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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Currently, knowledge of changes in cardiovascular function across the menstrual cycle and how these changes may inform upon underlying health is limited. Utilizing wrist-worn biometric data we developed a novel measure to quantify and investigate the cardiovascular fluctuation (i.e. cardiovascular amplitude) within resting heart rate (RHR) and heart rate variability (RMSSD) across 11,590 participants and 45,811 menstrual cycles. Within participants, RHR and RMSSD fluctuated in a regular pattern throughout the menstrual cycle, with population RHR\n                    <jats:sub>min<\/jats:sub>\n                    and RMSSD\n                    <jats:sub>max<\/jats:sub>\n                    at cycle day 5, RHR\n                    <jats:sub>max<\/jats:sub>\n                    at day 26, and RMSSD\n                    <jats:sub>min<\/jats:sub>\n                    at day 27. Cardiovascular amplitude was attenuated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in older participants and participants using birth control, suggesting the novel metric may mirror differences in hormonal fluctuations in these cohorts. Longitudinal tracking of cardiovascular amplitude may offer accessible non-invasive monitoring of female physiology and underlying health across the menstrual cycle.\n                  <\/jats:p>","DOI":"10.1038\/s41746-024-01394-0","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T01:59:49Z","timestamp":1734919189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Novel method for quantifying fluctuations in wearable derived daily cardiovascular parameters across the menstrual cycle"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6712-6570","authenticated-orcid":false,"given":"Summer R.","family":"Jasinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Presby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Grosicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-5693","authenticated-orcid":false,"given":"Emily R.","family":"Capodilupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"1394_CR1","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, Committee on Adolescence, American College of Obstetricians and Gynecologists & Committee on Adolescent Health Care. 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WHOOP is developing commercial products that build off the research presented in this manuscript and has filed a patent related to those inventions. The authors would like to declare the following patents\/patent applications associated with this research: the US application number is 18\/463,096. The patent name will be \u201c Coaching based on reproductive phases\u201d. This patent addresses coaching related to the cardiovascular amplitude of individuals. This does not alter our adherence to npj digital medicine policies on sharing data and materials.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"373"}}