{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:33:31Z","timestamp":1794270811207,"version":"4.9.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-003A"],"award-info":[{"award-number":["TJYXZDXK-3-003A"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0502200"],"award-info":[{"award-number":["2023ZD0502200"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403430"],"award-info":[{"award-number":["82403430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Program Joint Fund of Liaoning Province","award":["2023-BSBA-207"],"award-info":[{"award-number":["2023-BSBA-207"]}]},{"name":"Oncology Project of Liaoning Cancer Hospital","award":["2024-ZLKF-09"],"award-info":[{"award-number":["2024-ZLKF-09"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Precis. Onc."],"DOI":"10.1038\/s41698-026-01338-9","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T14:25:38Z","timestamp":1771856738000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["COL3A1high cancer-associated fibroblasts orchestrate metabolic and immune microenvironments to confer chemoresistance in breast cancer"],"prefix":"10.1038","volume":"10","author":[{"given":"Peicheng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Xiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"1338_CR1","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.annonc.2025.01.014","volume":"36","author":"C Santucci","year":"2025","unstructured":"Santucci, C. et al. European cancer mortality predictions for the year 2025 with focus on breast cancer. Ann. Oncol. 36, 460\u2013468 (2025).","journal-title":"Ann. Oncol."},{"key":"1338_CR2","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1001\/jama.2018.19323","volume":"321","author":"AG Waks","year":"2019","unstructured":"Waks, A. G. & Winer, E. P. Breast cancer treatment: a review. Jama 321, 288\u2013300 (2019).","journal-title":"Jama"},{"key":"1338_CR3","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41572-019-0111-2","volume":"5","author":"N Harbeck","year":"2019","unstructured":"Harbeck, N. et al. Breast cancer. Nat. Rev. Dis. Prim. 5, 66 (2019).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"1338_CR4","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1101\/gad.279737.116","volume":"30","author":"P Gascard","year":"2016","unstructured":"Gascard, P. & Tlsty, T. D. Carcinoma-associated fibroblasts: orchestrating the composition of malignancy. Genes Dev. 30, 1002\u20131019 (2016).","journal-title":"Genes Dev."},{"key":"1338_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.12.003","volume":"343","author":"Z Liao","year":"2019","unstructured":"Liao, Z., Tan, Z. W., Zhu, P. & Tan, N. S. Cancer-associated fibroblasts in tumor microenvironment\u2014accomplices in tumor malignancy. Cell Immunol. 343, 103729 (2019).","journal-title":"Cell Immunol."},{"key":"1338_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01958-9","volume":"10","author":"C Chen","year":"2024","unstructured":"Chen, C. et al. Crosstalk between cancer-associated fibroblasts and regulated cell death in tumors: insights into apoptosis, autophagy, ferroptosis, and pyroptosis. Cell Death Discov. 10, 189 (2024).","journal-title":"Cell Death Discov."},{"key":"1338_CR7","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.20162024","volume":"214","author":"D \u00d6hlund","year":"2017","unstructured":"\u00d6hlund, D. et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J. Exp. Med. 214, 579\u2013596 (2017).","journal-title":"J. Exp. Med."},{"key":"1338_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.20517\/cdr.2022.72","volume":"6","author":"R Butti","year":"2023","unstructured":"Butti, R., Khaladkar, A., Bhardwaj, P. & Prakasam, G. Heterotypic signaling of cancer-associated fibroblasts in shaping the cancer cell drug resistance. Cancer Drug Resist. 6, 182\u2013204 (2023).","journal-title":"Cancer Drug Resist."},{"key":"1338_CR9","doi-asserted-by":"crossref","unstructured":"Chen, X., Chen, S. & Yu, D. Metabolic reprogramming of chemoresistant cancer cells and the potential significance of metabolic regulation in the reversal of cancer chemoresistance. Metabolites 10, 289 (2020).","DOI":"10.3390\/metabo10070289"},{"key":"1338_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.621070","volume":"8","author":"J Linares","year":"2020","unstructured":"Linares, J., Mar\u00edn-Jim\u00e9nez, J. A., Badia-Ramentol, J. & Calon, A. Determinants and functions of CAFs secretome during cancer progression and therapy. Front. Cell Dev. Biol. 8, 621070 (2020).","journal-title":"Front. Cell Dev. Biol."