{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:14:16Z","timestamp":1788786856028,"version":"build-2803163510"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81941013"],"award-info":[{"award-number":["81941013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271022"],"award-info":[{"award-number":["32271022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32061143016"],"award-info":[{"award-number":["32061143016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1038\/s41684-024-01475-3","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T05:02:34Z","timestamp":1731387754000},"page":"376-386","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and evaluation of an autism pig model"],"prefix":"10.1038","volume":"53","author":[{"given":"Shuai","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benlei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-9887","authenticated-orcid":false,"given":"Yi-Hsuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-8460","authenticated-orcid":false,"given":"Xiao-Bing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"1475_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1001\/jama.2022.23661","volume":"329","author":"T Hirota","year":"2023","unstructured":"Hirota, T. & King, B. H. Autism spectrum disorder: a review. JAMA 329, 157\u2013168 (2023).","journal-title":"JAMA"},{"key":"1475_CR2","doi-asserted-by":"publisher","first-page":"e1.2803","DOI":"10.1111\/gbb.12803","volume":"21","author":"JL Silverman","year":"2022","unstructured":"Silverman, J. L. et al. Reconsidering animal models used to study autism spectrum disorder: current state and optimizing future. Genes Brain Behav 21, e1.2803 (2022).","journal-title":"Genes Brain Behav"},{"key":"1475_CR3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00401-017-1736-4","volume":"134","author":"M Varghese","year":"2017","unstructured":"Varghese, M. et al. Autism spectrum disorder: neuropathology and animal models. Acta Neuropathol. 134, 537\u2013566 (2017).","journal-title":"Acta Neuropathol."},{"key":"1475_CR4","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s12264-017-0115-4","volume":"33","author":"Z Qiu","year":"2017","unstructured":"Qiu, Z. & Li, X. Non-human primate models for brain disorders\u2014towards genetic manipulations via innovative technology. Neurosci. Bull. 33, 247\u2013250 (2017).","journal-title":"Neurosci. Bull."},{"key":"1475_CR5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/7854_2010_112","volume":"7","author":"ET Gieling","year":"2011","unstructured":"Gieling, E. T., Schuurman, T., Nordquist, R. E. & van der Staay, F. J. The pig as a model animal for studying cognition and neurobehavioral disorders. Curr. Top. Behav. Neurosci. 7, 359\u2013383 (2011).","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"1475_CR6","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.3390\/biomedicines11082165","volume":"11","author":"AH Netzley","year":"2023","unstructured":"Netzley, A. H. & Pelled, G. The pig as a translational animal model for biobehavioral and neurotrauma research. Biomedicines 11, 2165 (2023).","journal-title":"Biomedicines"},{"key":"1475_CR7","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1177\/0300985811402846","volume":"49","author":"MM Swindle","year":"2012","unstructured":"Swindle, M. M., Makin, A., Herron, A. J., Clubb, F. J. Jr. & Frazier, K. S. Swine as models in biomedical research and toxicology testing. Vet. Pathol. 49, 344\u2013356 (2012).","journal-title":"Vet. Pathol."},{"key":"1475_CR8","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2013.2270","volume":"309","author":"J Christensen","year":"2013","unstructured":"Christensen, J. et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 309, 1696\u20131703 (2013).","journal-title":"JAMA"},{"key":"1475_CR9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.2174\/1570159X22666231003121513","volume":"22","author":"D Zarate-Lopez","year":"2024","unstructured":"Zarate-Lopez, D., Torres-Chavez, A. L., Galvez-Contreras, A. Y. & Gonzalez-Perez, O. Three decades of valproate: a current model for studying autism spectrum disorder. Curr. Neuropharmacol. 22, 260\u2013289 (2024).","journal-title":"Curr. Neuropharmacol."},{"key":"1475_CR10","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1001\/jamaneurol.2022.1269","volume":"79","author":"MH Bjork","year":"2022","unstructured":"Bjork, M. H. et al. Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability. JAMA Neurol. 79, 672\u2013681 (2022).","journal-title":"JAMA Neurol."