{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:39:59Z","timestamp":1792431599912,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":93,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Catalan Agency for the Management of Grants for University Research","award":["Grant number 2017 SGR 1342"],"award-info":[{"award-number":["Grant number 2017 SGR 1342"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-62802-x","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:14:06Z","timestamp":1784398446000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ten-year epidemiological and clinical insights of pediatric influenza A and B hospitalizations: an observational study"],"prefix":"10.1038","volume":"16","author":[{"given":"Mireia","family":"Jan\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Soldevila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Torner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Borr\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAngeles","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Mar","family":"Mosquera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0ngela","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"issue":"10127","key":"62802_CR1","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","volume":"391","author":"AD Iuliano","year":"2018","unstructured":"Iuliano, A. D. et al. Estimates of global seasonal influenza-associated respiratory mortality: A modelling study. Lancet 391(10127), 1285\u20131300 (2018).","journal-title":"Lancet"},{"key":"62802_CR2","unstructured":"World Health Organization. Using a hospital admission survey to determine rates of severe acute respiratory infections. Supplement. Geneva , Switzerland: WHO Press, World Health Organization; (2019)."},{"issue":"11","key":"62802_CR3","doi-asserted-by":"publisher","first-page":"e903","DOI":"10.1016\/S2666-5247(23)00187-8","volume":"4","author":"KM Sumner","year":"2023","unstructured":"Sumner, K. M. et al. Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010\u201319: A repeated cross-sectional study. Lancet Microbe. 4(11), e903\u2013e912 (2023).","journal-title":"Lancet Microbe."},{"key":"62802_CR4","doi-asserted-by":"publisher","DOI":"10.1017\/S095026881900195X","volume":"147","author":"CA Minney-Smith","year":"2019","unstructured":"Minney-Smith, C. A., Selvey, L. A., Levy, A. & Smith, D. W. Post-pandemic influenza A\/H1N1pdm09 is associated with more severe outcomes than A\/H3N2 and other respiratory viruses in adult hospitalisations. Epidemiol. Infect. 147, e310 (2019).","journal-title":"Epidemiol. Infect."},{"issue":"1","key":"62802_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210353","volume":"14","author":"A Mart\u00ednez","year":"2019","unstructured":"Mart\u00ednez, A. et al. Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype. PLoS ONE 14(1), e0210353 (2019).","journal-title":"PLoS ONE"},{"issue":"5","key":"62802_CR6","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/irv.12985","volume":"16","author":"N Derqui","year":"2022","unstructured":"Derqui, N. et al. Predictors of influenza severity among hospitalized adults with laboratory confirmed influenza: Analysis of nine influenza seasons from the Valencia region, Spain. Influenza Other Respir. Viruses 16(5), 862\u2013872 (2022).","journal-title":"Influenza Other Respir. Viruses"},{"issue":"4","key":"62802_CR7","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1542\/peds.2006-2679","volume":"119","author":"SE Coffin","year":"2007","unstructured":"Coffin, S. E. et al. Incidence, complications, and risk factors for prolonged stay in children hospitalized with community-acquired influenza. Pediatrics 119(4), 740\u2013748 (2007).","journal-title":"Pediatrics"},{"issue":"1","key":"62802_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49273-z","volume":"9","author":"M Jan\u00e9","year":"2010","unstructured":"Jan\u00e9, M. et al. Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010\u20132016. Sci. Rep. 9(1), 12853 (2010).","journal-title":"Sci. Rep."