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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Endometriosis is a common, chronic condition associated with debilitating pain, fatigue, and heterogeneous symptom presentation. In this exploratory study, 68 participants with confirmed endometriosis were monitored for up to three 4\u20136-week smartwatch cycles. We collected daily self-reports of pain and fatigue as well as retrospective questionnaires assessing quality of life, and we extracted daily measures of physical activity (PA), sleep, and diurnal rhythms from wrist-worn actigraphy data. We found that daily PA was strongly negatively correlated with self-reported fatigue (repeated measures correlations\n                    <jats:inline-formula>\n                      <jats:alternatives>\n                        <jats:tex-math>$$R &lt; -0.3$$<\/jats:tex-math>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                          <mml:mrow>\n                            <mml:mi>R<\/mml:mi>\n                            <mml:mo>&lt;<\/mml:mo>\n                            <mml:mo>\u2212<\/mml:mo>\n                            <mml:mn>0.3<\/mml:mn>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:alternatives>\n                    <\/jats:inline-formula>\n                    ) and that participants with more severe or variable symptom trajectories displayed lower levels of PA, greater sleep disturbance, and more disrupted sleep and activity rhythms (Spearman\u2019s\n                    <jats:inline-formula>\n                      <jats:alternatives>\n                        <jats:tex-math>$${|R|} &gt; 0.3$$<\/jats:tex-math>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                          <mml:mrow>\n                            <mml:mi>|R|<\/mml:mi>\n                            <mml:mo>&gt;<\/mml:mo>\n                            <mml:mn>0.3<\/mml:mn>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:alternatives>\n                    <\/jats:inline-formula>\n                    ). Lastly, we found evidence of sleep and PA changes following surgery for endometriosis that reflected change in self-reported symptoms. Collectively, our findings suggest that passive data collection using wrist-worn wearables in endometriosis could facilitate individualized objective insights into symptom trajectories.\n                  <\/jats:p>","DOI":"10.1038\/s41746-025-01629-8","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:14:41Z","timestamp":1746170081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Insights into endometriosis symptom trajectories and assessment of surgical intervention outcomes using longitudinal actigraphy"],"prefix":"10.1038","volume":"8","author":[{"given":"Katherine","family":"Edgley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa T. 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