{"issue":"1","key":"61855_CR37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5357\/koubyou.80.1_15","volume":"80","author":"KASM Saadat","year":"2013","unstructured":"Saadat, K. A. S. M. Role of ARID3A in E2F target gene expression and cell growth. K\u014dk\u016bby\u014d Gakkai zasshi. J. Stomatol. Soc. 80 (1), 15\u201320 (2013).","journal-title":"K\u014dk\u016bby\u014d Gakkai zasshi. J. Stomatological Soc., J. apan"},{"issue":"4","key":"61855_CR38","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3892\/ijo.2021.5192","volume":"58","author":"KASM Saadat","year":"2021","unstructured":"Saadat, K. A. S. M. et al. Distinct and overlapping roles of ARID3A and ARID3B in regulating E2F\u2013dependent transcription via direct binding to E2F target genes. Int. J. Oncol. 58 (4), 12 (2021).","journal-title":"Int. J. Oncol."},{"key":"61855_CR39","first-page":"922","volume":"20","author":"S Rezghi Barez","year":"2021","unstructured":"Rezghi Barez, S., Movahedian Attar, A. & Aghaei, M. MicroRNA-30c-2-3p regulates ER stress and induces apoptosis in ovarian cancer cells underlying ER stress. EXCLI J. 20, 922\u2013934 (2021).","journal-title":"EXCLI J."},{"key":"61855_CR40","doi-asserted-by":"crossref","unstructured":"Koduru, L. et al. Systematic evaluation of genome-wide metabolic landscapes in lactic acid bacteria reveals diet-and strain-specific probiotic idiosyncrasies. Cell. Rep. 41(10). (2022).","DOI":"10.1016\/j.celrep.2022.111735"},{"key":"61855_CR41","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fmed.2018.00124","volume":"5","author":"LV McFarland","year":"2018","unstructured":"McFarland, L. V., Evans, C. T. & Goldstein, E. J. Strain-specificity and disease-specificity of probiotic efficacy: a systematic review and meta-analysis. Front. Med. 5, 124 (2018).","journal-title":"Front. Med."},{"key":"61855_CR42","first-page":"925","volume":"7","author":"A O\u2019callaghan","year":"2016","unstructured":"O\u2019callaghan, A. & Van Sinderen, D. Bifidobacteria and their role as members of the human gut microbiota. Front. Microbiol. 7, 925 (2016).","journal-title":"Front. Microbiol."},{"key":"61855_CR43","doi-asserted-by":"crossref","unstructured":"Biffi, A., Coradini, D., Larsen, R., Riva, L. & Di Fronzo, G. Antiproliferative effect of fermented milk on the growth of a human breast cancer cell line. (1997).","DOI":"10.1080\/01635589709514558"},{"issue":"2","key":"61855_CR44","first-page":"8","volume":"18","author":"C-F Liu","year":"2010","unstructured":"Liu, C-F. & Pan, T-M. In vitro effects of lactic acid bacteria on cancer cell viability and antioxidant activity. J. Food Drug Anal. 18 (2), 8 (2010).","journal-title":"J. Food Drug Anal."},{"issue":"4","key":"61855_CR45","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1080\/01635581.2019.1577984","volume":"71","author":"CA Fahmy","year":"2019","unstructured":"Fahmy, C. A. et al. Bifidobacterium longum suppresses murine colorectal cancer through the modulation of oncomiRs and tumor suppressor miRNAs. Nutr. Cancer. 71 (4), 688\u2013700 (2019).","journal-title":"Nutr. Cancer"},{"issue":"2","key":"61855_CR46","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4174\/astr.2017.92.2.55","volume":"92","author":"J-G Han","year":"2017","unstructured":"Han, J-G. et al. A novel panel of serum miR-21\/miR-155\/miR-365 as a potential diagnostic biomarker for breast cancer. Annals Surg. Treat. Res. 92 (2), 55 (2017).","journal-title":"Annals Surg. Treat. Res."},{"issue":"1","key":"61855_CR47","doi-asserted-by":"publisher","first-page":"17981","DOI":"10.1038\/s41598-018-36321-3","volume":"8","author":"S Khalighfard","year":"2018","unstructured":"Khalighfard, S., Alizadeh, A. M., Irani, S. & Omranipour, R. Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients. Sci. Rep. 8 (1), 17981 (2018).","journal-title":"Sci. Rep."},{"issue":"16","key":"61855_CR48","doi-asserted-by":"publisher","first-page":"5834","DOI":"10.3390\/ijms21165834","volume":"21","author":"AM Grimaldi","year":"2020","unstructured":"Grimaldi, A. M., Nuzzo, S., Condorelli, G., Salvatore, M. & Incoronato, M. Prognostic and clinicopathological significance of MiR-155 in breast cancer: a systematic review. Int. J. Mol. Sci. 21 (16), 5834 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"61855_CR49","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.apjtm.2016.09.011","volume":"10","author":"Y Yang","year":"2017","unstructured":"Yang, Y., Guo, J-X. & Shao, Z-Q. miR-21 targets and inhibits tumor suppressor gene PTEN to promote prostate cancer cell proliferation and invasion: An experimental study. Asian Pac. J. Trop. Med. 10 (1), 87\u201391 (2017).","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"6","key":"61855_CR50","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.3892\/ol.2017.6052","volume":"13","author":"Z Wang","year":"2017","unstructured":"Wang, Z. et al. Reduction of miR-21 induces SK-N-SH cell apoptosis and inhibits proliferation via PTEN\/PDCD4. Oncol. Lett. 13 (6), 4727\u20134733 (2017).","journal-title":"Oncol. Lett."},{"issue":"5","key":"61855_CR51","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3390\/cimb47050377","volume":"47","author":"MS Degheidy","year":"2025","unstructured":"Degheidy, M. S. et al. Regulatory Roles of miR-155-5p, miR-21-5p, miR-93-5p, and miR-140-5p in Breast Cancer Progression. Curr. Issues. Mol. Biol. 47 (5), 377 (2025).","journal-title":"Curr. Issues. Mol. Biol."},{"issue":"14","key":"61855_CR52","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.2174\/0118715303289859240214103350","volume":"24","author":"J Razaviyan","year":"2024","unstructured":"Razaviyan, J. et al. Inhibition of MiR-155 using exosomal delivery of antagomir can up-regulate PTEN in triple negative breast cancer. Endocr. Metabolic Immune Disorders-Drug Targets. 24 (14), 1664\u20131676 (2024).","journal-title":"Endocr. Metabolic Immune Disorders-Drug Targets"},{"issue":"7","key":"61855_CR53","doi-asserted-by":"publisher","first-page":"44","DOI":"10.14715\/cmb\/2020.66.7.8","volume":"66","author":"SA Ali","year":"2020","unstructured":"Ali, S. A., Abdulrahman, Z. F. A. & Faraidun, H. N. Circulatory miRNA-155, miRNA-21 target PTEN expression and activity as a factor in breast cancer development. Cell. Mol. Biol. 66 (7), 44\u201350 (2020).","journal-title":"Cell. Mol. Biol."},{"key":"61855_CR54","doi-asserted-by":"publisher","first-page":"921972","DOI":"10.3389\/fgene.2022.921972","volume":"13","author":"Z Schemczssen-Graeff","year":"2022","unstructured":"Schemczssen-Graeff, Z. & Pileggi, M. Probiotics and live biotherapeutic products aiming at cancer mitigation and patient recover. Front. Genet. 13, 921972 (2022).","journal-title":"Front. Genet."},{"key":"61855_CR55","doi-asserted-by":"crossref","unstructured":"Seyyedi, Z. et al. Integrating probiotics and microbiome-derived metabolites into cancer therapy: mechanistic insights, multi-omics strategies, and clinical potential. Curr. Res. Biotechnol. 100340. (2025).","DOI":"10.1016\/j.crbiot.2025.100340"},{"issue":"5","key":"61855_CR56","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1080\/14796694.2024.2438594","volume":"22","author":"E Ghorbani","year":"2026","unstructured":"Ghorbani, E., Afshari, A., Avan, A., Khazaei, M. & Soleimanpour, S. Review of potential anti-cancer properties of lactobacilli against breast cancer. Future Oncol. 