},{"key":"1475_CR11","doi-asserted-by":"publisher","first-page":"5043","DOI":"10.2174\/1381612811319280003","volume":"19","author":"A Contestabile","year":"2013","unstructured":"Contestabile, A. & Sintoni, S. Histone acetylation in neurodevelopment. Curr. Pharm. Des. 19, 5043\u20135050 (2013).","journal-title":"Curr. Pharm. Des."},{"key":"1475_CR12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/bs.pmbts.2020.05.002","volume":"173","author":"R Saxena","year":"2020","unstructured":"Saxena, R., Babadi, M., Namvarhaghighi, H. & Roullet, F. I. Role of environmental factors and epigenetics in autism spectrum disorders. Prog. Mol. Biol. Transl. Sci. 173, 35\u201360 (2020).","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"1475_CR13","doi-asserted-by":"publisher","first-page":"641284","DOI":"10.3389\/fnins.2021.641284","volume":"15","author":"H Liu","year":"2021","unstructured":"Liu, H. et al. Valproic acid induces autism-like synaptic and behavioral deficits by disrupting histone acetylation of prefrontal cortex ALDH1A1 in rats. Front. Neurosci. 15, 641284 (2021).","journal-title":"Front. Neurosci."},{"key":"1475_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0608-1","volume":"9","author":"H Zhao","year":"2019","unstructured":"Zhao, H. et al. Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates. Transl. Psychiatry 9, 267 (2019).","journal-title":"Transl. Psychiatry"},{"key":"1475_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25487-6","volume":"12","author":"S Watanabe","year":"2021","unstructured":"Watanabe, S. et al. Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease. Nat. Commun. 12, 5388 (2021).","journal-title":"Nat. Commun."},{"key":"1475_CR16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.bbr.2015.06.006","volume":"292","author":"M Yasue","year":"2015","unstructured":"Yasue, M. et al. Indifference of marmosets with prenatal valproate exposure to third-party non-reciprocal interactions with otherwise avoided non-reciprocal individuals. Behav. Brain Res. 292, 323\u2013326 (2015).","journal-title":"Behav. Brain Res."},{"key":"1475_CR17","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1080\/17460441.2016.1223039","volume":"11","author":"VK Singh","year":"2016","unstructured":"Singh, V. K., Thrall, K. D. & Hauer-Jensen, M. Minipigs as models in drug discovery. Expert Opin. Drug Discov. 11, 1131\u20131134 (2016).","journal-title":"Expert Opin. Drug Discov."},{"key":"1475_CR18","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1098\/rspb.1967.0002","volume":"166","author":"JW Dickerson","year":"1967","unstructured":"Dickerson, J. W. & Dobbing, J. Prenatal and postnatal growth and development of the central nervous system of the pig. Proc. R Soc. Lond. B 166, 384\u2013395 (1967).","journal-title":"Proc. R Soc. Lond. B"},{"key":"1475_CR19","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1002\/cne.25280","volume":"530","author":"E Sobierajski","year":"2022","unstructured":"Sobierajski, E. et al. Development of microglia in fetal and postnatal neocortex of the pig, the European wild boar (Sus scrofa). J. Comp. Neurol. 530, 1341\u20131362 (2022).","journal-title":"J. Comp. Neurol."},{"key":"1475_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","volume":"28","author":"A Ornoy","year":"2009","unstructured":"Ornoy, A. Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reprod. Toxicol. 28, 1\u201310 (2009).","journal-title":"Reprod. Toxicol."},{"key":"1475_CR21","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.annepidem.2011.08.002","volume":"21","author":"MM Werler","year":"2011","unstructured":"Werler, M. M. et al. Use of antiepileptic medications in pregnancy in relation to risks of birth defects. Ann. Epidemiol. 21, 842\u2013850 (2011).","journal-title":"Ann. Epidemiol."},{"key":"1475_CR22","doi-asserted-by":"publisher","first-page":"981","DOI":"10.2176\/nmc.29.981","volume":"29","author":"C Hung","year":"1989","unstructured":"Hung, C., Nakagata, N. & Sato, K. The morphogenesis of hindbrain crowding associated with lumbosacral myeloschisis. Neurol. Med. Chir. 29, 981\u2013988 (1989).","journal-title":"Neurol. Med. Chir."},{"key":"1475_CR23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2","volume":"370","author":"PM Rodier","year":"1996","unstructured":"Rodier, P. M., Ingram, J. L., Tisdale, B., Nelson, S. & Romano, J. Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. J. Comp. Neurol. 370, 247\u2013261 (1996).","journal-title":"J. Comp. Neurol."},{"key":"1475_CR24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0890-6238(97)80001-U","volume":"11","author":"PM Rodier","year":"1997","unstructured":"Rodier, P. M., Ingram, J. L., Tisdale, B. & Croog, V. J. Linking etiologies in humans and animal models: studies of autism. Reprod. Toxicol. 