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However, the interaction landscape of \u03b2-catenin remains incompletely understood, highlighting a need for new experimental approaches for the exploration of \u03b2-catenin biology. Proximity proteomics, which facilitate the discovery of molecules vicinal to proteins-of-interest by mass spectrometry, have recently emerged as a powerful complementary tool for the study of protein\u2013protein interactions, but have not been applied to \u03b2-catenin so far. We investigated the interactome of \u03b2-catenin in model cell lines by proximity proteomics using expression constructs with the biotin ligases BioID and TurboID. Mass spectrometry analyses following biotin labelling identified numerous candidate interactors of \u03b2-catenin, including many that had not been observed in earlier studies using standard proteomics. Enrichment analyses suggested that proximity proteomics capture proteins associated with the known biological functions of \u03b2-catenin, including cell adhesion, Wnt\/\u03b2-catenin signalling, and transcription regulation. The molecular tools and data generated in this study provide new insights into \u03b2-catenin biology and highlight potential new regulators of \u03b2-catenin function that warrant further exploration.<\/jats:p>","DOI":"10.1038\/s41598-026-68008-5","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:43:42Z","timestamp":1788234222000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive proximity proteomics expand the known interactome of the oncoprotein \u03b2-catenin"],"prefix":"10.1038","volume":"16","author":[{"given":"Lavanya","family":"Moparthi\u00a0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"68008_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/00001622-199801000-00013","volume":"10","author":"LC Bullions","year":"1998","unstructured":"Bullions, L. 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