{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:06:24Z","timestamp":1784898384411,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Basic Research Project of the Education Department of Heilongjiang Province","award":["2024-KYYWF-0585"],"award-info":[{"award-number":["2024-KYYWF-0585"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-62772-0","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:34:13Z","timestamp":1784403253000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FKBP10 may affect the malignant phenotype of oral squamous cell carcinoma cells through the ECM\/WNT signaling pathway"],"prefix":"10.1038","volume":"16","author":[{"given":"Chengyi","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meina","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"62772_CR1","doi-asserted-by":"publisher","unstructured":"Wang, P., Tian, J., Zheng, G., Chen, Y. & Ren, X. Application of artificial intelligence in head and neck squamous cell carcinoma. Ann. Med. 58 https:\/\/doi.org\/10.1080\/07853890.2026.2620191 (2026).","DOI":"10.1080\/07853890.2026.2620191"},{"key":"62772_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"62772_CR3","doi-asserted-by":"publisher","unstructured":"Hu, S. et al. TDO2\u2009+\u2009myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma. J. Clin. Invest. 132 https:\/\/doi.org\/10.1172\/JCI157649 (2022).","DOI":"10.1172\/JCI157649"},{"key":"62772_CR4","doi-asserted-by":"publisher","first-page":"105014","DOI":"10.1016\/j.oraloncology.2020.105014","volume":"110","author":"I Evren","year":"2020","unstructured":"Evren, I. et al. Annual malignant transformation rate of oral leukoplakia remains consistent: A long-term follow-up study. Oral Oncol. 110, 105014. https:\/\/doi.org\/10.1016\/j.oraloncology.2020.105014 (2020).","journal-title":"Oral Oncol."},{"key":"62772_CR5","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1111\/odi.13810","volume":"27","author":"JM Aguirre-Urizar","year":"2021","unstructured":"Aguirre-Urizar, J. M., Lafuente\u2010Ib\u00e1\u00f1ez de Mendoza, I. & Warnakulasuriya, S. Malignant transformation of oral leukoplakia: Systematic review and meta\u2010analysis of the last 5 years. Oral Dis. 27, 1881\u20131895. https:\/\/doi.org\/10.1111\/odi.13810 (2021).","journal-title":"Oral Dis."},{"key":"62772_CR6","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.4049\/jimmunol.143.5.1580","volume":"143","author":"JJ Siekierka","year":"1989","unstructured":"Siekierka, J. J., Staruch, M. J., Hung, S. H. & Sigal, N. H. FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin. J. Immunol. 143, 1580\u20131583 (1989).","journal-title":"J. Immunol."},{"key":"62772_CR7","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.coph.2011.03.012","volume":"11","author":"J Solassol","year":"2011","unstructured":"Solassol, J., Mange, A. & Maudelonde, T. FKBP family proteins as promising new biomarkers for cancer. Curr. Opin. Pharmacol. 11, 320\u2013325. https:\/\/doi.org\/10.1016\/j.coph.2011.03.012 (2011).","journal-title":"Curr. Opin. Pharmacol."},{"key":"62772_CR8","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1080\/15548627.2021.1904489","volume":"17","author":"BJ Bailus","year":"2021","unstructured":"Bailus, B. J. et al. Modulating FKBP5\/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy 17, 4119\u20134140. https:\/\/doi.org\/10.1080\/15548627.2021.1904489 (2021).","journal-title":"Autophagy"},{"key":"62772_CR9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/1874467208666150519113541","volume":"9","author":"M Tong","year":"2015","unstructured":"Tong, M. & Jiang, Y. FK506-binding proteins and their diverse functions. Curr. Mol. Pharmacol. 9, 48\u201365. https:\/\/doi.org\/10.2174\/1874467208666150519113541 (2015).","journal-title":"Curr. Mol. Pharmacol."