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This study utilized the phytochemical-rich extract as both a reducing and capping agent to produce quasi-spherical monoclinic CuO NPs with a diameter range of 35\u201387\u00a0nm. The resulting nanoparticles possessed a specific surface area of 4.5\u00a0m\u00b2 g\u207b\u00b9 with a mesoporous structure (pore volume of 0.018\u00a0cm\u00b3 g\u207b\u00b9), making them ideal candidates for drug loading applications. The CuO NPs were subsequently evaluated as nanocarriers for two clinically relevant platinum (II) chemotherapeutics: cisplatin and oxaliplatin. Characterization via Fourier-transform infrared spectroscopy confirmed successful coordination of platinum drug ligands to surface Cu\/O sites, while Brunauer\u2013Emmett\u2013Teller analysis demonstrated a substantial decrease in surface area upon drug loading, indicating effective pore occupancy. Cisplatin demonstrated an entrapment efficiency of 28% with a loading capacity of 56\u00a0mg\/g, while oxaliplatin exhibited comparable loading performance. The in vitro release profiles of cisplatin and oxaliplatin from mangrove-derived green CuO NPs show sustained release, with cisplatin reaching 70% cumulative release within 20\u00a0h and oxaliplatin approaching 80% in the same period. The release kinetics follow first-order behavior for cisplatin and Higuchi model for oxaliplatin, indicating that release is predominantly governed by diffusion from the mesoporous CuO matrix. These findings establish mangrove-derived CuO nanoparticles as a promising carrier for sustainable platinum-based drug delivery, offering an environmentally friendly approach and enhanced therapeutic potential while eliminating the need for toxic precursors and energy-intensive conventional synthesis methods.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-67347-7","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:36:03Z","timestamp":1788845763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green synthesis of CuO nanoparticles using mangrove leaves for targeted delivery of platinum (II) therapeutics"],"prefix":"10.1038","volume":"16","author":[{"given":"Shahdan","family":"Abdelkareem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly","family":"Reda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayyada M. 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