{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:16:22Z","timestamp":1788286582193,"version":"build-2803163510"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["223Z086"],"award-info":[{"award-number":["223Z086"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marmara University Scientific Research Project Fund","award":["FBA-2026-12472"],"award-info":[{"award-number":["FBA-2026-12472"]}]},{"name":"Marmara University Scientific Research Project Fund","award":["ADF-2024-11119"],"award-info":[{"award-number":["ADF-2024-11119"]}]},{"name":"Marmara University Scientific Research Project Fund","award":["FDK-2022-10757"],"award-info":[{"award-number":["FDK-2022-10757"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Deltamethrin (DLM) is a widely used synthetic pyrethroid insecticide known for its neurotoxic effects through interactions with voltage-gated sodium channels in insects. Despite its extensive application in agriculture, aquaculture, household settings, and animal husbandry, accumulating evidence indicates that DLM poses significant health risks to non-target organisms, including neurotoxicity, hepatotoxicity, nephrotoxicity, reproductive toxicity, metabolic disorders, and oxidative stress. Elucidating the cellular mode of action of DLM exposure is therefore critical. Previous studies have linked DLM exposure to endoplasmic reticulum (ER) stress and disrupted iron homeostasis; however, the metabolic adaptations underlying these responses remain poorly understood. In this study, we employed an integrated multi-omics approach to investigate the metabolic and transcriptomic responses of Saccharomyces cerevisiae exposed to non-lethal, chronic DLM doses over 30 days. Metabolomic profiling revealed significant alterations in amino acid metabolism, with notable accumulation of glycine and serine, amino acids known to mitigate ER stress. Transcriptomic analysis showed upregulation of iron deprivation response genes (\n                    <jats:italic>FRE3<\/jats:italic>\n                    ,\n                    <jats:italic>SIT1<\/jats:italic>\n                    ) and amino acid permease genes (\n                    <jats:italic>PUT4<\/jats:italic>\n                    ,\n                    <jats:italic>AGP1<\/jats:italic>\n                    ), indicating enhanced amino acid transport and iron uptake. Our findings demonstrate a coordinated adaptive response in which amino acid trafficking and iron homeostasis act in concert to alleviate DLM-induced ER stress, highlighting conserved stress adaptation mechanisms with potential relevance to human health.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-66841-2","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:24:04Z","timestamp":1788283444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A multi-omics systems toxicology framework reveals amino acid\u2013mediated stress adaptation to deltamethrin exposure in a yeast model"],"prefix":"10.1038","volume":"16","author":[{"given":"Mustafa","family":"Yavuz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakime Gul","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytac Dursun","family":"Oksuzoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyhun","family":"Bereketoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Mardinoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-9712","authenticated-orcid":false,"given":"Beste","family":"Calimlioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"66841_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.149938","volume":"802","author":"T Hu","year":"2022","unstructured":"Hu, T. et al. Estrogen receptor: A potential linker of estrogenic and dopaminergic pathways in zebrafish larvae following deltamethrin exposure. Sci. Total Environ.802, 149938. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.149938 (2022).","journal-title":"Sci. Total Environ."},{"issue":"21","key":"66841_CR2","doi-asserted-by":"publisher","first-page":"2305985121","DOI":"10.1073\/pnas.2305985121","volume":"121","author":"R van Zwieten","year":"2024","unstructured":"van Zwieten, R. et al. Mimicking natural deterrent strategies in plants using adhesive spheres. Proc. Natl. Acad. Sci.121 (21), 2305985121. https:\/\/doi.org\/10.1073\/pnas.2305985121 (2024).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"66841_CR3","doi-asserted-by":"publisher","first-page":"8977","DOI":"10.1021\/acs.est.6b02253","volume":"50","author":"SM Brander","year":"2016","unstructured":"Brander, S. M., Gabler, M. K., Fowler, N. L., Connon, R. E. & Schlenk, D. Pyrethroid pesticides as endocrine disruptors: Molecular mechanisms in vertebrates with a focus on fishes. Environ. Sci. Technol.50, 8977\u20138992. https:\/\/doi.org\/10.1021\/acs.est.6b02253 (2016).","journal-title":"Environ. Sci. Technol."},{"key":"66841_CR4","doi-asserted-by":"publisher","first-page":"113870","DOI":"10.1016\/j.envpol.2019.113870","volume":"259","author":"B Han","year":"2020","unstructured":"Han, B. et al. Zhang, Z. Deltamethrin induces liver fibrosis in quails via activation of the TGF-\u03b21\/Smad signaling pathway. Environ. Pollut.259, 113870. https:\/\/doi.org\/10.1016\/j.envpol.2019.113870 (2020).","journal-title":"Environ. Pollut."