},{"key":"62772_CR10","doi-asserted-by":"publisher","unstructured":"Agam, G., Atawna, B., Damri, O. & Azab, A. N. The role of FKBPs in complex disorders: Neuropsychiatric diseases, cancer, and type 2 diabetes mellitus. Cells 13 https:\/\/doi.org\/10.3390\/cells13100801 (2024).","DOI":"10.3390\/cells13100801"},{"key":"62772_CR11","doi-asserted-by":"publisher","unstructured":"H\u00e4hle, A., Merz, S., Meyners, C. & Hausch, F. The many faces of FKBP51. Biomolecules 9 https:\/\/doi.org\/10.3390\/biom9010035 (2019).","DOI":"10.3390\/biom9010035"},{"key":"62772_CR12","doi-asserted-by":"publisher","unstructured":"Criado-Marrero, M. et al. Hsp90 and FKBP51: complex regulators of psychiatric diseases. Philos. Trans. R Soc. Lond. B Biol. Sci. 373. https:\/\/doi.org\/10.1098\/rstb.2016.0532 (2018).","DOI":"10.1098\/rstb.2016.0532"},{"key":"62772_CR13","doi-asserted-by":"publisher","first-page":"11370","DOI":"10.1073\/pnas.1816847116","volume":"116","author":"AS Zannas","year":"2019","unstructured":"Zannas, A. S. et al. Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-\u03baB-driven inflammation and cardiovascular risk. Proc. Natl. Acad. Sci. U S A. 116, 11370\u201311379. https:\/\/doi.org\/10.1073\/pnas.1816847116 (2019).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"62772_CR14","doi-asserted-by":"publisher","unstructured":"Wang, C-C. et al. Penetrating exploration of prognostic correlations of the FKBP gene family with lung adenocarcinoma. J. Pers. Med. 13 https:\/\/doi.org\/10.3390\/jpm13010049 (2022).","DOI":"10.3390\/jpm13010049"},{"key":"62772_CR15","doi-asserted-by":"publisher","first-page":"7020","DOI":"10.3892\/ol.2018.9517","volume":"16","author":"Y Gao","year":"2018","unstructured":"Gao, Y. et al. FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF-\u03baB-dependent epithelial-to-mesenchymal transition. Oncol. Lett. 16, 7020\u20137028. https:\/\/doi.org\/10.3892\/ol.2018.9517 (2018).","journal-title":"Oncol. Lett."},{"key":"62772_CR16","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.31557\/APJCP.2025.26.12.4611","volume":"26","author":"M Mahajan","year":"2025","unstructured":"Mahajan, M. & Bhoosreddy, A. Salivary expression of cyclophilin A and FK506-binding protein 51 in oral submucous fibrosis versus healthy controls: A cross-sectional analysis. Asian Pac. J. Cancer Prev. 26, 4611\u20134615. https:\/\/doi.org\/10.31557\/APJCP.2025.26.12.4611 (2025).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"62772_CR17","doi-asserted-by":"publisher","unstructured":"Fu, Y. et al. Subcellular expression patterns of FKBP prolyl isomerase 10 (FKBP10) in colorectal cancer and its clinical significance. Int. J. Mol. Sci. 24 https:\/\/doi.org\/10.3390\/ijms241411415 (2023).","DOI":"10.3390\/ijms241411415"},{"key":"62772_CR18","doi-asserted-by":"publisher","first-page":"5490644","DOI":"10.1155\/2022\/5490644","volume":"2022","author":"Y Xiao","year":"2022","unstructured":"Xiao, Y. et al. FKBP10, for poor prognosis prediction in patients with clear cell renal cell carcinoma. Evid. Based Complement. Alternat Med. 2022, 5490644. https:\/\/doi.org\/10.1155\/2022\/5490644 (2022).","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"62772_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41419-024-06450-x","volume":"15","author":"R Liu","year":"2024","unstructured":"Liu, R. et al. FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2\u03b1 blockade by facilitating LDHA phosphorylation. Cell. Death Dis. 15, 64. https:\/\/doi.org\/10.1038\/s41419-024-06450-x (2024).","journal-title":"Cell. Death Dis."},{"key":"62772_CR20","doi-asserted-by":"publisher","first-page":"31584","DOI":"10.1074\/jbc.M802535200","volume":"283","author":"Y Ishikawa","year":"2008","unstructured":"Ishikawa, Y., Vranka, J., Wirz, J., Nagata, K. & B\u00e4chinger, H. P. The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens. J. Biol. Chem. 283, 31584\u201331590. https:\/\/doi.org\/10.1074\/jbc.M802535200 (2008).","journal-title":"J. Biol. Chem."},{"key":"62772_CR21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1164\/rccm.201412-2233OC","volume":"192","author":"CA Staab-Weijnitz","year":"2015","unstructured":"Staab-Weijnitz, C. A. et al. FK506-binding protein 10, a potential novel drug target for idiopathic pulmonary fibrosis. Am. J. Respir Crit. Care Med. 192, 455\u2013467. https:\/\/doi.org\/10.1164\/rccm.201412-2233OC (2015).