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These rates can be jeopardized by severe, difficult-to-treat opportunistic infections such as polyomavirus, which can lead to polyomavirus-associated nephropathy (PVAN). There is an urgent need for non-invasive biomarker tests to narrow down the number of patients who require a transplant biopsy to confirm PVAN. The chemokine CXCL10 was significantly elevated in urine samples from kidney transplant recipients (KTR) with biopsy-confirmed PVAN compared to KTRs with a protocol biopsy found to be normal (114.8\u2009\u00b1\u2009177.3 pg\/ml,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922 vs. 11.4\u2009\u00b1\u200922.3 pg\/ml,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200945). Therefore, we developed a lateral flow assay (LFA) for the detection of PVAN with an area under the curve (AUC) of 0.832 according to receiver operating characteristic analysis as a point-of-care test.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-66553-7","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:44:40Z","timestamp":1787838280000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lateral Flow Assay to detect CXCL10 as a diagnose-supporting biomarker for Polyomavirus-associated Nephropathy (PVAN) after kidney transplantation (KTx)"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9013-2597","authenticated-orcid":false,"given":"Emely","family":"Hauch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-5126","authenticated-orcid":false,"given":"Lisa K.","family":"Seiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5930-1866","authenticated-orcid":false,"given":"Irina","family":"Scheffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-893X","authenticated-orcid":false,"given":"Wilfried","family":"Gwinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7487-4884","authenticated-orcid":false,"given":"Cornelia","family":"Blume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"66553_CR1","doi-asserted-by":"publisher","first-page":"205435811879969","DOI":"10.1177\/2054358118799692","volume":"5","author":"J Cowan","year":"2018","unstructured":"Cowan, J. et al. 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