},{"issue":"5","key":"66841_CR5","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1039\/CS9780700473","volume":"7","author":"M Elliot","year":"1978","unstructured":"Elliot, M. & James, N. F. Synthetic pyrethroids\u2014a new class of insecticide. Chem. Soc. Rev.7 (5), 473\u2013505. https:\/\/doi.org\/10.1039\/CS9780700473 (1978).","journal-title":"Chem. Soc. Rev."},{"issue":"4","key":"66841_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1584\/jpestics.D19-102","volume":"44","author":"K Ujihara","year":"2019","unstructured":"Ujihara, K. The history of extensive structural modifications of pyrethroids. J. Pesticide Sci.44 (4), 215\u2013224. https:\/\/doi.org\/10.1584\/jpestics.D19-102 (2019).","journal-title":"J. Pesticide Sci."},{"key":"66841_CR7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12940-022-00846-9","volume":"21","author":"R Mesnage","year":"2022","unstructured":"Mesnage, R. et al. Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins. Environ. Health. 21, 46. https:\/\/doi.org\/10.1186\/s12940-022-00846-9 (2022).","journal-title":"Environ. Health"},{"key":"66841_CR8","doi-asserted-by":"publisher","first-page":"109132","DOI":"10.1016\/j.cbpc.2021.109132","volume":"248","author":"C Tschesche","year":"2021","unstructured":"Tschesche, C., Bekaert, M., Humble, J. L., Bron, J. E. & Sturm, A. Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis). Comp. Biochem. Physiol. Part. C: Toxicol. Pharmacol.248, 109132. https:\/\/doi.org\/10.1016\/j.cbpc.2021.109132 (2021).","journal-title":"Comp. Biochem. Physiol. Part. C: Toxicol. Pharmacol."},{"key":"66841_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgad085","volume":"2","author":"MA Curtis","year":"2023","unstructured":"Curtis, M. A. et al. Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice. PNAS Nexus2, 85. https:\/\/doi.org\/10.1093\/pnasnexus\/pgad085 (2023).","journal-title":"PNAS Nexus"},{"key":"66841_CR10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neuro.2023.12.003","volume":"103","author":"MA Curtis","year":"2024","unstructured":"Curtis, M. A. et al. Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood. NeuroToxicology103, 87\u201395. https:\/\/doi.org\/10.1016\/j.neuro.2023.12.003 (2024).","journal-title":"NeuroToxicology"},{"key":"66841_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2022.105114","volume":"184","author":"Z Qi","year":"2022","unstructured":"Qi, Z. et al. Transcriptome analysis provides insight into deltamethrin-induced fat accumulation in 3T3-L1 adipocytes. Pestic. Biochem. Physiol.184, 105114. https:\/\/doi.org\/10.1016\/j.pestbp.2022.105114 (2022).","journal-title":"Pestic. Biochem. Physiol."},{"key":"66841_CR12","doi-asserted-by":"publisher","first-page":"07215","DOI":"10.2903\/j.efsa.2022.e07215","volume":"30","author":"European Food Safety Authority (EFSA)","year":"2022","unstructured":"European Food Safety Authority (EFSA). The 2020 European Union report on pesticide residues in food. EFSA J.30, 07215. https:\/\/doi.org\/10.2903\/j.efsa.2022.e07215 (2022a).","journal-title":"EFSA J."},{"issue":"4","key":"66841_CR13","doi-asserted-by":"publisher","first-page":"8753","DOI":"10.2903\/j.efsa.2024.8753","volume":"22","author":"LC Cabrera","year":"2024","unstructured":"Cabrera, L. C., Di Piazza, G., Dujardin, B., Marchese, E. & Pastor, P. M. The 2022 European Union report on pesticide residues in food. EFSA J.22 (4), 8753. https:\/\/doi.org\/10.2903\/j.efsa.2024.8753 (2024).","journal-title":"EFSA J."},{"issue":"7","key":"66841_CR14","doi-asserted-by":"publisher","first-page":"07391","DOI":"10.2903\/j.efsa.2022.7391","volume":"20","author":"European Food Safety Authority (EFSA)","year":"2022","unstructured":"European Food Safety Authority (EFSA). Modification of the existing maximum residue level for deltamethrin in maize\/corn. EFSA J.20 (7), 07391. https:\/\/doi.org\/10.2903\/j.efsa.2022.7391 (2022b).","journal-title":"EFSA J."},{"key":"66841_CR15","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1002\/tox.22414","volume":"32","author":"TC Chueh","year":"2017","unstructured":"Chueh, T. C. et al. Transcriptome analysis of zebrafish embryos exposed to deltamethrin. Environ. Toxicol.32, 1548\u20131557. https:\/\/doi.org\/10.1002\/tox.22414 (2017).","journal-title":"Environ. Toxicol."},{"key":"66841_CR16","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1002\/jat.4176","volume":"41","author":"Y Hu","year":"2021","unstructured":"Hu, Y., Hu, J., Li, W., Gao, Y. & Tian, Y. Changes of embryonic development, locomotor activity, and metabolomics in zebrafish co-exposed to chlorpyrifos and deltamethrin. J. Appl. Toxicol.41, 1345\u20131356. https:\/\/doi.org\/10.1002\/jat.4176 (2021).","journal-title":"J. Appl. Toxicol."},{"issue":"15","key":"66841_CR17","doi-asserted-by":"publisher","first-page":"9515","DOI":"10.1021\/acs.est.4c02125","volume":"58","author":"J Wang","year":"2024","unstructured":"Wang, J. et al. Contribution of immune responses to the cardiotoxicity and hepatotoxicity of deltamethrin in early life stage zebrafish (Danio rerio). Environ. Sci. Technol.58 (15), 9515\u20139524. https:\/\/doi.org\/10.1021\/acs.est.4c02125 (2024a).","journal-title":"Environ. Sci. Technol."