{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:07:42Z","timestamp":1784664462905,"version":"3.55.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to investigate visibility and diameter changes of the thoracic duct (TD) on non-contrast MR-lymphangiography (MRL) after oral nutritional intake with different fat-content. Healthy adults prospectively underwent non-contrast thoracic MRL at 1.5 T on three separate days following an overnight fasting period. After baseline MRL, patients received standardized meals: (1) high-fat, (2) medium-chain-triglyceride (MCT), (3) fat-free. Thereafter hourly MR-scans were obtained for 6\u00a0h. TD-visibility was evaluated for the superior and inferior thoracic and abdominal TD-segment on a 6-point-scale (1:best; 6:worst). TD-diameters were measured independently by two readers. Statistical analysis was performed to evaluate systematic differences between the different meals using paired t-tests and a linear mixed-model analysis. 154 MRI-scans were performed in 22 volunteers (16 female, mean age 29.7\u2009\u00b1\u200914.3 years). Overall TD-visibility improved significantly after the high-fat meal (baseline: 2.9\u2009\u00b1\u20090.9 vs. 6\u00a0h-examination: 2.4\u2009\u00b1\u20090.8;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while it slightly deteriorated after the MCT-meal (2.7\u2009\u00b1\u20090.9 vs. 3.2\u2009\u00b1\u20091.0;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and fat-free meal (2.8\u2009\u00b1\u20090.9 vs. 3.1\u2009\u00b1\u20091.0;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). TD-diameter increased after the high-fat meal with a maximum at 5\u00a0h postprandially in the abdominal (2.4\u2009\u00b1\u20090.6\u00a0mm vs. 2.9\u2009\u00b1\u20091.0\u00a0mm, +\u200921.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and lower thoracic segment (2.1\u2009\u00b1\u20090.4\u00a0mm vs. 2.5\u2009\u00b1\u20090.5\u00a0mm, +\u200916.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) while the maximum mean increase in the upper thoracic segment was observed at 2\u00a0h postprandially (2.0\u2009\u00b1\u20090.3\u00a0mm vs. 2.3\u2009\u00b1\u20090.5\u00a0mm, +\u200913.8%). In contrast, no significant increase in TD-diameters over time was observed for the fat-free and MCT-meals. The observed improvement in TD visibility and increase in TD diameter after a high-fat meal suggest a relation to lymphatic resorption of long-chain triglycerides. Conversely, this effect was not observed after an MCT- and fat-free meal.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-62725-7","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:34:01Z","timestamp":1784662441000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of fat content of oral nutritional intake on visibility and diameter of the thoracic duct: a prospective study"],"prefix":"10.1038","volume":"16","author":[{"given":"Judith","family":"Padberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Henkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois Martin","family":"Sprinkart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Isaak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A.","family":"Luetkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus C.","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"62725_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.nut.2015.08.002","volume":"32","author":"K Sriram","year":"2016","unstructured":"Sriram, K., Meguid, R. & Meguid, M. 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