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"62772_CR22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12931-018-0768-1","volume":"19","author":"L Kn\u00fcppel","year":"2018","unstructured":"Kn\u00fcppel, L. et al. FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis. Respir Res. 19, 67. https:\/\/doi.org\/10.1186\/s12931-018-0768-1 (2018).","journal-title":"Respir Res."},{"key":"62772_CR23","doi-asserted-by":"publisher","first-page":"e12580","DOI":"10.1200\/JCO.2024.42.16_suppl.e12580","volume":"42","author":"W Chen","year":"2024","unstructured":"Chen, W., Zhu, B., Shao, Q. & Zheng, L. FKBP10-inhibited \u03b2-catenin ubiquitination in the malignant transformation of breast epithelial cells. J. Clin. Oncol. 42, e12580\u2013e12580. https:\/\/doi.org\/10.1200\/JCO.2024.42.16_suppl.e12580 (2024).","journal-title":"J. Clin. Oncol."},{"key":"62772_CR24","doi-asserted-by":"publisher","first-page":"697534","DOI":"10.3389\/fonc.2021.697534","volume":"11","author":"Z Sun","year":"2021","unstructured":"Sun, Z., Qin, X., Fang, J., Tang, Y. & Fan, Y. Multi-omics analysis of the expression and prognosis for FKBP gene family in renal cancer. Front. Oncol. 11, 697534. https:\/\/doi.org\/10.3389\/fonc.2021.697534 (2021).","journal-title":"Front. Oncol."},{"key":"62772_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12929-020-00705-3","volume":"28","author":"H-Q Cai","year":"2021","unstructured":"Cai, H-Q. et al. FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis. J. Biomed. Sci. 28, 13. https:\/\/doi.org\/10.1186\/s12929-020-00705-3 (2021).","journal-title":"J. Biomed. Sci."},{"key":"62772_CR26","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3892\/or.2019.7195","volume":"42","author":"L Liang","year":"2019","unstructured":"Liang, L. et al. Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. Oncol. Rep. 42, 615\u2013628. https:\/\/doi.org\/10.3892\/or.2019.7195 (2019).","journal-title":"Oncol. Rep."},{"key":"62772_CR27","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/kjm2.12174","volume":"36","author":"R-G Wang","year":"2020","unstructured":"Wang, R-G. et al. FKBP10 functioned as a cancer-promoting factor mediates cell proliferation, invasion, and migration via regulating PI3K signaling pathway in stomach adenocarcinoma. Kaohsiung J. Med. Sci. 36, 311\u2013317. https:\/\/doi.org\/10.1002\/kjm2.12174 (2020).","journal-title":"Kaohsiung J. Med. Sci."},{"key":"62772_CR28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.15557\/PiMR.2023.0007","volume":"19","author":"A Byrwa","year":"2023","unstructured":"Byrwa, A., \u0141uczak, E., G\u00f3rzy\u0144ska, I., Serwan, K. & Jakubowska-Pietkiewicz, E. Bruck syndrome \u2013 description of the first Polish infant with FKBP10 gene mutation. Pediatria i Medycyna Rodzinna. 19, 45\u201350. https:\/\/doi.org\/10.15557\/PiMR.2023.0007 (2023).","journal-title":"Pediatria i Medycyna Rodzinna"},{"key":"62772_CR29","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3390\/genes15060674","volume":"15","author":"ES Merkuryeva","year":"2024","unstructured":"Merkuryeva, E. S. et al. Presentation of rare phenotypes associated with the FKBP10 gene. Genes (Basel). 15, 674. https:\/\/doi.org\/10.3390\/genes15060674 (2024).","journal-title":"Genes (Basel)"},{"key":"62772_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/dds371","volume":"22","author":"U Schwarze","year":"2013","unstructured":"Schwarze, U. et al. Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen. Hum. Mol. Genet. 22, 1\u201317. https:\/\/doi.org\/10.1093\/hmg\/dds371 (2013).","journal-title":"Hum. Mol. Genet."},{"key":"62772_CR31","doi-asserted-by":"publisher","first-page":"11415","DOI":"10.3390\/ijms241411415","volume":"24","author":"Y Fu","year":"2023","unstructured":"Fu, Y. et al. Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in colorectal cancer and its clinical significance. Int. J. Mol. Sci. 24, 11415. https:\/\/doi.org\/10.3390\/ijms241411415 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"62772_CR32","doi-asserted-by":"publisher","first-page":"758","DOI":"10.7150\/ijbs.105265","volume":"21","author":"X Zhao","year":"2025","unstructured":"Zhao, X. et al. FKBP10 promotes the muscle invasion of bladder cancer via lamin A dysregulation. Int. J. Biol. Sci. 21, 758\u2013771. https:\/\/doi.org\/10.7150\/ijbs.105265 (2025).","journal-title":"Int. J. Biol. Sci."