},{"key":"66841_CR18","doi-asserted-by":"publisher","first-page":"135213","DOI":"10.1016\/j.jhazmat.2024.135213","volume":"476","author":"J Wang","year":"2024","unstructured":"Wang, J. et al. miR-29b-triggered epigenetic regulation of cardiotoxicity following exposure to deltamethrin in zebrafish. J. Hazard. Mater.476, 135213. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.135213 (2024b).","journal-title":"J. Hazard. Mater."},{"key":"66841_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2023.104155","volume":"100","author":"W Miao","year":"2023","unstructured":"Miao, W. et al. Systematic evaluation of the toxicological effects of deltamethrin exposure in zebrafish larvae. Environ. Toxicol. Pharmacol.100, 104155. https:\/\/doi.org\/10.1016\/j.etap.2023.104155 (2023).","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"66841_CR20","doi-asserted-by":"publisher","first-page":"109288","DOI":"10.1016\/j.cbpc.2021.109288","volume":"251","author":"NJ Wolmarans","year":"2022","unstructured":"Wolmarans, N. J., Bervoets, L., Meire, P. & Wepener, V. Sub-lethal exposure to malaria vector control pesticides causes alterations in liver metabolomics and behaviour of the African clawed frog (Xenopus laevis). Comp. Biochem. Physiol. Part. C: Toxicol. Pharmacol.251, 109288. https:\/\/doi.org\/10.1016\/j.cbpc.2021.109288 (2022).","journal-title":"Comp. Biochem. Physiol. Part. C: Toxicol. Pharmacol."},{"key":"66841_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113421","volume":"234","author":"H Wu","year":"2022","unstructured":"Wu, H. et al. Histopathology and transcriptome analysis reveals the gills injury and immunotoxicity in gibel carp following acute deltamethrin exposure. Ecotoxicol. Environ. Saf.234, 113421. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113421 (2022).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"66841_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110791","volume":"134","author":"L Yuan","year":"2019","unstructured":"Yuan, L. et al. Deltamethrin promotes adipogenesis via AMPK\u03b1 and ER stress-mediated pathway in 3T3-L1 adipocytes and Caenorhabditis elegans. Food Chem. Toxicol.134, 110791. https:\/\/doi.org\/10.1016\/j.fct.2019.110791 (2019).","journal-title":"Food Chem. Toxicol."},{"key":"66841_CR23","doi-asserted-by":"publisher","first-page":"100914","DOI":"10.1016\/j.margen.2021.100914","volume":"65","author":"G N\u00fa\u00f1ez-Acu\u00f1a","year":"2022","unstructured":"N\u00fa\u00f1ez-Acu\u00f1a, G., Fernandez, C., Sanhueza-Guevara, S. & Gallardo-Esc\u00e1rate, C. Transcriptome profiling of the early developmental stages in the giant mussel Choromytilus chorus exposed to delousing drugs. Mar. Genom.65, 100914. https:\/\/doi.org\/10.1016\/j.margen.2021.100914 (2022).","journal-title":"Mar. Genom."},{"key":"66841_CR24","doi-asserted-by":"publisher","first-page":"106832","DOI":"10.1016\/j.aquatox.2023.106832","volume":"267","author":"Q Ren","year":"2024","unstructured":"Ren, Q. et al. The crosstalk between Toll and AMPK signaling pathways mediates growth inhibition of Eriocheir sinensis under deltamethrin stress. Aquat. Toxicol.267, 106832. https:\/\/doi.org\/10.1016\/j.aquatox.2023.106832 (2024).","journal-title":"Aquat. Toxicol."},{"issue":"1","key":"66841_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228623","volume":"15","author":"Z Yang","year":"2020","unstructured":"Yang, Z. et al. Transcriptome analysis of hepatopancreas of Eriocheir sinensis with hepatopancreatic necrosis disease (HPND). PLoS One15(1), e0228623. https:\/\/doi.org\/10.1371\/journal.pone.0228623 (2020).","journal-title":"PLoS One"},{"issue":"10","key":"66841_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184581","volume":"12","author":"Z Yang","year":"2017","unstructured":"Yang, Z. et al. Transcriptional responses in the hepatopancreas of Eriocheir sinensis exposed to deltamethrin. PLoS One12(10), 0184581. https:\/\/doi.org\/10.1371\/journal.pone.0184581 (2017).","journal-title":"PLoS One"},{"key":"66841_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112716","volume":"225","author":"S Zhou","year":"2021","unstructured":"Zhou, S. et al. Effects of acute deltamethrin exposure on kidney transcriptome and intestinal microbiota in goldfish (Carassius auratus). Ecotoxicol. Environ. Saf.225, 112716. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112716 (2021).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"66841_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.916100","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang, Y. et al. RNA-seq and 16S rRNA analysis revealed the effect of deltamethrin on channel catfish in the early stage of acute exposure. Front. Immunol.13, 916100. https:\/\/doi.org\/10.3389\/fimmu.2022.916100 (2022).","journal-title":"Front. Immunol."},{"issue":"1","key":"66841_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/toxsci\/kfac055","volume":"186","author":"CA Marable","year":"2022","unstructured":"Marable, C. A. et al. Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations of In Vitro Neural Network Formation. Toxicol. Sci.186 (1), 118\u2013133. https:\/\/doi.org\/10.1093\/toxsci\/kfac055 (2022).","journal-title":"Toxicol. Sci."