22 (5), 595\u2013603 (2026).","journal-title":"Future Oncol."},{"key":"61855_CR57","unstructured":"Zuo, W-N., Zhu, H., Li, L-P., Jin, A-Y. & Wang, H-Q. MiR-155 promotes proliferation and inhibits apoptosis of nasopharyngeal carcinoma cells through targeting PTEN-PI3K\/AKT pathway. Eur. Rev. Med. Pharmacol. Sci. ;23(18). (2019)."},{"issue":"1","key":"61855_CR58","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3390\/ijms22010173","volume":"22","author":"D Miricescu","year":"2020","unstructured":"Miricescu, D. et al. PI3K\/AKT\/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects. Int. J. Mol. Sci. 22 (1), 173 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"61855_CR59","first-page":"9258396","volume":"2020","author":"MA Ortega","year":"2020","unstructured":"Ortega, M. A. et al. Signal transduction pathways in breast cancer: the important role of PI3K\/Akt\/mTOR. J. Oncol. 2020 (1), 9258396 (2020).","journal-title":"J. Oncol."},{"issue":"4","key":"61855_CR60","first-page":"3793","volume":"20","author":"B Li","year":"2019","unstructured":"Li, B. et al. Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K\/AKT\/mTOR pathway and carbohydrate metabolism. Mol. Med. Rep. 20 (4), 3793\u20133801 (2019).","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"61855_CR61","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jtcme.2023.02.001","volume":"13","author":"L Vallino","year":"2023","unstructured":"Vallino, L. et al. Cell-free Lactiplantibacillus plantarum OC01 supernatant suppresses IL-6-induced proliferation and invasion of human colorectal cancer cells: Effect on \u03b2-Catenin degradation and induction of autophagy. J. Traditional Complement. Med. 13 (2), 193\u2013206 (2023).","journal-title":"J. Traditional Complement. Med."},{"issue":"1","key":"61855_CR62","doi-asserted-by":"publisher","first-page":"37","DOI":"10.32598\/IMMUNOREGULATION.3.1.5","volume":"3","author":"Z Khosrovan","year":"2020","unstructured":"Khosrovan, Z., Haghighat, S. & Mahdavi, M. The probiotic bacteria induce apoptosis in breast and colon cancer cells: an immunostimulatory effect. Immunoregulation 3 (1), 37\u201350 (2020).","journal-title":"Immunoregulation"},{"key":"61855_CR63","doi-asserted-by":"crossref","unstructured":"De Chiara, I. et al. In vitro antitumor activity of Lactococcus lactis cell-free supernatant on human glioblastoma cell lines. Food Res. Int. 117840. (2025).","DOI":"10.1016\/j.foodres.2025.117840"},{"key":"61855_CR64","unstructured":"Mahdavi, M. Secreted chemicals from probiotic bacteria potentiate Th1 pattern of immune cells and apoptosis induction in breast cancer and gastric adenocarcinoma cell lines. (2020)."},{"issue":"4","key":"61855_CR65","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/gutjnl-2024-333530","volume":"74","author":"Z Shi","year":"2025","unstructured":"Shi, Z. et al. Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer\/T-cell lymphoma by dampening the JAK-STAT pathway. Gut 74 (4), 557\u2013570 (2025).","journal-title":"Gut"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-61855-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-61855-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-61855-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:21:47Z","timestamp":1791980507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-61855-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["61855"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-61855-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8065664\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"8 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"32189"}}