{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:48:45Z","timestamp":1791910125497,"version":"4.3.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-62322-8","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:15:17Z","timestamp":1783919717000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal Helicobacter pylori infection is associated with reproductive tract HPV prevalence in a propensity score-matched cross-sectional study of 7734 women"],"prefix":"10.1038","volume":"16","author":[{"given":"Meng","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai-jin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-hui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"issue":"3","key":"62322_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2537","volume":"34","author":"J Wolf","year":"2024","unstructured":"Wolf, J. et al. Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics. Rev. Med. Virol. 34(3), e2537 (2024).","journal-title":"Rev. Med. Virol."},{"issue":"4","key":"62322_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/00007435-199507000-00007","volume":"22","author":"JH Jamison","year":"1995","unstructured":"Jamison, J. H. et al. Spectrum of genital human papillomavirus infection in a female adolescent population. Sex Transm. Dis. 22(4), 236\u2013243 (1995).","journal-title":"Sex Transm. Dis."},{"key":"62322_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000358423","volume":"45","author":"G Gross","year":"2014","unstructured":"Gross, G. Genitoanal human papillomavirus infection and associated neoplasias. Curr. Probl. Dermatol. 45, 98\u2013122 (2014).","journal-title":"Curr. Probl. Dermatol."},{"issue":"Suppl 5","key":"62322_CR4","doi-asserted-by":"publisher","first-page":"F12","DOI":"10.1016\/j.vaccine.2012.07.055","volume":"30","author":"D Forman","year":"2012","unstructured":"Forman, D. et al. Global burden of human papillomavirus and related diseases. Vaccine 30(Suppl 5), F12-23 (2012).","journal-title":"Vaccine"},{"key":"62322_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.552028","volume":"8","author":"AJ Kombe Kombe","year":"2020","unstructured":"Kombe Kombe, A. J. et al. Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation. Front. Public Health 8, 552028 (2020).","journal-title":"Front. Public Health"},{"key":"62322_CR6","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjae046","author":"H Ni","year":"2025","unstructured":"Ni, H. et al. Targeting HPV for the prevention, diagnosis, and treatment of cervical cancer. J. Mol. Cell. Biol. https:\/\/doi.org\/10.1093\/jmcb\/mjae046 (2025).","journal-title":"J. Mol. Cell. Biol."},{"key":"62322_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2024.127857","volume":"287","author":"R Huang","year":"2024","unstructured":"Huang, R., Liu, Z., Sun, T. & Zhu, L. Cervicovaginal microbiome, high-risk HPV infection and cervical cancer: Mechanisms and therapeutic potential. Microbiol. Res. 287, 127857 (2024).","journal-title":"Microbiol. Res."},{"issue":"4","key":"62322_CR8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1017\/S1744133119000136","volume":"15","author":"AJ Leidner","year":"2020","unstructured":"Leidner, A. J., Chesson, H. W. & Talih, M. HPV vaccine status and sexual behavior among young sexually-active women in the US: Evidence from the National Health and Nutrition Examination Survey, 2007\u20132014. Health Econ. Policy Law. 15(4), 477\u2013495 (2020).","journal-title":"Health Econ. Policy Law."},{"issue":"1","key":"62322_CR9","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s12967-024-05124-8","volume":"22","author":"W Zhang","year":"2024","unstructured":"Zhang, W. et al. Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer. J. Transl. Med. 22(1), 396 (2024).","journal-title":"J. Transl. Med."},{"issue":"9","key":"62322_CR10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002905","volume":"95","author":"X Huang","year":"2016","unstructured":"Huang, X. et al. Metabolic syndrome and risk of cervical human papillomavirus incident and persistent infection. Medicine 95(9), e2905 (2016).","journal-title":"Medicine"},{"issue":"8","key":"62322_CR11","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1002\/hed.25716","volume":"41","author":"AH Mirza","year":"2019","unstructured":"Mirza, A. H., Thomas, G., Ottensmeier, C. H. & King, E. V. Importance of the immune system in head and neck cancer. Head Neck 41(8), 2789\u20132800 (2019).","journal-title":"Head Neck"},{"issue":"4","key":"62322_CR12","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s00018-020-03652-2","volume":"78","author":"SS Taghinezhad","year":"2021","unstructured":"Taghinezhad, S. S. et al. Twenty years of research on HPV vaccines based on genetically modified lactic acid bacteria: An overview on the gut-vagina axis. Cell. Mol. Life Sci. 78(4), 1191\u20131206 (2021).","journal-title":"Cell. Mol. Life Sci."},{"issue":"44","key":"62322_CR13","first-page":"576","volume":"49","author":"MC Chang","year":"2002","unstructured":"Chang, M. C. et al. Quantitative correlation of Helicobacter pylori stool antigen (HpSA) test with 13C-urea breath test (13C-UBT) by the updated Sydney grading system of gastritis. Hepatogastroenterology 49(44), 576\u2013579 (2002).","journal-title":"Hepatogastroenterology"},{"issue":"1","key":"62322_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/jmv.24931","volume":"90","author":"L Zhang","year":"2018","unstructured":"Zhang, L. et al. Comparison of the performance in detection of HPV infections between the high-risk HPV genotyping real time PCR and the PCR-reverse dot blot assays. J. Med. Virol. 