},{"key":"1338_CR11","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.21873\/anticanres.15594","volume":"42","author":"A Maeda","year":"2022","unstructured":"Maeda, A. et al. The interaction between cancer-associated fibroblasts and cancer cells enhances Bcl-xL and Mcl-1 in colorectal cancer. Anticancer Res. 42, 1277\u20131288 (2022).","journal-title":"Anticancer Res."},{"key":"1338_CR12","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.3892\/or.2012.2019","volume":"28","author":"L Bian","year":"2012","unstructured":"Bian, L., Sun, X., Jin, K. & He, Y. Oral cancer-associated fibroblasts inhibit heat-induced apoptosis in Tca8113 cells through upregulated expression of Bcl-2 through the Mig\/CXCR3 axis. Oncol. Rep. 28, 2063\u20132068 (2012).","journal-title":"Oncol. Rep."},{"key":"1338_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4320809","volume":"2022","author":"Y Li","year":"2022","unstructured":"Li, Y. et al. Cancer-Associated Fibroblasts Hinder Lung Squamous Cell Carcinoma Oxidative Stress-Induced Apoptosis via METTL3 Mediated m(6)A Methylation of COL10A1. Oxid. Med. Cell. Longev. 2022, 4320809 (2022).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"1338_CR14","doi-asserted-by":"publisher","first-page":"115390","DOI":"10.1016\/j.biopha.2023.115390","volume":"166","author":"Q Zhang","year":"2023","unstructured":"Zhang, Q., An, Z. Y., Jiang, W., Jin, W. L. & He, X. Y. Collagen code in tumor microenvironment: functions, molecular mechanisms, and therapeutic implications. Biomed. Pharmacother. 166, 115390 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"1338_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1605","volume":"14","author":"K Xu","year":"2024","unstructured":"Xu, K. et al. Distinct fibroblast subpopulations associated with bone, brain or intrapulmonary metastasis in advanced non-small-cell lung cancer. Clin. Transl. Med. 14, e1605 (2024).","journal-title":"Clin. Transl. Med."},{"key":"1338_CR16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2119168119","volume":"119","author":"MM LaRue","year":"2022","unstructured":"LaRue, M. M. et al. Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer. Proc. Natl. Acad. Sci. USA 119, e2119168119 (2022).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"1338_CR17","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.ccell.2022.06.011","volume":"40","author":"Y Chen","year":"2022","unstructured":"Chen, Y. et al. Oncogenic collagen I homotrimers from cancer cells bind to \u03b13\u03b21 integrin and impact tumor microbiome and immunity to promote pancreatic cancer. Cancer Cell 40, 818\u2013834.e9 (2022).","journal-title":"Cancer Cell"},{"key":"1338_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121422","volume":"283","author":"G Li","year":"2022","unstructured":"Li, G. et al. Collagen-targeted tumor-specific transepithelial penetration enhancer mediated intravesical chemoimmunotherapy for non-muscle-invasive bladder cancer. Biomaterials 283, 121422 (2022).","journal-title":"Biomaterials"},{"key":"1338_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03181-x","volume":"19","author":"JY Zhang","year":"2021","unstructured":"Zhang, J. Y. et al. Cancer-associated fibroblasts promote oral squamous cell carcinoma progression through LOX-mediated matrix stiffness. J. Transl. Med. 19, 513 (2021).","journal-title":"J. Transl. Med."},{"key":"1338_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1549797","volume":"15","author":"Y Zhou","year":"2025","unstructured":"Zhou, Y., Jiang, Z., Cao, L. & Yang, J. The role of various collagen types in tumor biology: a review. Front. Oncol. 15, 1549797 (2025).","journal-title":"Front. Oncol."},{"key":"1338_CR21","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1080\/21655979.2021.1949838","volume":"12","author":"H Zhang","year":"2021","unstructured":"Zhang, H. et al. Data mining-based study of collagen type III alpha 1 (COL3A1) prognostic value and immune exploration in pan-cancer. Bioengineered 12, 3634\u20133646 (2021).","journal-title":"Bioengineered"},{"key":"1338_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-024-00690-y","volume":"10","author":"DC Stewart","year":"2024","unstructured":"Stewart, D. C. et al. Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment. NPJ Breast Cancer 10, 86 (2024).","journal-title":"NPJ Breast Cancer"},{"key":"1338_CR23","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2024.2328382","volume":"25","author":"J Ren","year":"2024","unstructured":"Ren, J., Zhao, S. & Lai, J. Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells. Cancer Biol. Ther. 25, 2328382 (2024).","journal-title":"Cancer Biol. Ther."},{"key":"1338_CR24","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.ccell.2024.07.005","volume":"42","author":"Y Sun","year":"2024","unstructured":"Sun, Y. et al. Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers. Cancer Cell 42, 1386\u2013400.e8 (2024).","journal-title":"Cancer Cell"},{"key":"1338_CR25","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","volume":"18","author":"Y Chen","year":"2021","unstructured":"Chen, Y., McAndrews, K. M. & Kalluri, R. Clinical and therapeutic relevance of cancer-associated fibroblasts. Nat. Rev. Clin. Oncol. 18, 792\u2013804 (2021).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"1338_CR26","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/physrev.00048.2019","volume":"101","author":"G Biffi","year":"2021","unstructured":"Biffi, G. & Tuveson, D. A. Diversity and biology of cancer-associated fibroblasts. Physiol. Rev. 101, 147\u2013176 (2021).","journal-title":"Physiol. Rev."},{"key":"1338_CR27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ccell.2018.01.011","volume":"33","author":"A Costa","year":"2018","unstructured":"Costa, A. et al. Fibroblast heterogeneity and immunosuppressive environment in human breast cancer. Cancer Cell 33, 463\u201379.e10 (2018).","journal-title":"Cancer Cell"},{"key":"1338_CR28","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41588-024-01998-y","volume":"57","author":"Y Yan","year":"2025","unstructured":"Yan, Y. et al. Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer. Nat. Genet 57, 126\u2013139 (2025).","journal-title":"Nat. Genet"},{"key":"1338_CR29","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1158\/0008-5472.CAN-14-1616","volume":"75","author":"L Xiao","year":"2015","unstructured":"Xiao, L. et al. Tumor endothelial cells with distinct patterns of TGF\u03b2-driven endothelial-to-mesenchymal transition. Cancer Res. 75, 1244\u20131254 (2015).","journal-title":"Cancer Res."},{"key":"1338_CR30","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.ccell.2023.03.008","volume":"41","author":"A Mousset","year":"2023","unstructured":"Mousset, A. et al. Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-\u03b2 activation. Cancer Cell 41, 757\u201375.e10 (2023).","journal-title":"Cancer Cell"},{"key":"1338_CR31","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.1038\/onc.2010.215","volume":"29","author":"A Singh","year":"2010","unstructured":"Singh, A. & Settleman, J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29, 4741\u20134751 (2010).","journal-title":"Oncogene"},{"key":"1338_CR32","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.2174\/1389201024666230413084603","volume":"24","author":"S Saikia","year":"2023","unstructured":"Saikia, S. et al. Reprogramming of lipid metabolism in cancer: new insight into pathogenesis and therapeutic strategies. Curr. Pharm. Biotechnol. 24, 1847\u20131858 (2023).","journal-title":"Curr. Pharm. Biotechnol."},{"key":"1338_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02165-x","volume":"23","author":"S Liu","year":"2024","unstructured":"Liu, S. et al. Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer. Mol. Cancer 23, 261 (2024).","journal-title":"Mol. Cancer"},{"key":"1338_CR34","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12964-018-0221-6","volume":"16","author":"D Yang","year":"2018","unstructured":"Yang, D. et al. Utilization of adipocyte-derived lipids and enhanced intracellular trafficking of fatty acids contribute to breast cancer progression. Cell Commun. Signal. 16, 32 (2018).","journal-title":"Cell Commun. Signal."},{"key":"1338_CR35","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.immuni.2025.03.002","volume":"58","author":"L Yu","year":"2025","unstructured":"Yu, L. et al. Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer. Immunity 58, 909\u2013925.e7 (2025).","journal-title":"Immunity"},{"key":"1338_CR36","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1158\/1541-7786.MCR-11-0126","volume":"9","author":"UV Roongta","year":"2011","unstructured":"Roongta, U. V. et al. Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol. Cancer Res. 9, 1551\u20131561 (2011).","journal-title":"Mol. Cancer Res."},{"key":"1338_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2049-3002-1-3","volume":"1","author":"B Griffiths","year":"2013","unstructured":"Griffiths, B. et al. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab. 1, 3 (2013).","journal-title":"Cancer Metab."},{"key":"1338_CR38","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1158\/0008-5472.CAN-13-0382-T","volume":"73","author":"KJ Williams","year":"2013","unstructured":"Williams, K. J. et al. An essential requirement for the SCAP\/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res. 73, 2850\u20132862 (2013).","journal-title":"Cancer Res."