{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:56:38Z","timestamp":1787003798973,"version":"build-2736575974"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2R01GM084019"],"award-info":[{"award-number":["2R01GM084019"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2R01GM084019"],"award-info":[{"award-number":["2R01GM084019"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2R01GM084019"],"award-info":[{"award-number":["2R01GM084019"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2R01GM084019"],"award-info":[{"award-number":["2R01GM084019"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2R01GM084019"],"award-info":[{"award-number":["2R01GM084019"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Catal"],"DOI":"10.1038\/s41929-025-01366-x","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:02:59Z","timestamp":1752483779000},"page":"678-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Enantioselective Pd-catalysed nucleophilic C(sp3)\u2013H (radio)fluorination"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-3310","authenticated-orcid":false,"given":"Nikita","family":"Chekshin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3170-6976","authenticated-orcid":false,"given":"Luo-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1451-0601","authenticated-orcid":false,"given":"D. Quang","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5453-513X","authenticated-orcid":false,"given":"Yuxin","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kap-Sun","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6685-2092","authenticated-orcid":false,"given":"Jennifer X.","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-5774","authenticated-orcid":false,"given":"Jin-Quan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"1366_CR1","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1126\/science.1131943","volume":"317","author":"K M\u00fcller","year":"2007","unstructured":"M\u00fcller, K., Faeh, C. & Diederich, F. Fluorine in pharmaceuticals: looking beyond intuition. Science 317, 1881\u20131886 (2007).","journal-title":"Science"},{"key":"1366_CR2","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1039\/B610213C","volume":"37","author":"S Purser","year":"2008","unstructured":"Purser, S., Moore, P. R., Swallow, S. & Gouverneur, V. Fluorine in medicinal chemistry. Chem. Soc. Rev. 37, 320\u2013330 (2008).","journal-title":"Chem. Soc. Rev."},{"key":"1366_CR3","doi-asserted-by":"publisher","first-page":"8315","DOI":"10.1021\/acs.jmedchem.5b00258","volume":"58","author":"EP Gillis","year":"2015","unstructured":"Gillis, E. P., Eastman, K. J., Hill, M. D., Donnelly, D. J. & Meanwell, N. A. Applications of fluorine in medicinal chemistry. J. Med. Chem. 58, 8315\u20138359 (2015).","journal-title":"J. Med. Chem."},{"key":"1366_CR4","doi-asserted-by":"publisher","first-page":"10633","DOI":"10.1021\/acsomega.0c00830","volume":"5","author":"M Inoue","year":"2020","unstructured":"Inoue, M., Sumii, Y. & Shibata, N. Contribution of organofluorine compounds to pharmaceuticals. ACS Omega 5, 10633\u201310640 (2020).","journal-title":"ACS Omega"},{"key":"1366_CR5","doi-asserted-by":"publisher","first-page":"109780","DOI":"10.1016\/j.cclet.2024.109780","volume":"35","author":"Q Wang","year":"2024","unstructured":"Wang, Q. et al. FDA approved fluorine-containing drugs in 2023. Chin. Chem. Lett. 35, 109780 (2024).","journal-title":"Chin. Chem. Lett."},{"key":"1366_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s43586-021-00042-1","volume":"1","author":"R Britton","year":"2021","unstructured":"Britton, R. et al. Contemporary synthetic strategies in organofluorine chemistry. Nat. Rev. Methods Primers 1, 47 (2021).","journal-title":"Nat. Rev. Methods Primers"},{"key":"1366_CR7","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1021\/acs.oprd.0c00030","volume":"24","author":"S Caron","year":"2020","unstructured":"Caron, S. Where does the fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds. Org. Process Res. Dev. 24, 470\u2013480 (2020).","journal-title":"Org. Process Res. Dev."},{"key":"1366_CR8","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1126\/science.adi1557","volume":"381","author":"C Patel","year":"2023","unstructured":"Patel, C. et al. Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF. Science 381, 302\u2013306 (2023).","journal-title":"Science"},{"key":"1366_CR9","doi-asserted-by":"publisher","first-page":"e202200325","DOI":"10.1002\/ajoc.202200325","volume":"11","author":"M Khandelwal","year":"2022","unstructured":"Khandelwal, M., Pemawat, G. & Kanwar Khangarot, R. Recent developments in nucleophilic fluorination with potassium fluoride (KF): a review. Asian J. Org. Chem. 11, e202200325 (2022).","journal-title":"Asian J. Org. Chem."},{"key":"1366_CR10","doi-asserted-by":"publisher","first-page":"9928","DOI":"10.1021\/jacs.3c01824","volume":"145","author":"INM Leibler","year":"2023","unstructured":"Leibler, I. N. M., Gandhi, S. S., Tekle-Smith, M. A. & Doyle, A. G. Strategies for nucleophilic C(sp3)-(radio)fluorination. J. Am. Chem. Soc. 145, 9928\u20139950 (2023).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR11","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1021\/cr0782426","volume":"108","author":"SM Ametamey","year":"2008","unstructured":"Ametamey, S. M., Honer, M. & Schubiger, P. A. Molecular imaging with PET. Chem. Rev. 108, 1501\u20131516 (2008).","journal-title":"Chem. Rev."},{"key":"1366_CR12","doi-asserted-by":"publisher","first-page":"13873","DOI":"10.1021\/acs.joc.1c01474","volume":"86","author":"R Halder","year":"2021","unstructured":"Halder, R. & Ritter, T. 18F-Fluorination: challenge and opportunity for organic chemists. J. Org. Chem. 86, 13873\u201313884 (2021).","journal-title":"J. Org. Chem."},{"key":"1366_CR13","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1021\/acscentsci.4c00997","volume":"10","author":"JS Wright","year":"2024","unstructured":"Wright, J. S., Sharninghausen, L. S., Lapsys, A., Sanford, M. S. & Scott, P. J. H. C\u2013H labeling with [18F]fluoride: an emerging methodology in radiochemistry. ACS Cent. Sci. 10, 1674\u20131688 (2024).","journal-title":"ACS Cent. Sci."},{"key":"1366_CR14","doi-asserted-by":"publisher","first-page":"5746","DOI":"10.1039\/D3QO00772C","volume":"10","author":"TG Luu","year":"2023","unstructured":"Luu, T. G. & Kim, H.-K. Recent progress on radiofluorination using metals: strategies for generation of C\u201318F bonds. Org. Chem. Front. 10, 5746\u20135781 (2023).","journal-title":"Org. Chem. Front."},{"key":"1366_CR15","doi-asserted-by":"publisher","first-page":"e202400605","DOI":"10.1002\/ejoc.202400605","volume":"27","author":"B Li","year":"2024","unstructured":"Li, B., Xu, M., Feng, P. & Xu, S. Electrochemical construction of C\u2013F bonds: recent advances and future perspectives. Eur. J. Org. Chem. 27, e202400605 (2024).","journal-title":"Eur. J. Org. Chem."},{"key":"1366_CR16","doi-asserted-by":"publisher","first-page":"109794","DOI":"10.1016\/j.jfluchem.2021.109794","volume":"247","author":"TT Bui","year":"2021","unstructured":"Bui, T. T., Hong, W. P. & Kim, H. K. Recent advances in visible light-mediated mluorination. J. Fluor. Chem. 247, 109794 (2021).","journal-title":"J. Fluor. Chem."},{"key":"1366_CR17","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1002\/asia.202100399","volume":"16","author":"TT Bui","year":"2021","unstructured":"Bui, T. T. & Kim, H. K. Recent advances in photo-mediated radiofluorination. Chem. Asian J. 16, 2155\u20132167 (2021).","journal-title":"Chem. Asian J."},{"key":"1366_CR18","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1039\/c2cc16158c","volume":"48","author":"C Hollingworth","year":"2012","unstructured":"Hollingworth, C. & Gouverneur, V. Transition metal catalysis and nucleophilic fluorination. Chem. Commun. 48, 2929\u20132942 (2012).","journal-title":"Chem. Commun."},{"key":"1366_CR19","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1021\/cr500366b","volume":"115","author":"MG Campbell","year":"2015","unstructured":"Campbell, M. G. & Ritter, T. Modern carbon\u2013fluorine bond forming reactions for aryl fluoride synthesis. Chem. Rev. 115, 612\u2013633 (2015).","journal-title":"Chem. Rev."