},{"key":"66841_CR30","doi-asserted-by":"publisher","DOI":"10.1101\/2023.04.15.536961","author":"JH Nguyen","year":"2023","unstructured":"Nguyen, J. H. et al. Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain. bioRxiv preprint. https:\/\/doi.org\/10.1101\/2023.04.15.536961 (2023).","journal-title":"bioRxiv preprint"},{"issue":"3","key":"66841_CR31","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/bit.26905","volume":"116","author":"D Dikicioglu","year":"2019","unstructured":"Dikicioglu, D. & Oliver, S. G. Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron-recruiting enzyme abundance from cofactor requirements. Biotechnol. Bioeng.116(3), 610\u2013621. https:\/\/doi.org\/10.1002\/bit.26905 (2019).","journal-title":"Biotechnol. Bioeng."},{"issue":"23","key":"66841_CR32","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.21037\/atm-20-624a","volume":"8","author":"D Enko","year":"2020","unstructured":"Enko, D. et al. Branched-chain amino acids are linked with iron metabolism. Ann. Transl. Med.8(23), 1569. https:\/\/doi.org\/10.21037\/atm-20-624a (2020).","journal-title":"Ann. Transl. Med."},{"key":"66841_CR33","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.3390\/cells11121961","volume":"11","author":"MM Hossain","year":"2022","unstructured":"Hossain, M. M., Toltin, A. C., Gamba, L. M. & Molina, M. A. Deltamethrin-Evoked ER Stress Promotes Neuroinflammation in the Adult Mouse Hippocampus. Cells11, 1961. https:\/\/doi.org\/10.3390\/cells11121961 (2022).","journal-title":"Cells"},{"issue":"25","key":"66841_CR34","doi-asserted-by":"publisher","first-page":"5697","DOI":"10.1016\/j.febslet.2005.09.058","volume":"579","author":"E Peiter","year":"2005","unstructured":"Peiter, E., Fischer, M., Sidaway, K., Roberts, S. K. & Sanders, D. The Saccharomyces cerevisiae Ca2+ channel Cch1p Mid1p is essential for tolerance to cold stress and iron toxicity. FEBS Lett.579(25), 5697\u20135703. https:\/\/doi.org\/10.1016\/j.febslet.2005.09.058 (2005).","journal-title":"FEBS Lett."},{"key":"66841_CR35","doi-asserted-by":"publisher","first-page":"109508","DOI":"10.1016\/j.cbpc.2023.109508","volume":"263","author":"X Yuan","year":"2023","unstructured":"Yuan, X. et al. Acute deltamethrin exposure induces oxidative stress, triggers endoplasmic reticulum stress, and impairs hypoxic resistance of crucian carp. Comp. Biochem. Physiol. Part. C. 263, 109508. https:\/\/doi.org\/10.1016\/j.cbpc.2023.109508 (2023).","journal-title":"Comp. Biochem. Physiol. Part. C"},{"key":"66841_CR36","doi-asserted-by":"publisher","first-page":"6303","DOI":"10.3390\/molecules28156303","volume":"28","author":"C Chen","year":"2023","unstructured":"Chen, C. et al. High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1. Molecules28, 6303. https:\/\/doi.org\/10.3390\/molecules28156303 (2023).","journal-title":"Molecules"},{"key":"66841_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00154","volume":"4","author":"BD Gayt\u00e1n","year":"2013","unstructured":"Gayt\u00e1n, B. D., Loguinov, A. V., De La Rosa, V. Y., Lerot, J. M. & Vulpe, C. D. Functional genomics indicates yeast requires Golgi\/ER transport, chromatin remodeling, and DNA repair for low dose DMSO tolerance. Front. Genet.4, 154 (2013).","journal-title":"Front. Genet."},{"issue":"8","key":"66841_CR38","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1111\/1567-1364.12091","volume":"13","author":"I Sadowska-Bartosz","year":"2013","unstructured":"Sadowska-Bartosz, I., P\u0105czka, A., Mo\u0142o\u0144, M. & Bartosz, G. Dimethyl sulfoxide induces oxidative stress in the yeast Saccharomyces cerevisiae. FEMS Yeast Res.13(8), 820\u2013830. https:\/\/doi.org\/10.1111\/1567-1364.12091 (2013).","journal-title":"FEMS Yeast Res."},{"issue":"1","key":"66841_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-72400-4","volume":"14","author":"A \u015awi\u0119ci\u0142o","year":"2024","unstructured":"\u015awi\u0119ci\u0142o, A., Janu\u015b, E., Krzepi\u0142ko, A. & Skowro\u0144ska, M. The effect of DMSO on Saccharomyces cerevisiae yeast with different energy metabolism and antioxidant status. Sci. Rep.14(1), 21974. https:\/\/doi.org\/10.1038\/s41598-024-72400-4 (2024).","journal-title":"Sci. Rep."},{"key":"66841_CR40","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00294-016-0633-z","volume":"63","author":"C Bereketoglu","year":"2017","unstructured":"Bereketoglu, C., Arga, K. Y., Eraslan, S. & Mertoglu, B. Analysis of transcriptional profiles of Saccharomyces cerevisiae exposed to bisphenol A. Curr. Genet.63, 253\u2013274. https:\/\/doi.org\/10.1007\/s00294-016-0633-z (2017).","journal-title":"Curr. Genet."},{"issue":"3","key":"66841_CR41","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1002\/tox.24010","volume":"39","author":"C Bereketoglu","year":"2024","unstructured":"Bereketoglu, C., H\u00e4ggblom, I., Turanl\u0131, B. & Pradhan, A. Comparative analysis of diisononyl phthalate and di (isononyl) cyclohexane-1, 2 dicarboxylate plasticizers in regulation of lipid metabolism in 3T3\u2010L1 cells. Environ. Toxicol.39 (3), 1245\u20131257. https:\/\/doi.org\/10.1002\/tox.24010 (2024).","journal-title":"Environ. Toxicol."