},{"key":"62772_CR33","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","volume":"35","author":"J Cooper","year":"2019","unstructured":"Cooper, J. & Giancotti, F. G. Integrin signaling in cancer: Mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance. Cancer Cell. 35, 347\u2013367. https:\/\/doi.org\/10.1016\/j.ccell.2019.01.007 (2019).","journal-title":"Cancer Cell."},{"key":"62772_CR34","doi-asserted-by":"publisher","first-page":"7399","DOI":"10.2147\/OTT.S253154","volume":"13","author":"L-B Gong","year":"2020","unstructured":"Gong, L-B. et al. FKBP10 acts as a new biomarker for prognosis and lymph node metastasis of gastric cancer by bioinformatics analysis and in vitro experiments. Onco Targets Ther. 13, 7399\u20137409. https:\/\/doi.org\/10.2147\/OTT.S253154 (2020).","journal-title":"Onco Targets Ther."},{"key":"62772_CR35","doi-asserted-by":"publisher","first-page":"B56","DOI":"10.1158\/1557-3265.OVCA19-B56","volume":"26","author":"S Condello","year":"2020","unstructured":"Condello, S. et al. Abstract B56: Tissue transglutaminase\/Frizzled receptor clusters regulate WNT transcriptional activity in ovarian cancer stem cells. Clin. Cancer Res. 26, B56\u2013B56. https:\/\/doi.org\/10.1158\/1557-3265.OVCA19-B56 (2020).","journal-title":"Clin. Cancer Res."},{"key":"62772_CR36","doi-asserted-by":"publisher","first-page":"606","DOI":"10.3390\/cancers15030606","volume":"15","author":"A Ueki","year":"2023","unstructured":"Ueki, A. et al. Stromal POSTN enhances motility of both cancer and stromal cells and predicts poor survival in colorectal cancer. Cancers (Basel). 15, 606. https:\/\/doi.org\/10.3390\/cancers15030606 (2023).","journal-title":"Cancers (Basel)"},{"key":"62772_CR37","doi-asserted-by":"publisher","unstructured":"Tang, R. & Liu, X-Q. Modeling development of breast cancer: From tumor microenvironment to preclinical applications. Front. Pharmacol. 15 https:\/\/doi.org\/10.3389\/fphar.2024.1466017 (2024).","DOI":"10.3389\/fphar.2024.1466017"},{"key":"62772_CR38","doi-asserted-by":"publisher","first-page":"20141","DOI":"10.1038\/srep20141","volume":"6","author":"Y Tong","year":"2016","unstructured":"Tong, Y. et al. WISP1 mediates hepatic warm ischemia reperfusion injury via TLR4 signaling in mice. Sci. Rep. 6, 20141. https:\/\/doi.org\/10.1038\/srep20141 (2016).","journal-title":"Sci. Rep."},{"key":"62772_CR39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5152\/tjg.2024.23524","volume":"36","author":"J Yan","year":"2024","unstructured":"Yan, J. et al. WISP1 inhibits hepatocellular carcinoma cell proliferation by promoting CyclinD1 ubiquitination and downregulating its expression. Turkish J. Gastroenterol. 36, 247\u2013254. https:\/\/doi.org\/10.5152\/tjg.2024.23524 (2024).","journal-title":"Turkish J. Gastroenterol."},{"key":"62772_CR40","doi-asserted-by":"publisher","unstructured":"Liu, Y. et al. C1222C Deletion in exon 8 of ABL1 is involved in carcinogenesis and cell cycle control of colorectal cancer through IRS1\/PI3K\/Akt pathway. Front. Oncol. 10 https:\/\/doi.org\/10.3389\/fonc.2020.01385 (2020).","DOI":"10.3389\/fonc.2020.01385"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62772-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62772-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62772-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:53:52Z","timestamp":1784897632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62772-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["62772"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-62772-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9094874\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"11 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was approved by the Ethics Committee of the Affiliated Stomatological Hospital of Jiamusi University. Ethical Approval Number: KQYXY-2025-XS-M025. All the methods in this article were carried out in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"23219"}}