11, 417\u2013422 (1997).","journal-title":"Reprod. Toxicol."},{"key":"1475_CR25","doi-asserted-by":"crossref","unstructured":"Mikkelsen, L. F., Van Cruchten, S. & Makin, A. in Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays (eds F. J. Hock, Gralinski, M. R. & Pugsley, M. K.) 1\u201319 (Springer, 2022).","DOI":"10.1007\/978-3-030-73317-9_80-1"},{"key":"1475_CR26","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s10803-010-0981-3","volume":"40","author":"KA Fournier","year":"2010","unstructured":"Fournier, K. A., Hass, C. J., Naik, S. K., Lodha, N. & Cauraugh, J. H. Motor coordination in autism spectrum disorders: a synthesis and meta-analysis. J. Autism Dev. Disord. 40, 1227\u20131240 (2010).","journal-title":"J. Autism Dev. Disord."},{"key":"1475_CR27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/dmcn.15674","volume":"66","author":"HL Miller","year":"2024","unstructured":"Miller, H. L. et al. Motor problems in autism: co-occurrence or feature? Dev. Med. Child Neurol. 66, 16\u201322 (2024).","journal-title":"Dev. Med. Child Neurol."},{"key":"1475_CR28","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/aur.1408","volume":"7","author":"M McPhillips","year":"2014","unstructured":"McPhillips, M., Finlay, J., Bejerot, S. & Hanley, M. Motor deficits in children with autism spectrum disorder: a cross-syndrome study. Autism Res. 7, 664\u2013676 (2014).","journal-title":"Autism Res."},{"key":"1475_CR29","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1002\/aur.2302","volume":"13","author":"L Gong","year":"2020","unstructured":"Gong, L. et al. Abnormal gait patterns in autism spectrum disorder and their correlations with social impairments. Autism Res. 13, 1215\u20131226 (2020).","journal-title":"Autism Res."},{"key":"1475_CR30","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1002\/aur.2930","volume":"16","author":"LB Quetsch","year":"2023","unstructured":"Quetsch, L. B. et al. Understanding aggression in autism across childhood: comparisons with a non-autistic sample. Autism Res. 16, 1185\u20131198 (2023).","journal-title":"Autism Res."},{"key":"1475_CR31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41572-019-0138-4","volume":"6","author":"C Lord","year":"2020","unstructured":"Lord, C. et al. Autism spectrum disorder. Nat. Rev. Dis. Primers 6, 5 (2020).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"1475_CR32","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ydbio.2018.08.002","volume":"442","author":"HR Willsey","year":"2018","unstructured":"Willsey, H. R. et al. Katanin-like protein Katnal2 is required for ciliogenesis and brain development in Xenopus embryos. Dev. Biol. 442, 276\u2013287 (2018).","journal-title":"Dev. Biol."},{"key":"1475_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00787-009-0043-6","volume":"19","author":"CM Freitag","year":"2010","unstructured":"Freitag, C. M. et al. Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder. Eur. Child Adolesc. Psychiatry 19, 67\u201374 (2010).","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"1475_CR34","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature13908","volume":"515","author":"I Iossifov","year":"2014","unstructured":"Iossifov, I. et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature 515, 216\u2013221 (2014).","journal-title":"Nature"},{"key":"1475_CR35","doi-asserted-by":"publisher","first-page":"243","DOI":"10.4103\/ijp.IJP_183_17","volume":"49","author":"RK Ruhela","year":"2017","unstructured":"Ruhela, R. K., Sarma, P., Soni, S., Prakash, A. & Medhi, B. Congenital malformation and autism spectrum disorder: Insight from a rat model of autism spectrum disorder. Indian J. Pharmacol. 49, 243\u2013249 (2017).","journal-title":"Indian J. Pharmacol."},{"key":"1475_CR36","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/aur.2443","volume":"14","author":"JAG Lum","year":"2020","unstructured":"Lum, J. A. G. et al. Meta-analysis reveals gait anomalies in autism. Autism Res. 14, 733\u2013747 (2020).","journal-title":"Autism Res."},{"key":"1475_CR37","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/2051-5960-2-28","volume":"2","author":"J Wegiel","year":"2014","unstructured":"Wegiel, J. et al. Brain-region-specific alterations of the trajectories of neuronal volume growth throughout the lifespan in autism. Acta Neuropathol. Commun. 2, 28 (2014).","journal-title":"Acta Neuropathol. Commun."},{"key":"1475_CR38","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s40478-015-0241-z","volume":"3","author":"J Wegiel","year":"2015","unstructured":"Wegiel, J. et al. Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications. Acta Neuropathol. Commun. 3, 63 (2015).","journal-title":"Acta Neuropathol. Commun."},{"key":"1475_CR39","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nn.2741","volume":"14","author":"P Penzes","year":"2011","unstructured":"Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J. E. & Woolfrey, K. M. Dendritic spine pathology in neuropsychiatric disorders. Nat. Neurosci. 14, 285\u2013293 (2011).","journal-title":"Nat. Neurosci."},{"key":"1475_CR40","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3389\/fncel.2017.00359","volume":"11","author":"J Gilbert","year":"2017","unstructured":"Gilbert, J. & Man, H. Y. Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity. Front Cell Neurosci. 11, 359 (2017).","journal-title":"Front Cell Neurosci."},{"key":"1475_CR41","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/dneu.22417","volume":"77","author":"V Martinez-Cerdeno","year":"2017","unstructured":"Martinez-Cerdeno, V. Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models. Dev. Neurobiol. 77, 393\u2013404 (2017).","journal-title":"Dev. Neurobiol."},{"key":"1475_CR42","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000523995","volume":"44","author":"KK Chand","year":"2022","unstructured":"Chand, K. K., Pannek, K., Colditz, P. B. & Wixey, J. A. Brain outcomes in runted piglets: a translational model of fetal growth restriction. Dev. Neurosci. 44, 194\u2013204 (2022).","journal-title":"Dev. Neurosci."},{"key":"1475_CR43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.31083\/j.jin.2021.01.332","volume":"20","author":"BR Southey","year":"2021","unstructured":"Southey, B. R. et al. Effects of maternal immune activation in porcine transcript isoforms of neuropeptide and receptor genes. J. Integr. Neurosci. 20, 21\u201331 (2021).","journal-title":"J. Integr. Neurosci."},{"key":"1475_CR44","doi-asserted-by":"publisher","first-page":"1031812","DOI":"10.3389\/fcell.2022.1031812","volume":"10","author":"J Wei","year":"2022","unstructured":"Wei, J., Zhang, W., Li, J., Jin, Y. & Qiu, Z. Application of the transgenic pig model in biomedical research: a review. Front. Cell Dev. Biol. 10, 1031812 (2022).","journal-title":"Front. Cell Dev. Biol."},{"key":"1475_CR45","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1159\/000478725","volume":"39","author":"D Paval","year":"2017","unstructured":"Paval, D. A dopamine hypothesis of autism spectrum disorder. Dev. Neurosci. 39, 355\u2013360 (2017).","journal-title":"Dev. Neurosci."},{"key":"1475_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.irn.2023.08.009","volume":"173","author":"D Paval","year":"2023","unstructured":"Paval, D. The dopamine hypothesis of autism spectrum disorder: a comprehensive analysis of the evidence. Int. Rev. Neurobiol. 173, 1\u201342 (2023).","journal-title":"Int. Rev. Neurobiol."},{"key":"1475_CR47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1001\/archgenpsychiatry.2009.137","volume":"67","author":"K Nakamura","year":"2010","unstructured":"Nakamura, K. et al. Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. Arch. Gen. Psychiatry 67, 59\u201368 (2010).","journal-title":"Arch. Gen. Psychiatry"},{"key":"1475_CR48","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/aur.55","volume":"1","author":"BM Anderson","year":"2008","unstructured":"Anderson, B. M. et al. Examination of association to autism of common genetic variationin genes related to dopamine. Autism Res. 1, 364\u2013369 (2008).","journal-title":"Autism Res."},{"key":"1475_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.90","volume":"4","author":"E Bowton","year":"2014","unstructured":"Bowton, E. et al. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl. Psychiatry 4, e464 (2014).","journal-title":"Transl. Psychiatry"},{"key":"1475_CR50","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/mp.2013.102","volume":"18","author":"PJ Hamilton","year":"2013","unstructured":"Hamilton, P. J. et al. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Mol. Psychiatry 18, 1315\u20131323 (2013).","journal-title":"Mol. Psychiatry"},{"key":"1475_CR51","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1172\/JCI127411","volume":"129","author":"GE DiCarlo","year":"2019","unstructured":"DiCarlo, G. E. et al. Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. J. Clin. Invest. 129, 3407\u20133419 (2019).","journal-title":"J. Clin. Invest."