{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:43:16Z","timestamp":1786203796231,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with type 2 diabetes mellitus (T2DM) have elevated risk for aortic stenosis (AS). The impact of diabetes on prognosis and clinical progression in AS is not well documented. In this study we try to assess if patients with T2DM and AS have faster clinical progression compared to patients without diabetes. By linkage of nationwide Swedish registries, we identified 16,116 T2DM and AS individuals (cases) and compared them with 31,066 matched comparators (AS without diabetes) from general population concerning clinical progression, defined as progression from AS diagnosis to hospitalization for heart failure, aortic valve replacement, mortality, and composite outcome of these endpoints. Kaplan\u2013Meier curves were used to compare outcomes between cases and comparators and Cox proportional hazards analyses to account for confounders. AS individuals (total 47,182, 16,116 cases and 31,066 comparators) had mean age 71\u00a0years. The cases were younger, men predominated (58% versus 53%) and had more comorbidities. During follow-up, cases had faster clinical progression- 11% higher hazard for valve replacement (95% CI 1.04\u20131.18), 14% higher hazard for heart failure hospitalization (95% CI 1.03\u20131.26) and 4% higher hazard for composite outcome (95% CI 1.01\u20131.08), but with no mortality excess (HR1.00, 95%CI 0.97\u20131.05). Preexisting T2DM seems to be linked to moderately more rapid clinical progression in AS.<\/jats:p>","DOI":"10.1038\/s41598-026-64970-2","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T14:46:13Z","timestamp":1786200373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Type 2 diabetes is associated with clinical progression of aortic stenosis: a nationwide retrospective study in Sweden"],"prefix":"10.1038","volume":"16","author":[{"given":"Silvana","family":"Kontogeorgos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Anger\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petur","family":"Petursson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Zverkova Sandstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Sj\u00f6land","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"64970_CR1","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1161\/circulationaha.121.058072","volume":"146","author":"A Rawshani","year":"2022","unstructured":"Rawshani, A. et al. Left-sided degenerative valvular heart disease in type 1 and type 2 diabetes. Circulation 146, 398\u2013411. https:\/\/doi.org\/10.1161\/circulationaha.121.058072 (2022).","journal-title":"Circulation"},{"key":"64970_CR2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ijcard.2018.03.099","volume":"262","author":"SC Larsson","year":"2018","unstructured":"Larsson, S. C. et al. Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases. Int. J. Cardiol. 262, 66\u201370. https:\/\/doi.org\/10.1016\/j.ijcard.2018.03.099 (2018).","journal-title":"Int. J. Cardiol."},{"key":"64970_CR3","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.jacc.2017.01.025","volume":"69","author":"AT Yan","year":"2017","unstructured":"Yan, A. T. et al. Association between cardiovascular risk factors and aortic stenosis: The CANHEART aortic stenosis study. J. Am. 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Diabetol. 24, 105. https:\/\/doi.org\/10.1186\/s12933-025-02634-7 (2025).","journal-title":"Cardiovasc. Diabetol."},{"key":"64970_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2024-325150","author":"V Lind","year":"2025","unstructured":"Lind, V. et al. Dysglycaemia and incident aortic stenosis: A cohort study. Heart https:\/\/doi.org\/10.1136\/heartjnl-2024-325150 (2025).","journal-title":"Heart"},{"key":"64970_CR9","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.4239\/wjd.v6.i13.1246","volume":"6","author":"BM Leon","year":"2015","unstructured":"Leon, B. M. & Maddox, T. M. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J. Diabetes 6, 1246\u20131258. https:\/\/doi.org\/10.4239\/wjd.v6.i13.1246 (2015).","journal-title":"World J. 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OA declares institutional research grant Abbott and Astra Zeneca, lecture fee Meril Life, Abbott and Medtronic.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"24550"}}