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The anticancer efficacy of compounds\n                    <jats:bold>8a<\/jats:bold>\n                    and\n                    <jats:bold>8b<\/jats:bold>\n                    against the MCF-7 cell line demonstrated promising activity with IC50 values of 18.9 and 33.0\u00a0\u00b5g\/mL, respectively. On the other hand, the antitumor efficacy of compounds\n                    <jats:bold>12<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    against the HCT116 cell line demonstrated encouraging results, with IC50 values of 47.3 and 21.4\u00a0\u00b5g\/mL, respectively. Furthermore, in silico methodologies including ADME, BOILED-Egg, and bioactivity radar were employed to assess the oral bioavailability of the synthesized hybrids. Molecular docking was conducted to determine the docking poses and binding interactions of the derivatives with proteins bearing PDB: 6vj3 and 6GUE.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-64175-7","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:04:20Z","timestamp":1786554260000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of novel 11H-indeno[1,2-b]quinoxaline derivatives and their in vitro and in silico insights into anticancer activities"],"prefix":"10.1038","volume":"16","author":[{"given":"Fatma A.","family":"El-Samahy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada A.","family":"Eldeken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab M.","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez H.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galal E. 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