},{"key":"66841_CR42","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.procbio.2021.02.016","volume":"110","author":"EJ Yun","year":"2021","unstructured":"Yun, E. J. et al. Fast filtration with a vacuum manifold system as a rapid and robust metabolome sampling method for Saccharomyces cerevisiae. Process Biochem.110, 195\u2013200. https:\/\/doi.org\/10.1016\/j.procbio.2021.02.016 (2021).","journal-title":"Process Biochem."},{"issue":"8","key":"66841_CR43","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/S1044-0305(99)00097-5","volume":"10","author":"SE Stein","year":"1999","unstructured":"Stein, S. E. An integrated method for spectrum extraction and compound identification from gas chromatography\/mass spectrometry data. J. Am. Soc. Mass. Spectrom.10 (8), 770\u2013781. https:\/\/doi.org\/10.1016\/S1044-0305(99)00097-5 (1999).","journal-title":"J. Am. Soc. Mass. Spectrom."},{"issue":"8","key":"66841_CR44","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1093\/bioinformatics\/bti236","volume":"21","author":"J Kopka","year":"2005","unstructured":"Kopka, J. et al. GMD@CSB.DB: the Golm metabolome database. Bioinformatics21 (8), 1635\u20131638. https:\/\/doi.org\/10.1093\/bioinformatics\/bti236 (2005).","journal-title":"Bioinformatics"},{"issue":"3","key":"66841_CR45","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1021\/ac061539h","volume":"79","author":"MP Styczynski","year":"2007","unstructured":"Styczynski, M. P. et al. Systematic identification of conserved metabolites in GC\/MS data for metabolomics and biomarker discovery. Anal. Chem.79 (3), 966\u2013973. https:\/\/doi.org\/10.1021\/ac061539h (2007).","journal-title":"Anal. Chem."},{"key":"66841_CR46","unstructured":"R Core Team. R: A language and environment for statistical computing (Version 4.1.0). R Foundation for Statistical Computing (Vienna, 2002). https:\/\/www.R-project.org\/"},{"issue":"11","key":"66841_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005752","volume":"13","author":"F Rohart","year":"2017","unstructured":"Rohart, F., Gautier, B., Singh, A. & L\u00ea Cao, K. A. mixOmics: An R package for \u2018omics feature selection and multiple data integration. PLoS Comput. Biol.13(11), 1005752. https:\/\/doi.org\/10.1371\/journal.pcbi.1005752 (2017).","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"66841_CR48","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1093\/nar\/gkad408","volume":"52","author":"Z Pang","year":"2024","unstructured":"Pang, Z. et al. MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation. Nucleic Acids Res.52 (1), 398\u2013406. https:\/\/doi.org\/10.1093\/nar\/gkad408 (2024).","journal-title":"Nucleic Acids Res."},{"issue":"15","key":"66841_CR49","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics30(15), 2114\u20132020. https:\/\/doi.org\/10.1093\/bioinformatics\/btu170 (2014).","journal-title":"Bioinformatics"},{"key":"66841_CR50","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/nmeth.4324","volume":"14","author":"H Pimentel","year":"2017","unstructured":"Pimentel, H., Bray, N. L., Puente, S., Melsted, P. & Pachter, L. Differential analysis of RNA-seq incorporating quantification uncertainty. Nat. Methods. 14, 687\u2013690. https:\/\/doi.org\/10.1038\/nmeth.4324 (2017).","journal-title":"Nat. Methods"},{"key":"66841_CR51","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol.15, 550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8 (2014).","journal-title":"Genome Biol."},{"issue":"1","key":"66841_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun.10(1), 1523. https:\/\/doi.org\/10.1038\/s41467-019-09234-6 (2019).","journal-title":"Nat. Commun."},{"issue":"4","key":"66841_CR53","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u2206\u2206CT method. Methods25 (4), 402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262 (2001).","journal-title":"Methods"},{"key":"66841_CR54","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fgene.2012.00063","volume":"19","author":"SC dos Santos","year":"2012","unstructured":"dos Santos, S. C., Teixeira, M. C., Cabrito, T. R. & S\u00e1-Correia, I. Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology. Front. Genet.19, 63. https:\/\/doi.org\/10.3389\/fgene.2012.00063 (2012).","journal-title":"Front. Genet."},{"key":"66841_CR55","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.30919\/es8d955","volume":"26","author":"A Kadekar","year":"2023","unstructured":"Kadekar, A., Naik, N., Samrot, A. V., Bhat, P. & Salmataj, S. A. An Overview of Yeast-Based Toxicology: Unraveling Molecular Mechanisms, Advancing Drug Discovery, and Addressing Translational Complexities. Eng. Sci.26, 1063. https:\/\/doi.org\/10.30919\/es8d955 (2023).","journal-title":"Eng. Sci."},{"issue":"3","key":"66841_CR56","first-page":"413","volume":"16","author":"A Krzepi\u0142ko","year":"2007","unstructured":"Krzepi\u0142ko, A. & \u015awi\u0119ci\u0142o, A. The Influence of Selected Pyrethroid on the Growth and Number of \u03c1-Mutants in Saccharomyces Cerevisiae Yeast. Pol. J. Environ. Stud.16 (3), 413\u2013418 (2007).","journal-title":"Pol. J. Environ. Stud."