90(1), 177\u2013183 (2018).","journal-title":"J. Med. Virol."},{"issue":"43","key":"62322_CR15","doi-asserted-by":"publisher","first-page":"4928","DOI":"10.3748\/wjg.v24.i43.4928","volume":"24","author":"CRT de Souza","year":"2018","unstructured":"de Souza, C. R. T. et al. Association between Helicobacter pylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas. World J. Gastroenterol. 24(43), 4928\u20134938 (2018).","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"62322_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-28593-3","volume":"15","author":"X Jiang","year":"2025","unstructured":"Jiang, X., Huang, Y., Li, C. & Jiang, H. Oropharyngeal Helicobacter pylori colonization increases risk and worsens prognosis of head and neck squamous cell carcinoma. Sci. Rep. 15(1), 44627 (2025).","journal-title":"Sci. Rep."},{"issue":"7","key":"62322_CR17","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1136\/sextrans-2014-051936","volume":"91","author":"C Zhang","year":"2015","unstructured":"Zhang, C. et al. Seroprevalence of 10 human papillomavirus types in the general rural population of Anyang, China: A cross-sectional study. Sex Transm. Infect. 91(7), 506\u2013509 (2015).","journal-title":"Sex Transm. Infect."},{"key":"62322_CR18","doi-asserted-by":"publisher","first-page":"1403548","DOI":"10.3389\/fmed.2024.1403548","volume":"11","author":"C Cassani","year":"2024","unstructured":"Cassani, C., Dominoni, M., Pasquali, M. F., Gardella, B. & Spinillo, A. Multiple human papillomavirus infection and high-grade cervical squamous intraepithelial lesions among women with human immunodeficiency virus: A systematic review and a meta-analysis. Front. Med. 11, 1403548 (2024).","journal-title":"Front. Med."},{"issue":"10","key":"62322_CR19","doi-asserted-by":"publisher","first-page":"202","DOI":"10.5897\/JAHR2017.0445","volume":"9","author":"L Dylla","year":"2017","unstructured":"Dylla, L. et al. Human papillomavirus clustering patterns among HIV-infected and HIV-uninfected adolescent females in South Africa. J AIDS HIV Res. 9(10), 202\u2013206 (2017).","journal-title":"J AIDS HIV Res."},{"issue":"2","key":"62322_CR20","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","volume":"345","author":"F Wang","year":"2014","unstructured":"Wang, F., Meng, W., Wang, B. & Qiao, L. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett. 345(2), 196\u2013202 (2014).","journal-title":"Cancer Lett."},{"issue":"1","key":"62322_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01654-2","volume":"18","author":"Y Duan","year":"2025","unstructured":"Duan, Y., Xu, Y., Dou, Y. & Xu, D. Helicobacter pylori and gastric cancer: Mechanisms and new perspectives. J. Hematol. Oncol. 18(1), 10 (2025).","journal-title":"J. Hematol. Oncol."},{"key":"62322_CR22","doi-asserted-by":"publisher","first-page":"1339750","DOI":"10.3389\/fcimb.2024.1339750","volume":"14","author":"V Engelsberger","year":"2024","unstructured":"Engelsberger, V., Gerhard, M. & Mej\u00edas-Luque, R. Effects of Helicobacter pylori infection on intestinal microbiota, immunity and colorectal cancer risk. Front. Cell. Infect. Microbiol. 14, 1339750 (2024).","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"62322_CR23","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2519703","volume":"17","author":"V Arr\u00e8","year":"2025","unstructured":"Arr\u00e8, V. et al. Gastrointestinal inflammation and cancer: Viral and bacterial interplay. Gut Microbes 17(1), 2519703 (2025).","journal-title":"Gut Microbes"},{"issue":"18","key":"62322_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37585","volume":"10","author":"A Tandon","year":"2024","unstructured":"Tandon, A. et al. The role of Helicobacter pylori in augmenting the severity of SARS-CoV-2 related gastrointestinal symptoms: An insight from molecular mechanism of co-infection. Heliyon 10(18), e37585 (2024).","journal-title":"Heliyon"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62322-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62322-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62322-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:05:42Z","timestamp":1791907542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62322-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["62322"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-62322-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was reviewed and approved by the Medical Ethics Committee of Jiangxi Provincial People\u2019s Hospital (Approval Number: 2026(02)). The research was conducted in strict accordance with the ethical principles of the Declaration of Helsinki. The requirement for written informed consent was waived by the Medical Ethics Committee of Jiangxi Provincial People\u2019s Hospital due to the retrospective nature of the study and the use of anonymized health examination data.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. (The manuscript does not contain any individual person\u2019s data in any form, such as individual details, images, or videos).","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"32004"}}