{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:40:41Z","timestamp":1792539641654,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Qi-Hang Foundation","award":["2020QH1063"],"award-info":[{"award-number":["2020QH1063"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-62873-w","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:45:26Z","timestamp":1784619926000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Constructing the conditional association network and identifying central and bridge nodes in aneurysmal subarachnoid hemorrhage"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5123-1890","authenticated-orcid":false,"given":"Meixing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"5","key":"62873_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1007\/s00134-024-07387-7","volume":"50","author":"C Robba","year":"2024","unstructured":"Robba, C. et al. Contemporary management of aneurysmal subarachnoid hemorrhage. An update for the intensivist. Intensive Care Med. 50 (5), 646\u2013664 (2024).","journal-title":"Intensive Care Med."},{"issue":"1","key":"62873_CR2","first-page":"33","volume":"10","author":"WJ Tu","year":"2023","unstructured":"Tu, W. J. & Wang, L. D. China stroke surveillance report 2021. Mil Med. Res. 10 (1), 33 (2023).","journal-title":"Mil Med. Res."},{"issue":"11","key":"62873_CR3","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1001\/jamapsychiatry.2023.2823","volume":"80","author":"L Schumacher","year":"2023","unstructured":"Schumacher, L. et al. Implications of the Network Theory for the Treatment of Mental Disorders: A Secondary Analysis of a Randomized Clinical Trial. JAMA Psychiatry. 80 (11), 1160\u20131168 (2023).","journal-title":"JAMA Psychiatry"},{"issue":"24","key":"62873_CR4","first-page":"2229","volume":"38","author":"Y Junwen","year":"2023","unstructured":"Junwen, Y. et al. Specific measures of symptom networks. J. Adv. Nurs. Educ. 38 (24), 2229\u20132234 (2023).","journal-title":"J. Adv. Nurs. Educ."},{"issue":"8","key":"62873_CR5","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1136\/jnnp-2014-308992","volume":"86","author":"GM Ibrahim","year":"2015","unstructured":"Ibrahim, G. M. & Macdonald, R. L. The network topology of aneurysmal subarachnoid hemorrhage. J. Neurol. Neurosurg. Psychiatry. 86 (8), 895\u2013901 (2015).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"62873_CR6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1037\/met0000555","volume":"31","author":"MA Constantin","year":"2026","unstructured":"Constantin, M. A., Schuurman, N. K. & Vermunt, J. K. A general Monte Carlo method for sample size analysis in the context of network models. Psychol. Methods. 31, 385\u2013405 (2026).","journal-title":"Psychol. Methods"},{"issue":"1","key":"62873_CR7","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3758\/s13428-017-0862-1","volume":"50","author":"S Epskamp","year":"2018","unstructured":"Epskamp, S., Borsboom, D. & Fried, E. I. Estimating psychological networks and their accuracy: A tutorial paper. Behav. Res. Methods. 50 (1), 195\u2013212 (2018).","journal-title":"Behav. Res. Methods"},{"key":"62873_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v093.i08","volume":"93","author":"JMB Haslbeck","year":"2020","unstructured":"Haslbeck, J. M. B. & Waldorp, L. J. mgm: Estimating time-varying mixed graphical models in high-dimensional data. J. Stat. Softw. 93, 1\u201346 (2020).","journal-title":"J. Stat. Softw."},{"key":"62873_CR9","doi-asserted-by":"publisher","first-page":"115396","DOI":"10.1016\/j.expneurol.2025.115396","volume":"393","author":"Q Tang","year":"2025","unstructured":"Tang, Q. et al. Integrative multi-omics and machine learning identify CALR as a diagnostic and therapeutic target in aneurysmal subarachnoid hemorrhage. Exp. Neurol. 393, 115396 (2025).","journal-title":"Exp. Neurol."},{"key":"62873_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1136\/bmj.p90","volume":"380","author":"A Braillon","year":"2023","unstructured":"Braillon, A. & Naudet, F. STROBE and pre-registration of observational studies. Bmj 380, 90 (2023).","journal-title":"Bmj"},{"issue":"24","key":"62873_CR11","first-page":"2250","volume":"38","author":"Y Junwen","year":"2023","unstructured":"Junwen, Y. et al. Reporting guidelines for symptom network studies. J. Adv. Nurs. Educ. 38 (24), 2250\u20132254 (2023).","journal-title":"J. Adv. Nurs. Educ."},{"key":"62873_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v045.i03","volume":"45","author":"S van Buuren","year":"2011","unstructured":"van Buuren, S., Groothuis-Oudshoorn, K. & MICE Multivariate imputation by chained equations in R. J. Stat. Softw. 45, 1\u201367 (2011).","journal-title":"J. Stat. Softw."