},{"issue":"7","key":"66841_CR57","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/1567-1364.12125","volume":"14","author":"M Kwolek-Mirek","year":"2014","unstructured":"Kwolek-Mirek, M. & Zadrag-Tecza, R. Comparison of methods used for assessing the viability and vitality of yeast cells. FEMS Yeast Res.14 (7), 1068\u20131079. https:\/\/doi.org\/10.1111\/1567-1364.12125 (2014).","journal-title":"FEMS Yeast Res."},{"issue":"1","key":"66841_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/tox.23852","volume":"39","author":"H Wu","year":"2024","unstructured":"Wu, H. et al. Effect of chronic deltamethrin exposure on brain transcriptome and metabolome of juvenile crucian carp. Environ. Toxicol.39 (1), 1\u201312. https:\/\/doi.org\/10.1002\/tox.23852 (2024).","journal-title":"Environ. Toxicol."},{"issue":"1","key":"66841_CR59","doi-asserted-by":"publisher","first-page":"15674","DOI":"10.1038\/srep15674","volume":"5","author":"R Ch","year":"2015","unstructured":"Ch, R., Singh, A. K., Pandey, P., Saxena, P. N. & Reddy Mudiam, M. K. Identifying the metabolic perturbations in earthworm induced by cypermethrin using gas chromatography-mass spectrometry based metabolomics. Sci. Rep.5(1), 15674. https:\/\/doi.org\/10.1038\/srep15674 (2015).","journal-title":"Sci. Rep."},{"issue":"3","key":"66841_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15030143","volume":"15","author":"W Zhang","year":"2025","unstructured":"Zhang, W., Lei, W., Bo, T., Xu, J. & Wang, W. Metabolomics\u2019 change under \u03b2-cypermethrin stress and detoxification role of CYP5011A1 in Tetrahymena thermophila. Metabolites15(3), 143. https:\/\/doi.org\/10.3390\/metabo15030143 (2025a).","journal-title":"Metabolites"},{"key":"66841_CR61","doi-asserted-by":"publisher","unstructured":"Gibney, P. A., Schieler, A., Chen, J. C., Rabinowitz, J. D. & Bolstein, D. Characterization of the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter. Proceedings of the National Academy of Sciences 112(19):6116\u20136121. https:\/\/doi.org\/10.1073\/pnas.1505388112\u00a0(2015).","DOI":"10.1073\/pnas.1505388112"},{"key":"66841_CR62","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11306-011-0356-1","volume":"8","author":"E Szyma\u0144ska","year":"2012","unstructured":"Szyma\u0144ska, E., Saccenti, E., Smilde, A. K. & Westerhuis, J. A. Double-check: validation of diagnostic statistics for PLS-DA models in metabolomics studies. Metabolomics8, 3\u201316. https:\/\/doi.org\/10.1007\/s11306-011-0356-1 (2012).","journal-title":"Metabolomics"},{"key":"66841_CR63","doi-asserted-by":"publisher","first-page":"116379","DOI":"10.1016\/j.foodres.2024.116379","volume":"168","author":"X Zhang","year":"2025","unstructured":"Zhang, X. et al. Integrated analysis of characteristic volatile flavor formation mechanisms in probiotic co-fermented cheese by untargeted metabolomics and sensory predictive modeling. Food Res. Int.168, 116379. https:\/\/doi.org\/10.1016\/j.foodres.2024.116379 (2025b).","journal-title":"Food Res. Int."},{"issue":"8","key":"66841_CR64","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.4014\/jmb.2405.05020","volume":"34","author":"S Choi","year":"2024","unstructured":"Choi, S., Kronstad, J. W. & Jung, W. H. Siderophore biosynthesis and transport systems in model and pathogenic fungi. J. Microbiol. biotechnology. 34 (8), 1551. https:\/\/doi.org\/10.4014\/jmb.2405.05020 (2024).","journal-title":"J. Microbiol. biotechnology"},{"key":"66841_CR65","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-3-030-74180-8_3","volume-title":"Amino Acids in Nutrition and Health","author":"Y Yang","year":"2021","unstructured":"Yang, Y., He, Y., Jin, Y., Wu, G. & Wu, Z. Amino acids in endoplasmic reticulum stress and redox signaling. In Amino Acids in Nutrition and Health 35\u201349 (Springer International Publishing, 2021)."},{"issue":"10","key":"66841_CR66","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1271\/bbb.60298","volume":"70","author":"S Fukada","year":"2016","unstructured":"Fukada, S., Shimada, Y., Morita, T. & Sugiyama, K. Suppression of methionine-induced hyperhomocysteinemia by glycine and serine in rats. Biosci. Biotechnol. Biochem.70 (10), 2403\u20132409. https:\/\/doi.org\/10.1271\/bbb.60298 (2016).","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"3","key":"66841_CR67","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s00726-018-2690-5","volume":"51","author":"X Fan","year":"2019","unstructured":"Fan, X. et al. Glycine supplementation to breast-fed piglets attenuates post-weaning jejunal epithelial apoptosis: A functional role of CHOP signaling. Amino Acids. 51 (3), 463\u2013473. https:\/\/doi.org\/10.1007\/s00726-018-2690-5 (2019).","journal-title":"Amino Acids"},{"key":"66841_CR68","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.tiv.2016.04.006","volume":"34","author":"WC Sim","year":"2016","unstructured":"Sim, W. C. et al. Inhibition of homocysteine-induced endoplasmic reticulum stress and endothelial cell damage by l-serine and glycine. Toxicol. In Vitro. 