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The present study investigated the potential effects of prophylactic carvedilol administration on behavioral seizure progression and associated pathological alterations during the PTZ-induced kindling model, with particular emphasis on inflammatory and signaling pathways implicated in epileptogenesis. Repeated PTZ administration resulted in progressive behavioral seizure development, impaired open-field performance, hippocampal neuronal damage, reduced GABA levels, increased oxidative stress and inflammatory mediators, and altered hippocampal NLRP3 expression, along with changes in PI3K-, AKT-, and mTOR-related protein expression. Carvedilol treatment was associated with lower behavioral seizure scores, improved open-field performance, preservation of hippocampal architecture, restoration of GABA content, and attenuation of oxidative and inflammatory alterations. Carvedilol treatment was also accompanied by reduced NLRP3 levels and changes in PI3K\/AKT\/mTOR-related measurements. 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