},{"key":"62873_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s12975-024-01284-3","volume":"16","author":"E Sagues","year":"2025","unstructured":"Sagues, E., Gudino, A., Dier, C., Aamot, C. & Samaniego, E. A. Outcomes measures in subarachnoid hemorrhage research. Transl Stroke Res. 16, 25\u201336 (2025).","journal-title":"Transl Stroke Res."},{"issue":"2","key":"62873_CR14","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1227\/neu.0000000000002676","volume":"94","author":"CB Kilgore","year":"2024","unstructured":"Kilgore, C. B. et al. Perioperative Infection After Aneurysmal Subarachnoid Hemorrhage: Risk Factors, Causative Pathogens, and Long-Term Outcomes. Neurosurgery 94 (2), 325\u2013333 (2024).","journal-title":"Neurosurgery"},{"issue":"4","key":"62873_CR15","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s00134-004-2187-7","volume":"30","author":"A Anzueto","year":"2004","unstructured":"Anzueto, A. et al. Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients. Intensive Care Med. 30 (4), 612\u2013619 (2004).","journal-title":"Intensive Care Med."},{"issue":"9","key":"62873_CR16","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1097\/CCM.0000000000001091","volume":"43","author":"L Bouadma","year":"2015","unstructured":"Bouadma, L. et al. Ventilator-Associated Events: Prevalence, Outcome, and Relationship With Ventilator-Associated Pneumonia. Crit. Care Med. 43 (9), 1798\u20131806 (2015).","journal-title":"Crit. Care Med."},{"key":"62873_CR17","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.3390\/ijms21134609","volume":"21","author":"YN Paudel","year":"2020","unstructured":"Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I. & Shaikh, M. F. HMGB1-mediated neuroinflammatory responses in brain injuries: potential mechanisms and therapeutic opportunities. Int. J. Mol. Sci. 21, 4609 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"62873_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s12028-016-0255-9","volume":"25","author":"AK Boehme","year":"2016","unstructured":"Boehme, A. K. et al. Systemic Inflammatory Response Syndrome and Outcomes in Intracerebral Hemorrhage. Neurocrit. Care. 25 (1), 133\u2013140 (2016).","journal-title":"Neurocrit. Care"},{"key":"62873_CR19","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.3390\/ijms18081788","volume":"18","author":"AJ Sorby-Adams","year":"2017","unstructured":"Sorby-Adams, A. J., Marcoionni, A. M., Dempsey, E. R., Woenig, J. A. & Turner, R. J. The role of neurogenic inflammation in blood-brain barrier disruption and development of cerebral oedema following acute central nervous system (CNS) injury. Int. J. Mol. Sci. 18, 1788 (2017).","journal-title":"Int. J. Mol. Sci."},{"key":"62873_CR20","doi-asserted-by":"crossref","unstructured":"Sz\u00e1nt\u00f3, D. et al. Correlation of Inflammatory Parameters with the Development of Cerebral Vasospasm, Takotsubo Cardiomyopathy, and Functional Outcome after Spontaneous Subarachnoid Hemorrhage. J. Clin. Med. 13(7) (2024).","DOI":"10.3390\/jcm13071955"},{"issue":"1","key":"62873_CR21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12974-022-02564-1","volume":"19","author":"S-H Ahn","year":"2022","unstructured":"Ahn, S-H. et al. Systemic inflammatory markers of persistent cerebral edema after aneurysmal subarachnoid hemorrhage. J. Neuroinflamm. 19 (1), 199 (2022).","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"62873_CR22","doi-asserted-by":"publisher","first-page":"14736","DOI":"10.1038\/s41598-018-32938-6","volume":"8","author":"DB Antcliffe","year":"2018","unstructured":"Antcliffe, D. B. et al. Profiling inflammatory markers in patients with pneumonia on intensive care. Sci. Rep. 8 (1), 14736 (2018).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62873-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62873-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62873-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:21:52Z","timestamp":1792538512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-62873-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["62873"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-62873-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"4 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Branch for Medical Research and Clinical Technology Application, Ethics Committee of the First Affiliated Hospital of Fujian Medical University in January 2020 (Approval No.: MRCTA, ECFAH of FMU [2020] 004), which waived the requirement for informed consent for this retrospective study using fully de-identified data.","order":2,"name":"Ethics","label":"<b>Ethical statement and waiver of informed consent<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"33109"}}