34, 138\u2013145. https:\/\/doi.org\/10.1016\/j.tiv.2016.04.006 (2016).","journal-title":"Toxicol. In Vitro"},{"issue":"5","key":"66841_CR69","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1021\/acs.jproteome.4c00779","volume":"24","author":"L Gao","year":"2025","unstructured":"Gao, L. et al. Lipidomics atlas tracks alterations associated with deltamethrin-induced developmental neurotoxicity in embryonic zebrafish. J. Proteome Res.24 (5), 2280\u20132290. https:\/\/doi.org\/10.1021\/acs.jproteome.4c00779 (2025).","journal-title":"J. Proteome Res."},{"key":"66841_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132082","volume":"459","author":"C Jia","year":"2023","unstructured":"Jia, C. et al. Lipid metabolic links between serum pyrethroid levels and the risk of incident type 2 diabetes: A mediation study in the prospective design. J. Hazard. Mater.459, 132082. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.132082 (2023).","journal-title":"J. Hazard. Mater."},{"key":"66841_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113553","volume":"237","author":"Y Li","year":"2022","unstructured":"Li, Y. et al. Differential metabolome responses to deltamethrin between resistant and susceptible Anopheles sinensis. Ecotoxicol. Environ. Saf.237, 113553. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113553 (2022).","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"66841_CR72","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201909165","volume":"219","author":"N Ho","year":"2020","unstructured":"Ho, N. et al. Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress. J. Cell Biol.219(7), 201909165. https:\/\/doi.org\/10.1083\/jcb.201909165 (2020).","journal-title":"J. Cell Biol."},{"issue":"19","key":"66841_CR73","doi-asserted-by":"publisher","first-page":"3222","DOI":"10.1242\/jcs.201715","volume":"130","author":"N Cohen","year":"2017","unstructured":"Cohen, N. et al. Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling. J. Cell Sci.130(19), 3222\u20133233. https:\/\/doi.org\/10.1242\/jcs.201715 (2017).","journal-title":"J. Cell Sci."},{"issue":"4","key":"66841_CR74","doi-asserted-by":"publisher","first-page":"00118","DOI":"10.1042\/BSR20140104","volume":"34","author":"H Wu","year":"2014","unstructured":"Wu, H., Ng, B. S. & Thibault, G. Endoplasmic reticulum stress response in yeast and humans. Biosci. Rep.34 (4), 00118. https:\/\/doi.org\/10.1042\/BSR20140104 (2014).","journal-title":"Biosci. Rep."},{"key":"66841_CR75","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64860","volume":"10","author":"A Kaya","year":"2021","unstructured":"Kaya, A. et al. Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast. Elife10, 64860. https:\/\/doi.org\/10.7554\/eLife.64860 (2021).","journal-title":"Elife"},{"issue":"4","key":"66841_CR76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000921","volume":"6","author":"M Matecic","year":"2010","unstructured":"Matecic, M. et al. A microarray-based genetic screen for yeast chronological aging factors. PLoS Genet.6(4), 1000921. https:\/\/doi.org\/10.1371\/journal.pgen.1000921 (2010).","journal-title":"PLoS Genet."},{"issue":"6","key":"66841_CR77","doi-asserted-by":"publisher","first-page":"182","DOI":"10.15698\/mic2015.06.205","volume":"2","author":"A Serra-Cardona","year":"2015","unstructured":"Serra-Cardona, A., Canadell, D. & Ari\u00f1o, J. Coordinate responses to alkaline pH stress in budding yeast. Microb. Cell.2 (6), 182. https:\/\/doi.org\/10.15698\/mic2015.06.205 (2015).","journal-title":"Microb. Cell."},{"issue":"5\u20137","key":"66841_CR78","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1080\/02772248.2018.1545908","volume":"100","author":"AS Abbas","year":"2018","unstructured":"Abbas, A. S., Manzoor, F., Shahzad, K., Sheikh, N. & Tanveer, M. Deltamethrin-induced alteration of iron metabolism in Wistar rats. Toxicol. Environ. Chem.100 (5\u20137), 601\u2013606. https:\/\/doi.org\/10.1080\/02772248.2018.1545908 (2018).","journal-title":"Toxicol. Environ. Chem."},{"issue":"1","key":"66841_CR79","doi-asserted-by":"publisher","first-page":"319","DOI":"10.21608\/BVMJ.2018.39584","volume":"35","author":"HA Abdel-Maksoud","year":"2018","unstructured":"Abdel-Maksoud, H. A., Mahfouz, M. K., Soliman, M. I., Abbass, M. & El-Badry, M. A. Biochemical effects of deltamethrin on inflammatory markers and iron homeostasis. Benha Vet. Med. J.35(1), 319\u2013326. https:\/\/doi.org\/10.21608\/BVMJ.2018.39584 (2018).","journal-title":"Benha Vet. Med. J."},{"key":"66841_CR80","doi-asserted-by":"publisher","first-page":"1560192","DOI":"10.3389\/ftox.2025.1560192","volume":"7","author":"B Li","year":"2025","unstructured":"Li, B. et al. Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus). Front. Toxicol.7, 1560192. https:\/\/doi.org\/10.3389\/ftox.2025.1560192 (2025).","journal-title":"Front. Toxicol."},{"issue":"208","key":"66841_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112791","volume":"15","author":"D Al Shaer","year":"2020","unstructured":"Al Shaer, D., Al Musaimi, O., de la Torre, B. G. & Albericio, F. Hydroxamate siderophores: Natural occurrence, chemical synthesis, iron binding affinity and use as Trojan horses against pathogens. Eur. J. Med. Chem.15(208), 112791. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112791 (2020).","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"66841_CR82","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.bbapap.2013.12.015","volume":"1844","author":"V Gudipati","year":"2014","unstructured":"Gudipati, V., Koch, K., Lienhart, W. D. & Macheroux, P. The flavoproteome of the yeast Saccharomyces cerevisiae. Biochim. et Biophys. Acta (BBA)-Proteins Proteom.1844 (3), 535\u2013544. https:\/\/doi.org\/10.1016\/j.bbapap.2013.12.015 (2014).","journal-title":"Biochim. et Biophys. Acta (BBA)-Proteins Proteom."},{"issue":"1","key":"66841_CR83","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1128\/ec.00354-07","volume":"7","author":"CC Philpott","year":"2008","unstructured":"Philpott, C. C. & Protchenko, O. Response to iron deprivation in Saccharomyces cerevisiae. Eukaryot. Cell7(1), 20\u201327. https:\/\/doi.org\/10.1128\/ec.00354-07 (2008).","journal-title":"Eukaryot. Cell"},{"issue":"1","key":"66841_CR84","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1042\/BJ20082399","volume":"15","author":"MY Jeong","year":"2009","unstructured":"Jeong, M. Y. et al. A novel function of Aft1 in regulating ferrioxamine B uptake: Aft1 modulates Arn3 ubiquitination in Saccharomyces cerevisiae. Biochem. J.15 (1), 181\u2013191. https:\/\/doi.org\/10.1042\/BJ20082399 (2009).","journal-title":"Biochem. J."},{"issue":"21","key":"66841_CR85","doi-asserted-by":"publisher","first-page":"16354","DOI":"10.1074\/jbc.M001456200","volume":"275","author":"CW Yun","year":"2000","unstructured":"Yun, C. W., Tiedeman, J. S., Moore, R. E. & Philpott, C. C. Siderophore-iron uptake in Saccharomyces cerevisiae: identification of ferrichrome and fusarinine transporters. J. Biol. Chem.275 (21), 16354\u201316359. https:\/\/doi.org\/10.1074\/jbc.M001456200 (2000).","journal-title":"J. Biol. Chem."},{"key":"66841_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-017-0013-z","volume":"3","author":"EJ Calabrese","year":"2017","unstructured":"Calabrese, E. J. & Mattson, M. P. How does hormesis impact biology, toxicology, and medicine?. NPJ Aging Mech. Dis.3, 13. https:\/\/doi.org\/10.1038\/s41514-017-0013-z (2017).","journal-title":"NPJ Aging Mech. Dis."},{"issue":"1","key":"66841_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2007.08.007","volume":"7","author":"MP Mattson","year":"2008","unstructured":"Mattson, M. P. Hormesis defined. Ageing Res. Rev.7 (1), 1\u20137. https:\/\/doi.org\/10.1016\/j.arr.2007.08.007 (2008).","journal-title":"Ageing Res. Rev."},{"issue":"11","key":"66841_CR88","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.1091\/mbc.e07-07-0680","volume":"19","author":"DB Berry","year":"2008","unstructured":"Berry, D. B. & Gasch, A. P. Stress-activated genomic expression changes serve a preparative role for impending stress in yeast. Mol. Biol. Cell19(11), 4580\u20137. https:\/\/doi.org\/10.1091\/mbc.e07-07-0680 (2008).","journal-title":"Mol. Biol. Cell"},{"issue":"12","key":"66841_CR89","doi-asserted-by":"publisher","first-page":"4241","DOI":"10.1091\/mbc.11.12.4241","volume":"11","author":"AP Gasch","year":"2000","unstructured":"Gasch, A. P. et al. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell.11 (12), 4241\u20134257. https:\/\/doi.org\/10.1091\/mbc.11.12.4241 (2000).","journal-title":"Mol. Biol. Cell."},{"key":"66841_CR90","doi-asserted-by":"publisher","first-page":"117729","DOI":"10.1016\/j.ecoenv.2023.117729","volume":"290","author":"S Huang","year":"2025","unstructured":"Huang, S. et al. Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis. Ecotoxicol. Environ. Saf.290, 117729. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.117729 (2025).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"66841_CR91","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1534\/genetics.166.4.1727","volume":"166","author":"F Abdel-Sater","year":"2004","unstructured":"Abdel-Sater, F., Iraqui, I., Urrestarazu, A. & Andr\u00e9, B. The external amino acid signaling pathway promotes activation of Stp1 and Uga35\/Dal81 transcription factor for induction of the AGP1 gene in Saccharomyces cerevisiae. Genetics166, 1727\u20131739. https:\/\/doi.org\/10.1534\/genetics.166.4.1727 (2004).","journal-title":"Genetics"},{"issue":"3","key":"66841_CR92","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.biocel.2007.08.12","volume":"40","author":"JM Garret","year":"2008","unstructured":"Garret, J. M. Amino acid transport through the Saccharomyces cerevisae Gap1 permease is controlled by the Ras\/cAMP pathway. Int. J. Biochenmistry Cell. Biology. 40 (3), 496\u2013502. https:\/\/doi.org\/10.1016\/j.biocel.2007.08.12 (2008).","journal-title":"Int. J. Biochenmistry Cell. Biology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-66841-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-66841-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-66841-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:45:20Z","timestamp":1788284720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-66841-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":92,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["66841"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-66841-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"27411"}}