{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:48:52Z","timestamp":1785934132488,"version":"3.56.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Membrane-bound neuropilin-1 (Nrp-1) has been implicated as a regulator of insulin resistance-related lipid metabolism, but little is known about its circulating form, soluble Nrp-1 (sNrp-1), in a metabolic context. Here we investigated the association between plasma levels of sNrp-1 and metabolic variables in 501 participants from the Prospective investigation of Obesity, Energy and Metabolism (POEM) study. Metabolic phenotyping included blood sampling, dual energy X-ray absorptiometry scan, magnetic resonance imaging for fat distribution, and a glucose tolerance test. Associations were examined using linear regression models and Spearman\u2019s rank correlation. Plasma sNrp-1 levels were inversely associated with levels of total fatty acids, triglycerides and lactate, and positively associated with markers of insulin sensitivity. In human Simpson-Golabi-Behmel Syndrome (SGBS) adipocytes, we showed that treatment with recombinant Nrp-1 reduced phosphorylation of hormone-sensitive lipase in the basal state and attenuated isoproterenol-stimulated glycerol release, a measure of total lipolytic activity. Based on these findings, we thus postulate that sNrp-1-mediated suppression of lipolysis could explain our observed association between plasma sNrp-1 and a favorable lipid profile in humans. Further studies are warranted to establish causality and to clarify the role of sNrp-1 in promoting insulin sensitivity in human adipose tissue.<\/jats:p>","DOI":"10.1038\/s41598-026-65317-7","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:18:38Z","timestamp":1785932318000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals"],"prefix":"10.1038","volume":"16","author":[{"given":"Emanuel","family":"Fryk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagner Ramon Rodrigues","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bauz\u00e1-Thorbr\u00fcgge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Strindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Kullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Fischer-Posovszky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Vujicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Wernstedt","family":"Asterholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3212-2996","authenticated-orcid":false,"given":"Per-Anders","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"49","key":"65317_CR1","doi-asserted-by":"publisher","first-page":"29120","DOI":"10.1074\/jbc.R115.687327","volume":"290","author":"HF Guo","year":"2015","unstructured":"Guo, H. F. & Vander Kooi, C. W. Neuropilin functions as an essential cell surface receptor. J. Biol. Chem. 290(49), 29120\u201329126 (2015).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"65317_CR2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000520419","volume":"15","author":"D Soll","year":"2022","unstructured":"Soll, D. et al. Effects of weight loss on adipose and muscular neuropilin 1 mRNA expression in obesity: Potential implication in SARS-CoV-2 infections?. Obes. Facts 15(1), 90\u201398 (2022).","journal-title":"Obes. Facts"},{"issue":"7290","key":"65317_CR3","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature08945","volume":"464","author":"CE Hagberg","year":"2010","unstructured":"Hagberg, C. E. et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake. 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All participants provided written informed consent prior to participating in the POEM study. The study was conducted in full compliance with the ethical standards of the Declaration of Helsinki.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"24169"}}