},{"issue":"5","key":"62802_CR9","doi-asserted-by":"publisher","first-page":"e20201368","DOI":"10.1542\/peds.2020-1368","volume":"146","author":"AP Campbell","year":"2020","unstructured":"Campbell, A. P. et al. Vaccine effectiveness against pediatric influenza hospitalizations and emergency visits. Pediatrics 146(5), e20201368 (2020).","journal-title":"Pediatrics"},{"issue":"11","key":"62802_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187834","volume":"12","author":"SA Buchan","year":"2010","unstructured":"Buchan, S. A. et al. Vaccine effectiveness against laboratory-confirmed influenza hospitalizations among young children during the 2010-11 to 2013-14 influenza seasons in Ontario, Canada. PLoS ONE 12(11), e0187834 (2010).","journal-title":"PLoS ONE"},{"key":"62802_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvacx.2024.100570","volume":"20","author":"SL Lee","year":"2023","unstructured":"Lee, S. L. et al. Influenza vaccine effectiveness against influenza-associated hospitalizations in children, Hong Kong, November 2023 to June 2024. Vaccine X 20, 100570 (2023).","journal-title":"Vaccine X"},{"issue":"6","key":"62802_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.15585\/mmwr.mm7406a2","volume":"74","author":"AM Frutos","year":"2025","unstructured":"Frutos, A. M. et al. Interim estimates of 2024\u20132025 Seasonal influenza vaccine effectiveness: Four vaccine effectiveness networks, United States, October 2024\u2013February 2025. MMWR Morb Mortal Wkly Rep. 74(6), 83\u201390 (2025).","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"62802_CR13","unstructured":"Departament de Salut. Decret 203\/2015, de 15 de setembre, pel qual es crea la Xarxa de Vigil\u00e0ncia Epidemiol\u00f2gica i es regulen els sistemes de notificaci\u00f3 de malalties de declaraci\u00f3 obligat\u00f2ria i brots epid\u00e8mics. Diari Oficial de la Generalitat de Catalunya Diari Oficial de la Generalitat de Catalunya; 2015. [cited 2026 April 1].Available from: http:\/\/www.gencat.cat\/dogcN\u00fam.6958-17.9.2015 (2026)."},{"issue":"2","key":"62802_CR14","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.anpedi.2018.06.012","volume":"90","author":"J Ar\u00edstegui Fern\u00e1ndez","year":"2014","unstructured":"Ar\u00edstegui Fern\u00e1ndez, J. et al. Hospitalizaciones infantiles asociadas a infecci\u00f3n por virus de la gripe en 6 ciudades de Espa\u00f1a (2014-2016). An. Pediatr. 90(2), 86\u201393 (2014).","journal-title":"An. Pediatr."},{"issue":"41","key":"62802_CR15","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.15585\/mmwr.mm7241a2","volume":"72","author":"EB White","year":"2023","unstructured":"White, E. B. et al. High influenza incidence and disease severity among children and adolescents aged <18 years: United States, 2022\u201323 season. MMWR Morb Mortal Wkly Rep. 72(41), 1108\u20131114 (2023).","journal-title":"MMWR Morb Mortal Wkly Rep."},{"issue":"3","key":"62802_CR16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/INF.0000000000002961","volume":"40","author":"SM Teutsch","year":"2021","unstructured":"Teutsch, S. M. et al. Ten years of national seasonal surveillance for severe complications of influenza in Australian children. Pediatr Infect Dis J. 40(3), 191\u2013198 (2021).","journal-title":"Pediatr Infect Dis J."},{"issue":"7","key":"62802_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.15585\/mmwr.mm6907a1","volume":"69","author":"FS Dawood","year":"2019","unstructured":"Dawood, F. S. et al. Interim estimates of 2019\u201320 seasonal influenza vaccine effectiveness: United States, February 2020. MMWR Morb. Mortal. Wkly. Rep. 69(7), 177\u2013182 (2019).","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"issue":"6","key":"62802_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.ss7706a1","volume":"73","author":"A Naquin","year":"2010","unstructured":"Naquin, A. et al. Laboratory-confirmed influenza-associated hospitalizations among children and adults: Influenza Hospitalization Surveillance Network, United States, 2010\u20132023. MMWR Surveill. Summ. 73(6), 1\u201318 (2010).","journal-title":"MMWR Surveill. Summ."},{"issue":"1","key":"62802_CR19","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/irv.12692","volume":"14","author":"C Chong","year":"2020","unstructured":"Chong, C. et al. The burden and clinical manifestation of hospitalized influenza among different pediatric age\u2010groups in the tropics. Influenza Other Respir. Viruses 14(1), 46\u201354 (2020).","journal-title":"Influenza Other Respir. Viruses"},{"issue":"2","key":"62802_CR20","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/jmv.27400","volume":"94","author":"P Yazici \u00d6zkaya","year":"2022","unstructured":"Yazici \u00d6zkaya, P. et al. Severe influenza virus infection in children admitted to the PICU: Comparison of influenza A and influenza B virus infection. J. Med. Virol. 94(2), 575\u2013581 (2022).","journal-title":"J. Med. Virol."