},{"key":"1366_CR20","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1126\/science.1178239","volume":"325","author":"DA Watson","year":"2009","unstructured":"Watson, D. A. et al. Formation of ArF from LPdAr(F): catalytic conversion of aryl triflates to aryl fluorides. Science 325, 1661\u20131664 (2009).","journal-title":"Science"},{"key":"1366_CR21","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1126\/science.aar7941","volume":"360","author":"G Pupo","year":"2018","unstructured":"Pupo, G. et al. Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis. Science 360, 638\u2013642 (2018).","journal-title":"Science"},{"key":"1366_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1126\/science.aaf8078","volume":"353","author":"SM Banik","year":"2016","unstructured":"Banik, S. M., Medley, J. W. & Jacobsen, E. N. Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters. Science 353, 51\u201354 (2016).","journal-title":"Science"},{"key":"1366_CR23","doi-asserted-by":"publisher","first-page":"5004","DOI":"10.1021\/jacs.6b01183","volume":"138","author":"IG Moln\u00e1r","year":"2016","unstructured":"Moln\u00e1r, I. G. & Gilmour, R. Catalytic difluorination of olefins. J. Am. Chem. Soc. 138, 5004\u20135007 (2016).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR24","doi-asserted-by":"publisher","first-page":"16354","DOI":"10.1021\/ja9076588","volume":"131","author":"T Wu","year":"2009","unstructured":"Wu, T., Yin, G. & Liu, G. Palladium-catalyzed intramolecular aminofluorination of unactivated alkenes. J. Am. Chem. Soc. 131, 16354\u201316355 (2009).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR25","doi-asserted-by":"publisher","first-page":"14824","DOI":"10.1002\/anie.201814457","volume":"58","author":"R Szpera","year":"2019","unstructured":"Szpera, R., Moseley, D. F. J., Smith, L. B., Sterling, A. J. & Gouverneur, V. The fluorination of C\u2013H bonds: developments and perspectives. Angew. Chem. Int. Ed. 58, 14824\u201314848 (2019).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1366_CR26","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1126\/science.aav7019","volume":"364","author":"W Chen","year":"2019","unstructured":"Chen, W. et al. Direct arene C\u2013H fluorination with 18F\u2212 via organic photoredox catalysis. Science 364, 1170\u20131174 (2019).","journal-title":"Science"},{"key":"1366_CR27","doi-asserted-by":"publisher","first-page":"9342","DOI":"10.1021\/ja4047125","volume":"135","author":"T Truong","year":"2013","unstructured":"Truong, T., Klimovica, K. & Daugulis, O. Copper-catalyzed, directing group-assisted fluorination of arene and heteroarene C\u2013H bonds. J. Am. Chem. Soc. 135, 9342\u20139345 (2013).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR28","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1021\/ja909371t","volume":"132","author":"T Furuya","year":"2010","unstructured":"Furuya, T. et al. Mechanism of C\u2013F reductive elimination from palladium(IV) fluorides. J. Am. Chem. Soc. 132, 3793\u20133807 (2010).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR29","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1021\/ol301739f","volume":"14","author":"KB McMurtrey","year":"2012","unstructured":"McMurtrey, K. B., Racowski, J. M. & Sanford, M. S. Pd-catalyzed C\u2013H fluorination with nucleophilic fluoride. Org. Lett. 14, 4094\u20134097 (2012).","journal-title":"Org. Lett."},{"key":"1366_CR30","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3762\/bjoc.20.137","volume":"20","author":"AP Atkins","year":"2024","unstructured":"Atkins, A. P., Dean, A. C. & Lennox, A. J. J. Benzylic C(sp3)\u2013H fluorination. Beilstein J. Org. Chem. 20, 1527\u20131547 (2024).","journal-title":"Beilstein J. Org. Chem."},{"key":"1366_CR31","doi-asserted-by":"publisher","first-page":"12990","DOI":"10.1021\/ja407223g","volume":"135","author":"M Braun","year":"2013","unstructured":"Braun, M. & Doyle, A. G. Palladium-catalyzed allylic C\u2013H fluorination. J. Am. Chem. Soc. 135, 12990\u201312993 (2013).