},{"key":"1475_CR52","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1469-8749.1997.tb07437.x","volume":"39","author":"E Fernell","year":"1997","unstructured":"Fernell, E. et al. Possible effects of tetrahydrobiopterin treatment in six children with autism\u2013clinical and positron emission tomography data: a pilot study. Dev. Med. Child Neurol. 39, 313\u2013318 (1997).","journal-title":"Dev. Med. Child Neurol."},{"key":"1475_CR53","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1176\/ajp.141.10.1195","volume":"141","author":"LT Anderson","year":"1984","unstructured":"Anderson, L. T. et al. Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. Am. J. Psychiatry 141, 1195\u20131202 (1984).","journal-title":"Am. J. Psychiatry"},{"key":"1475_CR54","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/BF02211843","volume":"19","author":"LT Anderson","year":"1989","unstructured":"Anderson, L. T. et al. The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children. J. Autism Dev. Disord. 19, 227\u2013239 (1989).","journal-title":"J. Autism Dev. Disord."},{"key":"1475_CR55","doi-asserted-by":"publisher","first-page":"700968","DOI":"10.3389\/fncir.2021.700968","volume":"15","author":"P Kosillo","year":"2021","unstructured":"Kosillo, P. & Bateup, H. S. Dopaminergic dysregulation in syndromic autism spectrum disorders: insights from genetic mouse models. Front. Neural Circuits 15, 700968 (2021).","journal-title":"Front. Neural Circuits"},{"key":"1475_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01170-0","volume":"11","author":"NR Zurcher","year":"2021","unstructured":"Zurcher, N. R. et al. A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism. Transl. Psychiatry 11, 33 (2021).","journal-title":"Transl. Psychiatry"},{"key":"1475_CR57","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1038\/s41380-022-01464-3","volume":"27","author":"C Murayama","year":"2022","unstructured":"Murayama, C. et al. Extrastriatal dopamine D2\/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study. Mol. Psychiatry 27, 2106\u20132113 (2022).","journal-title":"Mol. Psychiatry"},{"key":"1475_CR58","doi-asserted-by":"publisher","first-page":"779745","DOI":"10.3389\/fvets.2022.779745","volume":"9","author":"Q Zhu","year":"2022","unstructured":"Zhu, Q. et al. Probiotics and synbiotics addition to Bama mini-pigs\u2019 diet improve carcass traits and meat quality by altering plasma metabolites and related gene expression of offspring. Front. Vet. Sci. 9, 779745 (2022).","journal-title":"Front. Vet. Sci."},{"key":"1475_CR59","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1177\/0023677217752747","volume":"52","author":"GU Musigazi","year":"2018","unstructured":"Musigazi, G. U., De Vleeschauwer, S., Sciot, R., Verbeken, E. & Depreitere, B. Brain perfusion fixation in male pigs using a safer closed system. Lab Anim. 52, 413\u2013417 (2018).","journal-title":"Lab Anim."},{"key":"1475_CR60","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1017\/S1751731109004649","volume":"3","author":"P Sauleau","year":"2009","unstructured":"Sauleau, P., Lapouble, E., Val-Laillet, D. & Malbert, C. H. The pig model in brain imaging and neurosurgery. Animal 3, 1138\u20131151 (2009).","journal-title":"Animal"},{"key":"1475_CR61","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.brainresbull.2006.06.009","volume":"70","author":"J Jelsing","year":"2006","unstructured":"Jelsing, J. et al. The prefrontal cortex in the Gottingen minipig brain defined by neural projection criteria and cytoarchitecture. Brain Res. Bull. 70, 322\u2013336 (2006).","journal-title":"Brain Res. Bull."},{"key":"1475_CR62","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1089\/brain.2019.0673","volume":"9","author":"G Simchick","year":"2019","unstructured":"Simchick, G. et al. Pig brains have homologous resting-state networks with human brains. Brain Connect. 9, 566\u2013579 (2019).","journal-title":"Brain Connect."}],"container-title":["Lab Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41684-024-01475-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41684-024-01475-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41684-024-01475-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T09:06:25Z","timestamp":1732611985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41684-024-01475-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1475"],"URL":"https:\/\/doi.org\/10.1038\/s41684-024-01475-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4356526\/v1","asserted-by":"object"}]},"ISSN":["0093-7355","1548-4475"],"issn-type":[{"value":"0093-7355","type":"print"},{"value":"1548-4475","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"1 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}