},{"key":"1338_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.940239","volume":"12","author":"JI Lai","year":"2022","unstructured":"Lai, J. I., Chao, T. C., Liu, C. Y., Huang, C. C. & Tseng, L. M. A systemic review of taxanes and their side effects in metastatic breast cancer. Front. Oncol. 12, 940239 (2022).","journal-title":"Front. Oncol."},{"key":"1338_CR40","doi-asserted-by":"publisher","first-page":"331","DOI":"10.6004\/jnccn.2024.0035","volume":"22","author":"WJ Gradishar","year":"2024","unstructured":"Gradishar, W. J. et al. Breast cancer, version 3.2024, NCCN clinical practice guidelines in oncology. J. Natl. Compr. Cancer Netw. 22, 331\u2013357 (2024).","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"1338_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1427380","volume":"15","author":"T Huang","year":"2024","unstructured":"Huang, T. et al. Current perspectives and trends of CD39-CD73-eAdo\/A2aR research in tumor microenvironment: a bibliometric analysis. Front. Immunol. 15, 1427380 (2024).","journal-title":"Front. Immunol."},{"key":"1338_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02226-9","volume":"24","author":"L Luo","year":"2025","unstructured":"Luo, L. et al. Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4\/6 inhibition in patients with HR+\/HER2- metastatic breast cancer. Mol. Cancer 24, 48 (2025).","journal-title":"Mol. Cancer"},{"key":"1338_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115555","volume":"44","author":"Z Liu","year":"2025","unstructured":"Liu, Z. et al. THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis. Cell Rep. 44, 115555 (2025).","journal-title":"Cell Rep."},{"key":"1338_CR44","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","volume":"564","author":"L Zhang","year":"2018","unstructured":"Zhang, L. et al. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature 564, 268\u2013272 (2018).","journal-title":"Nature"},{"key":"1338_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 12, 1088 (2021).","journal-title":"Nat. Commun."},{"key":"1338_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41385-5","volume":"14","author":"KA Tran","year":"2023","unstructured":"Tran, K. A. et al. Performance of tumour microenvironment deconvolution methods in breast cancer using single-cell simulated bulk mixtures. Nat. Commun. 14, 5758 (2023).","journal-title":"Nat. Commun."},{"key":"1338_CR47","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41587-021-01091-3","volume":"40","author":"D Sun","year":"2022","unstructured":"Sun, D. et al. Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data. Nat. Biotechnol. 40, 527\u2013538 (2022).","journal-title":"Nat. Biotechnol."},{"key":"1338_CR48","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s43018-022-00356-3","volume":"3","author":"T Chu","year":"2022","unstructured":"Chu, T., Wang, Z., Pe\u2019er, D. & Danko, C. G. Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology. Nat. Cancer 3, 505\u2013517 (2022).","journal-title":"Nat. Cancer"},{"key":"1338_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-01001-x","volume":"13","author":"C Fustero-Torre","year":"2021","unstructured":"Fustero-Torre, C. et al. Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data. Genome Med. 13, 187 (2021).","journal-title":"Genome Med."},{"key":"1338_CR50","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","volume":"14","author":"S Aibar","year":"2017","unstructured":"Aibar, S. et al. SCENIC: single-cell regulatory network inference and clustering. Nat. Methods 14, 1083\u20131086 (2017).","journal-title":"Nat. Methods"},{"key":"1338_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36062-6","volume":"14","author":"B Ru","year":"2023","unstructured":"Ru, B., Huang, J., Zhang, Y., Aldape, K. & Jiang, P. Estimation of cell lineages in tumors from spatial transcriptomics data. Nat. Commun. 14, 568 (2023).","journal-title":"Nat. Commun."}],"container-title":["npj Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41698-026-01338-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41698-026-01338-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41698-026-01338-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:19:13Z","timestamp":1774984753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41698-026-01338-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1338"],"URL":"https:\/\/doi.org\/10.1038\/s41698-026-01338-9","relation":{},"ISSN":["2397-768X"],"issn-type":[{"value":"2397-768X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"29 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"139"}}