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR32","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1055\/s-0034-1378824","volume":"47","author":"C Chatalova-Sazepin","year":"2015","unstructured":"Chatalova-Sazepin, C., Hemelaere, R., Paquin, J. F. & Sammis, G. M. Recent advances in radical fluorination. Synthesis 47, 2554\u20132569 (2015).","journal-title":"Synthesis"},{"key":"1366_CR33","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1126\/science.1222327","volume":"337","author":"W Liu","year":"2012","unstructured":"Liu, W. et al. Oxidative aliphatic C\u2013H fluorination with fluoride ion catalyzed by a manganese porphyrin. Science 337, 1322\u20131325 (2012).","journal-title":"Science"},{"key":"1366_CR34","doi-asserted-by":"publisher","first-page":"6024","DOI":"10.1002\/anie.201301097","volume":"52","author":"W Liu","year":"2013","unstructured":"Liu, W. & Groves, J. T. Manganese-catalyzed oxidative benzylic C\u2013H fluorination by fluoride ions. Angew. Chem. Int. Ed. 52, 6024\u20136027 (2013).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1366_CR35","doi-asserted-by":"publisher","first-page":"14241","DOI":"10.1002\/anie.202004902","volume":"59","author":"D Bafaluy","year":"2020","unstructured":"Bafaluy, D., Georgieva, Z. & Mu\u00f1iz, K. Iodine catalysis for C(sp3)\u2013H fluorination with a nucleophilic fluorine source. Angew. Chem. Int. Ed. 59, 14241\u201314245 (2020).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1366_CR36","doi-asserted-by":"publisher","first-page":"6950","DOI":"10.1038\/s41467-021-27165-z","volume":"12","author":"INM Leibler","year":"2021","unstructured":"Leibler, I. N. M., Tekle-Smith, M. A. & Doyle, A. G. A general strategy for C(sp3)-H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor. Nat. Commun. 12, 6950 (2021).","journal-title":"Nat. Commun."},{"key":"1366_CR37","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/s44160-024-00578-6","volume":"3","author":"S Mal","year":"2024","unstructured":"Mal, S., Jurk, F., Hiesinger, K. & van Gemmeren, M. Pd-catalysed direct \u03b2-C(sp3)\u2013H fluorination of aliphatic carboxylic acids. Nat. Synth. 3, 1292\u20131298 (2024).","journal-title":"Nat. Synth."},{"key":"1366_CR38","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41557-018-0048-1","volume":"10","author":"H Park","year":"2018","unstructured":"Park, H., Verma, P., Hong, K. & Yu, J. Q. Controlling Pd(IV) reductive elimination pathways enables Pd(II)-catalysed enantioselective C(sp3)\u2013H fluorination. Nat. Chem. 10, 755\u2013762 (2018).","journal-title":"Nat. Chem."},{"key":"1366_CR39","doi-asserted-by":"publisher","first-page":"7067","DOI":"10.1021\/jacs.5b04088","volume":"137","author":"RY Zhu","year":"2015","unstructured":"Zhu, R. Y. et al. Ligand-enabled stereoselective \u03b2-C(sp3)\u2013H fluorination: synthesis of unnatural enantiopure anti-\u03b2-fluoro-\u03b1-amino acids. J. Am. Chem. Soc. 137, 7067\u20137070 (2015).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR40","doi-asserted-by":"publisher","first-page":"8219","DOI":"10.1021\/jacs.5b03989","volume":"137","author":"Q Zhang","year":"2015","unstructured":"Zhang, Q., Yin, X. S., Chen, K., Zhang, S. Q. & Shi, B. F. Stereoselective synthesis of chiral \u03b2-fluoro \u03b1-amino acids via Pd(II)-catalyzed fluorination of unactivated methylene C(sp3)\u2013H bonds: scope and mechanistic studies. J. Am. Chem. Soc. 137, 8219\u20138226 (2015).","journal-title":"J. Am. Chem. Soc."},{"key":"1366_CR41","doi-asserted-by":"publisher","first-page":"7354","DOI":"10.1002\/anie.201703311","volume":"56","author":"DA Nagib","year":"2017","unstructured":"Nagib, D. A. Catalytic desymmetrization by C\u2013H functionalization as a solution to the chiral methyl problem. Angew. Chem. Int. Ed. 56, 7354\u20137356 (2017).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1366_CR42","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/bit.260130204","volume":"13","author":"CT Goodhue","year":"1971","unstructured":"Goodhue, C. T. & Schaeffer, J. R. Preparation of l (+)\u2010\u03b2\u2010hydroxyisobutyric acid by bacterial oxidation of isobutyric acid. Biotechnol. Bioeng. 13, 203\u2013214 (1971).","journal-title":"Biotechnol. Bioeng."},{"key":"1366_CR43","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1002\/anie.201005142","volume":"50","author":"KM Engle","year":"2011","unstructured":"Engle, K. M., Mei, T. S., Wang, X. & Yu, J. Q. Bystanding F+ oxidants enable selective reductive elimination from high-valent metal centers in catalysis. Angew. Chem. Int. Ed. 50, 1478\u20131491 (2011).