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However, large animal models for studying obesity-related meta-inflammation are lacking. Minipigs have great potential as models for human diseases, warranting investigation of the performance of the G\u00f6ttingen minipig as a model for obesity-associated meta-inflammation. Here, we fed 26 pigs a high-fat, fructose and cholesterol diet (HFFC) or a standard diet (SD) for 103\u2009days, resulting in the HFFC group having a 45% higher body weight and 16% larger abdominal circumference by the end of the experiment. Meta-inflammation was shown in the HFFC group by elevated serum concentrations of the acute phase protein C-reactive protein for more than 60\u2009days during development of obesity, accompanied by increased numbers of circulating neutrophils and monocytes. Additional obesity-related abnormalities included dyslipidemia, hepatosteatosis and transcriptional changes to genes related to inflammation and metabolism in circulating leukocytes, liver and visceral adipose tissue. Notably, the transcription of genes related to lipid metabolism, namely ATP-binding cassette subfamily A member 1 (\n                    <jats:italic>ABCA1<\/jats:italic>\n                    ) and ATP-binding cassette subfamily G member 1 (\n                    <jats:italic>ABCG1<\/jats:italic>\n                    ), was elevated in liver, visceral adipose tissue and circulating leukocytes (\n                    <jats:italic>ABCA1<\/jats:italic>\n                    only) in the HFFC group compared with the SD group. The development of obesity was accompanied by endotoxemia, indicated by a 2.5-fold increase in serum lipopolysaccharide concentration in the HFFC group compared with the SD group, suggesting increased intestinal permeability. In conclusion, the described G\u00f6ttingen minipig model convincingly links diet-induced obesity, meta-inflammation and endotoxemia, achieved by short-duration HFFC dieting.\n                  <\/jats:p>","DOI":"10.1038\/s41684-025-01588-3","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:03:45Z","timestamp":1754471025000},"page":"238-246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Meta-inflammation and endotoxemia in a highly translational porcine model of diet-induced obesity"],"prefix":"10.1038","volume":"54","author":[{"given":"Sofie M. 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