},{"issue":"6","key":"62802_CR21","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/INF.0000000000002610","volume":"39","author":"JM Mattila","year":"2020","unstructured":"Mattila, J. M., Vuorinen, T. & Heikkinen, T. Comparative severity of influenza A and B infections in hospitalized children. Pediatr. Infect. Dis. J. 39(6), 489\u2013493 (2020).","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"4","key":"62802_CR22","doi-asserted-by":"publisher","first-page":"397","DOI":"10.5152\/TurkArchPediatr.2024.23286","volume":"59","author":"A E\u015fki","year":"2024","unstructured":"E\u015fki, A., \u00d6zt\u00fcrk, G. K., \u00c7i\u00e7ek, C., G\u00fclen, F. & Demir, E. Comparison of clinical presentations and disease severity of children hospitalized with influenza A and B. Turkish Arch Pediatr. 59(4), 397\u2013403 (2024).","journal-title":"Turkish Arch Pediatr."},{"issue":"1","key":"62802_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66550-8","volume":"14","author":"VD Miron","year":"2024","unstructured":"Miron, V. D. et al. Age, comorbidity burden and late presentation are significant predictors of hospitalization length and acute respiratory failure in patients with influenza. Sci. Rep. 14(1), 15563 (2024).","journal-title":"Sci. Rep."},{"key":"62802_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2025.114594","volume":"282","author":"J Tam","year":"2004","unstructured":"Tam, J. et al. Influenza-associated mortality among children in Canada from 2004 to 2022. J. Pediatr. 282, 114594 (2004).","journal-title":"J. Pediatr."},{"issue":"12","key":"62802_CR25","doi-asserted-by":"publisher","first-page":"e2452512","DOI":"10.1001\/jamanetworkopen.2024.52512","volume":"7","author":"KM Sumner","year":"2015","unstructured":"Sumner, K. M. et al. Estimated vaccine effectiveness for pediatric patients with severe influenza, 2015-2020. JAMA Netw. Open 7(12), e2452512 (2015).","journal-title":"JAMA Netw. Open"},{"key":"62802_CR26","unstructured":"Grupo de trabajo de Recomendaciones de Vacunaci\u00f3n frente a gripe en poblaci\u00f3n infantil de 6 a 59 meses de la Ponencia de Programa y Registro de Vacunaciones. Recomendaciones de vacunaci\u00f3n frente a la gripe en poblaci\u00f3n infantil de 6 a 59 meses. Madrid: Comisi\u00f3n de Salud P\u00fablica del Consejo Interterritorial del Sistema Nacional de Salud, Ministerio de Sanidad; 2022 Oct [cited 2026 Jun 11]. Available from: Recomendaciones_vacunacion_gripe_PoblacionInfantil.pdf (2026)."},{"key":"62802_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2025.114558","volume":"282","author":"A Palma-Garc\u00eda","year":"2022","unstructured":"Palma-Garc\u00eda, A. et al. Effectiveness of influenza vaccination in children aged 6-59 months during the inaugural 2022-2023 season in Andalusia, Spain. J. Pediatr. 282, 114558 (2022).","journal-title":"J. Pediatr."},{"key":"62802_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines14050372","author":"S Burgaya-Subirana","year":"2026","unstructured":"Burgaya-Subirana, S. et al. Association between the introduction of pediatric influenza vaccination and influenza diagnoses in primary care and hospitalizations: An interrupted time series study. Vaccines https:\/\/doi.org\/10.3390\/vaccines14050372 (2026).","journal-title":"Vaccines"},{"key":"62802_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph23010032","author":"S Burgaya-Subirana","year":"2023","unstructured":"Burgaya-Subirana, S., Balaguer, M., Sola Reguant, L. & Ruiz-Comellas, A. Influenza vaccination in children during the first two seasons of routine vaccination programs (2023-24 and 2024-25) in Central Catalonia, Spain: A retrospective study. Int. J. Environ. Res. Public Health https:\/\/doi.org\/10.3390\/ijerph23010032 (2023).","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"9","key":"62802_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.rce.2025.502380","volume":"225","author":"FM Escandell Rico","year":"2019","unstructured":"Escandell Rico, F. M. & P\u00e9rez Fern\u00e1ndez, L. Vaccination coverage against flu: Advances, challenges and inequalities by autonomous communities in Spain (2019-2023). Rev. Clin. Esp. 225(9), 502380 (2019).","journal-title":"Rev. Clin. Esp."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62802-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62802-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62802-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:02:11Z","timestamp":1792429331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62802-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["62802"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-62802-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"23 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"32836"}}