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1366_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300854","volume":"62","author":"C Yuan","year":"2023","unstructured":"Yuan, C., Wang, X. & Jiao, L. Ligand\u2010enabled palladium(II)\u2010catalyzed enantioselective \u03b2\u2010C(sp3)\u2013H arylation of aliphatic tertiary amides. Angew. Chem. Int. Ed. 62, e202300854 (2023).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1366_CR45","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao4798","volume":"359","author":"TG Saint-Denis","year":"2018","unstructured":"Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F. & Yu, J.-Q. Enantioselective C(sp3)\u2012H bond activation by chiral transition metal catalysts. Science 359, eaao4798 (2018).","journal-title":"Science"},{"key":"1366_CR46","doi-asserted-by":"publisher","first-page":"9738","DOI":"10.1021\/acscatal.1c02808","volume":"11","author":"TG Saint-Denis","year":"2021","unstructured":"Saint-Denis, T. G. et al. Mechanistic study of enantioselective Pd-catalyzed C(sp3)\u2013H activation of thioethers involving two distinct stereomodels. ACS Catal. 11, 9738\u20139753 (2021).","journal-title":"ACS Catal."},{"key":"1366_CR47","doi-asserted-by":"publisher","first-page":"11180","DOI":"10.1002\/chem.201501123","volume":"21","author":"GJ Cheng","year":"2015","unstructured":"Cheng, G. J. et al. A combined IM-MS\/DFT study on [Pd(MPAA)]-catalyzed enantioselective C\u2013H activation: relay of chirality through a rigid framework. Chem. Eur. J. 21, 11180\u201311188 (2015).","journal-title":"Chem. Eur. J."},{"key":"1366_CR48","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.1055\/s-0039-1690012","volume":"51","author":"S Thompson","year":"2019","unstructured":"Thompson, S. et al. Synthesis of [18F]-\u03b3-fluoro-\u03b1,\u03b2-unsaturated esters and ketones via vinylogous 18F-fluorination of \u03b1-diazoacetates with [18F]AgF. Synthesis 51, 4401\u20134407 (2019).","journal-title":"Synthesis"},{"key":"1366_CR49","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2967\/jnumed.117.199596","volume":"59","author":"DJ Donnelly","year":"2018","unstructured":"Donnelly, D. J. et al. Synthesis and biologic evaluation of a novel 18F-labeled adnectin as a PET radioligand for imaging PD-L1 expression. J. Nucl. Med. 59, 529\u2013535 (2018).","journal-title":"J. Nucl. Med."},{"key":"1366_CR50","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1039\/C3SC52367E","volume":"5","author":"JR Brandt","year":"2014","unstructured":"Brandt, J. R., Lee, E., Boursalian, G. B. & Ritter, T. Mechanism of electrophilic fluorination with Pd(IV): fluoride capture and subsequent oxidative fluoride transfer. Chem. Sci. 5, 169\u2013179 (2014).","journal-title":"Chem. Sci."},{"key":"1366_CR51","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1021\/om401240p","volume":"33","author":"MH Katcher","year":"2014","unstructured":"Katcher, M. H., Norrby, P. O. & Doyle, A. G. Mechanistic investigations of palladium-catalyzed allylic fluorination. Organometallics 33, 2121\u20132133 (2014).","journal-title":"Organometallics"}],"container-title":["Nature Catalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41929-025-01366-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41929-025-01366-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41929-025-01366-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T04:04:12Z","timestamp":1757217852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41929-025-01366-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["1366"],"URL":"https:\/\/doi.org\/10.1038\/s41929-025-01366-x","relation":{},"ISSN":["2520-1158"],"issn-type":[{"value":"2520-1158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"23 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"N.C., D.Q.P., Y.O. and J.-Q.Y. are inventors on a patent application related to this work (USSN patent application 63\/797,339) filed by The Scripps Research Institute. D.J.D., K.-S.Y. and J.X.Q. are employees of Bristol Myers Squibb. The authors declare no other competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}